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61. 外观设计

USD625730S1 Receiver 有权
标题翻译：接收器
公开(公告)号：USD625730S1
公开(公告)日：2010-10-19
申请号：US29352994
申请日：2009-12-30
申请人： Christopher M. Cacioppo , Manuel Perez , Hector Padilla , Timothy Higgins , Louis Frank Genatossio , Rick Burnham , Dan DeOreo
设计人： Christopher M. Cacioppo , Manuel Perez , Hector Padilla , Timothy Higgins , Louis Frank Genatossio , Rick Burnham , Dan DeOreo

62. 发明授权

US5531154A Combination outdoor cooker and smoker 失效
公开(公告)号：US5531154A
公开(公告)日：1996-07-02
申请号：US560665
申请日：1995-11-20
申请人： Manuel Perez, III
发明人： Manuel Perez, III
IPC分类号： A47J36/26 , F24C3/14 , A47J37/04 , A47J37/07
CPC分类号： A47J36/26 , F24C3/14
摘要： A combination outdoor cooker and smoker having a cooker configuration for use as an outdoor cooker and a smoker configuration for use as a smoker comprising a cooker assembly including substantially cylindrical hollow housing having a heat source therein and a support grate supported thereon disposed in heat exchange relationship relative to the heat source and a plurality of support legs attached to the substantially cylindrical hollow housing each having a first support configuration to support the combination outdoor cooker and smoker on a table and a second support configuration to support the combination outdoor cooker and smoker on the ground, a smoker enclosure detachably mountable on the cooker assembly when the combination outdoor cooker and smoker is in the smoker configuration and a retention assembly comprising a plurality of retention brackets attached to the cooker assembly each having a cooker retention configuration to retain a cooking utensil in operative relationship relative to the support grate when the combination cooker and smoker is in the cooker configuration and a smoker retention configuration to retain the smoke enclosure in operative relationship relative to the support grate when the combination cooker and smoker is in the smoker configuration.

63. 发明授权

US11746329B2 Systems and methods for producing injectable enhanced stem cell exosomes, improved exosomes and methods of use 有权
公开(公告)号：US11746329B2
公开(公告)日：2023-09-05
申请号：US17119170
申请日：2020-12-11
申请人： Sharan Ramaswamy , Manuel Perez , Yih-Mei Lin
发明人： Sharan Ramaswamy , Manuel Perez , Yih-Mei Lin
IPC分类号： C12N5/0775 , A61K9/00 , A61K35/28 , C07K14/765 , C07K14/47 , A61P9/10
CPC分类号： C12N5/0663 , A61K9/0019 , A61K35/28 , A61P9/10 , C07K14/47 , C07K14/4717 , C07K14/765 , C12N2521/00 , C12N2533/40 , C12N2533/92
摘要： This disclosure pertains to a non-living biological product. Particularly, exosomes derived from stem cells can help restore heart function. According to certain embodiments, a fluid-induced shear stress mechanical stimulation process of stem cells is used to augmented quantity and quality of exosomes produced from stem cells. These exosomes serve as a therapeutic agent for the regenerative repair of diseases, such as diseased heart tissues. Therefore, compositions comprising the exosomes derived from stem cells and methods of treating a degenerative disease by administering the exosomes isolated from stem cells are also provided.

64. 发明授权

US10213458B2 Differential tumor cell cytotoxicity via contact with coated cerium oxide nanoparticles 有权
公开(公告)号：US10213458B2
公开(公告)日：2019-02-26
申请号：US14862548
申请日：2015-09-23
申请人： Jesus Manuel Perez , Atul Asati , Santimukul Santra , Charalambos Kaittanis
发明人： Jesus Manuel Perez , Atul Asati , Santimukul Santra , Charalambos Kaittanis
IPC分类号： A61K9/50 , A61K33/24 , A61K9/51
摘要： Differential surface-charge-dependent localization of nanoceria in normal cells and cancer cells plays a critical role in the toxicity profile of a nanoceria particle. Engineered surface-coated cerium oxide nanoparticles with different surface charges that are positive, negative and neutral provide therapeutic results for normal and cancer cell lines. Results show that nanoceria with a positive or neutral charge enters most of the cell lines studied, while nanoceria with a negative charge internalizes mostly in the cancer cell lines. Moreover, upon entry into the cells, nanoceria is localized to different cell compartments (e.g. cytoplasm and lysosomes) depending on the nanoparticle surface charge. The internalization and subcellular localization of nanoceria plays a key role in the nanoparticle cytotoxicity profile, exhibiting significant toxicity when they localize in the lysosomes of the cancer cell lines. In contrast, minimal toxicity is observed when they localize into the cytoplasm or do not enter the cells.

65. 发明申请

US20180229394A1 STRUCTURAL BUTT FINGER JOINT FOR FLAT BOARDS 审中-公开
公开(公告)号：US20180229394A1
公开(公告)日：2018-08-16
申请号：US15537000
申请日：2015-12-15
申请人： Manuel Perez-Romero , Jaime Tarazona-Lizarraga
发明人： Manuel Perez-Romero , Jaime Tarazona-Lizarraga
IPC分类号： B27F1/16 , B27M3/00 , F16B12/04
摘要： The present invention relates to a structural joint for attaching two boards by their butts, achieving the correct transmission of forces between them by means of a staggered configuration of the butts thereof to increase the contact surface between both boards, allowing the mutual coupling thereof, both being aligned and coplanar, and at least one of the steps of both boards having a finger profile to further increase the contact surface between both boards.

66. 发明申请

US20160074334A1 Differential Tumor Cell Cytotoxicity Via Contact With Coated Cerium Oxide Nanoparticles 审中-公开
标题翻译：通过与涂覆的氧化铈纳米颗粒接触的差异肿瘤细胞的细胞毒性
公开(公告)号：US20160074334A1
公开(公告)日：2016-03-17
申请号：US14862548
申请日：2015-09-23
申请人： Jesus Manuel Perez , Atul Asati , Santimukul Santra , Charalambos Kaittanis
发明人： Jesus Manuel Perez , Atul Asati , Santimukul Santra , Charalambos Kaittanis
IPC分类号： A61K9/50 , A61K33/24
CPC分类号： A61K33/24 , A61K9/5138 , A61K9/5161
摘要： Differential surface-charge-dependent localization of nanoceria in normal cells and cancer cells plays a critical role in the toxicity profile of a nanoceria particle. Engineered surface-coated cerium oxide nanoparticles with different surface charges that are positive, negative and neutral provide therapeutic results for normal and cancer cell lines. Results show that nanoceria with a positive or neutral charge enters most of the cell lines studied, while nanoceria with a negative charge internalizes mostly in the cancer cell lines. Moreover, upon entry into the cells, nanoceria is localized to different cell compartments (e.g. cytoplasm and lysosomes) depending on the nanoparticle surface charge. The internalization and subcellular localization of nanoceria plays a key role in the nanoparticle cytotoxicity profile, exhibiting significant toxicity when they localize in the lysosomes of the cancer cell lines. In contrast, minimal toxicity is observed when they localize into the cytoplasm or do not enter the cells.
摘要翻译：正常细胞和癌细胞中纳米囊的差异表面电荷依赖性定位在纳米颗粒的毒性特征中起关键作用。具有正，负和中性的不同表面电荷的工程表面包覆的氧化铈纳米颗粒为正常和癌细胞系提供治疗结果。结果表明，具有阳性或中性电荷的纳米药物进入研究的大部分细胞系，而具有负电荷的纳米药物主要在癌细胞系中内化。此外，在进入细胞后，根据纳米颗粒的表面电荷，将纳米片定位于不同的细胞区室（例如细胞质和溶酶体）。纳米颗粒的内化和亚细胞定位在纳米颗粒细胞毒性谱中起关键作用，当它们定位在癌细胞系的溶酶体中时显示出显着的毒性。相比之下，当它们定位到细胞质中或不进入细胞时，观察到最小的毒性。

67. 发明授权

US09057094B1 Nanoparticle-mediated methods for antimicrobial susceptibility testing of bacteria 有权
标题翻译：纳米粒子介导的细菌抗菌药敏试验方法
公开(公告)号：US09057094B1
公开(公告)日：2015-06-16
申请号：US12258785
申请日：2008-10-27
申请人： J. Manuel Perez , Charalambos Kaittanis , Sudip Nath
发明人： J. Manuel Perez , Charalambos Kaittanis , Sudip Nath
IPC分类号： C12Q1/18 , B82Y30/00 , A61K49/18
CPC分类号： C12Q1/18 , A61K49/1821 , B82Y15/00 , B82Y30/00
摘要： A method of testing bacterial cells for antimicrobial susceptibility includes preparing a suspension of the bacterial cells in a non-nutrient medium, mixing with the suspension an antimicrobial, a carbohydrate usable by the bacterial cells, metallic nanoparticles, and a lectin, and incubating the mixture while monitoring a parameter of the nanoparticles responsive to use of the carbohydrate by the bacterial cells. More broadly stated, the invention includes a method of testing an agent for its effect on cell metabolism by preparing a suspension of cells in a non-nutrient medium, mixing the suspension with the agent, adding a carbohydrate usable by the cells, metallic nanoparticles, and a lectin with binding specificity for the added carbohydrate, and monitoring a nanoparticle parameter responsive to the cells.
摘要翻译：测试细菌细胞用于抗微生物敏感性的方法包括在非营养培养基中制备细菌细胞的悬浮液，与悬浮液混合抗微生物剂，由细菌细胞可用的碳水化合物，金属纳米颗粒和凝集素，并将混合物同时监测响应于细菌细胞使用碳水化合物的纳米颗粒的参数。更广泛地说，本发明包括通过制备非营养培养基中的细胞悬浮液，将悬浮液与试剂混合，加入细胞可用的碳水化合物，金属纳米颗粒，以及对加入的碳水化合物具有结合特异性的凝集素，以及响应于细胞监测纳米颗粒参数。

68. 发明申请

US20130157242A1 GENERATING AND EVALUATING LEARNING ACTIVITIES FOR AN EDUCATIONAL ENVIRONMENT 审中-公开
标题翻译：生成和评估教育环境的学习活动
公开(公告)号：US20130157242A1
公开(公告)日：2013-06-20
申请号：US13595534
申请日：2012-08-27
申请人： Christopher Leonardo , Karen Mahon , Manuel Perez , Joseph Rocco , Kosmas Karadimitriou , Alyssa Porter , Christopher Cacioppo
发明人： Christopher Leonardo , Karen Mahon , Manuel Perez , Joseph Rocco , Kosmas Karadimitriou , Alyssa Porter , Christopher Cacioppo
IPC分类号： G09B7/00
CPC分类号： G09B7/00 , G09B7/02 , G09B7/07
摘要： An educational activity system allows a teacher to specify activity parameters, such as subject, grade level, and template format that define an activity for one or more students to complete on a computer. The system then uses the selected activity parameters to determine appropriate subject matter from a content asset database and generates an activity incorporating the determined appropriate subject matter. After a student completed the activity via a computer, the system evaluates the completed activity for correctness and stores the results of each student in a student performance database.
摘要翻译：教育活动系统允许教师指定活动参数，例如主题，年级和模板格式，以定义一个或多个学生在计算机上完成的活动。然后，系统使用所选择的活动参数来从内容资产数据库确定适当的主题，并生成包含确定的适当主题的活动。在学生通过计算机完成活动后，系统会对完成的活动进行评估，以确定是否正确，并将每个学生的结果存储在学生成绩数据库中。

69. 发明授权

US08409463B1 Aqueous method for making magnetic iron oxide nanoparticles 失效
标题翻译：制备磁性氧化铁纳米粒子的水性方法
公开(公告)号：US08409463B1
公开(公告)日：2013-04-02
申请号：US12174169
申请日：2008-07-16
申请人： Jesus Manuel Perez , Sudip Nath
发明人： Jesus Manuel Perez , Sudip Nath
IPC分类号： C04B35/04
CPC分类号： A61K49/1863 , A61K49/1836 , A61K49/1848 , A61K49/1866 , B82Y30/00 , C01G49/08 , C01P2002/72 , C01P2002/85 , C01P2004/04 , C01P2004/16 , C01P2004/32 , C01P2004/62 , C01P2004/84 , C01P2006/42
摘要： The invention discloses an aqueous method of making polymer coated superparamagnetic nanoparticles. The method comprises providing a mixture of iron salts in an aqueous solution of hydrochloric acid. A solution of ammonium hydroxide is added to the mixture and stirred. Stirring continues with an aqueous solution of one or more biocompatible polymers so as to promote formation of polymer coated iron nanoparticles in suspension, wherein optionally at least one of the polymers in the coating may be aminated. Centrifuging the suspension leaves a supernatant without large particles. Filtering the supernatant through an ultrafiltration membrane and collecting the filtrate recovers polymer coated nanoparticles. Crosslinking the polymer is effected by treatment with a solution of epichlorohydrin and sodium hydroxide while stirring vigorously for up to about eight hours. Optionally aminating the polymer may be accomplished by treatment with ammonia after crosslinking and then removing remaining free epichlorohydrin. Nanoparticles made by the method are included in the invention.
摘要翻译：本发明公开了一种制备聚合物涂覆的超顺磁性纳米颗粒的水性方法。该方法包括在盐酸水溶液中提供铁盐的混合物。向混合物中加入氢氧化铵溶液并搅拌。用一种或多种生物相容性聚合物的水溶液继续搅拌，以促进在悬浮液中形成聚合物涂覆的铁纳米颗粒，其中任选地，涂层中的至少一种聚合物可以被胺化。离心悬浮液留下没有大颗粒的上清液。通过超滤膜过滤上清液并收集滤液回收聚合物涂覆的纳米颗粒。聚合物的交联通过用表氯醇和氢氧化钠溶液处理，同时剧烈搅拌长达约8小时来实现。任选地胺化聚合物可以通过在交联后用氨处理然后除去剩余的游离表氯醇来完成。通过该方法制造的纳米颗粒包括在本发明中。

70. 发明申请

US20120010183A1 Chemical Compounds 有权
标题翻译：化学化合物
公开(公告)号：US20120010183A1
公开(公告)日：2012-01-12
申请号：US13179587
申请日：2011-07-11
申请人： Andrew Simon Bell , Alan Daniel Brown , Marcel John De Groot , Russell Andrew Lewthwaite , Ian Roger Marsh , David Simon Millan , Manuel Perez Pacheco , David James Rawson , Nunzio Sciammetta , Robert Ian Storer , Nigel Alan Swain , Steven Matthieu Gaulier
发明人： Andrew Simon Bell , Alan Daniel Brown , Marcel John De Groot , Russell Andrew Lewthwaite , Ian Roger Marsh , David Simon Millan , Manuel Perez Pacheco , David James Rawson , Nunzio Sciammetta , Robert Ian Storer , Nigel Alan Swain , Steven Matthieu Gaulier
IPC分类号： A61K31/44 , C07D401/04 , C07D215/20 , C07D405/12 , C07D231/56 , A61P29/00 , A61K31/506 , A61K31/47 , A61K31/4427 , A61K31/416 , A61K31/4545 , A61K31/4439 , C07D213/69 , C07D401/12
CPC分类号： C07D213/69 , C07D213/63 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/74 , C07D213/85 , C07D215/20 , C07D231/56 , C07D239/47 , C07D401/04 , C07D405/12 , C07D487/04
摘要： The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes.More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein Het1, X, R1, R2, R3, R4 and R5 are as defined in the description.Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
摘要翻译：本发明涉及磺酰胺衍生物，其在医学上的用途，含有它们的组合物，其制备方法以及在这些方法中使用的中间体。更具体地，本发明涉及式（I）的新的磺酰胺Nav1.7抑制剂：或其药学上可接受的盐，其中Het1，X，R1，R2，R3，R4和R5如说明书中所定义。 Nav 1.7抑制剂可用于治疗各种疾病，特别是疼痛。

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