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51. 发明授权

US08118751B2 Devices and methods for accelerometer-based characterization of cardiac function and identification of LV target pacing zones 失效
标题翻译：用于基于加速度计的心脏功能表征的装置和方法以及LV目标起搏区域的识别
公开(公告)号：US08118751B2
公开(公告)日：2012-02-21
申请号：US12396420
申请日：2009-03-02
申请人： John D. Dobak, III
发明人： John D. Dobak, III
IPC分类号： A61B5/04
CPC分类号： A61B5/02 , A61B5/0456 , A61B2562/0219 , A61B2562/028 , A61N1/056 , A61N1/3627 , A61N1/36542 , A61N1/36585 , A61N2001/0585
摘要： Systems according to the invention employ an acceleration sensor to characterize displacement and vibrational LV motion, and uses this motion data to characterize the different phases of the LV cycle for analyzing LV function. Systems may identify a target pacing region or regions in the LV or RV using the acceleration sensor by localizing regions of late onset of motion relative to the QRS, or isovolumic contraction, or mitral valve closure, or by pacing of target regions and measuring LV function in response to pacing. Systems further provide an implantable or non-implantable acceleration sensor device for measuring LV motion and characterizing LV function. An implantable myocardial acceleration sensing system (“IAD”) includes at least one acceleration sensor, a data acquisition and processing device, and an electromagnetic, e.g., RF, communication device. The IAD may be integrated into the pacing lead of a CRT device and can operate independently of the CRT IPG.
摘要翻译：根据本发明的系统采用加速度传感器来表征位移和振动LV运动，并且使用该运动数据来表征用于分析LV功能的LV循环的不同相位。系统可以使用加速度传感器来识别LV或RV中的目标起搏区域或区域，通过将相对于QRS的运动迟发性区域，或等容性收缩或二尖瓣闭合定位，或通过起搏区域和测量LV功能来定位响应起搏。系统还提供用于测量LV运动和表征LV功能的可植入或不可植入的加速度传感器装置。可植入心肌加速度感测系统（“IAD”）包括至少一个加速度传感器，数据采集和处理装置以及电磁（例如RF）通信装置。 IAD可以集成到CRT设备的起搏引线中，并且可独立于CRT IPG进行操作。

52. 发明授权

US08050775B2 Coronary vein lead having pre-formed biased portions for fixation 有权
标题翻译：冠状静脉引线具有用于固定的预先形成的偏置部分
公开(公告)号：US08050775B2
公开(公告)日：2011-11-01
申请号：US12608402
申请日：2009-10-29
申请人： Randy Westlund , Bruce A. Tockman , Christina Repasky , Lyle A. Bye , Brian D. Soltis
发明人： Randy Westlund , Bruce A. Tockman , Christina Repasky , Lyle A. Bye , Brian D. Soltis
IPC分类号： A61N1/00
CPC分类号： A61N1/056 , A61N1/057 , A61N2001/0585
摘要： A lead having pre-formed biased portion is adapted for implantation on or about the heart within the coronary vasculature and for connection to a signal generator. The lead is constructed and arranged so that when it is implanted, the electrodes are housed in the coronary vasculature and are biased toward a vessel wall by the preformed biased portion, which operates to fixate the lead against the vessel wall.
摘要翻译：具有预形成偏置部分的引线适于植入在冠状脉管系统内部或周围的心脏上，并用于连接到信号发生器。引线被构造和布置成使得当其被植入时，电极被容纳在冠状脉管系统中并且被预先设定的偏压部分偏压到血管壁，该部分操作以将引线固定在血管壁上。

53. 发明申请

US20110264157A1 SYSTEM AND METHOD FOR GRAPHICALLY CONFIGURING LEADS 有权
标题翻译：用于图形配置的系统和方法
公开(公告)号：US20110264157A1
公开(公告)日：2011-10-27
申请号：US13177000
申请日：2011-07-06
申请人： Par Lindh , James Kalgren , Rene H. Wentkowski , John Lockhart
发明人： Par Lindh , James Kalgren , Rene H. Wentkowski , John Lockhart
IPC分类号： A61N1/39 , A61N1/36
CPC分类号： A61N1/37264 , A61N1/0563 , A61N1/368 , A61N1/3684 , A61N1/37247 , A61N1/3962 , A61N1/3993 , A61N2001/0585 , Y10S128/92 , Y10S128/922 , Y10S128/923
摘要： Systems and methods are provided for graphically configuring leads for a medical device. According to one aspect, the system generally comprises a medical device and a processing device, such as a programmer or computer, adapted to be in communication with the medical device. The medical device has at least one lead with at least one electrode in a configuration that can be changed using the processing device. The processing device provides a graphical display of the configuration, including a representative image of a proposed electrical signal to be applied by the medical device between the at least one electrode of the medical device and at least one other electrode before the medical device applies the electrical signal between the at least one electrode and the at least one other electrode. In one embodiment, the graphical display graphically represents the lead(s), the electrode(s), a pulse polarity, and a vector.
摘要翻译：提供了用于图形化配置医疗设备引线的系统和方法。根据一个方面，系统通常包括医疗设备和适于与医疗设备通信的诸如编程器或计算机的处理设备。医疗装置具有至少一个引线，其中至少一个电极可以使用该处理装置进行改变。所述处理装置提供所述配置的图形显示，其包括所述医疗装置在所述医疗装置的所述至少一个电极与所述至少一个其它电极之间施加的所提出的电信号的代表性图像，信号在所述至少一个电极和所述至少一个其它电极之间。在一个实施例中，图形显示图形地表示引线，电极，脉冲极性和矢量。

54. 发明申请

US20110238077A1 INTRAVASCULAR MEDICAL DEVICE 有权
标题翻译：血管内科医疗器械
公开(公告)号：US20110238077A1
公开(公告)日：2011-09-29
申请号：US12767176
申请日：2010-04-26
申请人： William K. Wenger
发明人： William K. Wenger
IPC分类号： A61B17/00
CPC分类号： A61N1/375 , A61B17/3468 , A61N1/0573 , A61N1/37205 , A61N1/3756 , A61N2001/058 , A61N2001/0585
摘要： An implantable medical device system, including an implantable medical device and an associated implant tool. The device has a hermetic housing containing a power source and electronic circuitry. One or more tines are mounted to the housing movable from a first position extending away from the housing to a second position adjacent the housing. The device is provided with a rotational fixation mechanism. The Implant tool includes an elongated sheath sized to receive the device and provided with internal grooves sized to engage with the tines when the tines are located in their second position. The implant tool may further include a push tool located with the sheath and movable within the sheath to advance the device distally out of the sheath. The sheath may be provided with a closed distal end openable by passage of the device therethrough.
摘要翻译：一种可植入医疗装置系统，包括可植入医疗装置和相关植入工具。该装置具有包含电源和电子电路的密封外壳。一个或多个尖齿安装到壳体，其可从远离壳体的第一位置移动到邻近壳体的第二位置。该装置设置有旋转固定机构。植入物工具包括细长的护套，其尺寸适于接收该装置并且设置有内凹槽，其尺寸设计成当尖齿位于其第二位置时与尖齿接合。植入物工具还可以包括与护套定位并可在护套内移动的推动工具，以将器件向远端推出护套。护套可以设置有通过设备通过其可打开的封闭远端。

55. 发明授权

US07991473B2 System and method for graphically configuring leads 有权
标题翻译：用于图形化配置引线的系统和方法
公开(公告)号：US07991473B2
公开(公告)日：2011-08-02
申请号：US12838208
申请日：2010-07-16
申请人： Par Lindh , James Kalgren , Rene H. Wentkowski , John Lockhart
发明人： Par Lindh , James Kalgren , Rene H. Wentkowski , John Lockhart
IPC分类号： A61N1/08
CPC分类号： A61N1/37264 , A61N1/0563 , A61N1/368 , A61N1/3684 , A61N1/37247 , A61N1/3962 , A61N1/3993 , A61N2001/0585 , Y10S128/92 , Y10S128/922 , Y10S128/923
摘要： Systems and methods are provided for graphically configuring leads for a medical device. According to one aspect, the system generally comprises a medical device and a processing device, such as a programmer or computer, adapted to be in communication with the medical device. The medical device has at least one lead with at least one electrode in a configuration that can be changed using the processing device. The processing device provides a graphical display of the configuration, including a representative image of a proposed electrical signal to be applied by the medical device between the at least one electrode of the medical device and at least one other electrode before the medical device applies the electrical signal between the at least one electrode and the at least one other electrode. In one embodiment, the graphical display graphically represents the lead(s), the electrode(s), a pulse polarity, and a vector.
摘要翻译：提供了用于图形化配置医疗设备引线的系统和方法。根据一个方面，系统通常包括医疗设备和适于与医疗设备通信的诸如编程器或计算机的处理设备。医疗装置具有至少一个引线，其中至少一个电极可以使用该处理装置进行改变。所述处理装置提供所述配置的图形显示，其包括所述医疗装置在所述医疗装置的所述至少一个电极与所述至少一个其它电极之间施加的所提出的电信号的代表性图像，信号在所述至少一个电极和所述至少一个其它电极之间。在一个实施例中，图形显示图形地表示引线，电极，脉冲极性和矢量。

56. 发明授权

US07935056B2 Intravascularly implantable integrated circuits 有权
标题翻译：血管内植入式集成电路
公开(公告)号：US07935056B2
公开(公告)日：2011-05-03
申请号：US11731247
申请日：2007-03-29
申请人： Mark J. Zdeblick
发明人： Mark J. Zdeblick
IPC分类号： A61N1/08
CPC分类号： A61N1/372 , A61B5/04011 , A61B5/0422 , A61N1/056 , A61N1/36185 , A61N1/368 , A61N1/3684 , A61N1/3686 , A61N1/37211 , A61N1/37276 , A61N1/37288 , A61N2001/0585
摘要： Techniques for controlling one or more modular circuits (“satellites”) that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals (e.g., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned (e.g., heart muscles) or to sense analog signals (e.g., a propagating depolarization signal) within the tissue.
摘要翻译：用于控制用于放置在受检者体内的一个或多个模块化电路（“卫星”）的技术。通过在包括第一和第二导电路径的总线上发送信号来控制一个或多个卫星。在系统实施例中还耦合到总线的是诸如提供电力并包括控制电路的起搏器的装置。每个卫星包括卫星电路和与组织相互作用的一个或多个效应器。卫星电路耦合到总线，并且因此使控制器与一个或多个效应器接合，这些效应器可以用作致动器，传感器或两者。效应器可以是用于将模拟电信号（例如，一个或多个起搏脉冲）引入电极定位的局部区域（例如，心脏肌肉）中的组织中或用于感测模拟信号（例如，传播去极化信号）。

57. 发明申请

US20110030872A1 POLYMER LEAD COVERING WITH VARIED MATERIAL PROPERTIES 有权
标题翻译：聚合物铅覆盖有各种材料特性
公开(公告)号：US20110030872A1
公开(公告)日：2011-02-10
申请号：US12903702
申请日：2010-10-13
申请人： Christopher P. Knapp , Kyle Hoecke , Mohan Krishnan , Rebecca Aron
发明人： Christopher P. Knapp , Kyle Hoecke , Mohan Krishnan , Rebecca Aron
IPC分类号： H01B13/08
CPC分类号： A61N1/056 , A61N2001/0585
摘要： This document discusses, among other things, a lead assembly including a lead body, at least one conductor extending through the lead body, and a covering having varied material properties. In an example, the covering is made by forming pieces of material having varied material properties. In another example, the covering is made by varying parameters such as heat or tension during wrapping of a piece of material onto a lead assembly.
摘要翻译：该文件尤其涉及一种引线组件，其包括引线本体，延伸穿过引线主体的至少一个导体以及具有不同材料特性的覆盖物。在一个实例中，覆盖物通过形成具有不同材料性质的材料制成。在另一个示例中，通过在将一块材料包裹到引线组件上时，通过改变诸如热或张力的参数来进行覆盖。

58. 发明授权

US07865248B2 Biasing and fixation features on leads 有权
标题翻译：引线上的偏置和固定功能
公开(公告)号：US07865248B2
公开(公告)日：2011-01-04
申请号：US11548838
申请日：2006-10-12
申请人： Paul E. Zarembo , Brian D. Soltis
发明人： Paul E. Zarembo , Brian D. Soltis
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/057 , A61N2001/0585
摘要： A lead assembly for placement in a coronary vessel of the heart, the coronary vessel having a pericardial wall portion and a myocardial wall portion. The lead assembly comprises a lead body extending from a proximal end adapted for coupling to a pulse generator to a distal end adapted for implantation in the heart, an electrode positioned at the distal end of the lead body, and a loop biasing feature located at the distal end of the lead body. The loop biasing feature includes a resilient loop positioned to bias a portion of the electrode towards the myocardial wall portion of the coronary vessel by exerting a force against the pericardial wall portion. The loop biasing feature further includes a collar for coupling the loop biasing feature to the lead body. A method of implanting the lead assembly.
摘要翻译：用于放置在心脏的冠状血管中的引导组件，所述冠状血管具有心包壁部分和心肌壁部分。引线组件包括引线本体，其从适于联接到脉冲发生器的近端延伸到适于植入心脏的远端，位于引线主体的远端的电极以及位于引线主体的环偏置特征引线体的远端。环偏置特征包括弹性环，其定位成通过向心包壁部分施加力而将电极的一部分朝向冠状血管的心肌壁部分偏置。环偏置特征还包括用于将环偏置特征耦合到引线体的套环。一种植入引线组件的方法。

59. 发明申请

US20100324637A1 ELECTRODE PROBE FOR MEDICAL APPLICATION 审中-公开
标题翻译：用于医疗应用的电极探针
公开(公告)号：US20100324637A1
公开(公告)日：2010-12-23
申请号：US12783594
申请日：2010-05-20
申请人： Erik Trip , Erhard Flach , Christian Schnittker , Marc Steffen Schurr
发明人： Erik Trip , Erhard Flach , Christian Schnittker , Marc Steffen Schurr
IPC分类号： A61N1/05 , A61M5/00
CPC分类号： A61N1/057 , A61N1/0568 , A61N1/0575 , A61N2001/0585
摘要： An electrode probe for medical applications includes a tubular, flexible probe body, an electrode mounted at the distal end of the probe body, and an electrical supply line within the probe body and extending to the electrode. At least a portion of the distal end section of the probe body can be transformed into a radially broadened collar, preferably owing to relative motion between the electrical supply line and the probe body. Where a screw-in electrode is used, the distal end section may be deformed into a radially broadened collar when the electrode is screwed into the body tissue, owing to forces exerted by the body tissue onto the distal end section, and/or owing to forces exerted by the screw-in electrode on the distal end section via a thrust bearing.
摘要翻译：用于医疗应用的电极探针包括管状柔性探针体，安装在探针主体远端的电极以及探针体内的电极，并延伸到电极。探针主体的远端部分的至少一部分可以变换成径向变宽的套环，优选地由于电源线和探针体之间的相对运动。在使用螺旋电极的情况下，由于身体组织施加到远端部分上的力和/或由于在远端部分施加的力而使电极拧入身体组织中时，远端部分可变形为径向变宽的套环通过推力轴承由螺旋电极施加在远端部分上的力。

60. 发明授权

US07835802B2 Polymer lead covering with varied material properties 有权
标题翻译：具有不同材料性能的聚合物铅覆盖层
公开(公告)号：US07835802B2
公开(公告)日：2010-11-16
申请号：US12046407
申请日：2008-03-11
申请人： Christopher P. Knapp , Kyle Hoecke , Mohan Krishnan , Rebecca Aron
发明人： Christopher P. Knapp , Kyle Hoecke , Mohan Krishnan , Rebecca Aron
IPC分类号： A61N1/02
CPC分类号： A61N1/056 , A61N2001/0585
摘要： This document discusses, among other things, a lead assembly including a lead body, at least one conductor extending through the lead body, and a covering having varied material properties. In an example, the covering is made by forming pieces of material having varied material properties. In another example, the covering is made by varying parameters such as heat or tension during wrapping of a piece of material onto a lead assembly.
摘要翻译：该文件尤其涉及一种引线组件，其包括引线本体，延伸穿过引线主体的至少一个导体以及具有不同材料特性的覆盖物。在一个实例中，覆盖物通过形成具有不同材料性质的材料制成。在另一个示例中，通过在将一块材料包裹到引线组件上时，通过改变诸如热或张力的参数来进行覆盖。

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