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1. 发明授权

US07968100B2 Surface proteins from coagulase-negative staphylococci and Staphylococcus aureus that generate cross-reactive monoclonal and polyclonal antibodies 有权
标题翻译：产生交叉反应性单克隆和多克隆抗体的来自凝固酶阴性葡萄球菌和金黄色葡萄球菌的表面蛋白
公开(公告)号：US07968100B2
公开(公告)日：2011-06-28
申请号：US12365481
申请日：2009-02-04
申请人： Timothy Foster , Fiona Roche , Mark Pallen , Joseph M. Patti , Jeff T. Hutchins , Pietro Speziale
发明人： Timothy Foster , Fiona Roche , Mark Pallen , Joseph M. Patti , Jeff T. Hutchins , Pietro Speziale
IPC分类号： A61K39/085 , A61K38/16 , G01N33/569
CPC分类号： C07K16/1271
摘要： Surface proteins are provided which generate polyclonal and monoclonal antibodies which are cross-reactive to both coagulase-positive staphylococcus bacteria, such as S. aureus and to coagulase-negative bacteria, such as S. epidermidis and S. hemolyticus. The antibodies may be generated from surface proteins that have been isolated on the basis of characteristics that may be common between S. aureus and coagulase-negative staphylococci, or the A domains of those surface proteins, and these recombinant surface proteins are used to generate the cross-reactive antibodies. Vaccines comprising an immunologically effective amount of the proteins are also provided, and these vaccines are used in methods for the treatment or protection against a wide variety of staphylococcal infections.
摘要翻译：提供了表达蛋白，其产生与凝固酶阳性葡萄球菌如金黄色葡萄球菌和凝血酶阴性细菌如表皮葡萄球菌和溶血性葡萄球菌的交叉反应性的多克隆和单克隆抗体。抗体可以从基于在金黄色葡萄球菌和凝固酶阴性葡萄球菌或这些表面蛋白质的A结构域可能是常见的特征分离的表面蛋白产生，并且这些重组表面蛋白质用于产生交叉反应性抗体。还提供了包含免疫有效量的蛋白质的疫苗，并且这些疫苗用于治疗或保护免受各种葡萄球菌感染的方法中。

2. 发明授权

US07241592B2 Cross-reactive displacing antibodies from collagen-binding proteins and method of identification and use 有权
标题翻译：来自胶原蛋白结合蛋白的交叉反应置换抗体及鉴定和使用方法
公开(公告)号：US07241592B2
公开(公告)日：2007-07-10
申请号：US09810428
申请日：2001-03-19
申请人： Magnus Hook , Yi Xu , Pietro Speziale , Livia Visal , Fabrizia Casolini , Joseph M. Patti , Pratiksha Patel , Paul Domanski
发明人： Magnus Hook , Yi Xu , Pietro Speziale , Livia Visal , Fabrizia Casolini , Joseph M. Patti , Pratiksha Patel , Paul Domanski
IPC分类号： C12P21/08 , C12N1/00 , A61K39/395 , A61K39/40 , C07K16/12
CPC分类号： C07K16/1271 , A61K39/085 , A61K2039/505 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/56938 , G01N2333/31 , G01N2333/78 , G01N2500/00
摘要： Antibodies to the CNA protein and to other regions from the collagen binding domain, including domain CNA19, are provided, and antibodies produced in this manner have been shown to be cross reactive to both Staphylococcus aureus and Staphylococcus epidermidis bacteria and which can thus be used in the prevention and treatment of infections caused by both of these types of bacteria. In addition, medical instruments can be treated using the antibodies of the invention in order to reduce or eliminate the possibility of their becoming infected or further spreading the infection. In particular, the proteins are advantageous because they are cross-reactive and may thus be administered to patients so as to reduce or prevent severe infection by staphylococcal bacteria of more than one species. Antibodies generated in this manner have also been shown to exhibit displacement activity and can thus be utilized advantageously in methods wherein these antibodies will be administered to patients having pre-existing staphylococcal infections because of the ability to displace bacterial proteins from binding sites on the extracellular matrix. Finally, a method of identifying, isolating and utilizing displacing antibodies is also provided.
摘要翻译：提供了对CNA蛋白和来自胶原结合结构域的其他区域（包括结构域CNA19）的抗体，并且以这种方式产生的抗体已显示与金黄色葡萄球菌和表皮葡萄球菌交叉反应，因此可以用于预防和治疗由这两种细菌引起的感染。此外，可以使用本发明的抗体治疗医疗器械，以便减少或消除它们被感染或进一步扩散感染的可能性。特别地，蛋白质是有利的，因为它们是交叉反应性的，并且因此可以施用于患者，以便减少或预防多于一种物种的葡萄球菌细菌的严重感染。以这种方式产生的抗体也已显示出显示置换活性，因此可有利地用于其中将这些抗体施用于具有预先存在的葡萄球菌感染的患者的方法，因为能够从细胞外基质上的结合位点置换细菌蛋白质。最后，还提供了鉴定，分离和利用置换抗体的方法。

3. 发明授权

US06288214B1 Collagen binding protein compositions and methods of use 失效
标题翻译：胶原蛋白结合蛋白组合物和使用方法
公开(公告)号：US06288214B1
公开(公告)日：2001-09-11
申请号：US08856253
申请日：1997-05-14
申请人： Magnus Höök , Joseph M. Patti , Karen House-Pompeo , Narayana Sthanam , Jindrich Symersky
发明人： Magnus Höök , Joseph M. Patti , Karen House-Pompeo , Narayana Sthanam , Jindrich Symersky
IPC分类号： C07K1600
CPC分类号： C07K14/31 , A61K38/00 , A61K39/00 , C07K16/1271 , C07K2317/77
摘要： Disclosed are the cna gene and cna-derived nucleic acid segments from Staphylococcus aureus, and DNA segments encoding cna from related bacteria. Also disclosed are Col binding protein (CBP) compositions and methods of use. The CBP protein and antigenic epitopes derived therefrom are contemplated for use in the treatment of pathological infections, and in particular, for use in the prevention of bacterial adhesion to Col. DNA segments encoding these proteins and anti-(Col binding protein) antibodies will also be of use in various screening, diagnostic and therapeutic applications including active and passive immunization and methods for the prevention of bacterial colonization in an animal such as a human. These DNA segments and the peptides derived therefrom are contemplated for use in the preparation of vaccines and, also, for use as carrier proteins in vaccine formulations, and in the formulation of compositions for use in the prevention of S. aureus infection.
摘要翻译：公开了来自金黄色葡萄球菌的cna基因和cna衍生的核酸片段以及编码来自相关细菌的cna的DNA片段。还公开了Col结合蛋白（CBP）组合物和使用方法。 CBP蛋白和源自其的抗原表位被考虑用于治疗病理感染，特别是用于预防细菌粘附到Col。编码这些蛋白质的DNA片段和抗（Col结合蛋白）抗体也将可用于各种筛选，诊断和治疗应用，包括主动和被动免疫以及用于预防动物如人的细菌定植的方法。这些DNA片段及其衍生的肽被考虑用于疫苗的制备，也用作疫苗制剂中的载体蛋白，以及用于预防金黄色葡萄球菌感染的组合物的配方。

4. 发明授权

US5830710A Cloned porphyromonas gingivalis genes and probes for the detection of periodontal disease 失效
标题翻译：克隆牙龈卟啉单胞菌基因和探针，用于检测牙周病
公开(公告)号：US5830710A
公开(公告)日：1998-11-03
申请号：US353485
申请日：1994-12-09
申请人： Ann Progulske-Fox , Somying Tumwasorn , Guylaine Lepine , Naiming Han , Marilyn Lantz , Joseph M. Patti
发明人： Ann Progulske-Fox , Somying Tumwasorn , Guylaine Lepine , Naiming Han , Marilyn Lantz , Joseph M. Patti
IPC分类号： C12N15/02 , A61K31/00 , A61K38/00 , A61K39/00 , A61K39/02 , A61P1/00 , A61P1/02 , C07K14/195 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/52 , C12N15/09 , C12N15/31 , C12P21/08 , C12Q1/68 , G01N33/569 , C12P19/34 , C07H19/00
CPC分类号： C12N9/52 , C07K14/195 , A61K38/00 , A61K39/00
摘要： DNA fragments from Porphyromonas gingivalis which express proteins that elicit anti-P. gingivalis immunologic responses are described. Microorganisms, genetically modified to express P. gingivalis antigens, are provided. Also disclosed are probes, vaccines, and monoclonal antibodies for the detection and prevention of periodontal disease.
摘要翻译：来自牙龈卟啉单胞菌的DNA片段，其表达引起抗P的蛋白质。描述牙龈免疫反应。提供基因修饰以表达牙龈卟啉菌抗原的微生物。还公开了用于检测和预防牙周病的探针，疫苗和单克隆抗体。

5. 发明授权

US5648240A MHC II analog from Staphylococcus aureus 失效
标题翻译：来自金黄色葡萄球菌的MHC II类似物
公开(公告)号：US5648240A
公开(公告)日：1997-07-15
申请号：US248021
申请日：1994-05-24
申请人： Magnus Hook , Klas Jonsson , Joseph M. Patti , Sivashankarappa Gurusiddappa
发明人： Magnus Hook , Klas Jonsson , Joseph M. Patti , Sivashankarappa Gurusiddappa
IPC分类号： A61K39/00 , C07K14/31 , C12N15/31 , A61K39/085
CPC分类号： C07K14/31 , A61K39/00 , Y10S530/825
摘要： Staphylococcus aureus can bind a number of different extracellular matrix proteins. Recent studies have shown that one particular Staphylococcus protein has the capacity of binding several different matrix proteins. The gene encoding this staphylococcal protein has been cloned and sequenced and the nucleic acid and amino acid sequences are provided as a feature of the present invention. This staphylococcal protein has a high degree of homology with eukaryotic MHC Class II antigens. Further analyses of the binding specificities of this protein reveal that it functionally resembles an MHC II antigen in that it binds synthetic peptides. Additionally, the present invention provides a vaccine and an in vivo vaccine against staphylococcal infections, and methods for using same.
摘要翻译：金黄色葡萄球菌可以结合许多不同的细胞外基质蛋白质。最近的研究表明，一种特定的葡萄球菌蛋白具有结合几种不同基质蛋白的能力。编码该葡萄球菌蛋白质的基因已经被克隆和测序，并且提供了核酸和氨基酸序列作为本发明的特征。这种葡萄球菌蛋白与真核MHC II类抗原具有高度的同源性。该蛋白质的结合特异性的进一步分析表明，它功能上类似于MHC II抗原，因为它结合合成肽。另外，本发明提供了针对葡萄球菌感染的疫苗和体内疫苗及其使用方法。

6. 发明授权

US08377451B2 Polysaccharide-staphylococcal surface adhesin carrier protein conjugates for immunization against nosocomial infections 有权
标题翻译：多糖 - 葡萄球菌表面粘附素载体蛋白结合物免疫接种医院感染
公开(公告)号：US08377451B2
公开(公告)日：2013-02-19
申请号：US11593481
申请日：2006-11-07
申请人： Viliam Pavliak , Steven Morris Baker , Subramonia Padmanaba Pillai , Joseph M. Patti , Bradley D. Prater
发明人： Viliam Pavliak , Steven Morris Baker , Subramonia Padmanaba Pillai , Joseph M. Patti , Bradley D. Prater
IPC分类号： A61K39/02
CPC分类号： C07K14/31 , A61K39/085 , A61K39/092 , A61K47/61 , A61K47/646 , A61K2039/6068
摘要： Immunogenic polysaccharide-protein conjugates having a polysaccharide antigen (or its oligosaccharide fragment representing one or more antigenic epitopes) derived from a nosocomial pathogen conjugated to a staphylococcal surface adhesin carrier protein are used in immunogenic compositions to elicit antibody responses to both the polysaccharide antigen and the staphylococcal surface adhesin carrier protein. Such immunogenic compositions are used to immunize against diseases caused by Staphylococcal aureus, Staphylococcal epidermidis or other nosocomial pathogens.
摘要翻译：具有衍生自与葡萄球菌表面粘附素载体蛋白缀合的医院病原体的多糖抗原（或其代表一个或多个抗原表位的寡糖片段）的免疫原性多糖 - 蛋白质缀合物用于免疫原性组合物以引发对多糖抗原和葡萄球菌表面粘附素载体蛋白。这样的免疫原性组合物用于免疫金黄色葡萄球菌，表皮葡萄球菌或其他医院病原体引起的疾病。

7. 发明授权

US07850974B2 Bioinformatic method for identifying surface-anchored proteins from gram-positive bacteria and proteins obtained thereby 有权
标题翻译：用于从革兰氏阳性细菌和由此获得的蛋白质中鉴定表面锚定蛋白的生物信息学方法
公开(公告)号：US07850974B2
公开(公告)日：2010-12-14
申请号：US12575909
申请日：2009-10-08
申请人： Magnus Hook , Yi Xu , Jouko V. Sillanpaa , Narayana Sthanam , Karthe Ponnuraj , Joseph M. Patti , Jeff T. Hutchins , Andrea Hall , Maria G. Bowden
发明人： Magnus Hook , Yi Xu , Jouko V. Sillanpaa , Narayana Sthanam , Karthe Ponnuraj , Joseph M. Patti , Jeff T. Hutchins , Andrea Hall , Maria G. Bowden
IPC分类号： A61K39/02
CPC分类号： G01N33/56916 , A61K38/00 , C07K14/315 , C07K16/1267 , G01N33/56911 , G06F19/16 , G06F19/22 , Y02A90/26 , Y10S435/975
摘要： A bioinformatic method for identifying and isolating proteins and peptides with MSCRAMM®-like characteristics from Gram positive bacteria, such as Enterococcus, Staphylococcus, Streptococcus and Bacillus bacteria, and proteins and peptides obtained thereby are provided which can be utilized in methods to prevent and treat infections caused by Gram-positive bacteria. The method involves identifying from sequence information those proteins with a putative C-terminal LPXTG (SEQ ID NO:1) cell wall sorting signal and other structural similarities to MSCRAMM® proteins having the LPXTG-anchored cell wall proteins. The MSCRAMM® proteins and immunogenic regions therein that are identified and isolated using the present invention may be useful in the diagnosis, treatment or prevention of Gram positive bacterial infections.
摘要翻译：提供了用于从革兰氏阳性细菌如肠球菌属，葡萄球菌属，链球菌属和芽孢杆菌属细菌鉴定和分离具有MSCRAMM®样特征的蛋白质和肽的生物信息学方法，以及由此得到的蛋白质和肽，其可用于预防和治疗革兰氏阳性菌引起的感染。该方法包括从序列信息中鉴定具有推定的C末端LPXTG（SEQ ID NO：1）细胞壁分选信号的蛋白质和具有LPXTG锚定的细胞壁蛋白质的MSCRAMM®蛋白质的其他结构相似性的蛋白质。使用本发明鉴定和分离的MSCRAMM蛋白质及其免疫原性区域可用于革兰氏阳性细菌感染的诊断，治疗或预防。

8. 发明授权

US07816494B2 SdrC protein from Staphylococcus aureus and diagnostic kits including same 有权
标题翻译：来自金黄色葡萄球菌的SdrC蛋白质和包括其的诊断试剂盒
公开(公告)号：US07816494B2
公开(公告)日：2010-10-19
申请号：US12546268
申请日：2009-08-24
申请人： Joseph M. Patti , Timothy J. Foster , Elizabet Joseffson , Deidre Ni Eidhin , Magnus A. O. Hook , Samuel E. Perkins
发明人： Joseph M. Patti , Timothy J. Foster , Elizabet Joseffson , Deidre Ni Eidhin , Magnus A. O. Hook , Samuel E. Perkins
IPC分类号： C07K1/00
CPC分类号： G01N33/56938 , A61K38/00 , A61K39/00 , C07K14/31 , G01N2469/00 , Y10S435/975 , Y10S530/81 , Y10S530/825
摘要： An isolated extracellular matrix-binding protein, designated as SdrC and its corresponding amino acid and nucleic acid sequences and motifs are described. The proteins, peptides, fragments thereof or antigenic portions thereof are useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection and as scientific research tools. Further, antibodies or antibody fragments to the proteins, peptides, fragments thereof or antigenic portions thereof are also useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection. In particular, the proteins or antibodies thereof may be administered to wounds or used to coat biomaterials to act as blocking agents to prevent or inhibit the binding of S. aureus to wounds or biomaterials.
摘要翻译：描述了分离的细胞外基质结合蛋白，称为SdrC及其相应的氨基酸和核酸序列和基序。蛋白质，肽，其片段或其抗原部分可用于预防，抑制，治疗和诊断金黄色葡萄球菌感染以及科学研究工具。此外，蛋白质，肽，其片段或其抗原部分的抗体或抗体片段也可用于预防，抑制，治疗和诊断金黄色葡萄球菌感染。特别地，其蛋白质或其抗体可以施用于伤口或用于涂覆生物材料以用作阻断剂以预防或抑制金黄色葡萄球菌与伤口或生物材料的结合。

9. 发明申请

US20100068220A1 BIOINFORMATIC METHOD FOR IDENTIFYING SURFACE-ANCHORED PROTEINS FROM GRAM-POSITIVE BACTERIA AND PROTEINS OBTAINED THEREBY 有权
标题翻译：用于识别表面沉积的蛋白质从生物细菌和蛋白质获得的生物化学方法
公开(公告)号：US20100068220A1
公开(公告)日：2010-03-18
申请号：US12575909
申请日：2009-10-08
申请人： Magnus HOOK , Yi Xu , Jouko V. Sillanpaa , Narayana Sthanam , Karthe Ponnuraj , Joseph M. Patti , Jeff T. Hutchins , Andrea Hall , Maria G. Bowden
发明人： Magnus HOOK , Yi Xu , Jouko V. Sillanpaa , Narayana Sthanam , Karthe Ponnuraj , Joseph M. Patti , Jeff T. Hutchins , Andrea Hall , Maria G. Bowden
IPC分类号： A61K39/085 , C07K14/31 , A61K38/16 , G01N33/53 , A61P31/04 , A61P37/04
CPC分类号： G01N33/56916 , A61K38/00 , C07K14/315 , C07K16/1267 , G01N33/56911 , G06F19/16 , G06F19/22 , Y02A90/26 , Y10S435/975
摘要： A bioinformatic method for identifying and isolating proteins and peptides with MSCRAMM®-like characteristics from Gram positive bacteria, such as Enterococcus, Staphylococcus, Streptococcus and Bacillus bacteria, and proteins and peptides obtained thereby are provided which can be utilized in methods to prevent and treat infections caused by Gram-positive bacteria. The method involves identifying from sequence information those proteins with a putative C-terminal LPXTG (SEQ ID NO:1) cell wall sorting signal and other structural similarities to MSCRAMM® proteins having the LPXTG-anchored cell wall proteins. The MSCRAMM® proteins and immunogenic regions therein that are identified and isolated using the present invention may be useful in the diagnosis, treatment or prevention of Gram positive bacterial infections.
摘要翻译：提供了用于从革兰氏阳性细菌如肠球菌属，葡萄球菌属，链球菌属和芽孢杆菌属细菌鉴定和分离具有MSCRAMM®样特征的蛋白质和肽的生物信息学方法，以及由此得到的蛋白质和肽，其可用于预防和治疗革兰氏阳性菌引起的感染。该方法包括从序列信息中鉴定具有推定的C末端LPXTG（SEQ ID NO：1）细胞壁分选信号的蛋白质和具有LPXTG锚定的细胞壁蛋白质的MSCRAMM®蛋白质的其他结构相似性的蛋白质。使用本发明鉴定和分离的MSCRAMM蛋白质及其免疫原性区域可用于革兰氏阳性细菌感染的诊断，治疗或预防。

10. 发明授权

US07615616B2 Bioinformatic method for identifying surface-anchored proteins from gram-positive bacteria and proteins obtained thereby 有权
标题翻译：用于从革兰氏阳性细菌和由此获得的蛋白质中鉴定表面锚定蛋白的生物信息学方法
公开(公告)号：US07615616B2
公开(公告)日：2009-11-10
申请号：US10661809
申请日：2003-09-15
申请人： Magnus Hook , Yi Xu , Jouko V. Sillanpaa , Narayana Sthanam , Karthe Ponnuraj , Joseph M. Patti , Jeff T. Hutchins , Andrea Hall , Maria G. Bowden
发明人： Magnus Hook , Yi Xu , Jouko V. Sillanpaa , Narayana Sthanam , Karthe Ponnuraj , Joseph M. Patti , Jeff T. Hutchins , Andrea Hall , Maria G. Bowden
IPC分类号： C07K16/00
CPC分类号： G01N33/56916 , A61K38/00 , C07K14/315 , C07K16/1267 , G01N33/56911 , G06F19/16 , G06F19/22 , Y02A90/26 , Y10S435/975
摘要： A bioinformatic method is provided for identifying and isolating proteins with MSCRAMM®—like characteristics from Gram positive bacteria, such as Enterococcus, Staphylococcus, Streptococcus and Bacillus bacteria, which can then be utilized in methods to prevent and treat infections caused by Gram-positive bacteria. The method involves identifying from sequence information those proteins with a putative C-terminal LPXTG (SEQ ID NO:1) cell wall sorting signal and other structural similarities to MSCRAMM® proteins having the LPXTG-anchored cell wall proteins. The MSCRAMM® proteins and immunogenic regions therein that are identified and isolated using the present invention may be used to generate antibodies useful in the diagnosis, treatment or prevention of Gram positive bacterial infections.
摘要翻译：提供了一种生物信息学方法，用于从革兰氏阳性菌（例如肠球菌属，葡萄球菌属，链球菌属和芽孢杆菌属细菌）中鉴定和分离具有类似MSCRAMM（R）样特征的蛋白质，其可用于预防和治疗由革兰氏阴性菌引起的感染的方法，阳性细菌。该方法包括从序列信息中鉴定具有推定的C末端LPXTG（SEQ ID NO：1）细胞壁分选信号的蛋白质和具有LPXTG锚定的细胞壁蛋白质的MSCRAMM蛋白质的其它结构相似性的蛋白质。使用本发明鉴定和分离的MSCRAMM蛋白质及其免疫原性区域可用于产生用于诊断，治疗或预防革兰氏阳性细菌感染的抗体。

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