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51. 发明申请

US20030160166A1 Electrospray ionization device 有权
标题翻译：电喷雾离子化装置
公开(公告)号：US20030160166A1
公开(公告)日：2003-08-28
申请号：US10082664
申请日：2002-02-25
发明人： Gary L. Glish , Ryan M. Danell
IPC分类号： H01J049/00 , B01D059/44
CPC分类号： H01J49/165 , H01J49/0404
摘要： An electrospray ionization device is provided that includes one or more electrospray needles and an ion sampling device. Each needle has a distal end for receiving a sample, a tip for spraying the sample in fluid communication with the distal end, and an electrical contact for contacting at least some portion of sample therein. The ion sampling device has an entrance, an exit, and an interior in fluid communication with the entrance and the exit, and is located in proximity to the tip or tips of the one or more electrospray needles. The entrance defines an opening that has a larger area than an opening defined by the exit. The ion sampling device also has a counter-electrical contact. The electrospray ionization device further comprises means for generating an electrical potential difference between the counter-electrical contact and the electrical contact(s) of the one or more electrospray needles.
摘要翻译：提供了一种电喷雾离子化装置，其包括一个或多个电喷雾针和离子取样装置。每个针具有用于接收样品的远端，用于喷射与远端流体连通的样品的末端，以及用于使至少一部分样品与其接触的电接触。离子取样装置具有与入口和出口流体连通的入口，出口和内部，并且位于该一个或多个电喷雾针的尖端或尖端附近。入口限定了一个开口，该开口面积大于出口限定的开口面积。离子取样装置也具有反电气接触。电喷雾离子化装置还包括用于在反电接触和一个或多个电喷雾针的电接触之间产生电位差的装置。

52. 发明申请

US20030122070A1 Ion trap mass spectrometer 有权
标题翻译：离子阱质谱仪
公开(公告)号：US20030122070A1
公开(公告)日：2003-07-03
申请号：US10034459
申请日：2001-12-28
发明人： Huan-Cheng Chang , Wen-Ping Peng , Yong Cai , Shan-Jen Kuo
IPC分类号： H01J049/42
CPC分类号： H01J49/424 , G01N15/1459 , G01N15/1463 , H01J49/0404 , H01J49/165
摘要： A mass spectrometer that includes an ion source, an ion trap, and a light detection module. The ion trap has two end-cap electrodes and a ring electrode. The ring electrode is positioned relative to the end-cap electrodes to confine a charged particle from the ion source within a confinement region when an audio frequency voltage having a first amplitude is applied between the ring electrode and the two end-cap electrodes. The charged particle is ejected from the ion trap when the audio frequency voltage increases to a second amplitude. The light detection module includes a light source that illuminates the ejected particle and a light detector that detects light scattered from the ejected particle.
摘要翻译：一种包括离子源，离子阱和光检测模块的质谱仪。离子阱具有两个端盖电极和环形电极。当在环形电极和两个端盖电极之间施加具有第一幅度的音频电压时，环形电极相对于端帽电极定位，以将来自离子源的带电粒子限制在约束区域内。当音频电压增加到第二幅度时，带电粒子从离子阱中排出。光检测模块包括照射喷射的颗粒的光源和检测从喷出的颗粒散射的光的光检测器。

53. 发明授权

US06359275B1 Dielectric conduit with end electrodes 有权
标题翻译：带末端电极的介质导管
公开(公告)号：US06359275B1
公开(公告)日：2002-03-19
申请号：US09352467
申请日：1999-07-14
申请人： James L. Bertsch , Steven M. Fischer , Julie B. Riccomini
发明人： James L. Bertsch , Steven M. Fischer , Julie B. Riccomini
IPC分类号： H01J4904
CPC分类号： H01J49/0404
摘要： A conduit for conducting ions from a high pressure ion source to a mass analyzer in mass spectrometry apparatus includes a capillary tube in which the lumenal surface of the bore near at least one end is a surface of an electrically conductive material. In one embodiment the conduit is constructed of a dielectric material and has an electrically conductive coating on an end portion of the lumenal surface.
摘要翻译：用于将离子从高压离子源引导到质谱分析仪的质谱分析仪的导管包括毛细管，其中在至少一端附近的孔的内腔表面是导电材料的表面。在一个实施例中，导管由电介质材料构成，并且在腔表面的端部上具有导电涂层。

54. 发明申请

US20020026821A1 Gas inlet for reducing a directional and cooled gas jet 失效
标题翻译：用于减少定向和冷却气体射流的气体入口
公开(公告)号：US20020026821A1
公开(公告)日：2002-03-07
申请号：US09962945
申请日：2001-09-25
发明人： Ralf Zimmermann , Egmont Rohwer , Ralph Dorfner , Ulrich Boesl , Antonius Kettrup
IPC分类号： G01N030/02
CPC分类号： H01J49/0404 , G01N21/6402 , G01N2021/6482 , H01J49/0422 , H01J49/0468
摘要： In an arrangement for producing a directional and cooled gas jet in an ion source with a gas inlet or a UV/fluorescence detection cell including a gas inlet, wherein a capillary extends with one end into the interior of the ion source which is evacuated, the one end is provided with a nozzle for discharging a gas sample into the ion source while being subjected to adiabatic cooling and the width of the nozzle opening is at most 40% of the inner diameter of the capillary and the capillary is heatable for preventing condensation of gas sample components in the nozzle.
摘要翻译：在具有气体入口或包括气体入口的UV /荧光检测单元的离子源中产生定向和冷却的气体射流的布置中，其中毛细管一端延伸到被抽空的离子源的内部，一端设置有用于将气体样品排放到离子源中的喷嘴，同时进行绝热冷却，并且喷嘴开口的宽度至少为毛细管内径的40％，并且毛细管可加热以防止冷凝喷嘴中的气体样品组分。

55. 发明申请

US20020011561A1 Method and apparatus for automating an atmospheric pressure ionization (API) source for mass spectrometry 有权
标题翻译：用于自动化用于质谱的大气压电离（API）源的方法和装置
公开(公告)号：US20020011561A1
公开(公告)日：2002-01-31
申请号：US09883854
申请日：2001-06-18
发明人： Melvin A. Park
IPC分类号： H01J049/04
CPC分类号： H01J49/0404
摘要： The present invention provides an apparatus and method for automated and rapid loading of a large number of samples for mass spectrometric analysis using various ionization methods (e.g. matrix assisted desorption by laser bombardment (MALDI) and atmosperic pressure ionization (API) methods such as electrospray). The aparatus utilizes microtiter plates to hold the sample, optical elements (e.g. fiber optic) to facilitate automated transport of the ions, and a multiple part capillary comprising at least two capillary sections joined with airtight seal by a union for use in mass spectrometry (particularly with ionization sources) to transport ions between pressure regions of a mass spectrometer for analysis is described herein. Preferably, the capillary is useful to transport ions from an elevated pressure ionization source to a first vacuum region of a mass analysis system.
摘要翻译：本发明提供了一种用于使用各种电离方法（例如通过激光轰击（MALDI）的基质辅助解吸和诸如电喷雾的大气压力电离（API））方法自动和快速加载大量用于质谱分析的样品的装置和方法，。装置使用微量滴定板来保持样品，光学元件（例如光纤）以促进离子的自动输送，以及包括至少两个毛细管部分的多部分毛细管部分，通过用于质谱联用的联合体（特别是用于气密密封）连接。与电离源）在质谱仪的压力区域之间输送离子进行分析。优选地，毛细管可用于将离子从高压离子源输送到质量分析系统的第一真空区域。

56. 发明授权

US5736740A Method and device for transport of ions in gas through a capillary 失效
标题翻译：用于通过毛细管输送气体中的离子的方法和装置
公开(公告)号：US5736740A
公开(公告)日：1998-04-07
申请号：US622893
申请日：1996-03-29
申请人： Jochen Franzen
发明人： Jochen Franzen
IPC分类号： H01J49/04 , B01D59/44 , H01J49/00
CPC分类号： H01J49/0404
摘要： The invention relates to methods and devices for transporting ions in a laminar gas flow through a tube, preferably through a capillary tube. During the transport, the ions must not touch the wall of the capillary or else they will be discharged upon collision with the wall. The invention consists of keeping the ions in the gas flow free of any wall collisions by gas-dynamic focussing of the ions into the center of the gas stream. Focussing is achieved when the ions are decelerated by an electric field relative to the gas flow so that they have a lower transport velocity than the gas stream. Due to the parabolic velocity profile of the laminar gas stream, ions which are not at the center of the capillary are subjected to circumference by gas with different velocities at both sides, resulting in a force toward the capillary axis. This component of force is the stronger the farther the ions are away from the center axis and the more they are decelerated.
摘要翻译：本发明涉及用于将层流气体中的离子通过管优选通过毛细管输送的方法和装置。在运输过程中，离子不能接触毛细管壁，否则它们将在与墙壁碰撞时排出。本发明包括通过将离子气体动态聚焦到气流的中心来保持气流中的离子没有任何壁碰撞。当离子通过相对于气流的电场减速使得它们具有比气流更低的输送速度时，实现聚焦。由于层流气流的抛物线速度分布，不在毛细管中心的离子在两侧以不同速度的气体经受圆周，导致朝向毛细管轴的力。力的这个分量离离离中心轴越远越多，减速越多。

57. 发明授权

US5304798A Housing for converting an electrospray to an ion stream 失效
标题翻译：用于将电喷雾转换成离子流的外壳
公开(公告)号：US5304798A
公开(公告)日：1994-04-19
申请号：US866618
申请日：1992-04-10
申请人： Michael J. Tomany , Joseph A. Jarrell
发明人： Michael J. Tomany , Joseph A. Jarrell
IPC分类号： G01N30/72 , H01J49/04
CPC分类号： H01J49/0404 , G01N30/7273 , H01J49/165 , G01N30/7266 , G01N30/7293
摘要： A housing is provided for converting an electrospray into a desolvated ion stream for analysis. The housing is positioned between an electrospray device and an ion stream analytical device. The housing is heated and includes a passageway within which a moving electrospray is converted to the ion stream.
摘要翻译：提供了一种用于将电喷雾转化成脱溶剂离子流进行分析的壳体。壳体位于电喷雾装置和离子流分析装置之间。壳体被加热并且包括通道，移动的电喷雾转换成离子流。

58. 发明授权

US5068533A Manifold and method of batch measurement of Hg-196 concentration using a mass spectrometer 失效
标题翻译：使用质谱仪分批测定Hg-196浓度的方法
公开(公告)号：US5068533A
公开(公告)日：1991-11-26
申请号：US323737
申请日：1989-03-15
申请人： Mark W. Grossman , Roger Evans
发明人： Mark W. Grossman , Roger Evans
IPC分类号： G01N1/00
CPC分类号： H01J49/0404 , H01J49/0468
摘要： A sample manifold and method of its use has been developed so that milligram quantities of mercury can be analyzed mass spectroscopically to determine the .sup.196 Hg concentration to less than 0.02 atomic percent. Using natural mercury as a standard, accuracy of .+-.0.002 atomic percent can be obtained. The mass spectrometer preferably used is a commercially available GC/MS manufactured by Hewlett Packard. A novel sample manifold is contained within an oven allowing flow rate control of Hg into the MS. Another part of the manifold connects to an auxiliary pumping system which facilitates rapid clean up of residual Hg in the manifold. Sample cycle time is about 1 hour.
摘要翻译：已经开发了其采样歧管及其使用方法，使得可以通过质谱法分析毫克量的汞以确定196Hg浓度小于0.02原子％。以天然汞为标准，可获得+/- 0.002原子％的准确度。优选使用的质谱仪是由Hewlett Packard制造的市售GC / MS。一个新的样品歧管包含在烘箱内，允许Hg流入MS中。歧管的另一部分连接到辅助泵送系统，其有助于快速清除歧管中的残余Hg。样品循环时间约1小时。

59. 发明授权

US4982097A Vaporization device for continuous introduction of liquids into a mass spectrometer 失效
标题翻译：用于将液体连续引入质谱仪的气化装置
公开(公告)号：US4982097A
公开(公告)日：1991-01-01
申请号：US354643
申请日：1989-05-19
申请人： Laurence E. Slivon , Donald V. Kenny , Richard A. Severance
发明人： Laurence E. Slivon , Donald V. Kenny , Richard A. Severance
IPC分类号： G01N1/00 , G01N30/30 , G01N30/72 , H01J49/04
CPC分类号： H01J49/0431 , H01J49/0404 , H01J49/049 , G01N1/22 , G01N2030/3038 , G01N30/7253
摘要： This invention is designed to serve as an interface between a liquid chromatograph and a conventional or tandem mass spectrometer (LC/MS, LC/MS/MS). It may also be used for liquid sampling without prior separation of analytes by a liquid chromatograph. This invention differs from prior art in that vaporization of the analytical sample (LC eluent) occurs through the action of condensing pressurized steam on the exterior of a low thermal mass metal capillary, while the aqueous LC eluent is flowing through the metal capillary. The steam is obtained by heating a small volume of water sealed within the device. LC eluent entering the capillary results in localized cooling and subsequent condensation of the pressurized steam on the outer surface of the capillary. The process of condensation deposits energy to the capillary equivalent to the latent heat of vaporization of water. This energy results in flash vaporization of the LC eluent within the capillary. Condensed water flows along the outer wall of the metal capillary where it is returned to the trapped liquid reservoir for re-vaporization. Energy coupling to the LC eluent is substantially more efficient than methods used in prior art interface devices. This invention minimizes overheating of temperature sensitive analytes separated by the LC and rapidly self compensates for changes in eluent flow or eluent composition without the need for adjustment in operating temperature. This invention eliminates the need for aerosol desolvation prior to ionization.
摘要翻译：本发明设计用作液相色谱仪和常规或串联质谱仪（LC / MS，LC / MS / MS）之间的界面。它也可用于液体取样，而无需用液相色谱仪分离分析物。本发明与现有技术的不同之处在于，分析样品的蒸发（LC洗脱液）通过在低热质量金属毛细管的外部冷凝加压蒸汽的作用而水溶液LC洗脱液流过金属毛细管而发生。通过加热密封在装置内的少量水来获得蒸汽。进入毛细管的LC洗脱液导致局部冷却，并随后冷凝加压蒸汽在毛细管外表面。冷凝过程将毛细管的能量与水的蒸发潜热相当。该能量导致毛细管内LC洗脱液的闪蒸。冷凝水沿着金属毛细管的外壁流动，在此被返回到被捕获的液体储存器中，用于再蒸发。与LC洗脱液的能量耦合比现有技术界面装置中使用的方法显着更有效。本发明使由LC分离的温度敏感性分析物的过热最小化，并快速自我补偿洗脱剂流动或洗脱液组成的变化，而不需要调整工作温度。本发明消除了在电离之前气溶胶去溶剂化的需要。

60. 发明授权

US3999065A Leak detection system with wire probe 失效
标题翻译：漏电探测系统
公开(公告)号：US3999065A
公开(公告)日：1976-12-21
申请号：US476632
申请日：1974-06-05
申请人： Walton E. Briggs
发明人： Walton E. Briggs
IPC分类号： G01M3/20 , H01J49/04 , H01J39/34
CPC分类号： H01J49/0404 , G01M3/205
摘要： A leak detection system comprising a mass spectrometer tuned to detect the presence of helium in a gas sample, and a gas sample inlet member comprising a multichannel array of capillary passages. In an ideal embodiment, the gas sample inlet member comprises a segment of commercially obtainable multistrand electrical wire encased in an insulating plastic sheath. The spaces between the individual strands provide the capillary passages for the admission of the gas sample.
摘要翻译：一种泄漏检测系统，包括调谐为检测气体样品中氦气的存在的质谱仪，以及包括多通道阵列的毛细通道的气体样品入口构件。在理想的实施例中，气体样品入口构件包括一个可以被包装在绝缘塑料护套中的可商业获得的多股电线段。单个股线之间的空间提供用于进入气体样品的毛细管通道。

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