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51. 发明授权

US4018800A Organotin miticidal and insecticidal compounds 失效
标题翻译：有机锡杀虫剂和杀虫剂
公开(公告)号：US4018800A
公开(公告)日：1977-04-19
申请号：US646681
申请日：1976-01-05
申请人： Don R. Baker
发明人： Don R. Baker
IPC分类号： C07F9/02 , C07F9/44 , C07D307/64
CPC分类号： C07F9/02 , C07F9/4457
摘要： A composition of matter is described herein which has insecticidal and miticidal activity and methods of use. The composition may be defined by the following generic formula ##STR1## wherein R.sub.1 is lower alkyl having 1 to 4 carbon atoms, and R.sub.2 can be selected from alkylketoximino, piperidyl, cycloalkylketoximino, alkylaldoximino, alkylcarbamylalkoxy, hexamethyleneimino, alkyloxazolidine, and ##STR2## wherein R.sub.3 and R.sub.4 can be the same or different and can be selected from hydrogen, alkyl having 1 to 15 carbon atoms, alkoxyalkyl, alkenyl, benzyl, cyanoalkyl, alkanol, phenyl, alkylphenyl, sulfonamidophenyl, thiazolinyl, alkoxycarbamyl, halobenzyl, furfuryl, provided that when R.sub.3 is hydrogen, R.sub.4 is other than hydrogen.
摘要翻译：本文描述了具有杀虫和杀螨活性和使用方法的物质组合物。组合物可以由以下通式表示，其中R1是具有1-4个碳原子的低级烷基，R2可以选自烷基酮肟基，哌啶基，环烷基酮肟基，烷基肟基，烷基氨基甲酰基烷氧基，六亚甲基亚氨基，烷基恶唑烷和其中 R3和R4可以相同或不同，并且可以选自氢，具有1至15个碳原子的烷基，烷氧基烷基，烯基，苄基，氰基烷基，链烷醇，苯基，烷基苯基，磺酰胺基苯基，噻唑啉基，烷氧基氨基甲酰基，卤代苄基，糠基，条件是当R 3是氢时，R 4不是氢。

52. 发明授权

US3961093A Novel flavoring compositions and products containing 2-methyl-3-thio-(2-methylbutyryl)-furan 失效
标题翻译：新颖的调味组合物和含有2-甲基-3-硫代 - （2-甲基丁酰基） - 呋喃的产物
公开(公告)号：US3961093A
公开(公告)日：1976-06-01
申请号：US603934
申请日：1975-08-12
申请人： William J. Evers , Howard H. Heinsohn, Jr. , Bernard J. Mayers , Elizabeth A. Karoll
发明人： William J. Evers , Howard H. Heinsohn, Jr. , Bernard J. Mayers , Elizabeth A. Karoll
IPC分类号： A23L27/20 , C07D307/64 , A23L1/226
CPC分类号： C07D307/64 , A23L27/2052
摘要： Methods for altering, modifying or enhancing the roasted, nutty taste and aroma of foodstuffs comprising incorporating with such foodstuffs a small but effective amount of 2-methyl-3-thio-(2-methylbutyryl)-furan having the formula: ##SPC1##Together with compositions containing the 2-methyl-3-thio-(2-methylbutyryl)-furan for use in altering, modifying or enhancing such organoleptic properties.
摘要翻译：用于改变，改良或提高食品的烤，营养味和香气的方法，包括与这种食品一起加入少量但有效量的具有下式的2-甲基-3-硫代 - （2-甲基丁酰基） - 呋喃，

53. 发明授权

US3922288A Processes for producing 3-thia furans and 3-furan thiols 失效
标题翻译：生产3-硫呋呋喃和3-呋喃硫醇的方法
公开(公告)号：US3922288A
公开(公告)日：1975-11-25
申请号：US47836874
申请日：1974-06-11
申请人： INT FLAVORS & FRAGRANCES INC
发明人： EVERS WILLIAM J , HEINSOHN JR HOWARD R , MAYERS BERNARD J
IPC分类号： A23L27/20 , C07C45/59 , C07D307/32 , C07D307/64 , C07D307/68
CPC分类号： C07D307/32 , A23L27/2052 , C07C45/59 , C07D307/64 , C07D307/68 , C07C49/203
摘要： Processes for producing substituted or unsubstituted 3-thia furans and 3-furan thiols comprising the steps of: I. Providing a 2-ene-1,4 dione having the structure:

II. Intimately admixing said 2-ene-1,4 dione with a thiol having the formula R3SH thereby providing a substituted or unsubstituted 2-thia substituted 1,4 dione having the structure:

III. Cyclizing said 2-thia substituted 1,4 dione to form a substituted or unsubstituted 3-thia furan having the formula:

IV. Optionally but only when R3 hydrolyzing is acyl or aroyl, said 3-thia furan thereby forming a 3-mercapto furan having the structure:

V. Optionally, reacting said 3-mercapto furan with an acyl halide thereby forming a 3-thia furan having the formula:

WHEREIN R1 and R2 are the same or different lower alkyl; wherein R3 is either acyl, aroyl, or alkyl; wherein R4 is hydrogen or lower alkyl; and wherein R5 is different from R3 and is either acyl or aroyl. If either of R1 or R2 are hydrogen, then step (ii) is performed in the presence of an organic base such as piperidine, pyridine, triethyl amine, quinoline, or Alpha picoline.
摘要翻译：制备取代或未取代的3-硫杂呋喃和3-呋喃硫醇的方法包括以下步骤：

54. 发明授权

US3836563A 3-thioacetyl or benzoyl-alkane-1,4-diones 失效
标题翻译： 3-硫代乙酰基或苯甲酰基-L-蒎烯-1,4-二酮
公开(公告)号：US3836563A
公开(公告)日：1974-09-17
申请号：US38645473
申请日：1973-08-07
申请人： INT FLAVORS & FRAGRANCES INC
发明人： MAYER B , EVERS W , HEINSOHN H
IPC分类号： A23L27/20 , C07D307/64 , C07C149/14 , C07C149/32
CPC分类号： C07D307/64 , A23L27/20 , C07C327/00
摘要： NOVEL 3-THIA-1,4 DIONES HAVING THE STRUCTURE:

R1-CO-C(-R6)(-S-R3)-CH(-R4)-CO-R2

WHEREIN R1 AND R2 ARE THE SAME OR DIFFERENT AND ARE EITHER HYDROGEN OR LOWER ALKYL, R3 IS EITHER HYDROGEN, LOWER ALKYL, ACYL, AROYL, BENZYL OR PHENYL AND EACH OF R4 AND R6 ARE THE SAME OR DIFFERENT AND ARE EITHER HYDROGEN OR LOWER ALKYL, SUCH 3-THIA-1,4 ALKANE DIONES BEING USEFUL IN ALTERING THE ORGANOLEPTIC PROPERTIES OF FOODSTUFFS.

55. 发明授权

US3819666A Perfluoroalkyl carboxylic acids 失效
标题翻译：全氟烷基羧酸
公开(公告)号：US3819666A
公开(公告)日：1974-06-25
申请号：US28108572
申请日：1972-08-16
申请人： CIBA GEIGY CORP
发明人： KLEINER E , FALK R
IPC分类号： C07D307/64 , C08H3/00
CPC分类号： C07D307/64 , C07C323/00
摘要： NOVEL PREFLUOROALKYL GROUP CONTAINING ACIDS AND ESTERS OR ANHYDRIDES THEREOF ARE DISCLOSED WITH UTILITY AS INTERMEDIATES FOR THE SYNTHESIS OF POLYMERS OR SALTS SUCH AS CHROMIUM COMPLEXES HAVING OIL AND WATER REPELLENT PROPERTIES. THE NOVEL ACIDS ARE OBTAINED BY THE ADDITION OF MERCAPTO ACIDS TO PERFLUOROALKYL GROUP CONTAINING ESTERS OF FURMARIC, MALEIC, CITRACONIC, MESACONIC, ITACONIC, METHYLENE MALONIC OR ACONITIC ACIDS.

56. 发明授权

US3113939A Substituted maleic anhydrides and the corresponding lactones of 3-formylacrylic acid 失效
标题翻译：取代的马来酸酐和相应的3-甲酰基丙烯酸的内酯
公开(公告)号：US3113939A
公开(公告)日：1963-12-10
申请号：US81638259
申请日：1959-05-28
申请人： DU PONT
发明人： MARTIN ELMORE L
IPC分类号： C07D307/34 , C07D307/64 , C07D407/04 , C09B23/10
CPC分类号： C07D307/34 , C07D307/64 , C07D407/04 , C09B23/10

57. 发明授权

US11786501B2 Nitroxyl donors with improved therapeutic index 有权
公开(公告)号：US11786501B2
公开(公告)日：2023-10-17
申请号：US17694500
申请日：2022-03-14
申请人： Cardioxyl Pharmaceuticals, Inc.
发明人： Vincent Jacob Kalish , Frederick Arthur Brookfield , Stephen Martin Courtney , Lisa Marie Frost , John P. Toscano
IPC分类号： A61K31/341 , A61K31/18 , A61P9/04 , C07C317/14 , C07D307/64 , A61K31/255 , A61K31/343 , A61K31/381 , A61K31/404 , A61K31/42 , A61K31/433 , A61K31/4436 , A61K31/5377 , A61K31/538 , A61K47/12 , A61K31/222 , A61K31/24 , A61K9/00 , A61K9/08 , A61K47/40
CPC分类号： A61K31/341 , A61K9/0019 , A61K9/08 , A61K31/18 , A61K31/222 , A61K31/24 , A61K31/255 , A61K31/343 , A61K31/381 , A61K31/404 , A61K31/42 , A61K31/433 , A61K31/4436 , A61K31/538 , A61K31/5377 , A61K47/12 , A61K47/40 , A61P9/04 , C07C317/14 , C07D307/64
摘要： The disclosed subject matter provides N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.

58. 发明授权

US11760735B2 Compounds and compositions for treating conditions associated with NLRP activity 有权
公开(公告)号：US11760735B2
公开(公告)日：2023-09-19
申请号：US17711205
申请日：2022-04-01
申请人： Novartis AG
发明人： Gary Glick , Shomir Ghosh , William R. Roush
IPC分类号： C07D263/46 , A61K31/41 , C07D333/34 , C07D405/12 , C07D417/12 , C07D295/096 , C07D213/34 , C07D307/64 , C07D311/54 , C07D213/71 , C07D277/36 , C07C317/22
CPC分类号： C07D263/46 , A61K31/41 , C07C317/22 , C07D213/34 , C07D213/71 , C07D277/36 , C07D295/096 , C07D307/64 , C07D311/54 , C07D333/34 , C07D405/12 , C07D417/12 , C07C2603/10
摘要： In one aspect, compounds of Formulae (I) and (II), or pharmaceutically acceptable salts thereof, are featured; Formula (I), Formula (II) or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formulae (I) and (II) can be as defined anywhere herein.

59. 发明申请

US20230134776A1 CANNABINOID DERIVATIVES 有权
公开(公告)号：US20230134776A1
公开(公告)日：2023-05-04
申请号：US17626519
申请日：2020-07-10
申请人： CANOPY GROWTH CORPORATION
发明人： SIAWASH AHMAR , KRISHNA KUMAR GNANASEKARAN , JEFFREY ALAN OMEARA , JI SUNG PARK
IPC分类号： C07C311/29 , C07D295/26 , C07C311/51 , C07C317/22 , C07C69/16 , C07D213/71 , C07C309/42 , C07D307/64 , C07D233/84 , C07D305/08 , C07D207/404 , C07D211/54 , C07D239/38 , C07D205/06 , C07D205/12 , C07D487/10 , C07D249/08 , C07D249/10 , C07D235/16 , C07D277/30 , C07D263/32
摘要： This disclosure relates to cannabinoid derivatives having the structure of formula (I), pharmaceutical compositions comprising them, and methods of using the cannabinoid derivatives in treating or preventing a diseases associated with a cannabinoid receptor in subject in need thereof, wherein the cannabinoid receptor is one or more of CB1, CB2, 5HT1A, 5HT2A, GPR18, GPR55, GPR119, TRPV1, TRPV2, PPARγ or a μ-opioid receptor.

60. 发明申请

US20230132093A1 EXTRACELLULAR VESICLE-NLRP3 ANTAGONIST 有权
公开(公告)号：US20230132093A1
公开(公告)日：2023-04-27
申请号：US17635311
申请日：2020-08-14
申请人： Codiak BioSciences, Inc.
发明人： Joanne LIM , Katherine KIRWIN , Wendy BROOM , Sriram SATHYANARAYANAN , Ajay VERMA
IPC分类号： C12N15/113 , C07D307/64
摘要： The present disclosure relates to extracellular vesicles, e.g., exosomes, comprising an NLRP3 antagonist. In some aspects, the NLRP3 antagonist comprises an antisense oligonucleotide (ASO). Also provided herein are methods for producing the exosomes and methods for using the exosomes to treat and/or prevent diseases or disorders.

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