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51. 发明授权

US09453838B2 Methods for making microarrays and their uses 有权
标题翻译：制备微阵列的方法及其用途
公开(公告)号：US09453838B2
公开(公告)日：2016-09-27
申请号：US14203611
申请日：2014-03-11
申请人： Asociación Centro De Investigación Cooperative En Bioma Teriales
发明人： Ana Beloqui Elizazu , Neils-Christian Reichardt
IPC分类号： G01N33/531 , G01N33/543 , C40B50/18
CPC分类号： G01N33/54353 , C40B50/18 , G01N33/531 , G01N33/543 , G01N2610/00
摘要： The present invention provides microarrays that can be analysed by more than one technique using a non-covalent ligand attachment strategy to solid supports such as indium tin oxide (ITO) covered transparent glass slides. This provides, inter alia, glycan arrays on a micrometer scale which allow multimodal readout by MALDI-Tof-MS, fluorescence and optical microscopy. Glycans functionalized with a C5-aminolinker were attached in situ on a picomolar scale to a hydrophobic tag bound to this surface, thus avoiding the wasteful off-chip ligand tagging of other approaches. Glycan arrays prepared using this methodology were analysed both with a fluorescence scanner and by on-chip MALDI-mass spectrometry in a series of glycomics experiments specifically requiring a multimodal readout.
摘要翻译：本发明提供了可以通过使用非共价配体附着策略的多种技术来分析固体支持物如铟锡氧化物（ITO）覆盖的透明玻片的微阵列。这尤其提供了微米级别的聚糖阵列，其允许通过MALDI-Tof-MS进行多峰读取，荧光和光学显微镜。用C5-氨基洗涤剂官能化的糖以皮摩尔标度原位附着到与该表面结合的疏水性标签上，从而避免了其他方法的片外配体标签的浪费。使用该方法制备的糖阵列通过荧光扫描仪和通过片上MALDI-质谱在一系列特别需要多峰读数的糖组学实验中进行分析。

52. 发明申请

US20160228840A1 Processing Microtitre Plates for Covalent Immobilization Chemistries 有权
标题翻译：加工微量滴定板用于共价固定化学
公开(公告)号：US20160228840A1
公开(公告)日：2016-08-11
申请号：US14674183
申请日：2015-03-31
申请人： Stella H. North , Evgeniya H. Lock , Scott G. Walton , Chris Rowe Taitt
发明人： Stella H. North , Evgeniya H. Lock , Scott G. Walton , Chris Rowe Taitt
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01J2219/00587 , B01J2219/00596 , B01J2219/00711 , B01J2219/00725 , B29C59/14 , C08J7/123 , C08J7/16 , C08J2325/06 , G01N33/54353
摘要： Disclosed herein is a method of: treating an organic polymer with an electron beam-generated plasma; exposing the treated polymer to air or an oxygen- and hydrogen-containing gas, generating hydroxyl groups on the surface of the polymer; reacting the surface with an organosilane compound having a chloro, fluoro, or alkoxy group and a functional or reactive group that is less reactive with the surface than the chloro, fluoro, or alkoxy group; and covalently immobilizing a biomolecule to the functional or reactive group or a reaction product thereof.
摘要翻译：本文公开了一种用电子束产生的等离子体处理有机聚合物的方法; 将经处理的聚合物暴露于空气或含氧和氢的气体，在聚合物的表面上产生羟基; 使表面与具有氯，氟或烷氧基的有机硅烷化合物和与氯，氟或烷氧基相比表面反应性低的官能团或反应性基团反应; 并将生物分子共价固定在官能团或反应性基团或其反应产物上。

53. 发明授权

US09410951B2 Method for producing substrate for making microarray 有权
标题翻译：制备微阵列的基质的制备方法
公开(公告)号：US09410951B2
公开(公告)日：2016-08-09
申请号：US12458637
申请日：2009-07-17
申请人： Wataru Kusaki , Takeshi Kinsho , Toshinobu Ishihara
发明人： Wataru Kusaki , Takeshi Kinsho , Toshinobu Ishihara
IPC分类号： G01N33/543 , C40B40/04 , C40B50/18
CPC分类号： G01N33/54353 , B01J2219/00527 , B01J2219/00596 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , C40B40/04 , C40B50/18
摘要： There is disclosed a method for producing a substrate for making a microarray, the method comprising: at least, a step of forming a monomolecular film having orientated oxysilanyl groups toward an outmost surface on the substrate; and a step of forming a monomolecular film having orientated amino groups toward an outmost surface on the substrate by applying a solution containing a diamine compound to the oxysilanyl groups. There can be provided a method for producing a substrate for making a microarray in which density and orientation of amino groups orientated toward an outmost surface are controllable, and in addition, there is no delamination of a monomolecular film formed on the substrate.
摘要翻译：公开了一种制造微阵列的基板的制造方法，该方法至少包括：向基板的最外表面形成具有取向的氧联苯乙烯基的单分子膜的工序; 以及通过将含有二胺化合物的溶液施加到氧联苯乙酰基上而形成具有取向氨基的单分子膜朝向基板上的最外表面的步骤。可以提供一种制造用于制造微阵列的基板的方法，其中朝向最外表面取向的氨基的密度和取向是可控的，此外，在基板上形成的单分子膜不会发生分层。

54. 发明授权

US09405069B2 Method for preparing an outer surface of a planar waveguide to be capable of binding target samples along a plurality of predeterminded lines and a planar waveguide 有权
标题翻译：一种用于制备平面波导的外表面的方法，该平面波导能够沿着多个预先设计的线和平面波导
公开(公告)号：US09405069B2
公开(公告)日：2016-08-02
申请号：US14655923
申请日：2014-01-17
申请人： Hoffmann-La Roche Inc.
发明人： Christof Fattinger
IPC分类号： G02B6/036 , G02B6/26 , G01N33/543 , G02B6/34
CPC分类号： G02B6/26 , G01N33/54353 , G01N33/54373 , G01N33/54393
摘要： According to the invention there is provided a method for preparing the outer surface (11) of the planar waveguide (1) for binding target samples along the plurality of predetermined lines (4). The method comprises the following steps. Providing a planar waveguide (1) with an outer surface (11) adapted for attachment of a head group (21) of a linker molecule (2) to the outer surface (11). Sequentially applying at least one plurality of linker molecules (2, 5) to the outer surface (11). Each plurality of the at least one plurality of linker molecules (2, 5) assembles to form an individual layer of linker molecules (2, 5) with individual layers formed one above the other starting from the outer surface (11) of the planar waveguide (1). Each linker molecule (2, 5) comprises a functional group (22, 52) and the head group (21, 51) which is capable of attaching to the outer surface (11) of the planar waveguide (1) or to the functional groups (22) of the preceding layer of linker molecules (2). The functional groups (52) of the plurality of linker molecules (5; 2) of the uppermost layer are bound to photo-labile protecting groups (3) so that each functional group (52) bound to a said photo-labile protecting group (3) is incapable of attaching a complementary functional group of a further molecule. Exposing those photo-labile protecting groups (3) of the uppermost layer arranged along a plurality of predetermined lines (4) to light of a predetermined wavelength to remove the exposed photo-labile protecting groups (3) from the functional groups (52) to make these functional groups (52) capable of attaching a complementary functional group of a further molecule.
摘要翻译：根据本发明，提供了一种用于制备平面波导（1）的外表面（11）的方法，用于沿着多条预定线（4）结合目标样本。该方法包括以下步骤。提供具有适于将连接分子（2）的头基（21）附接到外表面（11）的外表面（11）的平面波导（1）。将至少一个多个接头分子（2,5）顺序施加到外表面（11）上。每个多个所述至少一个多个连接分子（2,5）组装形成一个单独的层，其中各个层从所述平面波导的外表面（11）开始形成一个彼此层叠的各个层（1）。每个连接体分子（2,5）包括能够连接到平面波导（1）的外表面（11）的官能团（22,52）和头基（21,51）或官能团（22）连接分子（2）的前一层。最上层的多个连接分子（5; 2）中的官能团（52）与光不稳定保护基（3）结合，使得每个官能团（52）与所述光不稳定保护基（ 3）不能连接另外分子的互补官能团。将沿着多个预定线（4）布置的最上层的那些光不稳定保护基（3）暴露于预定波长的光以将暴露的光不稳定保护基（3）从官能团（52）移除到使得能够附加另外分子的互补官能团的这些官能团（52）。

55. 发明授权

US09389227B2 Solid substrate comprising array of dendrons and methods for using the same 有权
标题翻译：包括树突的阵列的固体底物及其使用方法
公开(公告)号：US09389227B2
公开(公告)日：2016-07-12
申请号：US12102794
申请日：2008-04-14
申请人： Joon Won Park , Bong Jin Hong
发明人： Joon Won Park , Bong Jin Hong
IPC分类号： C12M1/34 , C12M1/00 , C12Q1/68 , C07H21/02 , C07H21/04 , C40B30/04 , G01N33/543 , C40B50/18
CPC分类号： G01N33/54353 , B01J2219/00605 , B01J2219/00608 , B01J2219/00626 , B01J2219/00637 , C12Q1/6834 , C40B50/18
摘要： The present invention provides solid supports comprising a surface bound array of dendrons and methods for using the same.
摘要翻译：本发明提供了包含树突状物的表面结合阵列的固体支持物及其使用方法。

56. 发明申请

US20160195521A1 Analyte Detection 有权
标题翻译：分析物检测
公开(公告)号：US20160195521A1
公开(公告)日：2016-07-07
申请号：US15073326
申请日：2016-03-17
申请人： TGR Biosciences Pty Ltd.
发明人： Antony James Sheehan , Ronald Ian William Osmond , Michael Francis Crouch , Anthony Ross Dyer
IPC分类号： G01N33/543
CPC分类号： G01N33/54306 , G01N33/54353 , G01N33/54366 , G01N33/54393
摘要： The present disclosure provides methods and/or kits for detecting an analyte in a sample. Some embodiments provide a method for detecting a non-nucleic acid analyte in a sample using a solid substrate comprising a bound immobilization agent and an capture agent and a detectable agent, which can bind to the analyte. The capture agent comprises, at a plurality of sites, a ligand for the immobilization agent. A complex between the analyte, the capture agent and a detectable agent is formed and immobilized on the solid substrate by binding between the immobilization agent and the ligand. In some embodiments, the ligand and the immobilization agent are a binding pair comprising a peptide tag and an anti-peptide tag antibody.
摘要翻译：本公开提供了用于检测样品中的分析物的方法和/或试剂盒。一些实施方案提供了使用固体底物检测样品中非核酸分析物的方法，所述固体底物包含可结合分析物的结合固定剂和捕获剂以及可检测试剂。捕获剂在多个位点包含用于固定剂的配体。通过固定化剂和配体之间的结合，形成分析物，捕获剂和可检测试剂之间的复合物并将其固定在固体基质上。在一些实施方案中，配体和固定剂是包含肽标签和抗肽标签抗体的结合对。

57. 发明授权

US09366670B2 Polymer including group having at least two hydroxyls or zwitterionic group and use thereof 有权
标题翻译：包括具有至少两个羟基或两性离子基团的聚合物及其用途
公开(公告)号：US09366670B2
公开(公告)日：2016-06-14
申请号：US13541378
申请日：2012-07-03
申请人： Chang-eun Yoo , Ga-hee Kim , Hyun-ju Kang
发明人： Chang-eun Yoo , Ga-hee Kim , Hyun-ju Kang
IPC分类号： G06F19/00 , G01N33/543 , C08F8/30 , C08F220/26 , C08F220/06
CPC分类号： G01N33/54353 , C08F8/30 , C08F220/06 , C08F220/26 , Y10T436/255
摘要： A solid support comprising a polymer that includes a group having at least two hydroxyls or a zwitterionic group and a method of using the same.
摘要翻译：包含含有至少两个羟基或两性离子基团的聚合物的固体载体及其使用方法。

58. 发明申请

US20160146802A1 POROUS MEMBRANES WITH A POLYMER GRAFTING, METHODS AND USES THEREOF 审中-公开
标题翻译：多孔膜与聚合物接枝，其方法和用途
公开(公告)号：US20160146802A1
公开(公告)日：2016-05-26
申请号：US14548383
申请日：2014-11-20
申请人： General Electric Company
发明人： Bing Li , Brian Christopher Bales , David Roger Moore , Jason Michael Nichols , Cathryn Ellen Olsen , William Christopher Alberts , Frank John Mondello
IPC分类号： G01N33/543 , G01N33/548 , G01N33/558
CPC分类号： G01N33/54386 , G01N33/54353 , G01N33/548 , G01N33/558
摘要： A device comprising a modified porous membrane is provided. The modified porous membrane comprises a polymer coating grafted to a porous membrane. The device is used for analyte detection from a biological sample using an immunoassay. The device comprises a sample application zone at one end of the device for applying a biological sample comprising a target analyte; and a detection zone present at another end of the device, downstream of the sample application zone for detecting the target analyte, wherein the detection zone comprises one or more first biomolecules immobilized on a modified porous membrane having a structure of Formula (I).
摘要翻译：提供了包含改性多孔膜的装置。改性多孔膜包括接枝到多孔膜上的聚合物涂层。该装置用于使用免疫测定从生物样品进行分析物检测。该装置包括用于施加包含目标分析物的生物样品的装置的一端处的样品施加区域; 以及位于所述装置的另一端的检测区，其位于所述样品施加区的下游，用于检测所述目标分析物，其中所述检测区包含固定在具有式（I）的结构的改性多孔膜上的一个或多个第一生物分子。

59. 发明授权

US09347931B2 Lateral flow assay device for coagulation monitoring and method thereof 有权
标题翻译：用于凝血监测的侧流测定装置及其方法
公开(公告)号：US09347931B2
公开(公告)日：2016-05-24
申请号：US13265813
申请日：2010-04-23
申请人： Anthony Joseph Killard , Magdalena Maria Dudek , Brian MacCraith , Ib Mendel-Hartvig , Ove Öhman
发明人： Anthony Joseph Killard , Magdalena Maria Dudek , Brian MacCraith , Ib Mendel-Hartvig , Ove Öhman
IPC分类号： G01N33/00 , G01N33/49 , G01N33/543 , G01N33/545 , G01N33/558 , G01N33/86 , B01L3/00
CPC分类号： G01N33/4905 , B01L3/502707 , B01L3/502753 , B01L2300/161 , B01L2400/0406 , B01L2400/086 , G01N33/54353 , G01N33/545 , G01N33/558 , G01N33/86
摘要： The present invention is directed to a lateral flow assay device for the monitoring and measuring of coagulation and method thereof. Ideally, the invention is directed to a lateral capillary flow device for the monitoring and/or measurement of coagulation in a liquid sample wherein the device comprises a non-porous substrate with a zone for receiving a sample and a defined flow path zone wherein a clotting agent is deposited on at least part of the defined flow path zone to accelerate the coagulation of the liquid sample, enable the formation of an evenly distributed clot along the defined flow path zone and to result in the change in flow rate or cessation of flow of the liquid sample along the defined flow path zone.
摘要翻译：本发明涉及一种用于监测和测量凝血的侧流测定装置及其方法。理想地，本发明涉及用于监测和/或测量液体样品中的凝结的侧向毛细管流动装置，其中该装置包括具有用于接收样品的区域和限定的流动路径区域的无孔基材，其中凝固试剂沉积在限定的流动路径区的至少部分上以加速液体样品的凝结，使得能够沿着限定的流动路径区形成均匀分布的凝块，并导致流速的变化或流动停止液体样品沿着限定的流路区域。

60. 发明授权

US09309268B2 Borate moiety-contained linker and bio-sensing element containing the same 有权
公开(公告)号：US09309268B2
公开(公告)日：2016-04-12
申请号：US14559934
申请日：2014-12-04
申请人： NATIONAL CHIAO TUNG UNIVERSITY
发明人： Yaw-Kuen Li , Mo-Yuan Shen , Yu-Ju Pien
IPC分类号： C07F5/02 , G01N33/543 , G01N33/574
CPC分类号： C07F5/025 , G01N33/54306 , G01N33/54353 , G01N33/574
摘要： A borate moiety-contained linker and a bio-sensing element containing the same are disclosed. The borate moiety-contained linker can be used to modify a sensing molecule and connect the sensing molecule to a substrate to form the bio-sensing element.

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