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61. 发明申请

US20150321025A1 APPARATUS FOR PARTICLE THERAPY VERIFICATION COMPRISING A COLLIMATOR WITH MULTIPLE OPENINGS 有权
标题翻译：用于包含多个开口的收缩机的颗粒处理验证的装置
公开(公告)号：US20150321025A1
公开(公告)日：2015-11-12
申请号：US14707828
申请日：2015-05-08
申请人： ION BEAM APPLICATIONS S.A. , Université Claude Bernard Lyon 1 , Institut National des Science Appliquées de Lyon , Centre de Recherche en Acquisition et Traitement of d'Images pour de Lyon
发明人： Nicolas FREUD , Frauke ROELLINGHOFF , Etienne TESTA , Marco PINTO , Julien SMEETS
IPC分类号： A61N5/10 , A61B6/00
CPC分类号： A61N5/1071 , A61B6/4216 , A61B6/4258 , A61B6/4291 , A61N5/1031 , A61N5/1043 , A61N5/1075 , A61N2005/1034 , A61N2005/1076 , A61N2005/1087 , G01T1/29
摘要： The disclosure is related to an apparatus and method for charged hadron therapy verification. The apparatus comprises a collimator comprising a plurality of collimator slabs of a given thickness, spaced apart so as to form an array of mutually slit-shaped openings, configured to be placed at a right angle to the beam line, so as to allow the passage of prompt gammas from the target, the collimator being defined at least by three geometrical parameters being the width and depth of the slit-shaped openings and a fill factor. The disclosure is also related to a method for charged hadron therapy verification with a multi-slit camera.
摘要翻译：本公开涉及用于充电强子治疗验证的装置和方法。该装置包括准直器，该准直器包括具有给定厚度的多个准直器板，间隔开以形成相互狭缝形开口的阵列，该阵列被配置成与梁线成直角放置，以允许通道来自目标的快速伽马，准直器被至少限定三个几何参数，即狭缝形开口的宽度和深度以及填充因子。本公开还涉及一种用多狭缝相机进行充电强子治疗验证的方法。

62. 发明申请

US20040223870A1 Apparatus and process for irradiating product pallets 失效
标题翻译：照射产品托盘的设备和工艺
公开(公告)号：US20040223870A1
公开(公告)日：2004-11-11
申请号：US10804605
申请日：2004-03-18
申请人： ION BEAM APPLICATIONS S.A.
发明人： Arnold S. Herer , Frederic Stichelbaut
IPC分类号： A61L002/08
CPC分类号： A61L2/08 , G21K5/08 , G21K5/10
摘要： The present invention is related to process and an apparatus for irradiating products by means of high energy X-ray beam source (1) in an installation having an irradiation chamber (2), said process comprising the following steps, controlled by controlling means: determining the density of the products to be irradiated, in order to irradiate said products as a stack predetermining, on the basis of said density, the optimal size of the product stack able to optimize the throughput of the installation and/or the dose uniformity ratio (DUR), in the irradiation chamber (2), loading products as a stack onto rotation means (3) located in front of the X-ray beam source (1), while rotating the rotation means around a rotation axis (10), irradiating said products from a lateral side of said product stack.
摘要翻译：本发明涉及在具有照射室（2）的设备中利用高能X射线束源（1）照射产品的方法和装置，所述方法包括以下步骤：由控制装置控制：确定要照射的产品的密度，以便基于所述密度将所述产品作为预先确定的所述产品照射能够优化安装生产量和/或剂量均匀性比的产品堆的最佳尺寸（ DUR），在照射室（2）中，将位于X射线束源（1）前方的旋转装置（3）上的叠加物加载到旋转轴（10）周围，照射所述产品从所述产品堆叠的侧面说。

63. 发明授权

US11554273B2 Phantom and method for the quality assurance of a hadron therapy apparatus 有权
公开(公告)号：US11554273B2
公开(公告)日：2023-01-17
申请号：US16900133
申请日：2020-06-12
申请人： Ion Beam Applications, S.A.
发明人： Simon Marcelis , Séverine Rossomme , Gaylor Deroissart , Jochen Krimmer
IPC分类号： A61N5/10
摘要： The disclosure provides a phantom and method for quality assurance of a hadron therapy apparatus used in the intensity modulated particle therapy mode. The phantom comprises a frame structure comprising a base plate, one or more energy wedges, an energy wedge first face inclined with respect to said base plate and an energy wedge second face perpendicular to said base plate, said one or more energy wedges being mounted on said base plate, a 2D detector; said one or more wedges, and 2D detector being in known fixed positions in relation to said frame structure. Said phantom comprises in addition a Spread-Out Bragg Peak wedge, said SOBP wedge having an SOBP wedge first face inclined with respect to said base plate, and a SOBP wedge second face, perpendicular to said base plate, said SOBP wedge being made of a material having a relative density higher than 1.3 preferably 1.5, more preferably 1.7, the distance between the SOBP wedge first face and SOBP second face varying between the penetration depth of a beam having an energy between the high and low limit energy of the beam of said hadron therapy apparatus. The disclosure also provides a method for determining the compliance of the planned SOBP with the actual SOBP.

64. 发明申请

US20210311212A1 SCINTILLATING DETECTORS FOR QUALITY ASSURANCE OF A THERAPY PHOTON BEAM 有权
公开(公告)号：US20210311212A1
公开(公告)日：2021-10-07
申请号：US17262066
申请日：2019-07-22
申请人： Ion Beam Applications S.A.
发明人： David Menichelli , Timo Hausbeck , Lutz Müller
IPC分类号： G01T1/29 , G01T1/203
摘要： The present disclosure relates to scintillating detector systems for radiation therapy beams. In one implementation, a detector system for evaluating radiation delivered by a radiation beam output from a beam generator may include a phantom enclosing an internal volume and having an outer surface, extending around the internal volume, for exposure to radiation, and an inner surface coated, at least in part, with a scintillating material and facing the internal volume. The system may further include a camera external to the enclosed volume and configured to view at least a portion of the inner surface, through an opening of the hollow phantom, when radiated by the radiation beam. The system may further include at least one processor configured to receive images from the camera and calculate, based on the received images, a spatial dose distribution produced by the radiation delivered by the radiation beam to the hollow phantom.

65. 发明授权

US10743401B2 Vario-energy electron accelerator 有权
公开(公告)号：US10743401B2
公开(公告)日：2020-08-11
申请号：US16698149
申请日：2019-11-27
申请人： Ion Beam Applications S.A.
发明人： Michel Abs , Jeremy Brison , Willem Kleeven
IPC分类号： H05H13/10 , G21K1/093 , G21K5/04 , H05H7/02 , H05H7/18 , H05H7/08 , H05H7/04
摘要： A vario-energy electron accelerator includes a resonant cavity consisting of a closed conductor, an electron source injecting a beam of electrons into the resonant cavity, an RF system coupled to the resonant cavity and generating an electric field in the resonant cavity, magnet units centred on a mid-plane and generating a field in a deflecting chamber in fluid communication with the resonant cavity, the magnetic field deflecting along a first deflecting trajectory of adding length an electron beam exiting the resonant cavity along a first radial trajectory to reintroduce it into the resonant cavity along a second radial trajectory, an outlet for extracting along an extraction path an accelerated electron beam from the resonant cavity towards a target, wherein at least one of the magnet units is adapted for modifying the first deflecting trajectory to a second deflecting trajectory, allowing a variation of the energy of the electron beam.

66. 发明授权

US10600528B2 Process for producing Gallium-68 through the irradiation of a solution target 有权
公开(公告)号：US10600528B2
公开(公告)日：2020-03-24
申请号：US15998846
申请日：2018-08-17
申请人： Ion Beam Applications S.A.
发明人： Antero Abrunhosa , Vitor Alves , Francisco Alves
IPC分类号： G21G1/00 , B01J47/00 , B01J41/05 , G21G1/10 , C22B58/00 , C07B59/00 , B01J41/12 , B01J39/18 , B01J39/05 , A61K51/08
摘要： The present disclosure relates to a process for purifying and concentrating 68Ga isotope produced by irradiation with an accelerated particle beam of a 68Zn target in solution. The process according to the present disclosure allows for the production of pure and concentrated 68Ga isotope in hydrochloric acid solution. The present disclosure also relates to a disposable cassette for performing the steps of purification and concentration of the process.

67. 发明申请

US20200085389A1 REDUNDANCY WEIGHTING FOR SHORT SCAN OFF-CENTER DETECTOR X-RAY TOMOGRAPHY 审中-公开
公开(公告)号：US20200085389A1
公开(公告)日：2020-03-19
申请号：US16470587
申请日：2017-12-19
申请人： KONINKLIJKE PHILIPS N.V. , ION BEAM APPLICATIONS S.A.
发明人： Dirk SCHÄFER
IPC分类号： A61B6/00 , A61B6/03 , A61B6/02 , G06T11/00
摘要： The invention relates to off-center detector X-ray tomography reconstruction of an image of an object on the basis of projection data acquired during a rotation of an X-ray source and the off-center detector around the object in two rotational passes of less than 360°, wherein a focus point of the X-ray beam travels along largely overlapping arcs (401, 402) in the two rotational passes, the off-center detector being positioned asymmetrically with respect to a central of the X-ray beam and a direction of a detector offset being reversed between the passes. According to the invention, redundancy weighting of the projection data with respect to a redundant acquisition of projection values during each of the rotational passes is made using a redundancy weighting function determined on the basis of a union of the arcs (401, 402).

68. 发明申请

US20180318609A1 APPARATUS AND METHOD FOR RADIATION THERAPY DEVICE COMMISSIONING AND QUALITY ASSURANCE 审中-公开
公开(公告)号：US20180318609A1
公开(公告)日：2018-11-08
申请号：US15968699
申请日：2018-05-01
申请人： Ion Beam Applications S.A.
发明人： Salih ARICAN , Christian VOGEL
IPC分类号： A61N5/10
摘要： This disclosure is related to an apparatus and method for commissioning or performing a quality assurance (QA) verification of a radiation therapy (RT) device. The device may comprise: (a) a motorised water phantom; (b) a RT controller configured for obtaining operation parameters of fields, and causing the RT device to emit a beam according to said operations parameters; (c) a QA controller having a memory for storing a measurements plan, the measurements plan including data defining a sequence of fields, and d) a reference radiation detector adapted and positioned for intercepting said radiation beam and for measuring the dose rate of said radiation beam. The reference radiation detector may be substantially transparent to the radiation beam. The QA controller may include an acquisition interface for acquiring and storing the dose rate from the reference radiation detector. The device may also include a processor configured to check the synchronism between the dose rate from the field radiation detector and the dose rate from the reference radiation detector.

69. 发明申请

US20180099160A1 PARTICLE THERAPY APPARATUS COMPRISING AN MRI 审中-公开
公开(公告)号：US20180099160A1
公开(公告)日：2018-04-12
申请号：US15727525
申请日：2017-10-06
申请人： Ion Beam Applications S.A.
发明人： Eric FORTON
IPC分类号： A61N5/10 , A61B5/055
CPC分类号： A61N5/1069 , A61B5/055 , A61N5/1039 , A61N5/1043 , A61N5/1049 , A61N5/1081 , A61N2005/1055 , A61N2005/1087 , G01R33/00 , G01R33/0213
摘要： The present disclosure relates to a particle therapy apparatus for irradiating a target with a charged particle beam and having a particle accelerator and an isocentric gantry rotatable about an axis. The gantry includes a sequence of bending magnets to successively bend and direct the particle beam towards the isocentre of the gantry. A last bending magnet of the sequence is configured to bend the particle beam in a first plane including the isocentre and making a large angle with the axis. The gantry further includes a first scanning magnet arranged upstream of the last bending magnet and configured to scan the particle beam over the target. The apparatus also includes a magnetic resonance imaging (MRI) system having two main magnet units arranged on both sides of the isocentre and configured to generate a main magnetic field parallel to or coaxial with the axis.

70. 发明申请

US20180099159A1 HADRON THERAPY APPARATUS FOR ADAPTIVE TREATMENT IN NON-SUPINE POSITION 审中-公开
公开(公告)号：US20180099159A1
公开(公告)日：2018-04-12
申请号：US15727503
申请日：2017-10-06
申请人： Ion Beam Applications S.A.
发明人： Eric FORTON , Damien BERTRAND , Yves CLAEREBOUDT , Erik VAN DER KRAAIJ
IPC分类号： A61N5/10 , A61B6/03
CPC分类号： A61N5/1069 , A61B6/03 , A61B6/0421 , A61N5/103 , A61N5/1037 , A61N5/1038 , A61N5/1049 , A61N5/1077 , A61N2005/1055 , A61N2005/1087
摘要： The present disclosure relates to an apparatus including a hadron therapy device and a magnetic resonance imaging device (MRI). The MRI may be an open MRI for acquiring magnetic resonance data in an MRI imaging volume. A nozzle of the apparatus may be fixed and positioned for directing a beam along a beam path substantially along an axis or substantially perpendicularly to the axis. The apparatus may further include a patient support system adapted for supporting a patient in a non-supine position in the MRI. The present disclosure also relates to methods for adapting a treatment plan to movements of organs resulting from displacement of a patient from a supine position in which treatment plan imaging was performed to a non-supine position in which a treatment will be performed.

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