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51. 发明授权

US08642536B2 Method of making biologically active alpha-beta peptides 有权
标题翻译：制备生物活性α-β肽的方法
公开(公告)号：US08642536B2
公开(公告)日：2014-02-04
申请号：US12578993
申请日：2009-10-14
申请人： William S. Horne , Samuel H. Gellman , Lisa M. Johnson
发明人： William S. Horne , Samuel H. Gellman , Lisa M. Johnson
IPC分类号： A01N37/18 , A61K38/55 , A61P31/18 , C12N5/071 , A61K38/00 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , A61K38/04
CPC分类号： C07K1/006 , C07K1/107 , C07K7/02 , C07K14/00 , C07K14/001 , C07K14/005 , C07K14/4702 , C12N2740/16122
摘要： Described is a method of fabricating biologically active, unnatural polypeptides. The method includes the steps of selecting a biologically active polypeptide or biologically active fragment thereof having an amino acid sequence comprising α-amino acid residues, and fabricating a synthetic polypeptide that has an amino acid sequence that corresponds to the sequence of the biologically active polypeptide, but wherein about 14% to about 50% of the α-amino acid residues found in the biologically active polypeptide or fragment of step (a) are replaced with β-amino acid residues, and the α-amino acid residues are distributed in a repeating pattern.
摘要翻译：描述了制造生物活性的非天然多肽的方法。该方法包括以下步骤：选择具有包含α-氨基酸残基的氨基酸序列的生物活性多肽或其生物活性片段，以及制备具有与生物活性多肽序列相对应的氨基酸序列的合成多肽，但是其中在生物活性多肽或步骤（a）的片段中发现的α-氨基酸残基中约14％至约50％被β-氨基酸残基替代，并且α-氨基酸残基以重复的模式。

52. 发明授权

US08628782B2 Deletion of the beta 20-21 loop in HIV gp120 exposes the CD4 binding site for improved antibody binding and antibody induction 有权
标题翻译： HIV gp120中的β20-21环的缺失暴露了CD4结合位点以改善抗体结合和抗体诱导
公开(公告)号：US08628782B2
公开(公告)日：2014-01-14
申请号：US12714085
申请日：2010-02-26
申请人： Ira Berkower
发明人： Ira Berkower
IPC分类号： A61K39/21
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/5258 , A61K2039/545 , A61K2039/55505 , A61K2039/55561 , A61K2039/6075 , C07K16/1063 , C07K2317/76 , C12N2740/16122 , C12N2740/16134
摘要： Disclosed herein are isolated immunogens including variant gp120 polypeptides. In an example, a variant gp120 polypeptide includes a deletion of at least 8 consecutive residues of the fourth conserved loop (C4) between residues 419 and 434 of gp120 according to HXB2 numbering. Also provided are isolated nucleic acid molecules encoding the disclosed isolated immunogens. In an example, an isolated nucleic acid molecule further includes a nucleic acid molecule encoding a hepatitis B surface antigen or a variant thereof. Compositions including the isolated immunogens including variant gp120 polypeptides are also disclosed. In some examples, a composition further includes a carrier protein, such as a hepatitis B surface antigen or a variant thereof (natural or recombinant). Viral-like particles are also provided including any of the disclosed isolated immunogens or compositions. Also disclosed are uses of these variant gp120 polypeptides and nucleic acids encoding variant polypeptides, such as to induce an immune response to HIV-1.
摘要翻译：本文公开了分离的免疫原，包括变体gp120多肽。在一个实例中，变体gp120多肽包括根据HXB2编号在gp120的残基419和434之间的第四保守环（C4）的至少8个连续残基的缺失。还提供了编码公开的分离的免疫原的分离的核酸分子。在一个实例中，分离的核酸分子还包括编码乙型肝炎表面抗原或其变体的核酸分子。还公开了包括分离的免疫原的组合物，包括变体gp120多肽。在一些实例中，组合物还包括载体蛋白，例如乙型肝炎表面抗原或其变体（天然或重组）。还提供病毒样颗粒，包括任何公开的分离的免疫原或组合物。还公开了这些变体gp120多肽和编码变体多肽的核酸的用途，例如诱导对HIV-1的免疫应答。

53. 发明授权

US08603490B2 Modified human immunodeficiency virus clade C envelope polypeptides obtained from a zambian isolate 失效
标题翻译：从赞比亚分离物获得的修饰的人类免疫缺陷病毒进化枝C包膜多肽
公开(公告)号：US08603490B2
公开(公告)日：2013-12-10
申请号：US12286159
申请日：2008-09-29
申请人： Ruth M. Ruprecht
发明人： Ruth M. Ruprecht
IPC分类号： A61K39/21 , C07H21/04
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , A61K2039/525 , A61K2039/53 , A61K2039/545 , C07K14/005 , C12N7/00 , C12N2740/15022 , C12N2740/15034 , C12N2740/16021 , C12N2740/16122 , C12N2740/16134 , C12N2740/16334
摘要： The invention provides methods and compositions for raising an immune response in a subject by administering an HIV antigen. The HIV antigens include HIV clade C polynucleotides and polypeptides. The invention also provides for recombinant HIV viral particles and compositions.
摘要翻译：本发明提供了通过施用HIV抗原来增加受试者的免疫应答的方法和组合物。 HIV抗原包括HIV进化枝C多核苷酸和多肽。本发明还提供重组HIV病毒颗粒和组合物。

54. 发明授权

US08603459B2 Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use 有权
公开(公告)号：US08603459B2
公开(公告)日：2013-12-10
申请号：US13337608
申请日：2011-12-27
申请人： James M Wilson , Guangping Gao , Soumitra Roy
发明人： James M Wilson , Guangping Gao , Soumitra Roy
IPC分类号： A61K35/76 , C12N15/11 , C12N15/63 , C12N15/33
CPC分类号： A61K39/235 , A61K39/00 , A61K48/00 , A61K2039/525 , A61K2039/5256 , A61K2039/57 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/10022 , C12N2710/10321 , C12N2710/10322 , C12N2710/10343 , C12N2710/10362 , C12N2710/20022 , C12N2740/16122 , C12N2740/17022 , C12N2750/14122 , C12N2760/14134 , C12N2760/16134 , C12N2760/20122 , C12N2830/002 , C12N2830/55
摘要： A recombinant vector comprises simian adenovirus sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.

55. 发明授权

US08597658B2 HIV-1 envelope glycoprotein oligomer and methods of use 失效
标题翻译： HIV-1包膜糖蛋白寡聚体和使用方法
公开(公告)号：US08597658B2
公开(公告)日：2013-12-03
申请号：US12742272
申请日：2008-11-12
申请人： Gerald Quinnan , Christopher Broder
发明人： Gerald Quinnan , Christopher Broder
IPC分类号： A61K39/00 , A61K39/21 , C07K14/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K16/1063 , C07K16/2812 , C07K2317/32 , C07K2319/70 , C12N2740/16122
摘要： This invention relates to fusion polypeptides comprised of a trimerization domain fused to a non-membrane bound, non-cleaved gp160 polypeptide derived from the R2 HIV-1 Env glycoprotein and to compositions comprising the fusion polypeptides. This invention further relates to oligomers of the fusion polypeptides. This invention also relates to nucleic acids encoding the fusion polypeptides. This invention also relates to diagnostic and therapeutic methods using the fusion polypeptides. Further, this invention relates to the induction of cross-reactive neutralizing antibodies against HIV-1, and to immunogenic compositions for the prevention and treatment of infection by HIV-1.
摘要翻译：本发明涉及融合多肽，其融合至衍生自R2 HIV-1 Env糖蛋白的非膜结合的未剪切的gp160多肽和包含融合多肽的组合物。本发明还涉及融合多肽的寡聚体。本发明还涉及编码融合多肽的核酸。本发明还涉及使用融合多肽的诊断和治疗方法。此外，本发明涉及针对HIV-1的交叉反应性中和抗体的诱导，以及用于预防和治疗HIV-1感染的免疫原性组合物。

56. 发明授权

US08586370B2 Chimeric protein, method for manufacturing the same, nano-sensor in which the chimeric protein is fixed, and application thereof 有权
标题翻译：嵌合蛋白，其制造方法，嵌合蛋白质固定的纳米传感器及其应用
公开(公告)号：US08586370B2
公开(公告)日：2013-11-19
申请号：US13225088
申请日：2011-09-02
申请人： Jee Won Lee , Young Keun Kim , Moon Kyu Cho , Jin Seung Park , Eun Jung Lee
发明人： Jee Won Lee , Young Keun Kim , Moon Kyu Cho , Jin Seung Park , Eun Jung Lee
IPC分类号： G01N21/64 , B82Y15/00
CPC分类号： G01N27/327 , B82Y30/00 , C07K14/005 , C07K14/31 , C12N2730/10122 , C12N2740/16122 , C25D5/022
摘要： There is provided a chimeric protein of capsid protein of Hepatitis B virus (HBV) and B domain of Staphylococcal protein A (SPAB); a method for fabricating the same; the substrate and nanosensor immobilized with HBV-derived chimeric protein; and the use of the above nanosensor.
摘要翻译：提供乙型肝炎病毒（HBV）衣壳蛋白和葡萄球菌蛋白A（SPAB）B结构域的嵌合蛋白; 其制造方法; 固定有HBV衍生嵌合蛋白的底物和纳米传感器; 并使用上述纳米传感器。

57. 发明授权

US08586056B2 HIV-1 envelope glycoprotein 有权
标题翻译： HIV-1包膜糖蛋白
公开(公告)号：US08586056B2
公开(公告)日：2013-11-19
申请号：US13039086
申请日：2011-03-02
申请人： Sanjay K. Phogat , Wayne C. Koff , Charles Richter King , Denise Wagner , Simon Hoffenberg
发明人： Sanjay K. Phogat , Wayne C. Koff , Charles Richter King , Denise Wagner , Simon Hoffenberg
IPC分类号： A61K39/12 , A61K39/21 , C07K1/00
CPC分类号： C07K14/005 , C12N2740/16122
摘要： The present application relates to a novel HIV-1 envelope glycoprotein which may be utilized as an HIV-1 vaccine immunogen, antigens for crystallization and for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and purification of immunogenic compositions which are formulated into the vaccines of the present invention.
摘要翻译：本申请涉及可用作HIV-1疫苗免疫原的新型HIV-1包膜糖蛋白，用于结晶的抗原和用于鉴定广泛的中和抗体。本发明包括配制成本发明疫苗的免疫原性组合物的制备和纯化。

58. 发明授权

US08470527B2 Method of inhibiting HIV-1 replication by administering modified GP41 C34 peptide derivatives with enhanced pharmacological properties 有权
标题翻译：通过施用具有增强的药理学性质的修饰的GP41 C34肽衍生物来抑制HIV-1复制的方法
公开(公告)号：US08470527B2
公开(公告)日：2013-06-25
申请号：US12567250
申请日：2009-09-25
申请人： Dong Xie , He Jiang
发明人： Dong Xie , He Jiang
IPC分类号： C12Q1/70 , A61K39/21 , A61K38/00
CPC分类号： C07K14/005 , A61K38/00 , A61K38/162 , A61K45/06 , A61K47/643 , A61K2121/00 , C07K14/162 , C12N2740/16122
摘要： The claimed invention is directed toward modified HIV-1 gp41 C-terminal heptad repeat fusion inhibitors. In particular, peptide derivatives of C-34 were prepared (e.g., FB006M) and modified with 3-maleimidoproionic acid (MPA), which allows rapid and irreversible conjugation to serum albumin at a 1:1 molar ratio. These polypeptides have an extended half-life in vivo and display potent antiviral activity against HIV-1.
摘要翻译：所要求保护的发明涉及修饰的HIV-1 gp41 C-末端七重复重组融合抑制剂。特别地，制备C-34的肽衍生物（例如FB006M）并用3-马来酰亚胺酸（MPA）修饰，其允许以1:1摩尔比快速和不可逆地与血清白蛋白缀合。这些多肽在体内具有延长的半衰期，并显示针对HIV-1的有效的抗病毒活性。

59. 发明授权

US08426167B2 Methods for producing fusion polypeptides or enhancing expression of fusion polypeptides 有权
公开(公告)号：US08426167B2
公开(公告)日：2013-04-23
申请号：US11786847
申请日：2007-04-13
申请人： Christian Scholz , Herbert Andres , Elke Faatz , Alfred Engel , Urban Schmitt , Ariuna Bazarsuren , Peter Schaarschmidt
发明人： Christian Scholz , Herbert Andres , Elke Faatz , Alfred Engel , Urban Schmitt , Ariuna Bazarsuren , Peter Schaarschmidt
IPC分类号： C12P21/04
CPC分类号： G01N33/56988 , A61K39/00 , A61K47/64 , C07K14/005 , C07K2319/00 , C12N9/90 , C12N2740/16122 , G01N33/54306 , G01N33/56911 , G01N33/56983 , G01N2333/005 , G01N2333/16 , G01N2333/195 , G01N2469/20
摘要： The present invention relates to the cloning and expression of foreign protein or polypeptides in bacteria, such as Escherichia coli. In particular, this invention relates to expression tools comprising a FKBP-type peptidyl prolyl isomerase selected from the group consisting of FkpA, SlyD, and trigger factor; methods of recombinant protein expression, the recombinant polypeptides thus obtained, as well as to the use of such polypeptides.

60. 发明授权

US08404248B2 Reassortant influenza B viruses 失效
标题翻译：重症病毒B型流感病毒
公开(公告)号：US08404248B2
公开(公告)日：2013-03-26
申请号：US13538972
申请日：2012-06-29
申请人： Chin-Fen Yang , George Kemble , Chongguang Liu
发明人： Chin-Fen Yang , George Kemble , Chongguang Liu
IPC分类号： A61K39/145 , C12N7/02
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/145 , A61K2039/5254 , A61K2039/53 , C07H21/04 , C12N7/00 , C12N9/2402 , C12N15/86 , C12N2740/16122 , C12N2740/16222 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16161 , C12N2760/16222 , C12N2760/16234 , C12N2760/16243 , C12N2760/16261
摘要： Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
摘要翻译：提供了包含流感血凝素和神经氨酸酶变体的多肽，多核苷酸，方法，组合物和疫苗。

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