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51. 发明授权

US08356631B2 Fluid transport device and fluid transport control method 有权
标题翻译：流体输送装置和流体输送控制方法
公开(公告)号：US08356631B2
公开(公告)日：2013-01-22
申请号：US12677199
申请日：2008-09-09
申请人： Hiroaki Suzuki , Wataru Satoh , Jun Nakamura
发明人： Hiroaki Suzuki , Wataru Satoh , Jun Nakamura
IPC分类号： F15C1/04
CPC分类号： B41J2/005 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502784 , B01L2200/027 , B01L2300/161 , B01L2400/0424 , B01L2400/0427 , B41J2002/14395 , Y10T137/0391 , Y10T137/2191
摘要： A fluid transport device transports fluid containing electrolytes within a flow channel. At least a portion of the inner walls of the flow channels are hydrophilic from the inlet to the outlet thereof except at at least one valve portion. The device also includes: the valve portions, which are hydrophobic and function to block transport of at least one fluid; electrodes, which are provided at the at least one valve portion and function to reduce the surface tension of the fluid; and air vents, which are provided at the at least one valve portion and function to introduce air in order to block the fluid.
摘要翻译：流体输送装置在流动通道内输送含有电解质的流体。除了在至少一个阀部分之外，流动通道的内壁的至少一部分从入口至出口是亲水的。该装置还包括：阀部分，其是疏水性的并且用于阻止至少一种流体的输送; 电极，其设置在所述至少一个阀部分处，并且具有降低流体的表面张力的功能; 和通气口，其设置在所述至少一个阀部分处，并且用于引入空气以阻塞流体的功能。

52. 发明申请

US20120256104A1 PHASE CHANGE DEVICE HAVING PHASE CHANGE RECORDING FILM, AND PHASE CHANGE SWITCHING METHOD FOR PHASE CHANGE RECORDING FILM 有权
标题翻译：具有相变记录膜的相变装置及相变记录膜的相变切换方法
公开(公告)号：US20120256104A1
公开(公告)日：2012-10-11
申请号：US13503346
申请日：2010-08-09
申请人： Muneaki Hase , Kotaro Makino , Junji Tominaga
发明人： Muneaki Hase , Kotaro Makino , Junji Tominaga
IPC分类号： B01J19/12
CPC分类号： G11C13/0004 , G02B26/001 , G11B7/00454 , G11B7/00456 , G11B7/1395 , G11B7/243 , G11B2007/24316 , G11C13/04 , H01L45/06 , H01L45/144 , H01S3/0057
摘要： Allow the rate of phase change to be controlled at the time period of phonons (approx. 270 fs) for the purpose of achieving a substantially higher recording-erasing speed compared to what can be achieved with conventional technologies relating to optical recording media using phase change. A femtosecond pulse laser is shaped into pulse trains each having a first pulse and a second pulse using a Michelson interferometer, and the time interval of first and second pulses is matched with the time period of lattice vibration of a material constituting the phase change recording film to be irradiated, thereby inducing phase change.
摘要翻译：为了实现相对于使用相变光学记录介质的传统技术可实现的记录擦除速度，可以在声子（约270 fs）的时间段内控制相位变化率。使用迈克尔逊干涉仪将飞秒脉冲激光器形成为具有第一脉冲和第二脉冲的脉冲串，并且将第一和第二脉冲的时间间隔与构成相变记录膜的材料的晶格振动的时间段相匹配被照射，从而引起相变。

53. 发明授权

US08153130B2 Graft-versus-host disease predicting marker and use thereof 有权
标题翻译：移植物抗宿主病预测标记及其用途
公开(公告)号：US08153130B2
公开(公告)日：2012-04-10
申请号：US12296345
申请日：2007-04-05
申请人： Akira Shibuya , Hiroshi Kojima
发明人： Akira Shibuya , Hiroshi Kojima
IPC分类号： A61K39/395
CPC分类号： G01N33/573 , A61K39/3955 , A61K2039/505 , C07K16/2803 , G01N2333/91245 , G01N2800/245
摘要： A test method that provides data useful in predicting the probability of onset of acute graft-versus-host disease (GVHD) is described along with a kit for performing the method, and a pharmaceutical preparation and a molecular targeted therapy for treating or preventing GVHD. The test method includes measuring the blood DNAM-1 concentration of a patient of hematopoietic stem cell transplantation from bone marrow or the like over a period after the transplantation to provide data concerning the transition of the concentration to an abnormally high level deviating from the normal range, whereby the probability of the development of acute graft-versus-host disease is predicted, the risk of the development is estimated, or therapeutic effects after the development are evaluated. Concerning the molecular targeted therapy and pharmaceutical preparation used therefor wherein blood DNAM-1 of a GVHD patient or a graft recipient that is a possible patient is used as a target molecule, GVHD is treated or prevented by administering an anti-DNAM-1 antibody that is a neutralizing antibody.
摘要翻译：描述了提供用于预测急性移植物抗宿主病（GVHD）发病概率的数据的测试方法以及用于进行该方法的试剂盒以及用于治疗或预防GVHD的药物制剂和分子靶向治疗。测试方法包括在移植后的一段时间内测量来自骨髓等的造血干细胞移植患者的血液DNAM-1浓度，以提供关于浓度向偏离正常范围的异常高水平转变的数据预测急性移植物抗宿主病发展的可能性，估计发展的风险，或发展后的治疗效果。关于其中使用的分子靶向治疗和药物制剂，其中GVHD患者的血液DNAM-1或作为可能患者的移植物接受体用作靶分子，通过施用抗-DNAM-1抗体来治疗或预防GVHD，是中和抗体。

54. 外观设计

USD650566S1 Shoe 有权
公开(公告)号：USD650566S1
公开(公告)日：2011-12-20
申请号：US29366875
申请日：2010-07-30
申请人： Hidenori Yamashita , Yoshiyuki Sankai , Tomohiro Hayashi , Takashi Okamoto
设计人： Hidenori Yamashita , Yoshiyuki Sankai , Tomohiro Hayashi , Takashi Okamoto

55. 发明申请

US20110262944A1 CONSTRUCTION AND CRYSTALLIZATION OF EXPRESSION SYSTEM FOR RNA POLYMERASE PB1-PB2 PROTEIN DERIVED FROM INFLUENZA VIRUS 有权
标题翻译：来自流感病毒的RNA聚合酶PB1-PB2蛋白的表达系统的构建和结晶
公开(公告)号：US20110262944A1
公开(公告)日：2011-10-27
申请号：US13124581
申请日：2009-10-16
申请人： Eiji Obayashi , Sam-Yong Park , Kyosuke Nagata , Atsushi Kawaguchi
发明人： Eiji Obayashi , Sam-Yong Park , Kyosuke Nagata , Atsushi Kawaguchi
IPC分类号： C12Q1/48 , C12N5/10 , C12N1/21 , C07H21/04 , C12N15/63 , C07K14/11 , C07K16/08 , C07K1/32 , C12P21/06 , C12N1/19
CPC分类号： C07K14/005 , C07K2299/00 , C12N9/127 , C12N2760/16122 , G01N33/573 , G01N2333/11 , G01N2333/91275 , G01N2500/02
摘要： The present invention aims to express influenza virus RNA polymerase on a large scale, to crystallize the influenza virus RNA polymerase, and to provide a method for screening a substance capable of serving as an active ingredient in anti-influenza drugs.The present invention provides a complex comprising a polypeptide consisting of an amino acid sequence at positions 678-757 of the RNA polymerase PB1 subunit in influenza A/Puerto Rico/8/34 H1N1 and a polypeptide consisting of an amino acid sequence at positions 1-37 of RNA polymerase PB2 subunit in influenza A/Puerto Rico/8/34 H1N1. This complex can be crystallized in the presence of a precipitant such as potassium phosphate and PEG4000. Moreover, with the use of information on the crystal structure of this complex, it is possible to provide a method for screening a substance capable of serving as an active ingredient in anti-influenza drugs.
摘要翻译：本发明旨在大规模地表达流感病毒RNA聚合酶，以使流感病毒RNA聚合酶结晶，并提供一种筛选能够作为抗流感药物中的活性成分的物质的方法。本发明提供了一种复合物，其包含由流感A /波多黎各/ 8/34 / H1N1中的RNA聚合酶PB1亚基的678-757位的氨基酸序列组成的多肽，以及由1-位的氨基酸序列组成的多肽， 37流感病毒A /波多黎各/ 8/34 H1N1 RNA聚合酶PB2亚基。该络合物可以在沉淀剂例如磷酸钾和PEG4000的存在下结晶。此外，通过使用关于该复合物的晶体结构的信息，可以提供一种筛选能够用作抗流感药物中的活性成分的物质的方法。

56. 发明授权

US07997563B2 Micro-bubble generator, vortex breakdown nozzle for micro-bubble generator, vane swirler for micro-bubble generator, micro-bubble generating method, and micro-bubble applying device 有权
标题翻译：微气泡发生器，微气泡发生器的涡流破坏喷嘴，微气泡发生器的叶片旋流器，微气泡发生方法和微气泡施加装置
公开(公告)号：US07997563B2
公开(公告)日：2011-08-16
申请号：US11813793
申请日：2005-11-17
申请人： Harumichi Abe , Kazuo Matsuuchi , Minoru Iidaka
发明人： Harumichi Abe , Kazuo Matsuuchi , Minoru Iidaka
IPC分类号： B01F3/04 , B01F5/02
CPC分类号： C02F1/006 , A01K63/042 , B01F3/0446 , B01F5/0646 , B01F5/0651 , B01F5/0665 , B01F5/0671 , B01F2003/04858 , B01F2003/04865 , B01F2003/04872 , B01F2003/04879 , B01F2003/04886 , B01F2003/04914 , B01F2005/0017 , B01F2215/0052 , C02F1/72 , C02F1/78 , C02F2301/024 , C02F2301/026
摘要： There is provided a micro-bubble generator including a swirling-flow generating vane nozzle and vortex breakdown nozzle connected coaxially to each other. The swirling flow generating vane nozzle produces a swirling flow of a liquid having a gas introduced to the center thereof from a gas feeding unit. The swirling flow is supplied to a flow constricting section included in the vortex breakdown nozzle to provide micro bubbles from a vortex breakdown section also included in the vortex breakdown nozzle.
摘要翻译：提供了包括旋流产生叶片喷嘴和彼此同轴连接的涡流破坏喷嘴的微气泡发生器。旋流产生叶片喷嘴产生具有从气体供给单元引入其中心的气体的液体的旋转流。涡旋流被提供到包括在涡流破坏喷嘴中的流动收缩部分，以提供也包括在涡流破坏喷嘴中的涡流击穿部分的微气泡。

57. 发明申请

US20100271051A1 CENTROID POSITION DETECTOR DEVICE AND WEARING TYPE ACTION ASSISTANCE DEVICE INCLUDING CENTROID POSITION DETECTOR DEVICE 有权
标题翻译：中心位置检测装置和包含中心位置检测装置的磨损型动作辅助装置
公开(公告)号：US20100271051A1
公开(公告)日：2010-10-28
申请号：US12810102
申请日：2008-12-09
申请人： Yoshiyuki Sankai , Kazuki Into
发明人： Yoshiyuki Sankai , Kazuki Into
IPC分类号： G01R27/26
CPC分类号： A61H3/008 , A61B5/1038 , A61B5/1116 , A61B5/4528 , A61B5/6807 , A61B5/6812 , A61B2503/10 , A61B2562/0247 , A61B2562/046 , A61H1/0262 , A61H3/00 , A61H2201/1215 , A61H2201/163 , A61H2201/1642 , A61H2201/165 , A61H2201/1676 , A61H2201/5061 , A61H2201/5069 , A61H2230/605
摘要： Load measuring parts 50 and 52 are provided with reaction sensors 50a, 50b, 52a and 52b to measure loads at two positions, the tiptoe and the heel, on each sole of right and left feet of a wearing person 12. The reaction sensor 50a detects a reaction force to a load on a front side of the right foot (right tiptoe), the reaction sensor 50b detects a reaction force to a load on a rear side of the right foot (right heel), the reaction sensor 52a detects a reaction force to a load on a front side of the left foot (left tiptoe), and the reaction sensor 52b detects a reaction force to a load on a rear side of the left foot (left heel). The reaction sensors 50a, 50b, 52a and 52b are arranged to detect, based on a change of a capacitance, the loads on the right and left feet during a walk action. A change of the load accompanied with a shift of the weight and a contact between the wearing person's foot and the ground can be detected.
摘要翻译：负载测量部件50和52设置有反应传感器50a，50b，52a和52b，用于测量穿戴者12的右脚和左脚的每个鞋底上的脚趾和脚后跟两个位置处的负载。反作用传感器50a检测反作用传感器50b检测到对右脚（右后跟）的后方的负载的反作用力，反作用力传感器52a检测出反作用力对左脚（左脚尖）的前侧的负载施力，反作用力传感器52b检测对左脚后方的负荷的反作用力（左脚跟）。反应传感器50a，50b，52a和52b被布置成基于电容的变化来检测步行动作期间右脚和左脚的负荷。可以检测伴随着重量的偏移和穿戴者的脚与地面之间的接触的负载变化。

58. 发明申请

US20100166840A1 LIPOSOME HAVING LIPID MEMBRANE CONTAINING BACTERIAL CELL COMPONENT 审中-公开
标题翻译：具有含有细胞细胞组分的脂质膜的脂质体
公开(公告)号：US20100166840A1
公开(公告)日：2010-07-01
申请号：US12300622
申请日：2007-05-11
申请人： Homhuan Atthachai , Kentaro Kogure , Hideyoshi Harashima , Ikuya Yano , Yoshio Hatakeyama , Hidehiro Yokomizo , Hideyuki Akaza
发明人： Homhuan Atthachai , Kentaro Kogure , Hideyoshi Harashima , Ikuya Yano , Yoshio Hatakeyama , Hidehiro Yokomizo , Hideyuki Akaza
IPC分类号： A61K9/127 , A61K39/04 , A61K39/05 , A61K39/02 , A61P35/00 , A61P37/04
CPC分类号： A61K9/127 , A61K9/1271 , A61K35/74 , A61K39/04 , A61K39/39 , A61K2039/55511 , A61K2039/55555 , A61K2039/57
摘要： The object is to provide a liposome by which a bacterial cell component insoluble in water and an organic solvent (e.g., BCG-CW) can be pharmaceutically prepared in a form applicable to a living body (i.e., a form in which the bacterial cell component can be dispersed in an aqueous solvent and has a controlled size) without using any surfactant. Disclosed is a liposome having a lipid membrane containing a bacterial cell component insoluble in water and an organic solvent (e.g., BCG-CW).
摘要翻译：本发明的目的是提供一种可溶于水和有机溶剂（例如BCG-CW）的细菌细胞组分可以以适用于生物体的形式（即细菌细胞成分可以分散在水性溶剂中并具有受控的尺寸），而不使用任何表面活性剂。公开了具有含有不溶于水的细菌细胞成分和有机溶剂（例如BCG-CW）的脂质膜的脂质体。

59. 发明申请

US20090187396A1 Software Behavior Modeling Apparatus, Software Behavior Monitoring Apparatus, Software Behavior Modeling Method, And Software Behavior Monitoring Method 失效
标题翻译：软件行为建模设备，软件行为监控设备，软件行为建模方法和软件行为监控方法
公开(公告)号：US20090187396A1
公开(公告)日：2009-07-23
申请号：US12296999
申请日：2007-04-12
申请人： Akira Kinno , Takehiro Nakayama , Atsushi Takeshita , Kazuhiko Kato , Hirotake Abe , Katsuhiro Suzuki
发明人： Akira Kinno , Takehiro Nakayama , Atsushi Takeshita , Kazuhiko Kato , Hirotake Abe , Katsuhiro Suzuki
IPC分类号： G06F9/45
CPC分类号： G06F11/28 , G06F8/20 , G06F21/552
摘要： A software operation modeling device (100) includes: a stack information recording unit (120), an end information recording unit (150), a stack difference information generation unit (130) for generating information for generating stack difference information by concatenating a call stack upper node of stack information with information until the end information is detected by using the end information recorded by the end information recording unit (150), and a model generation unit (140) for generating a software operation model from the stack difference information.
摘要翻译：软件操作建模装置（100）包括：堆栈信息记录单元（120），结束信息记录单元（150），堆栈差异信息生成单元（130），用于生成用于通过连接呼叫栈通过使用由结束信息记录单元（150）记录的结束信息来检测结束信息，并且从堆栈差异信息生成软件操作模型的模型生成单元（140），生成具有信息的堆叠信息的上层节点。

60. 发明申请

US20090022782A1 Blood Retainable Device Exhibiting Selective Degradability in Tumor Tissue 审中-公开
标题翻译：血液保留装置展示肿瘤组织中的选择性降解性
公开(公告)号：US20090022782A1
公开(公告)日：2009-01-22
申请号：US11817096
申请日：2006-02-24
申请人： Hidetaka Akita , Hiroto Hatakeyama , Yukio Nagasaki , Hiroshi Kikuchi , Hideo Kobayashi , Hideyoshi Harashima , Motoi Oishi
发明人： Hidetaka Akita , Hiroto Hatakeyama , Yukio Nagasaki , Hiroshi Kikuchi , Hideo Kobayashi , Hideyoshi Harashima , Motoi Oishi
IPC分类号： A61K9/127 , C07K7/00 , A61K31/7088 , A61K31/715 , A61K31/7105 , A61P31/00
CPC分类号： A61K9/127 , A61K9/0019 , A61K9/1272 , A61K31/711 , A61K47/60 , A61K47/62 , C07K7/08
摘要： A phospholipid derivative useful for the preparation of liposomes for efficient uptake of an antitumor agent or a gene intracellularly by a target tumor cell, which comprises a residue of an alcohol compound and a residue of a phospholipid, and comprising a peptide between the residue of an alcohol compound and the residue of a phospholipid, and wherein (a) the alcohol compound is an alcohol compound selected from poly(alkylene glycols) and the like, (b) the phospholipid is a phospholipid selected from phosphatidylethanolamines, phosphatidylcholines, phosphatidylserines and the like, and (c) the peptide is a peptide comprising a substrate peptide that can serve as a substrate of a matrix metalloproteinase, provided that one amino acid residue or an oligopeptide containing 2 to 8 amino acid residues may bind to one or both ends of the substrate peptide.
摘要翻译：一种用于制备脂质体以有效吸收目标肿瘤细胞的细胞内抗肿瘤剂或细胞基因的磷脂衍生物，其包含醇化合物和磷脂残基的残基，并且包含在醇化合物和磷脂的残基，其中（a）醇化合物是选自聚（亚烷基二醇）等的醇化合物，（b）磷脂是选自磷脂酰乙醇胺，磷脂酰胆碱，磷脂酰丝氨酸等的磷脂，和（c）肽是包含可用作基质金属蛋白酶底物的底物肽的肽，条件是含有2-8个氨基酸残基的一个氨基酸残基或寡肽可以结合到底物肽。

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