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51. 发明授权

US5030455A Sustained-release drug preparation 失效
标题翻译：持续释放药物制剂
公开(公告)号：US5030455A
公开(公告)日：1991-07-09
申请号：US396838
申请日：1989-08-22
申请人： Hidenobu Andoh , Sumio Watanabe , Yasuo Miyake
发明人： Hidenobu Andoh , Sumio Watanabe , Yasuo Miyake
IPC分类号： A61K9/16 , A61K9/20 , A61K9/22 , A61K9/26 , A61K31/135 , A61K31/52 , A61K31/55 , A61K47/00 , A61K47/14 , A61K47/26 , A61K47/44
CPC分类号： A61K9/2013 , A61K47/44
摘要： A sustained-release drug preparation comprises a water-soluble drug, a lipidic substance and an oil as its essential components. The drug level in the blood is sustained at a preferable concentation for a long period of time.

52. 发明授权

US5980947A Process for producing drug-containing microspheres by oil-in-water evaporation process 失效
标题翻译：通过水包油蒸发法生产含药微球的方法
公开(公告)号：US5980947A
公开(公告)日：1999-11-09
申请号：US352188
申请日：1994-12-01
申请人： Ichiro Yamakawa , Ryoichi Machida , Sumio Watanabe
发明人： Ichiro Yamakawa , Ryoichi Machida , Sumio Watanabe
IPC分类号： A61K9/16 , A61K9/50 , B01J13/12 , A61K9/14
CPC分类号： A61K9/1694 , A61K9/1617 , A61K9/1647
摘要： Formation of a drug into microspheres by an oil-on-water solvent evaporation process in which a mixed solvent of at least one water-insoluble solvent and at least one water-miscible solvent is used as a solvent of an oil phase. A fatty acid or a salt thereof or at least one glycerin fatty acid ester and/or at least one propylene glycol fatty acid ester are added to the mixed solvent. The oil phase may also comprise the mixed solvent; a fatty acid or a salt thereof; and at least one glycerin fatty acid ester and/or at least one propylene glycol fatty acid ester. This oil phase is mixed and emulsified with an aqueous phase to form an oil-in-water emulsion. The emulsion with a drug contained therein is then subjected to an oil-in water solvent evaporation to produce the microspheres. The resulting drug-containing microspheres contain the drug at a high concentration and slowly release from the initial stage after administration.
摘要翻译：通过油包水溶剂蒸发方法将药物形成为微球，其中使用至少一种水不溶性溶剂和至少一种与水相混溶的溶剂的混合溶剂作为油相的溶剂。向混合溶剂中加入脂肪酸或其盐或至少一种甘油脂肪酸酯和/或至少一种丙二醇脂肪酸酯。油相也可以包含混合溶剂; 脂肪酸或其盐; 和至少一种甘油脂肪酸酯和/或至少一种丙二醇脂肪酸酯。将该油相与水相混合并乳化以形成水包油乳液。然后将其中含有药物的乳液进行油包水溶剂蒸发以产生微球体。所得含药微球含有高浓度的药物，并在给药后从初始阶段缓慢释放。

53. 发明授权

US5576021A Sustained-release multi-granule tablet 失效
标题翻译：持续释放多颗粒片剂
公开(公告)号：US5576021A
公开(公告)日：1996-11-19
申请号：US275240
申请日：1994-07-15
申请人： Hidenobu Andoh , Sumio Watanabe , Yasuo Miyake
发明人： Hidenobu Andoh , Sumio Watanabe , Yasuo Miyake
IPC分类号： A61K9/20 , A61K9/22 , A61K9/26 , A61K31/551
CPC分类号： A61K9/2081 , A61K31/551 , Y10S514/96 , Y10S514/961 , Y10S514/965
摘要： A sustained-release multi-granule tablet is obtained by compressing sustained-release granules, which contains an active substance, and a formulation adjuvant. Each of the granules has been coated in advance with a layer of the formulation adjuvant and/or a layer of a mixture of the formulation adjuvant and the active substance. The tablet releases an active substance at a suitable velocity into the digestion tract, resulting in that the variability in the absorption of the drug in each patient and among individual patients is minimized to achieve maximum bioavailability.
摘要翻译：通过压缩含有活性物质的缓释颗粒和制剂佐剂获得缓释多颗粒片剂。预先用制剂佐剂层和/或制剂佐剂和活性物质的混合物层预先涂覆每种颗粒。片剂以适当的速度将活性物质释放到消化道中，导致每个患者和个体患者中药物的吸收变化最小化以达到最大生物利用度。

54. 发明授权

US5093200A Multilayer sustained release granule 失效
标题翻译：多层可持续发布GRANULE
公开(公告)号：US5093200A
公开(公告)日：1992-03-03
申请号：US253367
申请日：1988-09-30
申请人： Sumio Watanabe , Ichiro Yamakawa , Hidenobu Ando , Nobutaka Noda , Yasuo Miyake
发明人： Sumio Watanabe , Ichiro Yamakawa , Hidenobu Ando , Nobutaka Noda , Yasuo Miyake
IPC分类号： A61K9/56 , A61K9/16 , A61K9/22 , A61K9/24 , A61K9/50 , A61K9/54
CPC分类号： A61K9/5078 , Y10T428/2984 , Y10T428/2985 , Y10T428/2989 , Y10T428/2991 , Y10T428/2998
摘要： A multilayer granule of the invention comprises a core, a slow-release layer, a rapid-release layer to be provided outer of said slow-release layer and a film layer containing a metal stearate and being deposited between the slow-release layer and the rapid-release layer. A pharmacologically effective component is kept to discharge for long.
摘要翻译：本发明的多层颗粒包括芯，缓释层，提供在所述缓释层外部的快速释放层和含有金属硬脂酸盐的膜层，并沉积在缓释层和缓释层之间快速释放层。药理学有效成分长时间保持放电。

55. 发明授权

US4127622A Process for the preparation of hollow particulates 失效
标题翻译：中空颗粒的制备方法
公开(公告)号：US4127622A
公开(公告)日：1978-11-28
申请号：US615086
申请日：1975-09-19
申请人： Sumio Watanabe , Yasuhiko Mizuno , Masanori Kayano , Yoshio Ishino
发明人： Sumio Watanabe , Yasuhiko Mizuno , Masanori Kayano , Yoshio Ishino
IPC分类号： A61K9/00 , A61K9/50 , B01J13/02 , B01J2/02
CPC分类号： A61K9/0065 , A61K9/5047 , A61K9/5089
摘要： A hollow particulate for gastric medicines and other durable medicines suspendable in the gastric juice and remainable in the stomach for a long period of time is provided which has been prepared by dissolving ethylcellulose in a lower chlorinated hydrocarbon, or a mixed solution of the lower chlorinated hydrocarbon and a lower chlorofluorinated hydrocarbon and/or water, so that the concentration of ethylcellulose is 0.5 - 4% by weight on the basis of the total weight of the resulting solution, and then spray-drying the solution at an inlet temperature of higher than 50.degree. C.
摘要翻译：提供了一种用于胃药和其它耐用药物的中空颗粒，其可在胃液中悬浮并长时间保留在胃中，其通过将乙基纤维素溶解在较低氯化烃或下氯化烃的混合溶液中而制备和较低的氯氟化烃和/或水，使得基于所得溶液的总重量，乙基纤维素的浓度为0.5-4重量％，然后在高于50℃的入口温度下将溶液喷雾干燥 DEG C.

56. 发明授权

US5984123A Container having screw-threaded captive cap 失效
标题翻译：集装箱有螺纹封盖
公开(公告)号：US5984123A
公开(公告)日：1999-11-16
申请号：US750791
申请日：1997-02-27
申请人： Tatsuro Mogami , Akira Miyazaki , Sumio Watanabe , Masaharu Nakao
发明人： Tatsuro Mogami , Akira Miyazaki , Sumio Watanabe , Masaharu Nakao
IPC分类号： B65D55/16 , B65D41/04
CPC分类号： B65D55/16
摘要： A packaging container having a container body and a lid unit which is undetachably mounted on the container body. The container body has a neck portion provided with an opening. An external thread cut in the outer periphery of the neck portion, and a lid mounting portion is provided below the external thread. The lid unit has a lid body and a fitting member. The lid body is provided with an internal thread engageable with the external thread of the container body, and has a function of hermetically sealing the opening of the container body. The fitting member is rotatably fitted around the lid mounting portion of the container body, but vertical movement of the fitting member is restricted within a predetermined range. The fitting member is held undetachable from the lid mounting portion by a collar of the container body. The lid body and the fitting member are connected to each other by a connecting member in such a manner that the lower surface of the lid body can rest on and separate from the upper surface of the fitting member.
摘要翻译： PCT No.PCT / JP96 / 00970 Sec。 371日期1997年2月27日 102（e）日期1997年2月27日PCT提交1996年4月9日PCT公布。公开号WO96 / 32339 日期1996年10月17日具有容器主体和不可拆卸地安装在容器主体上的盖单元的包装容器。容器主体具有设置有开口的颈部。在颈部的外周切割的外螺纹和在外螺纹的下方设置有盖安装部。盖单元具有盖体和配合构件。盖体设置有可与容器主体的外螺纹接合的内螺纹，并且具有气密地密封容器主体的开口的功能。装配构件可旋转地安装在容器主体的盖安装部分周围，但是装配构件的垂直运动被限制在预定范围内。装配构件通过容器主体的轴环被保持不能从盖安装部分脱离。盖体和配合构件通过连接构件彼此连接，使得盖体的下表面可以安装在配合构件的上表面上并与安装构件的上表面分离。

57. 发明授权

US5821281A Organic polymer compound and production thereof 失效
标题翻译：有机高分子化合物及其制备方法
公开(公告)号：US5821281A
公开(公告)日：1998-10-13
申请号：US735210
申请日：1996-10-22
申请人： Masayuki Kuzuya , Sumio Watanabe
发明人： Masayuki Kuzuya , Sumio Watanabe
IPC分类号： A61K47/48 , C08F2/46 , C08F2/56 , C08F20/10 , C08F20/54 , C08F120/10
CPC分类号： A61K47/48176 , C08F120/10 , C08F20/10 , C08F20/54
摘要： A homopolymer of acrylic acid or methacrylic acid derivatives having the general formula: ##STR1## wherein R.sup.1 represents a hydrogen atom or methyl group; R.sup.2 is a residue of a compound having physiological activity; X is a residue of a compound having a hydroxyl group, amino group or carboxyl group at both ends in its chemical structure after bonding between such compound and acrylic or methacrylic acid, and between such compound and the physiologically active compound; and the homopolymer has a number-average molecular weight ranging from 20,000 to 200,000; and a process for the preparation thereof by a mechanochemical polymerization reaction; as well as a polymeric drug and prodrug comprising the homopolymer.
摘要翻译：具有以下通式的丙烯酸或甲基丙烯酸衍生物的均聚物：其中R 1表示氢原子或甲基; R2是具有生理活性的化合物的残基; X是在该化合物与丙烯酸或甲基丙烯酸接合之后，在该化合物与生理活性化合物之间的化学结构的两端具有羟基，氨基或羧基的化合物的残基; 均聚物的数均分子量为20,000〜200,000; 和通过机械化学聚合反应制备的方法; 以及包含均聚物的聚合物药物和前药。

58. 发明授权

US5811953A Motor driving circuit and method 失效
标题翻译：电机驱动电路及方法
公开(公告)号：US5811953A
公开(公告)日：1998-09-22
申请号：US771807
申请日：1996-12-20
申请人： Sumio Watanabe , Katsuhiro Maeda , Shuko Yamaji
发明人： Sumio Watanabe , Katsuhiro Maeda , Shuko Yamaji
IPC分类号： H02P8/10 , H02P8/00 , H02P8/12 , H02P27/02 , H02P1/54
CPC分类号： H02P8/12 , H02P27/02 , H02P29/026
摘要： A motor driving circuit coupled to a motor having a plurality of phases of coils includes a standard power source generating a first power supply voltage, and a step-up power source for generating a second power supply voltage greater than the first power supply voltage. A selecting circuit selects either the first power supply voltage or the second power supply voltage in response to a selecting signal. A motor driving circuit causes currents to flow in the phases of the motor in accordance with motor driving signals respectively related to the phases in a state in which a selected power supply voltage output by the selecting circuit is applied to one or more phases. A switching unit generates the selecting signal on the basis of the motor driving signals and a voltage signal corresponding to a current flowing through at least one of the phases of the motor so that the second power supply voltage is selected first and the first power supply voltage is selected second with respect to each of the phases.
摘要翻译：耦合到具有多相线圈的电动机的电动机驱动电路包括产生第一电源电压的标准电源和用于产生大于第一电源电压的第二电源电压的升压电源。选择电路响应于选择信号选择第一电源电压或第二电源电压。电动机驱动电路根据在由选择电路输出的选定电源电压施加到一个或多个相的状态下，根据与相位分别相关的电动机驱动信号，使电流在电动机的相位中流动。开关单元基于电动机驱动信号和对应于流过电动机的至少一相的电流的电压信号来产生选择信号，使得首先选择第二电源电压和第一电源电压相对于每个相位被选择为第二。

59. 发明授权

US5624683A Sustained-release multi-granule tablet 失效
标题翻译：持续释放多颗粒片剂
公开(公告)号：US5624683A
公开(公告)日：1997-04-29
申请号：US192603
申请日：1994-02-07
申请人： Hidenobu Andoh , Sumio Watanabe , Yasuo Miyake
发明人： Hidenobu Andoh , Sumio Watanabe , Yasuo Miyake
IPC分类号： A61K9/20 , A61K9/22 , A61K9/26 , A61K31/551
CPC分类号： A61K9/2081 , A61K31/551 , Y10S514/96 , Y10S514/961 , Y10S514/965
摘要： A sustained-release multi-granule tablet is obtained by compressing sustained-release granules, which contains a basis, and a formulation adjuvant. Each of the granules has been coated in advance with a layer of the formulation adjuvant and/or a layer of a mixture of the formulation adjuvant and the basis. The tablet releases an active substance at a suitable velocity into the digestion tract, resulting in that the inbalance in the absorption of the drug in each patient and among individual patients is minimized to achieve maximum bioavailability.
摘要翻译：通过压缩含有基础的缓释颗粒和制剂佐剂获得缓释多颗粒片剂。预先将各颗粒剂用制剂佐剂层和/或制剂佐剂和基质的混合物层进行包衣。片剂以适当的速度将活性物质释放到消化道中，导致每个患者和个体患者中药物吸收的不平衡被最小化以达到最大生物利用度。

60. 发明授权

US5425943A Modified tPA-containing injection composition having increased solubility 失效
标题翻译：改进的含tPA的注射组合物具有增加的溶解度
公开(公告)号：US5425943A
公开(公告)日：1995-06-20
申请号：US900796
申请日：1992-06-22
申请人： Masahiro Kawahara , Yuichiro Hayashi , Naoki Asakawa , Sumio Watanabe , Yasuo Miyake
发明人： Masahiro Kawahara , Yuichiro Hayashi , Naoki Asakawa , Sumio Watanabe , Yasuo Miyake
IPC分类号： A61K38/46 , A61K9/08 , A61K38/49 , A61K47/00 , A61K47/18 , A61K38/48 , C12N9/50 , C12N9/64
CPC分类号： A61K9/0019 , A61K38/49 , A61K47/183
摘要： An injection composition comprises a pharmacologically effective amount of a modified tPA, 47.5 mM or more of an amino acid or a salt thereof and is improved in view of stability and solubility.
摘要翻译：注射组合物包含药理学上有效量的修饰的tPA，47.5mM或更多的氨基酸或其盐，并且从稳定性和溶解性的观点来看是有改进的。

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