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    • 51. 发明申请
    • ANTIBACTERIAL HYBRID LAYER OPERATING AGAINST PATHOGENIC BACTERIAL STRAINS, PARTICULARLY AGAINST THE BACTERIAL STRAIN MRSA, AND A METHOD OF ITS DEVELOPMENT
    • US20150064279A1
    • 2015-03-05
    • US14468486
    • 2014-08-26
    • Technicka univerzita v Liberci
    • Irena LOVETINSKA-SLAMBOROVAVeronika ZAJICOVAPetr EXNARIvan STIBOR
    • A01N25/10A01N59/20A01N59/16
    • A01N25/10A01N59/16A01N59/20C08G77/58C08K2003/2241C09D183/14C08K3/015C08K3/28
    • The invention hereunder concerns an antibacterial hybrid layer operating against pathogenic bacteria, particularly against the bacterial strain MRSA, made up of hybrid polymer resulting from the reaction of 3-(trialkoxysilyl) propyl methacrylate and/or 3-(trialkoxysilyl) propyl acrylate with 3-glycidoxy-propyltrialkoxy-silane, titanium alkoxide and silicon alkoxide with addition of soluble salts of silver, copper and zinc and potentially also with addition of titanium oxide nanoparticles. The hybrid polymer may further also contain addition of soluble salts of chromium (III) and/or vanadium or up to 90 mol. % of 3-(trialkoxysilyl) propyl methacrylate may be replaced with an equimolar mixture of methyl methacrylate and silicon alkoxide and, similarly, up to 90 mol. % of 3-(trialkoxysilyl) propyl acrylate may be replaced with an equimolar mixture of methyl acrylate and silicon alkoxide.The invention hereunder further concerns development of an antibacterial hybrid layer operating against pathogenic bacteria, particularly against the bacterial strain MRSA, by application of sol prepared by the sol-gel method on substrate surface and subsequent polymerization of the layer. The sol is prepared from 3-(trialkoxysilyl) propyl methacrylate and/or 3-(trialkoxysilyl) propyl acrylate, 3-glycidoxy-propyltrialkoxy-silane, titanium alkoxide, silicon alkoxide, soluble salts of silver, copper and zinc, radical polymerization catalyst, alcohol as solvent, water and acid as catalyst of polycondensation of an inorganic part of the hybrid network so that the molar ratio of 3-(trialkoxysilyl) propyl methacrylate and/or 3-(trialkoxysilyl)propyl acrylate to 3-glycidoxy-propyltrialkoxy-silane is 99:1 to 70:30, the molar ratio of 3-(trialkoxysilyl) propyl methacrylate and/or 3-(trialkoxysilyl)propyl acrylate to titanium alkoxide is 95:5 to 50:50, the molar ratio of 3-(trialkoxysilyl) propyl methacrylate and/or 3-(trialkoxysilyl)propyl acrylate to silicon alkoxide (without the share of silicon alkoxide replacing in the equimolar mixture with alkyl methacrylate and/or alkyl acrylate a part of 3-(trialkoxysilyl) propyl methacrylate or 3-(trialkoxysilyl)propyl acrylate) is 99:1 to 40:60, the content of silver, copper and zinc compounds (recalculated to metals in dry matter) is 0.1 to 5 wt. % for Ag, 0.1 to 10 wt. % for Cu and 0.1 to 5 wt. % for Zn, the content of radical polymerization catalyst is 0.2 to 10 wt. % related to dry matter weight and the molar ratio of the water content k=[H2O]/[3-(trialkoxysilyl) propyl methacrylate+3-(trialkoxysilyl) propyl acrylate+3-glycidoxypropyltrialkoxysilan+titanium alkoxide+silicon alkoxide] reaches the values of k=1.6 to 2.8, while the sol after the application and solvent evaporation undergoes thermally initiated polymerization at 80 to 200° C. for 30 minutes to 6 hours or photoinitiated polymerization for 1 second to 3 hours.
    • 60. 发明申请
    • Use of Finely Dispersed Metal Particles in a Material, a Skin Patch and an Orthopedic Article
    • 使用精细分散的金属颗粒在材料,皮肤补丁和矫形物品
    • US20110280957A1
    • 2011-11-17
    • US13194264
    • 2011-07-29
    • Klaus-Peter ANHALT
    • Klaus-Peter ANHALT
    • A61K33/38B32B3/00C08L75/04C08L53/00A61P31/04C08L83/04
    • C08K3/08C08K3/015C08K2003/0806C08K2201/014Y10T428/249921
    • The invention relates to a material which is provided for use in direct contact with the skin of a user and which contains a percentage in silver that is finely dispersed in said material. The material is provided with a content in another metal that is finely dispersed in the material in addition to the silver content. The metals of the group including aluminum, magnesium, zinc, bronze, titanium and platinum are suitable either individually or in combination and in amounts between 0.1 and 1% by weight. The use of the metal particles is also suitable to conceal discolorations in a pigmented or dyed synthetic material when the material is used in air or on the skin. The metal particles do not impair the properties of the material. The material can be used to produce skin patches of any kind, especially for use in orthopedics.
    • 本发明涉及一种材料,其被提供用于与使用者的皮肤直接接触并且其含有细分散在所述材料中的银百分比。 除了银含量之外,材料还被提供在除了银含量之外还精细分散在材料中的另一种金属中。 包括铝,镁,锌,青铜,钛和铂的组合金属可以单独使用或组合使用,其用量为0.1-1重量%。 当材料用于空气或皮肤时,金属颗粒的使用也适合于在着色或染色的合成材料中隐藏变色。 金属颗粒不会损害材料的性能。 该材料可用于生产任何类型的皮肤贴片,特别适用于骨科。