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51. 发明申请

US20160175828A1 N-HETEROCYCLIC CARBENE TYPE PALLADIUM CATALYST AND ITS PREPARATION METHOD AS WELL AS APPLICATIONS 有权
标题翻译： N-杂环碳酸盐型钯催化剂及其制备方法
公开(公告)号：US20160175828A1
公开(公告)日：2016-06-23
申请号：US14910456
申请日：2014-05-28
申请人： SHANGHAI RESEARCH INSTITUTE OF CHEMICAL INDUSTRY
发明人： An SHEN , Yucai CAO , Xiangyang WU , Xiaofeng YE , Chen NI , Yongqing LI
IPC分类号： B01J31/22 , C07D213/16 , C07C67/343 , C07C213/08 , C07C1/26 , C07D265/30 , C07D333/10 , C07D307/36 , C07C45/68 , C07C1/32 , C07F15/00 , C07C209/10
CPC分类号： B01J31/2273 , B01J31/1805 , B01J31/2226 , B01J31/28 , B01J2231/4205 , B01J2231/4277 , B01J2531/824 , C07C1/26 , C07C1/321 , C07C1/325 , C07C1/326 , C07C45/68 , C07C49/67 , C07C49/784 , C07C67/343 , C07C209/10 , C07C213/08 , C07C2531/22 , C07C2601/14 , C07D213/16 , C07D265/30 , C07D295/096 , C07D307/36 , C07D333/10 , C07D333/16 , C07F15/006 , C07C69/734 , C07C69/618
摘要： The present invention relates to an n-heterocyclic carbene (NHC) type palladium catalyst and its preparation method as well as applications. Its preparation process is as below: select glyoxal as the raw material to synthesize glyoxaldiimine in the presence of Lewis acid or Bronsted acid, and then react with paraformaldehyde to get the NHC type ligand. Use palladium(II) to react with the compound containing carbon-nitrogen double bonds to get palladium(II) cyclic dimer; make the palladium cyclic dimer and the NHC type ligand coordinated to get the NHC type palladium catalyst. The palladium catalyst with a brand new structure according to the present invention, boasts high activity and multi-purpose. In addition, it shows excellent reaction activity in a lot of catalytic-coupling reactions including Suzuki-Miyaura, Heck, Buchwald-Hartwig, Kumada-Tamao-Corriu, Sonogashira, Negishi and α-ketone arylation reactions, and some reactions even can be carried out with the presence of an extremely low concentration of catalyst, exhibiting favorable industrialization prospect.
摘要翻译：本发明涉及一种N-杂环卡宾（NHC）型钯催化剂及其制备方法以及应用。其制备方法如下：选择乙二醛作为原料，在路易斯酸或布朗斯台德酸存在下合成乙二醛，然后与多聚甲醛反应得到NHC型配体。使用钯（II）与含有碳 - 氮双键的化合物反应得到钯（II）环状二聚体; 使钯环二聚体和NHC型配体配位得到NHC型钯催化剂。本发明具有全新结构的钯催化剂具有活性高，多用途。另外，在Suzuki-Miyaura，Heck，Buchwald-Hartwig，Kumada-Tamao-Corriu，Sonogashira，Negishi和α-酮芳基化反应等大量的催化偶合反应中显示出优异的反应活性，甚至可以进行一些反应出现催化剂浓度极低的情况，表现出良好的工业化前景。

52. 发明申请

US20150344596A1 CATALYSTS 有权
标题翻译：催化剂
公开(公告)号：US20150344596A1
公开(公告)日：2015-12-03
申请号：US14654405
申请日：2013-12-19
申请人： BOREALIS AG
发明人： Luigi RESCONI , Pascal CASTRO , Ville VIRKKUNEN , Vyatcheslav V. IZMER , Dmitry S. KONONOVICH , Pavel Sergeevich KULYABIN , Alexander Z. VOSKOBOYNIKOV
IPC分类号： C08F110/06 , C07F17/00 , C07C1/32
CPC分类号： C08F110/06 , C07C1/326 , C07C2531/18 , C07F7/081 , C07F17/00 , C08F4/65912 , C08F4/65927 , C08F10/06 , C08F4/02 , C08F2500/03 , C08F2500/12 , C08F2500/15 , C08F210/06 , C08F210/16
摘要： A catalyst comprising (i) an asymmetric complex of formula (I) wherein M is zirconium or hafnium; each X is a sigma ligand; L is a divalent bridge selected from —R′2C—, —R′2C—CR′2—, —R′2Si—, —R′2Si—SiR′2—, —R′2Ge—, wherein each R′ is independently a hydrogen atom, C1-C20-alkyl, tri(C1-C20-alkyl)silyl, C6-C20-aryl, C7-C20-arylalkyl or C7-C20-alkylaryl; R2 and R2′ are each independently linear C1-10 hydrocarbyl; R5 and R5′ are each independently hydrogen or a C1-20 hydrocarbyl group; R6 and R6′ are each independently hydrogen or a C1-20 hydrocarbyl group; R7 is hydrogen or a C1-20 hydrocarbyl group or is ZR3; Z is O or S, preferably O; R3 is a C1-10 hydrocarbyl group; Ar is an aryl or heteroaryl group having up to 20 carbon atoms optionally substituted by one or more groups R8; Ar′ is an aryl or heteroaryl group having up to 20 carbon atoms optionally substituted by one or more groups R8′; and R8 and R8′ are each independently is a C1-20 hydrocarbyl group; with the proviso that at least one of R6 or R7 is not H; and (ii) a cocatalyst comprising a compound of a group 13 metal, e.g. boron.
摘要翻译：一种催化剂，其包含（i）式（I）的不对称配合物，其中M为锆或铪; 每个X是σ配体; L是选自-R'2C-，-R'2C-CR'2-，-R'2Si-，-R'2Si-SiR'2-，-R'2Ge-的二价桥，其中每个R' 独立地为氢原子，C 1 -C 20烷基，三（C 1 -C 20 - 烷基）甲硅烷基，C 6 -C 20 - 芳基，C 7 -C 20 - 芳基烷基或C 7 -C 20 - 烷基芳基; R2和R2'各自独立地为直链C 1-10烃基; R5和R5'各自独立地为氢或C1-20烃基; R6和R6'各自独立地为氢或C1-20烃基; R 7为氢或C 1-20烃基或ZR 3; Z是O或S，优选O; R3是C1-10烃基; Ar是任选被一个或多个基团R 8取代的具有至多20个碳原子的芳基或杂芳基; Ar'是任选被一个或多个R 8'基团取代的具有至多20个碳原子的芳基或杂芳基; R8和R8'各自独立地为C1-20烃基; 条件是R6或R7中的至少一个不是H; 和（ii）包含第13族金属化合物的助催化剂，例如硼。

53. 发明授权

US09024045B2 Process for preparing styrene derivatives 有权
标题翻译：制备苯乙烯衍生物的方法
公开(公告)号：US09024045B2
公开(公告)日：2015-05-05
申请号：US13907228
申请日：2013-05-31
申请人： Saltigo GmbH
发明人： Matthias Gotta , Bernd Wilhelm Lehnemann , Axel Von Wangelin Jacobi , Samet Guelak
IPC分类号： C07D317/46 , C07C209/74 , C07C17/278 , C07C41/30 , C07C2/66 , C07D317/50 , C07B37/04 , C07B49/00 , C07C209/68 , C07C1/32 , C07C17/263 , C07D309/12 , C07D317/54 , C07D319/06 , C07C213/08
CPC分类号： C07D317/46 , C07B37/04 , C07B49/00 , C07C1/326 , C07C2/66 , C07C17/2632 , C07C17/278 , C07C41/30 , C07C209/68 , C07C209/74 , C07C213/08 , C07C2601/02 , C07C2601/14 , C07D309/12 , C07D317/50 , C07D317/54 , C07D319/06 , C07C211/48 , C07C211/52 , C07C43/215 , C07C43/225 , C07C43/205 , C07C15/50 , C07C25/24 , C07C217/80 , C07C13/28 , C07C15/46 , C07C15/44 , C07C15/52
摘要： A process is provided which allows the synthesis of a large number of styrene derivatives with formation of C—C bonds, with use being possible of economically advantageous substrates, readily available carbon nucleophiles, and both inexpensive and environmentally unproblematic catalyst systems, permitting reaction under mild conditions and a high compatibility with functional groups on the reactants involved.
摘要翻译：提供了一种方法，其允许合成大量苯乙烯衍生物形成C-C键，可以使用经济上有利的底物，容易获得的碳亲核试剂以及廉价和环境无问题的催化剂体系，允许温和的反应条件和与所涉及的反应物上的官能团的高相容性。

54. 发明申请

US20140303333A1 IRON BISPHENOLATE COMPLEXES AND METHODS OF USE AND SYNTHESIS THEREOF 审中-公开
标题翻译：铁双酚A复合物及其使用及合成方法
公开(公告)号：US20140303333A1
公开(公告)日：2014-10-09
申请号：US14351550
申请日：2012-10-15
申请人： UNIVERSITY OF PRINCE EDWARD ISLAND , GENESIS GROUP INC.
发明人： Michael P. Shaver , Christopher M. Kozak
IPC分类号： C08F4/80 , C07D213/38 , C07C213/02 , C07C217/08 , C07F15/02 , C07C215/50 , C07D307/14
CPC分类号： C07C213/02 , B01J31/2243 , B01J2231/4205 , B01J2231/4233 , B01J2531/0238 , B01J2531/0241 , B01J2531/842 , C07B37/04 , C07C1/326 , C07C17/2632 , C07C29/32 , C07C41/30 , C07C67/293 , C07C67/343 , C07C215/50 , C07C217/08 , C07C253/30 , C07C2601/14 , C07C2602/42 , C07D213/38 , C07D307/14 , C07D319/06 , C07F15/025 , C08F2/38 , C08F4/04 , C08F4/80 , C08F2438/01 , C07C13/28 , C07C15/16 , C07C15/107 , C07C15/02 , C07C11/02 , C07C15/44 , C07C25/18 , C07C25/13 , C07C22/04 , C07C22/08 , C07C255/50 , C07C13/40 , C07C43/21 , C07C43/164 , C07C43/205 , C07C33/20 , C07C69/612 , C07C69/65 , C07C69/78 , C07C69/76 , C07C43/2055
摘要： The present application, relates to iron bisphenolate complexes and methods of use and synthesis thereof. The iron complexes are prepared from tridentate or tetradentate ligands of Formula I: wherein R1 and R2 are as defined herein. Also provided are methods and processes of using the iron bisphenolate complexes as catalysts in cross-coupling reactions and in controlled radical polymerizations.
摘要翻译：本申请涉及双酚铁复合物及其使用和合成方法。铁配合物由式I的三齿或四齿配体制备：其中R1和R2如本文所定义。还提供了在交叉偶联反应和受控自由基聚合中使用双酚铁复合物作为催化剂的方法和方法。

55. 发明授权

US08722942B2 Method for producing biphenyl derivative 有权
标题翻译：联苯衍生物的制备方法
公开(公告)号：US08722942B2
公开(公告)日：2014-05-13
申请号：US12377892
申请日：2007-10-12
申请人： Tamio Hayashi , Jiro Nakatani
发明人： Tamio Hayashi , Jiro Nakatani
IPC分类号： C07C43/164 , C07C17/269 , C07C2/84 , C07C43/205 , C07C17/263
CPC分类号： C07C43/2055 , C07B37/04 , C07B49/00 , C07C1/26 , C07C1/326 , C07C2/84 , C07C17/2632 , C07C15/14
摘要： A method produces a biphenyl derivative, with an industrially high yield and excellent productivity, by use of a raw material which is low in cost and toxicity. The method for producing the biphenyl derivative represented by Formula (1) is characterized in that a chlorine atom in a benzene derivative represented by Formula (2) reacts with magnesium metal to convert the benzene derivative into a Grignard reagent, and then the Grignard reagent is subjected to a coupling reaction in the presence of a catalyst and a dichloropropane: (wherein A represents at least one selected from alkyl groups, alkoxy groups, alkoxymethyl groups, a vinyl group, phenyl groups and chlorine, and n represents an integer of 1 to 4).
摘要翻译：通过使用低成本，低毒性的原料，能够得到工业上高产率，优异的生产率的联苯衍生物。由式（1）表示的联苯衍生物的制造方法的特征在于，式（2）表示的苯衍生物中的氯原子与镁金属反应，将苯衍生物转化成格氏试剂，然后将格氏试剂在催化剂和二氯丙烷的存在下进行偶联反应：（其中A表示选自烷基，烷氧基，烷氧基甲基，乙烯基，苯基和氯中的至少一种，n表示1〜 4）。

56. 发明授权

US08604249B2 Process for producing phosphonium borate compound, novel phosphonium borate compound, and method of using the same 有权
标题翻译：硼酸鏻化合物的制造方法，新型硼酸鏻化合物及其使用方法
公开(公告)号：US08604249B2
公开(公告)日：2013-12-10
申请号：US12947311
申请日：2010-11-16
申请人： Shin Masaoka , Hideyuki Iwazaki
发明人： Shin Masaoka , Hideyuki Iwazaki
IPC分类号： C07F9/28 , C07F9/54
CPC分类号： B01J31/32 , B01J31/0268 , B01J31/04 , B01J31/146 , B01J31/2234 , B01J31/24 , B01J31/2404 , B01J31/26 , B01J31/28 , B01J2231/4205 , B01J2231/4283 , B01J2531/72 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/828 , B01J2531/84 , C07C1/325 , C07C1/326 , C07C29/32 , C07C41/16 , C07C45/68 , C07C67/343 , C07C209/10 , C07C213/08 , C07C227/08 , C07C253/30 , C07F9/54 , C07C49/782 , C07C49/796 , C07C69/612 , C07C69/618 , C07C211/54 , C07C215/68 , C07C229/44 , C07C255/41 , C07C255/49 , C07C33/483 , C07C33/30 , C07C43/263 , C07C43/275
摘要： The invention relates to novel phosphonium borate compounds represented by the Formula: (R1)(R2)(R3)PH.BAr4, wherein R1, R2, R3 and Ar4 are as defined herein, and compositions including such phosphonium borate compounds in combination with a transition metal, transition metal salt, transition metal oxide or transition metal complex for use in carbon-carbon bond forming reactions, carbon-nitrogen bond forming reactions and carbon-oxygen bond forming reactions.
摘要翻译：本发明涉及由式（R1）（R2）（R3）PH.BAr4表示的新的硼酸鏻化合物，其中R1，R2，R3和Ar4如本文所定义，组合物包括这种硼酸鏻化合物与过渡金属，过渡金属盐，用于碳 - 碳键形成反应的过渡金属氧化物或过渡金属络合物，碳 - 氮键形成反应和碳 - 氧键形成反应。

57. 发明授权

US08030520B2 Process for preparing organic compounds by a transition metal-catalysed cross-coupling reaction of an aryl-X, heteroaryl-X, cycloalkenyl-X or alkenyl-X compound with an alkyl, alkenyl, cycloalkyl or cycloalkenyl halide 失效
标题翻译：通过芳基-X，杂芳基-X，环烯基-X或烯基-X化合物与烷基，烯基，环烷基或环烯基卤化物的过渡金属催化交叉偶联反应制备有机化合物的方法
公开(公告)号：US08030520B2
公开(公告)日：2011-10-04
申请号：US12407947
申请日：2009-03-20
申请人： Mark Sundermeier , Matthias Gotta , Axel Jacobi von Wangelin , Waldemar Maximilian Czaplik
发明人： Mark Sundermeier , Matthias Gotta , Axel Jacobi von Wangelin , Waldemar Maximilian Czaplik
IPC分类号： C07C211/00
CPC分类号： C07C1/326 , C07B37/04 , C07C2523/745 , C07C2523/75
摘要： This invention relates to a process for preparing functionalized aryl, heteroaryl, cycloalkenyl, or alkenyl compounds, by a transition-metal-catalyzed cross-coupling reaction of a substituted or unsubstituted aryl-X, heteroaryl-X, cycloalkenyl-X or alkenyl-X compound with an alkyl, alkenyl, cycloalkyl or cycloalkenyl halide, where X is a halide, diazonium, tosylate (p-toluenesulphonate), mesylate (methanesulphonate) or triflate (trifluoromethanesulphonate) leaving group.
摘要翻译：本发明涉及通过取代或未取代的芳基-X，杂芳基-X，环烯基-X或链烯基-X的过渡金属催化交叉偶联反应制备官能化芳基，杂芳基，环烯基或烯基化合物的方法与烷基，烯基，环烷基或环烯基卤化物的化合物，其中X是卤化物，重氮，甲苯磺酸酯（对甲苯磺酸酯），甲磺酸酯（甲磺酸酯）或三氟甲磺酸酯（三氟甲磺酸酯）离去基团。

58. 发明申请

US20100185019A1 CATALYST COMPOSITION AND PROCESS FOR PRODUCING CROSS-COUPLED COMPOUND USING SAME 审中-公开
标题翻译：催化剂组合物和使用其制备交联偶联剂的方法
公开(公告)号：US20100185019A1
公开(公告)日：2010-07-22
申请号：US12668338
申请日：2008-07-09
申请人： Masaharu Nakamura , Takuji Hatakeyama , Hisao Eguchi , Hirokazu Yano
发明人： Masaharu Nakamura , Takuji Hatakeyama , Hisao Eguchi , Hirokazu Yano
IPC分类号： C07C43/205 , B01J31/02 , B01J23/755 , C07C1/00
CPC分类号： B01J31/2273 , B01J31/0244 , B01J31/24 , B01J31/2404 , B01J31/30 , B01J2231/4233 , B01J2231/4238 , B01J2531/847 , C07B37/04 , C07C1/325 , C07C1/326 , C07C43/30 , C07C67/343 , C07C253/30 , C07C2521/02 , C07C2521/18 , C07C2527/128 , C07C2527/138 , C07C2531/24 , C07C15/14 , C07C69/76 , C07C255/50
摘要： A catalyst composition for a cross-coupling reaction comprising a nickel metal source, a fluorine source, and a nitrogen-containing heterocyclic compound having a specific structure, or a phosphine compound. Using this catalyst composition, a cross-coupled compound R5—R6 (wherein R5 and R6 are an aryl or heteroaryl group, or a linear, branched or cyclic alkyl group or a linear, branched or cyclic alkenyl group) is produced with a high selectivity by allowing an organometallic compound of the formula (2) R5-MY1 or the formula (3) R5-M-R5 (wherein R5 is the same as defined above, M is a Mg or Zn atom, and Y1 is a halogen atom) to react with a compound of the formula (4) R6—Y2 (wherein R6 is the same as defined above, and Y2 is a halogen atom, a methanesulfonate group, a toluenesulfonate group or a trifluoromethanesulfonate group).
摘要翻译：包含镍金属源，氟源和具有特定结构的含氮杂环化合物的交联反应催化剂组合物或膦化合物。使用该催化剂组合物，以高选择性制备交联体化合物R5-R6（其中R5和R6为芳基或杂芳基，或直链，支链或环状烷基或直链，支链或环状烯基）通过使式（2）R5-MY1或式（3）R5-M-R5（其中R5与上述定义相同，M为Mg或Zn原子，Y1为卤素原子）的有机金属化合物，与式（4）R6-Y2（其中R6与上述定义相同，Y2是卤素原子，甲磺酸酯基，甲苯磺酸酯基或三氟甲磺酸酯基）的化合物反应。

59. 发明申请

US20090247764A1 PROCESS FOR PREPARING ORGANIC COMPOUNDS BY A TRANSITION METAL-CATALYSED CROSS-COUPLING REACTION OF AN ARYL-X, HETEROARYL-X, CYCLOALKENYL-X OR ALKENYL-X COMPOUND WITH AN ALKYL, ALKENYL, CYCLOALKYL OR CYCLOALKENYL HALIDE 失效
公开(公告)号：US20090247764A1
公开(公告)日：2009-10-01
申请号：US12407947
申请日：2009-03-20
申请人： Mark Sundermeier , Matthias Gotta , Axel Jacobi von Wangelin , Waldermar Maximilian Czaplik
发明人： Mark Sundermeier , Matthias Gotta , Axel Jacobi von Wangelin , Waldermar Maximilian Czaplik
IPC分类号： C07D213/127 , C07C2/58
CPC分类号： C07C1/326 , C07B37/04 , C07C2523/745 , C07C2523/75
摘要： A process for preparing organic compounds of the general formula (I) R—R′ (I), where R is a substituted or unsubstituted aromatic, heteroaromatic, cycloalkenylic or alkenylic radical and R′ is a substituted or unsubstituted alkylic, alkenylic, cycloalkylic or cycloalkenylic radical, by reacting a corresponding compound of the general formula (II) R—X (II), where X is chlorine, bromine, iodine, diazonium, mesylate (methanesulphonate), tosylate (p-toluenesulphonate) or triflate (trifluorosutphonate) and R is as defined for formula (I), with a corresponding compound of the general formula (III) R′—Y (III), where Y is chlorine, bromine or iodine and R′ is as defined for formula (I), wherein the reaction is carried out in the presence of a) stoichiometric amounts of elemental magnesium, based on the compound of the general formula (II), and b) catalytic amounts of a transition metal compound, based on the compound of the general formula (II), and, if appropriate, c) in the presence of a nitrogen-, oxygen- and/or phosphorus-containing additive in a catalytic or stoichiometric amount, based on the compound of the general formula (II), is described. It is particularly advantageous that the process of the invention is carried out as a one-pot reaction and the organomagnesium compound (Grignard compound) formed in situ as intermediate is not isolated.

60. 发明授权

US07105467B2 Nickel catalyzed cross-coupling reactions between organomagnesium compounds and anisole derivatives 失效
标题翻译：有机镁化合物和苯甲醚衍生物之间的镍催化交叉偶联反应
公开(公告)号：US07105467B2
公开(公告)日：2006-09-12
申请号：US10615810
申请日：2003-07-08
申请人： John W. Dankwardt
发明人： John W. Dankwardt
IPC分类号： B01J31/00 , B01J37/00 , C08F4/02 , C08F4/60 , C07C15/67
CPC分类号： C07C1/326 , C07C2531/24 , C07C15/14
摘要： The present invention provides nickel catalysts and solvents which are useful in a cross-coupling reaction between an organomagnesium compound and an aromatic ether compound, such as an anisole derivative.
摘要翻译：本发明提供了可用于有机镁化合物和芳族醚化合物如茴香醚衍生物之间的交叉偶联反应的镍催化剂和溶剂。

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