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51. 发明授权

US06582355B2 Cardiac disease treatment method 有权
公开(公告)号：US06582355B2
公开(公告)日：2003-06-24
申请号：US09565041
申请日：2000-05-04
申请人： Clifton A. Alferness , Hani N. Sabbah
发明人： Clifton A. Alferness , Hani N. Sabbah
IPC分类号： A61F204
CPC分类号： A61F2/2481 , A61F2002/0068 , D04B21/12 , D10B2509/08
摘要： A jacket of biological compatible material has an internal volume dimensioned for an apex of the heart to be inserted into the volume and for the jacket to be slipped over the heart. The jacket has a longitudinal dimension between upper and lower ends sufficient for the jacket to surround a lower portion of the heart with the jacket surrounding a valvular annulus of the heart and further surrounding the lower portion to cover at least the ventricular lower extremities of the heart. The jacket is adapted to be secured to the heart with the jacket surrounding at least the valvular annulus and the ventricular lower extremities. The jacket is adjustable on the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume for the jacket to constrain circumferential expansion of the heart beyond the maximum adjusted volume during diastole and to permit unimpeded contraction of the heart during systole.

52. 发明授权

US06561970B1 Methods for treating implantable biological tissues to mitigate the calcification thereof and bioprosthetic articles treated by such methods 失效
标题翻译：用于治疗可植入生物组织以减轻其钙化的方法和通过这些方法治疗的生物假体制品
公开(公告)号：US06561970B1
公开(公告)日：2003-05-13
申请号：US08764821
申请日：1996-12-12
申请人： Sophie M. Carpentier , Alain F. Carpentier
发明人： Sophie M. Carpentier , Alain F. Carpentier
IPC分类号： A61F204
CPC分类号： A61L27/3687 , A61L27/3604 , A61L2400/02 , Y10S623/915
摘要： A method for treating fixed biological tissue inhibits calcification of the biological tissue following implantation thereof in a mammalian body. The method includes placing the biological tissue in contact with glutaraldehyde and then heating the glutaraldehyde. Alternatively, methods other than heating (e.g., chemical or mechanical means), for effecting polymerization of the glutaraldehyde may also be utilized. Alternatively, the tissue may be heat treated prior to fixing thereof. Alternatively, methods other than glutaraldehyde may also be used for fixing the tissue. The biological tissue may be so treated at any time prior to implantation thereof in a mammalian body.
摘要翻译：用于治疗固定生物组织的方法在植入哺乳动物体内后抑制生物组织的钙化。该方法包括将生物组织与戊二醛接触，然后加热戊二醛。或者，也可以使用加热以外的方法（例如化学或机械方法）来实现戊二醛的聚合。或者，组织可以在其固定之前进行热处理。或者，除了戊二醛之外的方法也可以用于固定组织。生物组织在植入哺乳动物体内之前可以随时进行处理。

53. 发明授权

US06551353B1 Synthetic fibers for medical use and method of making the same 有权
公开(公告)号：US06551353B1
公开(公告)日：2003-04-22
申请号：US09530183
申请日：2000-04-26
申请人： William R. Baker , William H. Hills , Arnold E. Wilkie
发明人： William R. Baker , William H. Hills , Arnold E. Wilkie
IPC分类号： A61F204
CPC分类号： A61K9/0092 , A61L15/44 , A61L17/005 , A61L2300/00 , D01D5/24 , D01D5/30 , D01D5/36 , D01F1/10 , D01F8/04 , D01F8/12 , Y10T442/2525
摘要： A synthetic fiber is formed with a plurality of longitudinally-extending cavities (16, 54 and 64) which hold a medicament that is intended to be absorbed into tissue brought into contact with the fiber. The fiber can be formed by dissolving a soluble polymer component 14 of an extruded plural-component fiber 10, leaving cavities 16 that extend inward from the outer surface of the fiber in the locations of the dissolved polymer. After the fiber has been exposed to a solvent, the cavities left by the dissolved component are filled with a medicament 18. Specifically, the cavities are filled with a medicament that is mixed with a viscous carrier which solidifies within the cavities. The fibers can be used to make sutures, textile prostheses for insertion into the body, and epidermal pads and bandages. Fibers having internal cavities 64, i.e., cavities not extending to the external surface of the fiber, can be formed by extruding a single-component fiber 60 from a spinneret orifice 72 having a number of T-shaped slots extending from a central hub. A medicament is introduced into the internal cavities by soaking the fiber in a liquid containing the medicament. The internal-cavity fiber is therefore formed of polymer having some capability for liquid transport, e.g., nylon.

54. 发明授权

US06537202B1 Method for polishing surgical stents 失效
标题翻译：抛光手术支架的方法
公开(公告)号：US06537202B1
公开(公告)日：2003-03-25
申请号：US09072605
申请日：1998-05-05
申请人： John J. Frantzen
发明人： John J. Frantzen
IPC分类号： A61F204
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/068 , A61F2002/91541 , A61F2002/91558 , A61F2002/91566 , A61F2240/001 , B24B31/003 , B24B31/116 , B24C3/32 , B24C3/327 , B24C5/005 , Y10S623/901 , Y10S623/921
摘要： A method for polishing radially expandable surgical stents is disclosed where fluid abrasive media M flows over surfaces of the stent 10 causing the surfaces of the stent 10 to be polished and streamlined. The stent 10 is temporarily provided with cylindrical support ends 20, which are not radially expandable to support the stent 10 during the polishing process. An interior polishing fixture 100 is provided which has cylindrical chambers 135 therein adapted to receive a stent 10 therein. Fluid abrasive media M then flows into bores 108 in the fixture 100 leading to the cylindrical chambers 135 and adjacent the inner diameter surfaces of the stent 10. Surfaces of the stent 10 forming the outer diameter are polished by placing the stent 10 within an exterior polishing fixture 200 which has a cylindrical recess 220 therein. The cylindrical recess 220 has a diameter greater than a diameter of outer surfaces of the stent 10 and includes a cylindrical shaft 270 passing axially through the cylindrical recess 220 upon which the stent 10 is located. Slanted bores 208 pass through walls of the exterior polishing fixture 200 and into the cylindrical recess 220, directing the abrasive media M adjacent exterior surfaces of the stent 10 and causing polishing of the exterior surfaces of the stent 10. The direction of abrasive media M flow can be reversed to make streamlining of segments of the stent 10 occur in a symmetrical fashion. After polishing of the stent 10 is completed, the cylindrical support ends 20 are removed and the stent 10 is ready for implantation and radial expansion within a body lumen L. When polished and streamlined, the radially expandable surgical stent 10 more effectively supports a body lumen L without excessive thrombus, restenosis and other medical complications.
摘要翻译：公开了一种用于抛光径向可扩张的外科支架的方法，其中流体研磨介质M流过支架10的表面，导致支架10的表面被抛光和流线型化。支架10临时设置有圆柱形支撑端20，其在径向可扩张以在抛光过程中支撑支架10。提供了内部抛光固定器100，其具有适于在其中容纳支架10的圆柱形腔室135。流体研磨介质M然后流入定位装置100中的通孔108中的孔108，其通向圆柱形腔135并邻近支架10的内径表面。通过将支架10置于外部抛光中来形成外径的支架10的表面被抛光夹具200，其中具有圆柱形凹部220。圆柱形凹部220的直径大于支架10的外表面的直径，并且包括圆柱形轴270，其轴向地穿过支架10所在的圆柱形凹部220。倾斜孔208穿过外部抛光夹具200的壁并进入圆柱形凹槽220，将研磨介质M引导到支架10的外表面附近，并引起支架10的外表面的抛光。研磨介质M的流动方向可以逆转以使支架10的段的精简以对称的方式发生。在完成支架10的抛光之后，移除圆柱形支撑端20，并且支架10准备好在体腔L内进行植入和径向扩张。当抛光和流线型时，可径向扩张的手术支架10更有效地支撑体腔 L无血栓过多，再狭窄等医疗并发症。

55. 发明授权

US06491623B2 Device for preventing fecal incontinence 失效
标题翻译：防止大便失禁的装置
公开(公告)号：US06491623B2
公开(公告)日：2002-12-10
申请号：US09769504
申请日：2001-01-25
申请人： Daniel R. Snyder , Harriet A. Fellows
发明人： Daniel R. Snyder , Harriet A. Fellows
IPC分类号： A61F204
CPC分类号： A61F2/004 , A61B2017/00805
摘要： An implantable device for controlling a body conduit including a cuff portion adapted to substantially encircle a body conduit. An inlet tube is operatively connected for delivering fluid to the cuff portion. The inlet tube has a one-way valve. An outlet tube is operatively connected to the cuff portion for releasing fluid therefrom and includes a normally closed valve. A pumping reservoir is in communication with the inlet tube and the outlet tube, wherein manipulation of the pumping reservoir inflates the cuff portion and manipulation of the normally closed valve deflates the cuff portion. An inflatable lumen surrounds the pumping reservoir and the cuff portion to provide rigidity and balance pressure between the cuff portion and the pumping reservoir.
摘要翻译：一种用于控制身体导管的可植入装置，其包括适于基本上环绕体导管的箍部分。入口管可操作地连接以将流体输送到袖带部分。入口管具有单向阀。出口管可操作地连接到袖带部分，用于从其中释放流体，并且包括常闭阀。泵送储存器与入口管和出口管连通，其中泵送储存器的操作使袖带部分膨胀，并且常闭阀的操纵使袖带部分缩小。充气腔围绕泵送容器和袖带部分以提供刚性并平衡袖带部分和抽吸容器之间的压力。

56. 发明授权

US06387133B1 Reconstruction implant 有权
标题翻译：重建植入
公开(公告)号：US06387133B1
公开(公告)日：2002-05-14
申请号：US09353789
申请日：1999-07-15
申请人： Eric Perouse
发明人： Eric Perouse
IPC分类号： A61F204
CPC分类号： A61F2/02 , A61F2/0059
摘要： A reconstruction implant (10) of predetermined shape has a deformable outer envelope (12) containing a filler liquid (15) whose viscosity is substantially equal to that of water. The thickness of the envelope (12) is sufficient to confer on the envelope a shape substantially identical to the predetermined shape in the absence of the filler liquid. The pressure of the filler liquid contained in the envelope (12) is substantially equal to the pressure outside the envelope. The implant can be used as a testicle prosthesis.
摘要翻译：具有预定形状的重建植入物（10）具有包含其粘度基本上等于水的填充液体（15）的可变形的外壳（12）。在没有填充液体的情况下，外壳（12）的厚度足以赋予外壳与预定形状基本相同的形状。容纳在外壳（12）中的填充液的压力基本上等于外壳外的压力。植入物可用作睾丸假体。

57. 发明授权

US06344053B1 Endovascular support device and method 失效
标题翻译：血管内支持装置及方法
公开(公告)号：US06344053B1
公开(公告)日：2002-02-05
申请号：US09287216
申请日：1999-04-05
申请人： Michael D. Boneau
发明人： Michael D. Boneau
IPC分类号： A61F204
CPC分类号： A61F2/86 , A61F2210/0042
摘要： An endovascular support device for treatment of chronic restenosis or other vascular narrowing is disclosed together with a method of manufacture and a method for delivering a plurality of such devices to an affected area of a vessel. In a preferred embodiment, the endovascular support device comprises a unitary wire-like structure configured to form a plurality of upper and lower peaks which may be compressed for delivery to an affected area of a coronary or peripheral vessel in a human, and then expanded to maintain a passageway through the vessel.
摘要翻译：公开了一种用于治疗慢性再狭窄或其它血管狭窄的血管内支持装置以及用于将多个这种装置输送到血管的受影响区域的制造方法和方法。在优选实施例中，血管内支撑装置包括整体的线状结构，其被构造成形成多个上部和下部峰，其可被压缩以输送到人的冠状动脉或外周血管的受影响区域，然后扩大到保持通过船只的通道。

58. 发明授权

US06267782B1 Medical article with adhered antimicrobial metal 有权
公开(公告)号：US06267782B1
公开(公告)日：2001-07-31
申请号：US09143989
申请日：1998-08-31
申请人： Matthew F. Ogle , William R. Holmberg , Richard F. Schroeder , Donald S. Guzik , M. William Mirsch, II , Darrin J. Bergman , Hallie A. Finucane , Katherine S. Tweden
发明人： Matthew F. Ogle , William R. Holmberg , Richard F. Schroeder , Donald S. Guzik , M. William Mirsch, II , Darrin J. Bergman , Hallie A. Finucane , Katherine S. Tweden
IPC分类号： A61F204
CPC分类号： A61L31/16 , A01N59/16 , A61F2/2412 , A61L15/18 , A61L15/44 , A61L15/46 , A61L27/30 , A61L27/306 , A61L27/54 , A61L29/10 , A61L29/16 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/45 , Y10S623/901 , Y10T428/31692 , Y10T428/31707 , A01N2300/00
摘要： A variety of new ways can be used for associating antimicrobial elemental metal with a medical article. The associated antimicrobial metal reduces the risk of infection associated with the medical use of the medical article. New medical articles are produced by some of these new approaches. Some of the methods involve ways of adjusting the dissociation rate of associated elemental metal such that desired degrees of antimicrobial activity can be achieved over selected periods of time.

59. 发明授权

US06264685B1 Flexible high radial strength stent 有权
标题翻译：柔性高径向强度支架
公开(公告)号：US06264685B1
公开(公告)日：2001-07-24
申请号：US09347747
申请日：1999-07-06
申请人： Frederick Ahari
发明人： Frederick Ahari
IPC分类号： A61F204
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91508 , A61F2002/91516 , A61F2002/91541 , A61F2002/9155 , A61F2002/91558
摘要： A flexible high radial strength stent comprising one or more flex cells and primary cells. The primary cells comprising elongated members having first and second ends and extending in a circumferential direction around an axis and curving in two opposite directions transverse to the circumferential direction. The elongated members are joined to one another on their first ends forming cusps. The flex cell may comprise a member in the shape of a U, V, ellipse, rhombus, parallelogram, or other similar shape. The flex cell has two ends, or in the case of the parallelogram two vertices, each of which is attached to the adjacent second end of a neighboring elongated member.
摘要翻译：柔性高径向强度支架，其包括一个或多个柔性细胞和原始细胞。主电池包括具有第一和第二端并且沿圆周方向围绕轴线延伸并且沿与圆周方向横向的两个相反方向弯曲的细长构件。细长构件在它们的第一端上形成彼此相互连接。柔性电池可以包括U，V，椭圆形，菱形，平行四边形或其它类似形状的构件。柔性单元具有两个端部，或者在平行四边形的情况下具有两个顶点，每个顶点附接到相邻细长构件的相邻的第二端。

60. 发明授权

US06206915B1 Drug storing and metering stent 失效
标题翻译：药物储存和计量支架
公开(公告)号：US06206915B1
公开(公告)日：2001-03-27
申请号：US09162540
申请日：1998-09-29
申请人： John R. Fagan , Chirag B. Shah
发明人： John R. Fagan , Chirag B. Shah
IPC分类号： A61F204
CPC分类号： A61F2/07 , A61F2220/0033 , A61F2220/005 , A61F2220/0058 , A61F2250/0067
摘要： A drug storing and metering stent for placement within a vessel comprising an outer member having a lumen, an inner member positioned within the lumen of the outer member. A space separates the inner member from the outer member and within which space a therapeutic drug is disposed. The stent includes at least one protrusion provided on at least one of the inner and outer members and extending across the space so as to cause a friction fit between the inner and outer members. The stent also includes a pattern of perforation across both the inner and outer members to permit the stent to expand radially. The invention also relates to a method of making such a stent, and a method of releasing a therapeutic drug within a vessel.
摘要翻译：一种用于放置在容器内的药物储存和计量支架，包括具有内腔的外部构件，位于外部构件的内腔内的内部构件。空间将内部构件与外部构件隔开，并且在该空间内设置治疗药物。所述支架包括设置在所述内部构件和所述外部构件中的至少一个上的至少一个突起，并延伸穿过所述空间，以便在所述内部构件和所述外部构件之间形成摩擦配合。支架还包括穿过内部构件和外部构件的穿孔图案，以允许支架径向扩张。本发明还涉及制造这种支架的方法以及在血管内释放治疗药物的方法。

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