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51. 发明授权

US4484004A Substituted 1,11-diaminoundecanes, processes for producing them and their use 失效
标题翻译：取代的1,11-二氨基十一烷，其制备方法及其用途
公开(公告)号：US4484004A
公开(公告)日：1984-11-20
申请号：US421209
申请日：1982-09-22
申请人： Dieter Reinehr , Josef Pfeifer
发明人： Dieter Reinehr , Josef Pfeifer
IPC分类号： C07D225/00 , C07D225/02 , C07D225/04 , C07D307/52 , C07D333/20 , C08G59/50 , C08G69/26 , C07C87/02 , C07C87/00
CPC分类号： C07C251/72 , C07D225/00 , C07D225/02 , C07D225/04 , C07D307/52 , C07D333/20 , C08G59/50 , C08G69/26
摘要： There are described novel substituted 1,11-diaminoundecanes, particularly those of the formula ##STR1## [R.sub.1 is alkyl having 1-12 C atoms, R.sub.2 is hydrogen or alkyl having 1-12 C atoms, R.sub.3 is alkyl having 1-12 C atoms, cycloalkyl having 4-12 C atoms, aralkyl having 7 or 8 C atoms, unsubstituted or substituted aryl, pyridyl, furyl or thienyl, R.sub.4 is hydrogen, alkyl having 1-12 C atoms, cycloalkyl having 4-12 C atoms, or unsubstituted or substituted aryl, or R.sub.1 and R.sub.2 and/or R.sub.3 and R.sub.4 together are alkylene having 3-11 C atoms], and processes for producing them. The compound of the formula I can be used for example for producing polycondensation products, particularly polyamides. They can be used also as curing agents for epoxide resins.
摘要翻译：描述了新的取代的1,11-二氨基十一烷，特别是式（I）的那些：[R1是具有1-12个碳原子的烷基，R2是氢或具有1-12个C原子的烷基，R3是具有1个 -12个C原子，具有4-12个C原子的环烷基，7或8个C原子的芳烷基，未取代或取代的芳基，吡啶基，呋喃基或噻吩基，R4是氢，具有1-12个碳原子的烷基，具有4-12个碳原子的环烷基原子或未取代或取代的芳基，或R 1和R 2和/或R 3和R 4一起是具有3-11个碳原子的亚烷基）和其制备方法。式I化合物可用于制备缩聚产物，特别是聚酰胺。它们也可以用作环氧树脂的固化剂。

52. 发明授权

US4126613A Substituted cycloalkyl lactamimides 失效
公开(公告)号：US4126613A
公开(公告)日：1978-11-21
申请号：US386995
申请日：1973-08-09
申请人： Johann M. Grisar , Thomas R. Blohm , Edward M. Roberts
发明人： Johann M. Grisar , Thomas R. Blohm , Edward M. Roberts
IPC分类号： C07C17/26 , C07C45/28 , C07C45/68 , C07D211/72 , C07D211/76 , C07D333/20 , C07D207/22 , C07D223/00 , C07D225/00
CPC分类号： C07C17/263 , C07C17/2632 , C07C45/28 , C07C45/68 , C07D211/72 , C07D211/76 , C07D333/20 , Y10S514/822 , Y10S514/866 , Y10S514/869
摘要： Compounds possessing hypoglycemic, hypotensive, anti-inflammatory, anticoagulant and diuretic activity are represented by compounds of the following formula ##STR1## where Y is thienyl, cycloalkyl of from 5 to 7 carbon atoms, phenyl or substituted phenyl in which case the substituents on the substituted phenyl are selected from halogen, such as fluorine, chlorine, bromine or iodine, lower alkyl of from 1 to 4 carbon atoms and lower alkoxy of from 1 to 4 carbon atoms; Z is hydrogen or hydroxy; R is hydrogen, lower alkyl of from 1 to 4 carbon atoms, phenyl or benzyl; R.sup.1 is hydrogen, lower alkyl of from 1 to 4 carbon atoms or halogen, such as chlorine, fluorine, bromine or iodine; m is from 3 to 6; and n is from 3 to 11. Pharmaceutical compositions of these compounds and their use are also disclosed.

53. 发明授权

US08945514B2 Contrast agents for magnetic resonance imaging 有权
标题翻译：磁共振成像对比剂
公开(公告)号：US08945514B2
公开(公告)日：2015-02-03
申请号：US11547088
申请日：2005-03-31
申请人： Jens Hasserodt
发明人： Jens Hasserodt
IPC分类号： A61K49/00 , A61B5/055 , A61K49/12 , C07D225/00 , A61K49/10 , A61K49/08 , C07D401/14
CPC分类号： A61K49/106 , A61K49/085 , A61K49/10 , C07D401/14
摘要： The invention relates to contrast agents for magnetic resonance imaging comprising a chelating ligand and a transition metal ion, said ligand carrying a substituent capable of reacting chemically or biochemically with a target substance while bringing about a change in the spin state.
摘要翻译：本发明涉及包含螯合配体和过渡金属离子的磁共振成像造影剂，所述配体携带能够在引起自旋状态改变的同时化学或生物化学地与目标物质反应的取代基。

54. 发明授权

US08410271B2 Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 有权
标题翻译：色烯-2-酮衍生物及其作为单胺神经递质再摄取抑制剂的用途
公开(公告)号：US08410271B2
公开(公告)日：2013-04-02
申请号：US12615925
申请日：2009-11-10
申请人： Dan Peters , Gunnar M. Olsen , Jorgen Scheel-Kruger , Elsebet Ostergaard Nielsen
发明人： Dan Peters , Gunnar M. Olsen , Jorgen Scheel-Kruger , Elsebet Ostergaard Nielsen
IPC分类号： C07D401/00 , C07D225/00 , A61K31/00
CPC分类号： C07D405/12 , C07D451/06 , C07D451/12
摘要： This invention relates to chromen-2-one derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及可用作单胺神经递质再摄取抑制剂的色烯-2-酮衍生物。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

55. 发明申请

US20100234338A1 CHELATING AGENTS OF METAL IONS, THEIR METHODS OF PREPARATION AND THEIR APPLICATIONS 有权
标题翻译：金属螯合剂，其制备方法及其应用
公开(公告)号：US20100234338A1
公开(公告)日：2010-09-16
申请号：US12403806
申请日：2009-03-13
申请人： Pascale Delangle , Christelle Gateau , Anais Pujol
发明人： Pascale Delangle , Christelle Gateau , Anais Pujol
IPC分类号： A61K31/33 , C07D225/00 , C07C237/00 , A61K31/16
CPC分类号： C07D255/02 , C07C323/59
摘要： The present invention relates to compounds that can be used as metal-ion-chelating agents or as depolluting agents, corresponding to general formula (I) below: and also to precursor compounds of formula (II) and labelled compounds of formula (III) deriving from the compounds of formula (I).The present invention also relates to the use of the compounds (I), (II) or (III) as a medicament, and also the use thereof for the diagnosis, prevention and treatment of neurodegenerative diseases such as Wilson's disease and Alzheimer's disease.
摘要翻译：本发明涉及可用作对应于下列通式（I）的金属离子螯合剂或去污剂的化合物：还涉及式（II）的前体化合物和衍生出的式（III）的标记化合物由式（I）的化合物制备。本发明还涉及化合物（I），（II）或（III）作为药物的用途，以及其用于诊断，预防和治疗诸如威尔逊氏病和阿尔茨海默病的神经变性疾病的用途。

56. 发明授权

US07759331B2 Pyridine-containing macroheterococylic compounds as kinase inhibitors 失效
标题翻译：含吡啶的大型鞘氨醇化合物作为激酶抑制剂
公开(公告)号：US07759331B2
公开(公告)日：2010-07-20
申请号：US11716185
申请日：2007-03-09
申请人： Han-Cheng Zhang , Llorente Vincente R. Bonaga , Claudia K. Derian , Bruce E. Maryanoff , Hong Ye
发明人： Han-Cheng Zhang , Llorente Vincente R. Bonaga , Claudia K. Derian , Bruce E. Maryanoff , Hong Ye
IPC分类号： A01N43/00 , A61K31/33 , C07D225/00 , C07D295/00
CPC分类号： C07D471/22
摘要： This invention is directed to pyridine-containing macroheterocyclic compounds useful as kinase inhibitors, methods for producing such compounds and methods for treating or preventing a kinase mediated disorder.
摘要翻译：本发明涉及可用作激酶抑制剂的含吡啶的大杂环化合物，用于制备这些化合物的方法以及用于治疗或预防激酶介导的病症的方法。

57. 发明申请

US20090240050A1 Method Of Preparing Macrocylic Metal Cyanine Compound 有权
标题翻译：制备大环金属菁菁化合物的方法
公开(公告)号：US20090240050A1
公开(公告)日：2009-09-24
申请号：US12475570
申请日：2009-05-31
申请人： Simone Charlotte Vonwiller , Scott Matthew Starling , Damon Donald Ridley , Lachlan Everett Hall , Simon Fielder , Graciel Gonzaga , Kia Silverbrook , Paul Lapstun
发明人： Simone Charlotte Vonwiller , Scott Matthew Starling , Damon Donald Ridley , Lachlan Everett Hall , Simon Fielder , Graciel Gonzaga , Kia Silverbrook , Paul Lapstun
IPC分类号： C07D225/00
CPC分类号： C09B47/0675 , C07D487/22 , C09D11/328
摘要： A method of preparing a macrocyclic metal cyanine. The method comprises the step of providing a corresponding macrocyclic metal-free cyanine compound dissolved in a solvent and adding a metal reagent thereto. The metal reagent is highly soluble in the solvent and typically comprises one or more organic ligands.
摘要翻译：一种制备大环金属花青的方法。该方法包括提供溶解在溶剂中的相应的大环无金属菁化合物并向其中加入金属试剂的步骤。金属试剂在溶剂中高度可溶，通常包含一种或多种有机配体。

58. 发明申请

US20090155829A1 HEME CHOLINE ESTERS AND USES THEREOF 有权
标题翻译： HEME COLINE ESTERS及其用途
公开(公告)号：US20090155829A1
公开(公告)日：2009-06-18
申请号：US11958671
申请日：2007-12-18
申请人： Thomas Pirrie Treynor , Anup Sood , Sean Richard Dinn
发明人： Thomas Pirrie Treynor , Anup Sood , Sean Richard Dinn
IPC分类号： C12Q1/28 , C12N9/08 , C07D225/00
CPC分类号： C07D487/22 , G01N33/581
摘要： Methods of activating an apo-peroxidase are provided. The methods include the steps of providing a solution comprising an apo-peroxidase and a heme choline ester, hydrolyzing the heme choline ester with a choline esterase, and converting the apo-peroxidase to active peroxidase. The methods disclosed herein also provide for detecting the presence of an analyte in a sample. The methods include providing a binder capable of specifically binding the analyte wherein the binder is attached to a solid surface, applying the sample to the solid surface under conditions that permit binder-analyte binding, adding a choline esterase-conjugated binder that binds to the analyte, adding an apo-peroxidase, a heme choline ester, a peroxide, and a peroxide-activated signal generator, and detecting the signal produced by the peroxide-activated signal generator. An associated kit and components are also provided.
摘要翻译：提供了活化过氧化物酶的方法。所述方法包括提供包含过氧化物酶和血红素胆碱酯的溶液的步骤，用胆碱酯酶水解血红素胆碱酯，并将过氧化物酶转化成活性过氧化物酶。本文公开的方法还提供了检测样品中分析物的存在。所述方法包括提供能够特异性结合分析物的粘合剂，其中粘合剂连接到固体表面，在允许粘合剂分析物结合的条件下将样品施加到固体表面，加入与分析物结合的胆碱酯酶缀合的粘合剂，加入过氧化物酶，血红素胆碱酯，过氧化物和过氧化物激活的信号发生器，并检测由过氧化物激活的信号发生器产生的信号。还提供了相关的套件和组件。

59. 发明授权

US07468434B2 Diazene-bridge crown ether lithium compounds and methods for their use 有权
标题翻译：二氮烯桥冠醚锂化合物及其使用方法
公开(公告)号：US07468434B2
公开(公告)日：2008-12-23
申请号：US11313513
申请日：2005-12-21
申请人： Paul Michel Georges Vanhoutte , Chi-Ming Che , Kwok-Fai So , Iona Hiu Tung Sham
发明人： Paul Michel Georges Vanhoutte , Chi-Ming Che , Kwok-Fai So , Iona Hiu Tung Sham
IPC分类号： C07D225/00
CPC分类号： A61K33/00 , A61K31/09 , A61K33/14 , A61K45/06 , A61K2300/00
摘要： This invention provides a method for treating an eye disease in a patient comprising: providing a photosensitive prodrug that releases upon exposure to light an active ingredient to treat the eye disease; administering the prodrug in a pharmaceutically accepted vehicle to the subject, and exposing the eye of the subject to an external light source to cause the prodrug to release the active ingredient. This invention also provides a composition for the treatment of glaucoma, comprising a compound containing a lithium ion-chelated in a crown ether- or aza-crown ether-containing chromene or diazene derivative and a pharmaceutically acceptable carrier.
摘要翻译：本发明提供了一种治疗患者眼部疾病的方法，包括：提供光敏前体药物，其在暴露于光时释放活性成分以治疗眼睛疾病; 在药学上可接受的载体中将前药施用于受试者，并将受试者的眼睛暴露于外部光源以使前药释放活性成分。本发明还提供了用于治疗青光眼的组合物，其包含在含冠醚或氮杂冠醚的色烯或二氮烯衍生物中含有锂离子螯合的化合物和药学上可接受的载体。

60. 发明授权

US07368100B2 Backbone-substituted bifunctional DOTA ligands, complexes and compositions thereof, and methods of using same 失效
标题翻译：骨架取代的双功能DOTA配体，其复合物及其组合物及其使用方法
公开(公告)号：US07368100B2
公开(公告)日：2008-05-06
申请号：US10525673
申请日：2003-09-05
申请人： Martin W. Brechbiel , Hyun-Soon Chong
发明人： Martin W. Brechbiel , Hyun-Soon Chong
IPC分类号： A61B5/055 , C07F5/00 , C07D225/00 , C07D255/02 , C07D257/02 , C07D259/00 , C07D245/00 , C07D487/00
CPC分类号： A61K51/1051 , C07D257/02 , C07D257/10
摘要： Backbone-substituted 1,4,7,10-tetraaza cyclododecane-N,N′,N″,N′″-tetraacetic acid compounds, metal complexes thereof, compositions thereof, conjugates thereof, and methods of use in diagnostic imaging and treatment of a cellular disorder.
摘要翻译：骨架取代的1,4,7,10-四氮杂环十二烷-N，N'，N“，N” - 四乙酸化合物，其金属络合物，其组合物，其缀合物，以及用于诊断成像和治疗细胞病症。

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