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61. 发明申请

US20170233701A1 NOVEL SYNTHETIC PEPTIDE AND USE THEREOF 审中-公开
公开(公告)号：US20170233701A1
公开(公告)日：2017-08-17
申请号：US15321276
申请日：2015-06-22
申请人： Toagosei Co., Ltd. , Keio University , National University Corporation Nagoya University
发明人： Tetsuhiko Yoshida , Nahoko Baileykobayashi , Mikio Niwa , Jun Kudo , Tomohiro Izumiyama , Makoto Sawada
IPC分类号： C12N5/074 , C07K7/06
CPC分类号： C12N5/0696 , A61K38/00 , C07K7/06 , C07K14/00 , C12N2501/40 , C12N2506/1307
摘要： Provided are a synthetic peptide that induces the reprogramming of a differentiated cell, a reprogramming-inducing pharmaceutical composition that contains this synthetic peptide, and a method for producing an undifferentiated cell from a differentiated cell using this synthetic peptide. The peptide provided by the present invention is a synthetic peptide having a reprogramming-inducing peptide sequence formed of the amino acid sequence given by SEQ ID NO: 1 or a modified amino acid sequence thereof. The method for producing an undifferentiated cell provided by the present invention includes inducing the reprogramming of a target cell by culturing a cell culture which contains the target cell and to which the synthetic peptide has been supplied.

62. 发明授权

US09725307B2 Method for producing microchannel, and microchannel 有权
公开(公告)号：US09725307B2
公开(公告)日：2017-08-08
申请号：US14655239
申请日：2013-12-18
申请人： CITIZEN WATCH CO., LTD. , KEIO UNIVERSITY
发明人： Seiko Kato , Masafumi Ide , Takaaki Nozaki , Takaaki Takeishi , Takaaki Ishigure , Kazutomo Soma
IPC分类号： B81C1/00 , B01J19/00 , B01L3/00 , B29C67/00 , B29C35/08 , B81B1/00 , C12M3/06 , G01N37/00
CPC分类号： B81C1/00071 , B01J19/0093 , B01J2219/00783 , B01J2219/00833 , B01J2219/0086 , B01L3/502707 , B01L2300/12 , B29C67/0048 , B29C2035/0827 , B81B1/00 , B81B2203/0338 , B81C1/00 , C12M23/16 , G01N37/00 , Y10T428/24744
摘要： Provided is a method for producing a microchannel including an approximately circular cross section with neither a joined surface nor an inlet in a smaller number of steps than has been conventional. The method for producing a microchannel includes the steps of forming a layer of an uncured curable resin (2) on a substrate (1), inserting into the curable resin a needle body (3) that can inject a liquid (4), injecting a liquid in a tubular shape into the curable resin via the needle body while moving the needle body, extracting the needle body from the curable resin, and curing the curable resin to form a channel (4A) in a tubular region injected with the liquid.

63. 发明授权

US09709555B2 Compound for generating second harmonic of light, dye composition for generating second harmonic of light, and cell examination method 有权
公开(公告)号：US09709555B2
公开(公告)日：2017-07-18
申请号：US14892464
申请日：2014-05-23
申请人： KEIO UNIVERSITY , University of Tsukuba
发明人： Mutsuo Nuriya , Masato Yasui , Tatsuo Arai , Atsuya Momotake , Syun Fukushima
IPC分类号： G01N33/50 , G01N21/63 , C09B29/036 , C09B29/08 , C09B44/12 , C09B29/42
CPC分类号： G01N33/5091 , C09B29/0048 , C09B29/0803 , C09B29/0805 , C09B29/081 , C09B29/3639 , C09B44/126 , G01N21/636
摘要： Provided are a compound that generates an SHG signal but has suppressed generation of a TPF signal. Also provided is a cell examination method using the same. A compound for generating a second harmonic of light, the compound being an azobenzene derivative of formula (1), or a salt thereof. (R1 and R2 independently represent alkyl groups having 6-12 carbon atoms, and R3 to R18 independently represent substituents selected from hydrogen, halogens, alkyl groups, alkoxy groups, aryl groups, amino groups, hydroxyl groups, nitro groups, and cyano groups, but R5 and R6, R9 and R10, R13 and R14, and R17 and R18 may combine together and form a ring structure having 5-7 carbon atoms. X represents —N+R19R20R21, a sulfonyl group, a carboxyl group, or an —OR group. Here, R19, R20, and R21 independently represent straight-chain or branched alkyl groups having 1-5 carbon atoms, and —OR represents a monovalent polyalkylene oxide group terminated by an alkoxy group. a is 0 or 1, b is 0 or 1, and n is an integer of 1-10.)

64. 发明授权

US09551843B2 Connector 有权
标题翻译：连接器
公开(公告)号：US09551843B2
公开(公告)日：2017-01-24
申请号：US15082351
申请日：2016-03-28
申请人： HONDA TSUSHIN KOGYO CO., LTD. , KEIO UNIVERSITY
发明人： Shigehiro Oi , Koichiro Yoshimura , Yasuhiro Koike
IPC分类号： G02B6/38 , H01R13/58
CPC分类号： G02B6/3887 , G02B6/3809 , G02B6/3838 , H01R13/5812
摘要： When a moving member moves to a fixing position, a fixing member moves to a second fixing position, a blade of the fixing member cuts into a protection layer of a cord, and thereby the cord is fixed. When the moving member moves to a releasing position, the fixing member moves to a second releasing position, the blade leaves the protection layer, and thereby the cord is released.
摘要翻译：当移动构件移动到固定位置时，固定构件移动到第二固定位置，固定构件的刀片切入帘线的保护层，从而绳索被固定。当移动构件移动到释放位置时，固定构件移动到第二释放位置，叶片离开保护层，从而释放绳索。

65. 发明申请

US20160340578A1 CARBON NANOTUBE SINGLE-PHOTON SOURCE 审中-公开
标题翻译：碳纳米管单晶光源
公开(公告)号：US20160340578A1
公开(公告)日：2016-11-24
申请号：US15131722
申请日：2016-04-18
申请人： KEIO UNIVERSITY
发明人： Hideyuki MAKI
IPC分类号： C09K11/65
CPC分类号： C09K11/65 , H01L25/167 , H01L33/00
摘要： An atom, molecule, atomic layer, or molecular layer is adhered to a carbon nanotube surface, or the surface is doped with the atom, molecule, atomic layer, or molecular layer, to form a deep localized level so that an exciton is localized. Alternatively, an atom, molecule, inorganic or organic substance of an atomic or molecular layer, a metal, a semiconductor, or an insulator is absorbed to, deposited on, or encapsulated in the carbon tube inside surface to make permittivity of the portion undergoing the absorption, deposition, or encapsulation higher than that of a clean portion free of the absorption, deposition, or encapsulation so that binding energy of the exciton in the clean portion is high, or reduce a band gap of the portion undergoing the absorption, deposition, or encapsulation so that the exciton is confined and localized in the clean portion or the position undergoing the absorption, deposition, or encapsulation.
摘要翻译：原子，分子，原子层或分子层粘附到碳纳米管表面，或者表面掺杂有原子，分子，原子层或分子层，以形成深的局部化水平，使激子定位。或者，原子或分子层的原子，分子，无机或有机物质，金属，半导体或绝缘体被吸收到，沉积在或封装在碳管内表面中，以使经历该碳管的部分的介电常数吸收，沉积或封装比没有吸收，沉积或封装的清洁部分的吸收，沉积或封装更高，使得清洁部分中的激子的结合能高，或者减少经历吸收，沉积的部分的带隙，或封装，使得激子被限制和定位在清洁部分或经历吸收，沉积或封装的位置。

66. 发明授权

US09403077B2 Golf swing analyzing apparatus and method of analyzing golf swing 有权
标题翻译：高尔夫挥杆分析装置及高尔夫挥杆分析方法
公开(公告)号：US09403077B2
公开(公告)日：2016-08-02
申请号：US14043340
申请日：2013-10-01
申请人： Seiko Epson Corporation , Keio University
发明人： Ken Ota , Kazuhiro Shibuya
IPC分类号： A63B60/46 , A63B69/36 , G09B19/00
CPC分类号： A63B69/3632 , G09B19/0038
摘要： An aspect of the invention relates to a golf swing analyzing apparatus, comprising: an arithmetic section operating to process the output of a first inertial sensor and the output of a second inertial sensor to calculate a relative angle between a forearm of a golfer and a golf club, the first inertial sensor being attached to a portion of the upper body of the golfer, the second inertial sensor being attached to the golf club.
摘要翻译：本发明的一个方面涉及一种高尔夫挥杆分析装置，包括：运算部，用于处理第一惯性传感器的输出和第二惯性传感器的输出，以计算高尔夫球手的前臂与高尔夫球之间的相对角度所述第一惯性传感器附接到所述高尔夫球员的上身的一部分，所述第二惯性传感器附接到所述高尔夫球杆。

67. 发明申请

US20160119034A1 COVERED WIRE COUPLING TYPE INFORMATION COMMUNICATION NETWORK, ELECTROMAGNETIC FIELD COUPLING COMMUNICATION METHOD AND ELECTROMAGNETIC FIELD COUPLER 有权
标题翻译：覆盖式联轴器类型信息通信网络，电磁场耦合通信方法和电磁场耦合器
公开(公告)号：US20160119034A1
公开(公告)日：2016-04-28
申请号：US14891016
申请日：2014-05-09
申请人： KEIO UNIVERSITY
发明人： Tadahiro Kuroda
IPC分类号： H04B5/00 , H04B3/46
CPC分类号： H04B5/0075 , H01R13/6473 , H04B3/46 , H04B5/0012
摘要： This invention relates to a covered wire coupling type information communication network, an electromagnetic field coupling communication method and an electromagnetic field coupler, which makes it possible to solve the problem with the mechanical contact system and the structure where wires are exposed in a connector. A first covered wire and a second covered wire are placed in close proximity to each other in a coupling unit, and electromagnetic coupling in the coupling unit creates a data connection between the first and second covered wire.
摘要翻译：本发明涉及一种覆盖线耦合型信息通信网络，电磁场耦合通信方法和电磁场耦合器，这使得可以解决机械接触系统和电线在连接器中暴露的结构的问题。第一包线和第二包线在耦合单元中彼此靠近地放置，并且耦合单元中的电磁耦合在第一和第二包线之间形成数据连接。

68. 发明授权

US09286670B2 Pathological diagnosis assisting apparatus, pathological diagnosis assisting method and non-transitory computer readable medium storing pathological diagnosis assisting program 有权
标题翻译：病理诊断辅助设备，病理诊断辅助方法和非暂时性计算机可读介质，存储病理诊断辅助程序
公开(公告)号：US09286670B2
公开(公告)日：2016-03-15
申请号：US13686768
申请日：2012-11-27
申请人： KEIO UNIVERSITY , NEC CORPORATION
发明人： Michiie Sakamoto , Akinori Hashiguchi , Tokiya Abe , Akira Saito , Maki Sano
IPC分类号： G06K9/00 , G06T7/00
CPC分类号： G06T7/0012 , G06K9/00147 , G06T2207/10056 , G06T2207/20081 , G06T2207/30024
摘要： A pathological diagnosis assisting apparatus according to the present invention provides the diagnosis assisting information for assisting diagnosis of tissue fibrosis from the image of the stained sample, and includes an image reading unit configured to read the image of the stained sample and an image processing unit configured to process the image. The image processing unit includes an image classification unit configured to classify the collagenous fiber and the elastic fiber, a tissue area extraction unit configured to extract a tissue area, an occupancy rate calculation unit configured to calculate the occupancy rates of the collagenous fiber and the elastic fiber in the tissue area, and a diagnosis assisting information providing unit configured to provide the diagnosis assisting information based on the calculated occupancy rates of the collagenous fiber and the elastic fiber.
摘要翻译：根据本发明的病理诊断辅助装置提供诊断辅助信息，用于从染色样品的图像中辅助诊断组织纤维化，并且包括：图像读取单元，被配置为读取染色样品的图像;以及图像处理单元，处理图像。图像处理单元包括被配置为对胶原纤维和弹性纤维进行分类的图像分类单元，构造成提取组织区域的组织区域提取单元，被配置为计算胶原纤维和弹性体的占有率的占有率计算单元以及诊断辅助信息提供单元，其被配置为基于计算出的胶原纤维和弹性纤维的占有率来提供诊断辅助信息。

69. 发明申请

US20150369963A1 ACRYLIC COPOLYMER, OPTICAL FILM, POLARIZING PLATE AND LIQUID CRYSTAL DISPLAY DEVICE 审中-公开
标题翻译：丙烯酸共聚物，光学膜，极化板和液晶显示装置
公开(公告)号：US20150369963A1
公开(公告)日：2015-12-24
申请号：US14646894
申请日：2013-11-22
申请人： KEIO UNIVERSITY , JX NIPPON OIL & ENERGY CORPORATION
发明人： Yasuhiro KOIKE , Akihiko TAGAYA , Sayako UCHIZAWA , Akira MATSUO , Yasuo MATSUMURA
IPC分类号： G02B1/08 , C08J5/18 , G02B5/30 , C08F220/10
CPC分类号： G02B1/08 , C08F220/10 , C08F220/14 , C08F220/18 , C08F222/40 , C08F2500/26 , C08F2800/20 , C08J5/18 , C08J2333/06 , C08J2333/12 , G02B5/30 , G02B5/3083 , G02F1/133528 , C08F2222/402 , C08F2220/185 , C08F2220/281
摘要： There are provided an optical film having both low orientation birefringence and low photoelastic birefringence and, at the same time, having excellent transparency and heat resistance, and a polarizing plate including the optical film and a liquid crystal display device. An acrylic copolymer according to the present invention includes as constituent units 0.5 to 35% by mass of N-aromatic substituted maleimide units and 60 to 85% by mass of alkyl (meth)acrylate units having a negative intrinsic birefringence in terms of a homopolymer.
摘要翻译：提供了具有低取向双折射和低光弹性双折射的光学膜，同时具有优异的透明性和耐热性，以及包括该光学膜和液晶显示装置的偏振片。根据本发明的丙烯酸共聚物包含作为构成单元的N-芳族取代的马来酰亚胺单元为0.5〜35质量％，以均聚物为基准的具有负固有双折射的（甲基）丙烯酸烷基酯单元60〜85质量％。

70. 发明申请

US20150353603A1 ENDOMETRIOSIS CELL TARGETING PEPTIDE AND USES THEREOF 审中-公开
标题翻译：内分泌细胞靶向肽及其用途
公开(公告)号：US20150353603A1
公开(公告)日：2015-12-10
申请号：US14683520
申请日：2015-04-10
申请人： Sanford-Burnham Medical Research Institute , Keio University
发明人： Fukuda Michiko , Daisuke Aoki , Shiro Nozawa
IPC分类号： C07K7/06 , A61K49/00 , G01N33/569 , C07K7/08 , A61K31/7028 , A61K45/06 , A61K47/48 , C07K14/00
CPC分类号： C07K7/08 , A61K31/7028 , A61K38/08 , A61K45/06 , A61K47/64 , A61K49/0056 , C07K7/06 , C07K14/001 , G01N33/56966 , G01N2800/364 , A61K2300/00
摘要： Provided herein are compositions and methods for selectively targeting an endometriosis cell.
摘要翻译：本文提供了选择性靶向子宫内膜异位症细胞的组合物和方法。

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