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1. 发明授权

US6030799A Immunoassays for detecting chlamydial antigens or antibodies thereto using recombinant or synthetic major outer membrane protein polypeptides as substitute antigens 失效
标题翻译：使用重组或合成的主要外膜蛋白多肽作为替代抗原来检测衣原体抗原或其抗体的免疫测定
公开(公告)号：US6030799A
公开(公告)日：2000-02-29
申请号：US466152
申请日：1995-06-06
申请人： Nina Agabian , Richard Stephens , Cho-Chou Kuo , Guy Mullenbach
发明人： Nina Agabian , Richard Stephens , Cho-Chou Kuo , Guy Mullenbach
IPC分类号： C07K14/295 , C12Q1/68 , G01N33/569 , G01N33/571 , A61K38/00 , C12N15/00 , C12P21/04
CPC分类号： C07K14/295 , C12Q1/689 , G01N33/56927 , C07K2319/00 , C07K2319/035 , C07K2319/40 , C07K2319/61 , G01N2333/295 , G01N2469/20
摘要： Methods and compositions are provided for the production of a polypeptide which is immunologically cross-reactive with a naturally-occurring major outer membrane protein (MOMP) of Chlamydia trachomatis. A DNA construct including a replication system recognized by E. coli, and an MOMP gene under the transcriptional control of a .beta.-glactosidase promoter and terminator is provided. Recombinant phage .lambda.gtll/L2/33 was deposited at the American Type Culture Collection, 12301 Parklawn Drive, Rockville, Md. 20852, on Jan. 10, 1985 and granted accession no. 40157. L2 B9-F DNA was deposited at the American Type Culture Collection on Dec. 31, 1985, and granted accession No. 40217.
摘要翻译：提供了用于产生与沙眼衣原体的天然存在的主要外膜蛋白（MOMP）具有免疫交叉反应性的多肽的方法和组合物。提供了包含由大肠杆菌识别的复制系统的DNA构建体和在β-谷氨酸酶启动子和终止子的转录控制下的MOMP基因。 1985年1月10日，重组噬菌体λgtll/ L2 / 33保藏于美国典型培养物保藏中心（American Type Culture Collection），12301 Parklawn Drive，Rockville，Md。20852，并授予登录号。 L15B9-F DNA于1985年12月31日在美国典型培养物保藏中心保藏，授予第40217号。

2. 发明授权

US5821055A Chlamydia major outer membrane protein 失效
公开(公告)号：US5821055A
公开(公告)日：1998-10-13
申请号：US468451
申请日：1995-06-06
申请人： Nina Agabian , Richard Stephens , Cho-Chou Kuo , Guy Mullenbach
发明人： Nina Agabian , Richard Stephens , Cho-Chou Kuo , Guy Mullenbach
IPC分类号： C07K14/295 , C12Q1/68 , G01N33/569 , C07H21/02 , C07H21/04 , C12P19/34
CPC分类号： C07K14/295 , C12Q1/689 , G01N33/56927 , C07K2319/00 , C07K2319/035 , C07K2319/40 , C07K2319/61 , G01N2333/295 , G01N2469/20
摘要： Methods and compositions are provided for the production of a polypeptide which is immunologically cross-reactive with a naturally-occurring major outer membrane protein (MOMP) of Chlamydia trachomatis. A DNA construct including a replication system recognized by E. coli, and an MOMP gene under the transcriptional control of a .beta.-galactosidase promoter and terminator is provided. Recombinant phage .lambda.gt11/L2/33 was deposited at the American Type Culture Collection, 12301 Parklawn Drive, Rockville, Md. 20852, on Jan. 10, 1985 and granted accession no. 40157. L2 B9-F DNA was deposited at the American Type Culture Collection on Dec. 31, 1985, and granted accession No. 40217.

3. 发明授权

US5770714A Chlamydia major outer membrane protein 失效
标题翻译：衣原体主要外膜蛋白
公开(公告)号：US5770714A
公开(公告)日：1998-06-23
申请号：US466814
申请日：1995-06-06
申请人： Nina Agabian , Richard Stephens , Cho-Chou Kuo , Guy Mullenbach
发明人： Nina Agabian , Richard Stephens , Cho-Chou Kuo , Guy Mullenbach
IPC分类号： C07K14/295 , C12Q1/68 , G01N33/569 , C07H21/02 , C07H21/04 , C07K5/00 , C07K13/00
CPC分类号： C07K14/295 , C12Q1/689 , G01N33/56927 , C07K2319/00 , C07K2319/035 , C07K2319/40 , C07K2319/61 , G01N2333/295 , G01N2469/20
摘要： Methods and compositions are provided for the production of a polypeptide which is immunologically cross-reactive with a naturally-occurring major outer membrane protein (MOMP) of Chlamydia trachomatis. A DNA construct including a replication system recognized by E. coli, and an MOMP gene under the transcriptional control of a .beta.-galactosidase promoter and terminator is provided. Recombinant phage .lambda.gt11/L2/33 was deposited at the American Type Culture Collection, 12301 Parklawn Drive, Rockville, Md. 20852, on Jan. 10, 1985 and granted accession no. 40157. L2 B9-F DNA was deposited at the American Type Culture Collection on Dec. 31, 1985, and granted accession No. 40217.
摘要翻译：提供了用于产生与沙眼衣原体的天然存在的主要外膜蛋白（MOMP）具有免疫交叉反应性的多肽的方法和组合物。提供了包括大肠杆菌识别的复制系统的DNA构建体和在β-半乳糖苷酶启动子和终止子的转录控制下的MOMP基因。重组噬菌体λgt11/ L2 / 33于1985年1月10日保藏于美国典型培养物保藏中心（American Type Culture Collection），12301 Parklawn Drive，Rockville，Md。20852。 L15B9-F DNA于1985年12月31日在美国典型培养物保藏中心保藏，授予第40217号。

4. 发明授权

US4118469A Antigen for trachoma lymphogranuloma venereum (LGV) and non-gonococcal urethritis (NGU) 失效
标题翻译：沙眼衣原体淋巴肉芽肿（LGV）和非淋菌性尿道炎（NGU）的抗原
公开(公告)号：US4118469A
公开(公告)日：1978-10-03
申请号：US680927
申请日：1976-04-27
申请人： Harlan D. Caldwell , Cho-Chou Kuo , George E. Kenny
发明人： Harlan D. Caldwell , Cho-Chou Kuo , George E. Kenny
IPC分类号： A61K39/118 , C07K16/12 , G01N33/571 , G01N33/16 , A61K43/00
CPC分类号： A61K39/118 , C07K16/125 , G01N33/571 , Y10S436/804 , Y10S436/805 , Y10S530/806 , Y10S530/823
摘要： Solubilized antigens of C. trachomatis strain LGV-434 upon analysis using two-dimensional immunoelectrophoresis yielded a single antigen which was found to be consistently precipitated by sera of patients with C. trachomatis infections. This antigen as antigen-antibody complex was employed as an immunogen to prepare a rabbit monospecific antiserum to this component or antigen. This monospecific antiserum demonstrated the presence of the antigen in each of the 15 strains of C. trachomatis organisms and was non-reactive with strains of C. psittaci. The C. trachomatis specific antigen was purified by immunoadsorption chromatography using monospecific antiserum as a specific ligand covalently bound to agarose gel columns and the resulting purified antigen employed to detect antibody from the sera of lymphogranuloma venereum patients using counterimmunoelectrophoresis. When the C. trachomatis specific antigen is isotopically labeled and utilized in the highly sensitive radioimmune assay antibody to the antigen should be demonstrated and a serological test based thereon should be applicable for the serological diagnosis of non-gonococcal urethritis (NGU).
摘要翻译：使用二维免疫电泳分析后，沙眼衣原体菌株LGV-434的溶解性抗原产生单一抗原，其被发现由沙眼衣原体感染患者的血清一致地沉淀。将该抗原作为抗原 - 抗体复合物用作免疫原，以制备该成分或抗原的兔单特异性抗血清。这种单特异性抗血清证实了15种沙眼衣原体生物体中的每一种中存在抗原，并且与鹦鹉热鹦鹉with菌株无反应。沙眼衣原体特异性抗原通过免疫吸附色谱纯化，使用单特异性抗血清作为与琼脂糖凝胶柱共价结合的特异性配体，所得到的纯化抗原用于使用抗免疫电泳从淋巴肉芽肿患者的血清检测抗体。当沙眼衣原体特异性抗原被同位素标记并用于高度敏感的放射免疫测定中时，应该证明抗原抗体的抗体，并且其基础上的血清学检测应适用于非淋球菌性尿道炎（NGU）的血清学诊断。

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