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    • 61. 发明申请
    • MULTICOMPONENT VACCINES
    • 多器官疫苗
    • US20100150956A1
    • 2010-06-17
    • US12710790
    • 2010-02-23
    • JOSEPH M. PATTITIMOTHY J. FOSTERMAGNUS HOOK
    • JOSEPH M. PATTITIMOTHY J. FOSTERMAGNUS HOOK
    • A61K39/085A61P31/04A61K39/385
    • C07K16/1271A61K39/085
    • Multicomponent vaccines are provided which aid in the prevention and treatment of staphylococcal infections and which include certain selected combinations of bacterial binding proteins or fragments thereof, or antibodies to those proteins or fragments. By careful selection of the proteins, fragments, or antibodies, a vaccine is provided that imparts protection against a broad spectrum of Staphylococcus and other bacterial strains and against proteins that are expressed at different stages of the logarithmic growth curve. In one embodiment of the invention, a composition is provided that includes a fibrinogen binding domain of a fibrinogen binding protein and a bacterial component such as a capsular polysaccharide, and both active and passive vaccines based on these components are also provided, along with methods of treating infection using these compositions and vaccines.
    • 提供了有助于预防和治疗葡萄球菌感染的多组分疫苗,其包括某些所选择的细菌结合蛋白或其片段的组合,或对那些蛋白质或片段的抗体。 通过仔细选择蛋白质,片段或抗体,提供疫苗,其对广泛的葡萄球菌和其他细菌菌株和针对在对数生长曲线的不同阶段表达的蛋白质提供保护。 在本发明的一个实施方案中,提供了包括纤维蛋白原结合蛋白的纤维蛋白原结合结构域和诸如荚膜多糖的细菌组分的组合物,以及基于这些组分的主动和被动疫苗以及方法 使用这些组合物和疫苗治疗感染。
    • 62. 发明授权
    • Multicomponent vaccines
    • 多组分疫苗
    • US07666438B1
    • 2010-02-23
    • US10795267
    • 2004-03-09
    • Joseph M. PattiTimothy J. FosterMagnus Hook
    • Joseph M. PattiTimothy J. FosterMagnus Hook
    • A61K39/085
    • C07K16/1271A61K39/085
    • Multicomponent vaccines are provided which aid in the prevention and treatment of staphylococcal infections and which include certain selected combinations of bacterial binding proteins or fragments thereof, or antibodies to those proteins or fragments. By careful selection of the proteins, fragments, or antibodies, a vaccine is provided that imparts protection against a broad spectrum of Staphylococcus and other bacterial strains and against proteins that are expressed at different stages of the logarithmic growth curve. In one embodiment of the invention, a composition is provided that includes a fibrinogen binding domain of a fibrinogen binding protein and a bacterial component such as ca capsular polysaccharide, and both active and passive vaccines based on these components are also provided, along with methods of treating infection using these compositions and vaccines.
    • 提供了有助于预防和治疗葡萄球菌感染的多组分疫苗,其包括某些所选择的细菌结合蛋白或其片段的组合,或对那些蛋白质或片段的抗体。 通过仔细选择蛋白质,片段或抗体,提供疫苗,其对广泛的葡萄球菌和其他细菌菌株和针对在对数生长曲线的不同阶段表达的蛋白质提供保护。 在本发明的一个实施方案中,提供了包含纤维蛋白原结合蛋白的纤维蛋白原结合结构域和诸如ca荚膜多糖的细菌组分的组合物,并且还提供了基于这些组分的主动和被动疫苗以及两者的方法 使用这些组合物和疫苗治疗感染。
    • 66. 发明授权
    • Multicomponent vaccines
    • 多组分疫苗
    • US06703025B1
    • 2004-03-09
    • US09386959
    • 1999-08-31
    • Joseph M. PattiTimothy J. FosterMagnus Hook
    • Joseph M. PattiTimothy J. FosterMagnus Hook
    • A61K39085
    • C07K16/1271A61K39/085
    • Multicomponent vaccines are provided which aid in the prevention and treatment of staphylococcal infections and which include certain selected combinations of bacterial binding proteins or fragments thereof, or antibodies to those proteins or fragments. By careful selection of the proteins, fragments, or antibodies, a vaccine is provided that imparts protection against a broad spectrum of Staphylococcus bacterial strains and against proteins that are expressed at different stages of the logarithmic growth curve. In one embodiment of the invention, a composition is provided that includes at least a collagen binding protein or peptide (or an appropriate site directed mutated sequence thereof) such as CNA, or a protein or fragment with sufficiently high homology thereto, in combination with a fibrinogen binding protein, preferably Clumping factor A (“ClfA”) or Clumping factor B (“ClfB”), or a useful fragment thereof or a protein or fragment with sufficiently high homology thereto. The vaccines and products of the present invention are advantageous in that they respond to the urgent need of the medical community for a substitute for small molecule antibiotics, which are rapidly losing effectiveness and provide effective combinations of the large number of known bacterial surface adhesins which can impart effective protection against a broad spectrum of bacterial infections.
    • 提供了有助于预防和治疗葡萄球菌感染的多组分疫苗,其包括某些所选择的细菌结合蛋白或其片段的组合,或对那些蛋白质或片段的抗体。 通过仔细选择蛋白质,片段或抗体,提供疫苗,其对广泛的葡萄球菌细菌菌株和针对在对数生长曲线的不同阶段表达的蛋白质提供保护。 在本发明的一个实施方案中,提供了一种组合物,其包含至少一种胶原结合蛋白或肽(或其适当的定点突变的序列),例如CNA或与其具有足够高同源性的蛋白质或片段,与 纤维蛋白原结合蛋白,优选结合因子A(“ClfA”)或凝集因子B(“ClfB”)或其有用片段或与其同源性具有足够高同源性的蛋白质或片段。 本发明的疫苗和产品是有利的,因为它们响应医学界迫切需要替代小分子抗生素,其正在快速丧失有效性并提供大量已知细菌表面粘附素的有效组合,其可以 有效保护免受广泛的细菌感染。