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    • 51. 发明授权
    • Cycloaliphatic polyepoxy compounds and preparation thereof
    • 环脂族聚环氧化合物及其制备
    • US07615656B2
    • 2009-11-10
    • US11819615
    • 2007-06-28
    • Takashi KuboTatsuya NakanoTakahiro Iwahama
    • Takashi KuboTatsuya NakanoTakahiro Iwahama
    • C07D303/06
    • C08G59/24C07D303/16C07D303/40
    • Is disclosed a cycloaliphatic polyepoxy compound represented by following Formula (1): wherein Y represents a linkage group or a single bond; and HAs each represent hydrogen atom at the junction between cyclohexane ring and oxirane ring, and the cyclohexane rings may each further have one or more substituents in addition to the groups shown in the formula. The cycloaliphatic polyepoxy compound contains stereoisomers in such proportions as to have a ratio A/B of 1.8 or more, wherein “A” and “B” are integrated intensities of signals of protons at the junction between cyclohexane ring and oxirane ring as determined by 1H-NMR spectroscopy of the compound, in which “A” represents the integrated intensity of a signal observed at a lower magnetic field, and “B” represents the integrated intensity of a signal observed at a higher magnetic field.
    • 公开了由下式(1)表示的脂环族聚环氧化合物:其中Y表示连接基团或单键; 并且HAs各自表示环己烷环和环氧乙烷环之间的连接处的氢原子,除了式中所示的基团之外,环己烷环还可以具有一个或多个取代基。 脂环族聚环氧化合物含有比例A / B为1.8以上的立体异构体,其中“A”和“B”是环己烷环与环氧乙烷环之间的连接处质子信号的积分强度,由1H 化合物的-NMR光谱,其中“A”表示在较低磁场下观察到的信号的积分强度,“B”表示在较高磁场下观察到的信号的积分强度。
    • 56. 发明申请
    • Novel derivatives of carnosic acid
    • 鼠尾草酸的新衍生物
    • US20040014808A1
    • 2004-01-22
    • US10409204
    • 2003-04-08
    • John P.N. RosazzaMohammed HosnyHolly Ann Johnson
    • A61K031/335A61K031/337C07C061/29C07D303/06
    • C07D493/08A61K31/335A61K31/337C07C43/23C07C62/34C07C2603/26
    • Incubations with Nocardia sp., NRRL 5646 were conducted to produce new derivatives of the abietane-diterpene chemoprotectant and antioxidant, carnosic acid. Reduction of the C-20 carboxylic acid functional group followed by methylation at the C-12 phenol afforded the novel compound 11,20-dihydroxy-12-methoxy-abiet-8,11,13-triene. Oxidative cyclization of carnosic acid to carnosol followed by dihydroxylation at the isopropyl moiety afforded the novel compound 11,12,16,17-tetrahydroxy-7-10-(epoxymethano)-abiet-8,11,13-triene-20-one. The metabolites are new carnosic acid derivatives whose structures were confirmed by mass spectrometry and NMR spectroscopic analysis. The radical quenching properties of the new metabolites using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free-radical scavenging assay showed activities improved over that of mixed tocopherols and carnosic acid.
    • 与诺卡氏菌(Nocardia sp。),NRRL 5646进行孵育以产生二亚烷基二萜化学保护剂和抗氧化剂,鼠尾草酸的新衍生物。 C-20羧酸官能团的还原,然后在C-12苯酚甲基化,得到新的化合物11,20-二羟基-12-甲氧基 - 芳基-8,11,13-三烯。 将鼠尾草氧化环化到鼠尾草酚,然后在异丙基部分进行二羟基化,得到新化合物11,12,16,17-四羟基-7-10-(环氧甲烷) - iet-8,11,13-三烯-20-酮。 代谢物是新的鼠尾草酸衍生物,其结构通过质谱和NMR光谱分析证实。 使用2,2-二苯基-1-苦基肼(DPPH)自由基清除试验的新代谢物的自由基猝灭性质显示出比混合的生育酚和鼠尾草酸活性提高的活性。