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51. 发明授权

US12011701B2 Chemical reactors 有权
公开(公告)号：US12011701B2
公开(公告)日：2024-06-18
申请号：US17415121
申请日：2019-12-20
申请人： PHARMAFLUIDICS NV
发明人： Jeff Op De Beeck , Bo Claerebout , Wim De Malsche , Paul Jacobs
IPC分类号： B01J19/00 , B01D15/22
CPC分类号： B01J19/0093 , B01D15/22 , B01J2219/00916 , B01J2219/2408 , B01J2219/2448
摘要： A chemical reactor is implemented on a substrate. The chemical reactor has multiple ducts for transporting a fluid and/or gas during use of the chemical reactor, in which the ducts optionally include pillar structures and at least one connection duct connected between two of the multiple ducts for transporting the fluid and/or gas from one duct to another. In the connection duct, a series of individual pillar structures are positioned behind each other in the longitudinal direction of the connection duct.

52. 发明申请

US20160115092A1 DEVICE AND METHOD FOR THE PRODUCTION OF RADIOCHEMICAL COMPOUNDS 有权
标题翻译：用于生产放射化学化合物的装置和方法
公开(公告)号：US20160115092A1
公开(公告)日：2016-04-28
申请号：US14990567
申请日：2016-01-07
申请人： ABX ADVANCED BIOCHEMICAL COMPOUNDS GMBH , GESIM-GESELLSCHAFT FUER SILIZIUM-MIKROSYSTEME MBH
发明人： Marco Mueller , Steffen Howitz
IPC分类号： C07B59/00 , C07H5/02
CPC分类号： C07B59/005 , B01J19/004 , B01J19/0046 , B01J19/0093 , B01J2219/00038 , B01J2219/0004 , B01J2219/00094 , B01J2219/00132 , B01J2219/00141 , B01J2219/00283 , B01J2219/00333 , B01J2219/00364 , B01J2219/00585 , B01J2219/00599 , B01J2219/00704 , B01J2219/0072 , B01J2219/00731 , B01J2219/00788 , B01J2219/0081 , B01J2219/00882 , B01J2219/00889 , B01J2219/00916 , B01J2219/00941 , C07B59/00 , C07B2200/05 , C07H5/02
摘要： The invention relates to a method for the preparation of radiochemical compounds using a device having at least a reaction module, a dosing module, and a storage module, wherein the reaction module has at least one reaction vessel having a closable opening through which substances needed for the preparation of a predetermined radiochemical compound can be introduced into the reaction vessel of the reaction module and through which the prepared radiochemical compound can be removed from the reaction vessel of the reaction module; the dosing module has at least one pipetting head which can be moved relative to the storage module and the reaction module and in x, y, and z directions and also has at least one dosing unit; and at least one reservoir for one of the substances needed for the preparation of the respective radiochemical compound is formed in the storage module. Substances needed for the preparation of the respective radiochemical compound are introduced into the reaction vessel of the reaction module by means of dosing units, wherein the dosing units can be moved via a pipetting head in x, y directions or in x, y, and z directions.
摘要翻译：本发明涉及使用至少具有反应模块，剂量模块和储存模块的装置来制备放射化学化合物的方法，其中反应模块具有至少一个具有可闭合的开口的反应容器，可以将预定的放射化学化合物的制备物引入反应模块的反应容器中，通过该反应装置可以从反应模块的反应容器中除去所制备的放射化学化合物; 所述计量模块具有至少一个移液头，其可相对于所述储存模块和所述反应模块以及x，y和z方向移动，并且还具有至少一个计量单元; 并且在储存模块中形成用于制备各放射化学化合物所需的物质之一的至少一个贮存器。制备相应的放射化学化合物所需的物质通过计量单元被引入反应模块的反应容器中，其中计量单元可以通过移液头沿x，y方向或x，y和z移动方向。

53. 发明申请

US20150375209A1 METHODS OF CATALYTIC HYDROGENATION FOR ETHYLENE GLYCOL FORMATION 审中-公开
标题翻译：乙烯甘油酯形成催化氢化方法
公开(公告)号：US20150375209A1
公开(公告)日：2015-12-31
申请号：US14749441
申请日：2015-06-24
申请人： UNIVERSITY OF WYOMING
发明人： Maohong FAN , Tiberiu POPA
IPC分类号： B01J23/72 , B01J8/02 , B01J37/03 , B01J37/08 , C07C29/149 , B01J37/04
CPC分类号： B01J23/72 , B01J19/0093 , B01J29/064 , B01J29/14 , B01J29/46 , B01J35/023 , B01J37/035 , B01J37/036 , B01J37/08 , B01J2208/02 , B01J2219/00792 , B01J2219/00835 , B01J2219/00873 , B01J2219/00909 , B01J2219/00916 , B01J2219/00961 , B01J2219/00963 , B01J2219/00986 , B01J2523/00 , C07C29/149 , Y02P20/52 , C07C31/202 , B01J2523/17 , B01J2523/41
摘要： Embodiments described herein generally relate to hydrogenation catalysts, syntheses of hydrogenation catalysts, and apparatus and methods for hydrogenation. Methods for forming a hydrogenation catalyst may include mixing a silica generating precursor with a copper precursor and adding an ammonium salt to an end pH of between about 5 to about 9. Methods for hydrogenating an oxalate may include forming a reaction mixture by flowing a hydrogenation catalyst to a reactor, flowing a hydrogen source to the reactor, and flowing an oxalate to the reactor, wherein the hydrogenation catalyst has a particle size between about 10 nm to about 40 nm. Methods may further include reacting the oxalate to form ethylene glycol.
摘要翻译：本文所述的实施方案通常涉及氢化催化剂，氢化催化剂的合成，以及用于氢化的装置和方法。形成氢化催化剂的方法可以包括将二氧化硅生成前体与铜前体混合并加入铵盐至约5至约9的终止pH。用于氢化草酸盐的方法可包括通过使氢化催化剂到一个反应器中，将氢源流到反应器中，并使草酸盐流到反应器中，其中氢化催化剂的粒度在约10nm到约40nm之间。方法还可包括使草酸酯反应形成乙二醇。

54. 发明授权

US08980184B2 Device and method for the preparation of radiochemical compounds 有权
标题翻译：用于制备放射化学化合物的装置和方法
公开(公告)号：US08980184B2
公开(公告)日：2015-03-17
申请号：US13806019
申请日：2011-06-20
申请人： Marco Mueller , Steffen Howitz
发明人： Marco Mueller , Steffen Howitz
IPC分类号： B01J19/00 , C07B59/00
CPC分类号： C07B59/005 , B01J19/004 , B01J19/0046 , B01J19/0093 , B01J2219/00038 , B01J2219/0004 , B01J2219/00094 , B01J2219/00132 , B01J2219/00141 , B01J2219/00283 , B01J2219/00333 , B01J2219/00364 , B01J2219/00585 , B01J2219/00599 , B01J2219/00704 , B01J2219/0072 , B01J2219/00731 , B01J2219/00788 , B01J2219/0081 , B01J2219/00882 , B01J2219/00889 , B01J2219/00916 , B01J2219/00941 , C07B59/00 , C07B2200/05 , C07H5/02
摘要： The invention relates to a device for the preparation of radiochemical compounds. It is provided that the device comprises at least a reaction module, a dosing module, and a storage module, wherein; the reaction module has at least one reaction vessel having a closable opening through which substances needed for the preparation of a predetermined radiochemical compound can be introduced into the reaction vessel of the reaction module and through which the prepared radiochemical compound can be removed from the reaction vessel of the reaction module; the dosing module has at least one pipetting head which can be moved relative to the storage module and the reaction module and in x, y, and z directions and also has at least one dosing unit; and at least one reservoir for one of the substances needed for the preparation of the respective radiochemical compound is formed in the storage module.
摘要翻译：本发明涉及一种用于制备放射化学化合物的装置。提供的是，该装置至少包括反应模块，计量模块和存储模块，其中：反应模块具有至少一个反应容器，该反应容器具有可闭合的开口，通过该开关可制备预定的放射化学化合物所需的物质可以被引入到反应模块的反应容器中，通过该反应容器可以从反应容器中除去所制备的放射化学化合物的反应模块; 所述计量模块具有至少一个移液头，其可相对于所述储存模块和所述反应模块以及x，y和z方向移动，并且还具有至少一个计量单元; 并且在储存模块中形成用于制备各放射化学化合物所需的物质之一的至少一个贮存器。

55. 发明申请

US20150056105A1 AUTOMATIC SYSTEM FOR SYNTHESIZING 123I-MIBG AND AUTOMATIC DEVICE FOR SYNTHESIZING AND DISPENSING 123I-MIBG COMPRISING THE SAME 有权
标题翻译：用于合成123I-MIBG的自动系统和用于合成和分配包含其的123I-MIBG的自动装置
公开(公告)号：US20150056105A1
公开(公告)日：2015-02-26
申请号：US14464461
申请日：2014-08-20
申请人： Institute of Nuclear Energy Research Atomic Energy Council, Executive Yuan
发明人： Tsai-Yueh LUO , Te-Sheng LIANG , Ying-Hsia SHIH , Wuu-Jyh LIN
IPC分类号： B01J19/00 , B01J19/24 , A61K51/04
CPC分类号： B01J19/0006 , A61K51/04 , A61K51/0406 , B01J19/00 , B01J19/0013 , B01J19/0093 , B01J19/24 , B01J2219/00051 , B01J2219/00182 , B01J2219/00799 , B01J2219/00862 , B01J2219/00869 , B01J2219/00873 , B01J2219/00894 , B01J2219/00916 , B01J2219/00961 , B01J2219/00986 , B01J2219/0099 , C07B59/00
摘要： The present invention relates to an automatic system for synthesizing iodine-123 meta-iodobenzylguanidine (123I-MIBG), which comprises a first reactor for subjecting radioactive iodine-containing sodium iodide and meta-iodobenzylguanidine (MIBG) sulfate to an iodine-iodine exchange reaction to obtain radioactive iodine labeled MIBG; a purification unit for purifying the iodine labeled MIBG; and a second reactor for substituting a solvent used in purification with a phosphate buffer to obtain a phosphate solution containing 123I-MIBG. The present invention also relates to an automatic device for dispensing 123I-MIBG, which comprises the automatic system for synthesizing 123I-MIBG, a radioactivity measuring unit, and a dispensing and packing unit.
摘要翻译：本发明涉及一种用于合成碘-123间碘碘苄基胍（123I-MIBG）的自动化系统，其包括用于使放射性碘碘化钠和间碘碘苄基胍（MIBG）硫酸盐进行碘 - 碘交换反应的第一反应器获得放射性碘标记的MIBG; 用于纯化碘标记的MIBG的纯化单元; 和用磷酸盐缓冲液代替纯化用溶剂的第二反应器，得到含有123I-MIBG的磷酸盐溶液。本发明还涉及用于分配123I-MIBG的自动装置，其包括用于合成123I-MIBG的自动系统，放射性测量单元和分配和包装单元。

56. 发明申请

US20130144052A1 DEVICE FOR THE SYNTHESIS OF RADIO-LABELED COMPOUNDS 审中-公开
标题翻译：用于合成无线标签化合物的装置
公开(公告)号：US20130144052A1
公开(公告)日：2013-06-06
申请号：US13809506
申请日：2011-07-05
申请人： Marco Mueller
发明人： Marco Mueller
IPC分类号： C07B59/00 , C07H5/02
CPC分类号： C07B59/005 , B01J19/0093 , B01J2219/00788 , B01J2219/0081 , B01J2219/00813 , B01J2219/00817 , B01J2219/00891 , B01J2219/00898 , B01J2219/00916 , B01J2219/00927 , C07B59/00 , C07B2200/05 , C07H5/02 , Y02P20/55
摘要： The invention relates to a device for the synthesis of radio-labeled compounds, which comprisesa reaction vessel for reacting a precursor compound having protective groups with a radioactive isotope to obtain a first reaction product; a first cartridge for hydrolyzing the protective groups of the first reaction product to obtain a second reaction product; and a second cartridge for purifying the second reaction product, wherein the reaction vessel, the first cartridge, and the second cartridge are connected to each other via pipelines. Here it is provided that the first cartridge contains 801 to 1200 mg of a solid carrier and/or the reaction vessel is a reaction vessel made of a temperature-resistant plastic with the plastic having a temperature resistance of at least 120° C.
摘要翻译：本发明涉及一种用于合成放射性标记化合物的装置，其包括用于使具有保护基团的前体化合物与放射性同位素反应以获得第一反应产物的反应容器; 用于水解第一反应产物的保护基团以获得第二反应产物的第一筒; 以及用于净化所述第二反应产物的第二筒，其中所述反应容器，所述第一盒和所述第二盒通过管道相互连接。这里规定，第一筒包含801至1200mg的固体载体和/或反应容器是由具有至少120℃的耐温性的塑料制成的耐温塑料的反应容器。

57. 发明申请

US20120298037A1 MICROCHEMICAL NANOFACTORIES 审中-公开
标题翻译：微生物纳米生物
公开(公告)号：US20120298037A1
公开(公告)日：2012-11-29
申请号：US13489118
申请日：2012-06-05
申请人： Brian Kevin Paul , Chih-hung Chang , Vincent Thomas Remcho
发明人： Brian Kevin Paul , Chih-hung Chang , Vincent Thomas Remcho
IPC分类号： B05C11/00
CPC分类号： C07D255/02 , B01F5/0475 , B01F5/0641 , B01F5/0646 , B01F5/0647 , B01F13/0062 , B01F13/0066 , B01J19/0093 , B01J2219/00783 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00907 , B01J2219/00914 , B01J2219/00916 , B01J2219/00972 , B01L3/502707 , B01L2200/0631 , B01L2300/0864 , B01L2300/0867 , B01L2300/0887 , B01L2400/0655 , C08L101/005 , G01N27/44791 , G01N30/0005 , G01N30/6095
摘要： Embodiments of an apparatus, system, and method for chemical synthesis and/or analysis are disclosed. One embodiment of a disclosed apparatus comprises a laminated, microfluidic structure defining a reactor and a separator. Such apparatuses, or portions thereof, generally have dimensions ranging from about 1 micrometer to about 100 micrometers. To implement synthetic processes, disclosed embodiments of the apparatus generally include at least one unit operation, such as a mixer, a valve, a separator, a detector, and combinations thereof. Individual apparatuses may be coupled both in series and in parallel to form a system for making chemical compounds. An individual apparatus or a system also can be used in combination with known devices and processes.
摘要翻译：公开了用于化学合成和/或分析的装置，系统和方法的实施例。公开的装置的一个实施例包括限定反应器和分离器的层压的微流体结构。这种装置或其部分通常具有约1微米至约100微米的尺寸。为了实现合成方法，所公开的设备的实施例通常包括至少一个单元操作，例如混合器，阀，分离器，检测器及其组合。单个装置可以串联耦合并联，以形成用于制备化合物的系统。单独的设备或系统也可以与已知的设备和过程组合使用。

58. 发明申请

US20120076692A1 Modular Component Synthesis Unit 审中-公开
标题翻译：模块化组件合成单元
公开(公告)号：US20120076692A1
公开(公告)日：2012-03-29
申请号：US13242503
申请日：2011-09-23
申请人： Reza Miraghaie
发明人： Reza Miraghaie
IPC分类号： B01J19/00
CPC分类号： B01J19/0093 , B01J2219/00788 , B01J2219/0081 , B01J2219/00813 , B01J2219/00815 , B01J2219/00817 , B01J2219/00822 , B01J2219/00833 , B01J2219/00871 , B01J2219/00916 , B01J2219/00918
摘要： A kit, for synthesizing a compound or element, which includes a modular reagent source, a modular trap and release apparatus, and a modular reaction unit. The modular reagent source includes a reagent. The modular trap and release apparatus is configured to separate components of the reagent. The modular reaction unit which is in fluid communication with the modular reagent source and the modular trap and release apparatus. In addition, the modular reaction unit includes a reaction vessel configured to facilitate a chemical reaction.
摘要翻译：用于合成化合物或元件的试剂盒，其包括模块化试剂源，模块式捕集器和释放装置以及模块化反应单元。模块化试剂源包括试剂。模块化捕集器和释放装置被配置为分离试剂的组分。模块化反应单元与模块化试剂源和模块式捕集和释放装置流体连通。此外，模块化反应单元包括配置为促进化学反应的反应容器。

59. 发明申请

US20080274557A1 Permethylation Of Oligosaccharides 审中-公开
标题翻译：寡糖的乙基化
公开(公告)号：US20080274557A1
公开(公告)日：2008-11-06
申请号：US11817436
申请日：2006-03-03
申请人： Pilsoo Kang , Yehia S. Mechref , Milos V. Novotny
发明人： Pilsoo Kang , Yehia S. Mechref , Milos V. Novotny
IPC分类号： G01N33/00 , B01J19/00 , C07H1/00
CPC分类号： B01J19/0093 , B01J2219/00788 , B01J2219/00824 , B01J2219/00835 , B01J2219/00837 , B01J2219/00891 , B01J2219/00916 , B01J2219/00957 , C07K1/1077 , G01N30/02 , Y10T436/11 , Y10T436/143333 , Y10T436/25 , B01D15/325
摘要： A solid-phase permethylation procedure is described. For example, solid-phase permethylation can be utilized to prepare permethylated linear and branched, neutral and sialylated oligosaccharides, which can be analyzed by MALDI-MS.
摘要翻译：描述了固相去甲基化方法。例如，可以使用固相甲基化来制备可以通过MALDI-MS分析的二甲基化的直链和支链，中性和唾液酸化寡糖。

60. 发明授权

US07314567B2 Method for transferring heterogeneous liquids in microchannels without the occurrence of mixing 失效
标题翻译：在不发生混合的情况下在微通道中转移异质液体的方法
公开(公告)号：US07314567B2
公开(公告)日：2008-01-01
申请号：US10515873
申请日：2003-05-26
申请人： Patrick Wagler , John Simpson McCaskill , Tobias Foster
发明人： Patrick Wagler , John Simpson McCaskill , Tobias Foster
IPC分类号： B01D15/08
CPC分类号： B01L3/502784 , B01F13/0059 , B01F13/0071 , B01J19/0093 , B01J2219/00837 , B01J2219/0086 , B01J2219/00891 , B01J2219/00916 , B01L3/502723 , B01L3/502753 , B01L2200/0605 , B01L2200/0673 , G01N30/84 , G01N35/08 , G01N2001/4061 , G01N2030/065 , Y10T137/0391 , Y10T137/218 , Y10T436/2575
摘要： In the method for mixing-free transport of homogeneous liquids in microchannels a heterogeneous liquid flow (14) is autonomously divided into portions, transported over a distance and then autonomously recombined. When the flow is divided into portions, individual volumes of a second liquid (16), which may be but must not be homogeneous, are introduced between volume fractions lying one behind the other of the heterogeneous liquid flow (14). While the volume fractions of the heterogeneous liquid (14) that lye close to one another would mix with each other without this measure being taken, separation of the individual volume fractions allows these volume fractions, and thus the heterogeneous liquid (14), to be transported over large distances without any mixing occurring. Treatment of the volume fractions of the heterogeneous liquid (14) requires separation of the liquid flow (12) of alternating volume fractions of the two liquids (14,16) such that again two flows are produced, one of which being the heterogeneous starting liquid and the other being the second liquid. Since both processes can take place autonomously by self-organization of the phases, an overall solution for the mixing-free transport of a heterogeneous liquid without employment of expensive fractionating apparatus can be achieved.
摘要翻译：在微通道中均匀液体的无混合输送方法中，将非均相液体流（14）自主分成部分，运输一段距离然后自主重组。当流被分成多个部分时，可以但不一定是均匀的第二液体（16）的单独体积被引入位于异质液体流（14）的另一个之后的体积分数之间。尽管在不采取这种措施的情况下，碱液彼此接近的非均相液体（14）的体积分数将彼此混合，但是各体积分数的分离允许这些体积分数，从而使异质液体（14）为运输很大距离，没有任何混合发生。处理非均相液体（14）的体积分数需要分离两种液体（14,16）的交替体积分数的液体流（12），使得再次产生两个流，其中之一是异质起始液体另一个是第二个液体。由于这两个过程可以通过相的自组织自主发生，所以可以实现不使用昂贵的分馏装置的不混合液体的无混合输送的整体解决方案。

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