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51. 发明授权

US06632599B1 Detection and determination of solid phase-associated factors 有权
标题翻译：固相相关因素的检测和测定
公开(公告)号：US06632599B1
公开(公告)日：2003-10-14
申请号：US09215209
申请日：1998-12-18
申请人： Michael Kraus , Carsten Schelp , Wilhelm Schuy
发明人： Michael Kraus , Carsten Schelp , Wilhelm Schuy
IPC分类号： C12Q100
CPC分类号： G01N33/554 , G01N33/54313 , G01N2333/295 , Y10S435/81 , Y10S435/962 , Y10S435/968
摘要： The present invention relates to procedures for the detection or for the determination of solid phase-associated factors, which are multiply associated with the same solid phase. According to the invention, the sample is brought into contact with a transmitter particle, on which at least one ligand having binding affinity for a solid phase-associated factor and a transmitter are immobilized, and a receiver particle, on which at least one ligand having binding affinity for said solid phase-associated factor and a receiver is immobilized, and then the signal is determined which results when transmitter and receiver are brought sufficiently close to one another. In particular, the invention relates to the detection of cell surface receptors which can be used for the typing of cells or for the determination of cell activation states. It is thus possible to replace the hitherto widely customary flow cytometry by a more simple procedure.
摘要翻译：本发明涉及用于检测固相相关因子的测定方法，其与相同的固相相关联。根据本发明，使样品与其上固定有至少一种与固相相关因子和发射体具有结合亲和力的配体的发射体颗粒和接收剂颗粒接触，其中至少一种配体具有对所述固相关因子和接收器的结合亲和力被固定，然后确定当发送器和接收器彼此充分接近时导致的信号。特别地，本发明涉及可用于细胞分型或确定细胞活化状态的细胞表面受体的检测。因此，可以通过更简单的程序来替代迄今广泛使用的流式细胞术。

52. 发明申请

US20030099929A1 Saliva immunoassay for detection of exposure to infectious agents 审中-公开
标题翻译：用于检测暴露于感染因子的唾液免疫测定
公开(公告)号：US20030099929A1
公开(公告)日：2003-05-29
申请号：US10007768
申请日：2001-11-08
发明人： Aristo Vojdani
IPC分类号： C12Q001/70 , G01N033/53 , G01N033/569 , G01N033/554 , G01N033/537 , G01N033/543
CPC分类号： G01N33/6854 , G01N33/569 , G01N2333/045 , G01N2333/05 , G01N2333/085 , G01N2333/10 , G01N2333/20 , G01N2333/295 , G01N2333/30 , G01N2333/315 , G01N2469/20 , Y02A50/54 , Y02A50/57
摘要： A method for diagnosing the exposure to infectious agents in a patient is disclosed. The method determines the levels of antibodies against infectious agents, including bacterial, parasitic, and viral agents. It then compares the results to normal levels to determine the exposure to infectious agents.
摘要翻译：公开了一种用于诊断患者中感染因子暴露的方法。该方法确定针对感染因子的抗体的水平，包括细菌，寄生虫和病毒剂。然后将结果与正常水平进行比较，以确定感染因子的暴露量。

53. 发明授权

US6030799A Immunoassays for detecting chlamydial antigens or antibodies thereto using recombinant or synthetic major outer membrane protein polypeptides as substitute antigens 失效
标题翻译：使用重组或合成的主要外膜蛋白多肽作为替代抗原来检测衣原体抗原或其抗体的免疫测定
公开(公告)号：US6030799A
公开(公告)日：2000-02-29
申请号：US466152
申请日：1995-06-06
申请人： Nina Agabian , Richard Stephens , Cho-Chou Kuo , Guy Mullenbach
发明人： Nina Agabian , Richard Stephens , Cho-Chou Kuo , Guy Mullenbach
IPC分类号： C07K14/295 , C12Q1/68 , G01N33/569 , G01N33/571 , A61K38/00 , C12N15/00 , C12P21/04
CPC分类号： C07K14/295 , C12Q1/689 , G01N33/56927 , C07K2319/00 , C07K2319/035 , C07K2319/40 , C07K2319/61 , G01N2333/295 , G01N2469/20
摘要： Methods and compositions are provided for the production of a polypeptide which is immunologically cross-reactive with a naturally-occurring major outer membrane protein (MOMP) of Chlamydia trachomatis. A DNA construct including a replication system recognized by E. coli, and an MOMP gene under the transcriptional control of a .beta.-glactosidase promoter and terminator is provided. Recombinant phage .lambda.gtll/L2/33 was deposited at the American Type Culture Collection, 12301 Parklawn Drive, Rockville, Md. 20852, on Jan. 10, 1985 and granted accession no. 40157. L2 B9-F DNA was deposited at the American Type Culture Collection on Dec. 31, 1985, and granted accession No. 40217.
摘要翻译：提供了用于产生与沙眼衣原体的天然存在的主要外膜蛋白（MOMP）具有免疫交叉反应性的多肽的方法和组合物。提供了包含由大肠杆菌识别的复制系统的DNA构建体和在β-谷氨酸酶启动子和终止子的转录控制下的MOMP基因。 1985年1月10日，重组噬菌体λgtll/ L2 / 33保藏于美国典型培养物保藏中心（American Type Culture Collection），12301 Parklawn Drive，Rockville，Md。20852，并授予登录号。 L15B9-F DNA于1985年12月31日在美国典型培养物保藏中心保藏，授予第40217号。

54. 发明授权

US4652518A Diagnosing chlamydia infections with Re-lipopolysaccharide complexed to carrier or antibody thereto 失效
标题翻译：用与其载体或抗体复合的再脂多糖诊断衣原体感染
公开(公告)号：US4652518A
公开(公告)日：1987-03-24
申请号：US507788
申请日：1983-06-24
申请人： Pirjo H. Makela , Maija K. Leinonen , Marjatta H. Nurminen-Kalliokoski , Pekka A. I. Saikku
发明人： Pirjo H. Makela , Maija K. Leinonen , Marjatta H. Nurminen-Kalliokoski , Pekka A. I. Saikku
IPC分类号： A61K35/74 , A61K39/00 , A61K39/118 , C12Q1/04 , G01N33/569 , G01N33/53 , G01N33/546 , G01N33/561 , G01N33/571
CPC分类号： G01N33/56927 , G01N2333/295 , G01N2400/50 , Y10S435/879 , Y10S436/811 , Y10S436/823
摘要： A preparation for the detection of chlamydial infections using lipopolysaccharide of Re-lipopolysaccharide mutants of gram-negative bacteria. The lipopolysaccharide preparation is used in the production of group-specific antibodies to chlamydiae for diagnostic purposes or for the demonstration of antibodies to chlamydial group antigen in specimens.
摘要翻译：使用革兰氏阴性菌的再脂多糖突变体的脂多糖检测衣原体感染的制剂。脂多糖制剂用于生产针对衣原体的组特异性抗体用于诊断目的或用于证明样品中衣原体组抗原的抗体。

55. 发明申请

US20180092970A1 CHLAMYDIA ANTIGENS 审中-公开
公开(公告)号：US20180092970A1
公开(公告)日：2018-04-05
申请号：US15590570
申请日：2017-05-09
申请人： GLAXOSMITHKLINE BIOLOGICALS SA
发明人： Guido GRANDI , Renata Maria GRIFANTINI , Oretta FINCO
IPC分类号： A61K39/118 , A61K39/395 , C07K14/295 , C07K16/12 , G01N33/569 , A61K39/00
CPC分类号： A61K39/118 , A61K39/3955 , A61K2039/543 , A61K2039/545 , A61K2039/55544 , A61K2039/55561 , A61K2039/57 , A61P31/04 , C07K14/295 , C07K16/125 , G01N33/56927 , G01N2333/295 , G01N2469/10
摘要： The invention provides Chlamydia antigens for use in the treatment, prevention and/or diagnosis of Chlamydia infection. In particular, the invention provides antigens CT733, CT153, CT601, CT279, CT443, CT372, CT456, CT381, CT255, CT341, CT716, CT745, CT387, CT812, CT869, CT166, CT175, CT163, CT214, CT721, CT127, CT043, CT823 and/or CT600 from C. trachomatis for the treatment, prevention or diagnosis of Chlamydia infection.

56. 发明授权

US08329194B2 Vaccine composition for vaccinating dogs against canine infectious respiratory disease (CIRD) 有权
标题翻译：针对犬传染性呼吸系统疾病（CIRD）接种疫苗的疫苗组合物
公开(公告)号：US08329194B2
公开(公告)日：2012-12-11
申请号：US10563199
申请日：2004-07-01
申请人： John Brownlie , Victoria Jane Chalker , Kerstin Erles
发明人： John Brownlie , Victoria Jane Chalker , Kerstin Erles
IPC分类号： A61K39/09
CPC分类号： G01N33/6854 , A61K39/0241 , A61K39/092 , A61K39/118 , A61K2039/505 , A61K2039/552 , G01N2333/295 , G01N2333/30 , G01N2333/315 , G01N2800/12
摘要： A vaccine composition for vaccinating dogs comprising any one or more of (a) an agent capable of raising an immune response against Streptococcus equi sub species zooepidemicus in a dog, (b) an agent capable of raising an immune response against Mycoplasma cynos in a dog, and (c) an agent capable of raising an immune response against a Chlamydophila in a dog.
摘要翻译：一种用于疫苗接种疫苗的疫苗组合物，其包含以下一种或多种：（a）能够对狗中的链球菌属动物疫苗提供免疫应答的试剂，（b）能够增加狗中支原体的免疫应答的试剂，和（c）能够在狗中提高针对衣原体的免疫应答的药剂。

57. 发明授权

US08142997B2 Mixed cell diagnostic systems for detection of respiratory, herpes and enteric viruses 有权
标题翻译：用于检测呼吸道，疱疹和肠道病毒的混合细胞诊断系统
公开(公告)号：US08142997B2
公开(公告)日：2012-03-27
申请号：US12253127
申请日：2008-10-16
申请人： David R. Scholl , Yung T. Huang , Patricia Gail Ray Goodrum
发明人： David R. Scholl , Yung T. Huang , Patricia Gail Ray Goodrum
IPC分类号： C12Q1/70
CPC分类号： C12Q1/02 , C12N7/00 , C12N2710/16611 , C12N2760/16051 , C12N2770/20011 , C12N2770/32311 , C12Q1/04 , C12Q1/18 , G01N2333/11 , G01N2333/29 , G01N2333/295
摘要： The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of organisms to antimicrobial agents.
摘要翻译：本发明一般涉及诊断微生物领域，更具体地，涉及用于检测和分化存在于样品中的一种或多种病毒或其它细胞内寄生虫的组合物和方法。本发明还提供了评估生物体对抗微生物剂的敏感性的组合物和方法。

58. 发明授权

US08114401B2 Chlamydia trachomatis antigens 有权
标题翻译：沙眼衣原体抗原
公开(公告)号：US08114401B2
公开(公告)日：2012-02-14
申请号：US12586601
申请日：2009-09-24
申请人： Giulio Ratti
发明人： Giulio Ratti
IPC分类号： A61K39/00 , A61K39/118
CPC分类号： A61K39/118 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/295 , C07K16/125 , G01N33/56927 , G01N2333/295
摘要： Proteins encoded by Chlamydia trachomatis which are immunogenic in humans as a consequence of infection have been identified using Western blots of two-dimensional electrophoretic maps. Several known immunogens were identified, as were proteins not previously known to be immunogens, and proteins not previously reported as expressed gene products.
摘要翻译：已经使用Western印迹的二维电泳图鉴定了沙眼衣原体编码的蛋白质，其在人体中作为感染的结果是免疫原性的。鉴定了几种已知的免疫原，以及以前不知道是免疫原的蛋白质，以及先前未被报道为表达基因产物的蛋白质。

59. 发明申请

US20110059128A1 VACCINE COMPOSITION FOR VACCINATING DOGS AGAINST CANINE INFECTIOUS RESPIRATORY DISEASE (CIRD) 审中-公开
标题翻译：用于感染犬感染性呼吸道疾病（CIRD）的疫苗组合物
公开(公告)号：US20110059128A1
公开(公告)日：2011-03-10
申请号：US12816214
申请日：2010-06-15
申请人： JOHN BROWNLIE , VICTORIA JANE CHALKER , KERSTIN ERLES
发明人： JOHN BROWNLIE , VICTORIA JANE CHALKER , KERSTIN ERLES
IPC分类号： A61K39/116 , A61K39/02 , A61P31/04 , A61P37/04
CPC分类号： G01N33/6854 , A61K39/0241 , A61K39/092 , A61K39/118 , A61K2039/505 , A61K2039/552 , G01N2333/295 , G01N2333/30 , G01N2333/315 , G01N2800/12
摘要： A vaccine composition for vaccinating dogs comprising any one or more of (a) an agent capable of raising an immune response against Streptococcus equi sub species zooepidemicus in a dog, (b) an agent capable of raising an immune response against Mycoplasma cynos in a dog, and (c) an agent capable of raising an immune response against a Chlamydophila in a dog.
摘要翻译：一种用于疫苗接种疫苗的疫苗组合物，其包含以下一种或多种：（a）能够对狗中的链球菌属动物疫苗提供免疫应答的试剂，（b）能够增加狗中支原体的免疫应答的试剂，和（c）能够在狗中提高针对衣原体的免疫应答的药剂。

60. 发明申请

US20100143952A1 BIOCHIP, AND METHOD FOR THE SELECTIVE IDENTIFICATION OF CHLAMYDIA TRACHOMATIS INFECTIONS 有权
标题翻译：生物技术和选择性鉴定氯霉素感染的方法
公开(公告)号：US20100143952A1
公开(公告)日：2010-06-10
申请号：US12527388
申请日：2008-03-07
申请人： Ulrike Simnacher , Vera Forsbach-Birk , Andreas Essig , Klaus-Ingmar Pfrepper
发明人： Ulrike Simnacher , Vera Forsbach-Birk , Andreas Essig , Klaus-Ingmar Pfrepper
IPC分类号： G01N33/53
CPC分类号： G01N33/56927 , G01N2333/295
摘要： The present invention relates to a method for the selective identification of Chlamydia trachomatis infections wherein the antigens CT017, CT098, CT318-L1 P, CT431-TARP, CT603-TSAP, and CT664 are used for the specific identification of Chlamydia trachomatis antibodies in samples from mammals. The method according to the invention facilitates the selective identification method of identification of Chlamydia trachomatis infections, in which no false positive results are generated by other Chlamydia species such as, for example, Chlamydia pneumoniae. The invention further relates to a biochip which has the aforementioned Chlamydia trachomatis-specific antigens for the identification of antibodies. The biochip with antigens according to the invention is suitable for multiparameter identification methods in particular.
摘要翻译：本发明涉及一种选择性鉴定沙眼衣原体感染的方法，其中抗原CT017，CT098，CT318-L1P，CT431-TARP，CT603-TSAP和CT664用于沙眼衣原体抗体的特异性鉴定哺乳动物。根据本发明的方法有助于沙眼衣原体感染的鉴定的选择性鉴定方法，其中其它衣原体物种例如肺炎衣原体不会产生假阳性结果。本发明还涉及具有上述用于鉴定抗体的沙眼衣原体特异性抗原的生物芯片。具有本发明抗原的生物芯片特别适用于多参数识别方法。

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