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51. 发明申请

US20060140905A1 Chemokine beta-7 variants 审中-公开
公开(公告)号：US20060140905A1
公开(公告)日：2006-06-29
申请号：US11357223
申请日：2006-02-21
申请人： Haodong Li , Steven Ruben , Theodora Salcedo , Vikram Patel , Robert Nibbs , Gerard Graham
发明人： Haodong Li , Steven Ruben , Theodora Salcedo , Vikram Patel , Robert Nibbs , Gerard Graham
IPC分类号： A61K38/19 , C07K14/52 , C07H21/04 , C12P21/02
CPC分类号： C07K14/523 , A61K38/00
摘要： The present invention relates to deletion and substitution mutant polypeptides of human chemokine β-7 (Ckβ-7), as well as nucleic acid molecules encoding such polypeptides and processes for producing such polypeptides using recombinant techniques. In one aspect, the invention also relates to uses of the full-length and mature forms of Ckβ-7, as well as deletion and substitution mutants, in medical treatment regimens. In particular, the Ckβ-7 polypeptides described herein may be employed to treat a variety of conditions, including rheumatoid arthritis, inflammation, respiratory diseases, allergy, and IgE-mediated allergic reactions.

52. 发明申请

US20060052328A1 Connective tissue growth factor-2 审中-公开
公开(公告)号：US20060052328A1
公开(公告)日：2006-03-09
申请号：US11222019
申请日：2005-09-09
申请人： Haodong Li , Mark Adams , Valerie Calenda , Virginie Fataccioli
发明人： Haodong Li , Mark Adams , Valerie Calenda , Virginie Fataccioli
IPC分类号： A61K48/00 , A61K38/18
CPC分类号： A61K38/1841 , A61K48/005 , C07K14/475 , C12N15/86 , C12N2710/10343
摘要： The present invention relates to a human CTGF-2 polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist/inhibitors against such polypeptide. Also provided are methods of using the polypeptide therapeutically for stimulating angiogenesis enhancing the repair of connective and support tissue, promoting the attachment, fixation and stabilization of tissue implants and enhancing wound healing. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.

53. 发明申请

US20060040313A1 Human chemokine beta-9 失效
标题翻译：人趋化因子β-9
公开(公告)号：US20060040313A1
公开(公告)日：2006-02-23
申请号：US11260166
申请日：2005-10-28
申请人： Haodong Li , Mark Adams
发明人： Haodong Li , Mark Adams
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/04 , C07K14/52
CPC分类号： C07K16/24 , A61K38/00 , A61K2039/505 , C07K14/523 , G01N33/564 , G01N33/57426 , G01N33/6863 , G01N2333/52
摘要： Human Ckβ-9 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Ckβ-9 polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Diagnostic assays are also disclosed which detect the presence of mutations in the Ckβ-9 coding sequence and over-expression of the Ckβ-9 protein.
摘要翻译：公开了人Ckbeta-9多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。还公开了利用这种Ckbeta-9多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。还公开了抗这些多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。还公开了诊断测定法，其检测Ckbeta-9编码序列中突变的存在和Ckbeta-9蛋白的过表达。

54. 发明申请

US20050244888A1 ANTIBODIES TO HUMAN CHEMOKINE BETA-9 有权
标题翻译：抗体人类抗体BETA-9
公开(公告)号：US20050244888A1
公开(公告)日：2005-11-03
申请号：US10329472
申请日：2002-12-27
申请人： Haodong Li , Mark Adams
发明人： Haodong Li , Mark Adams
IPC分类号： G01N33/53 , A61K38/00 , A61K45/00 , A61K48/00 , A61P7/00 , A61P11/00 , A61P11/06 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/02 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07K14/52 , C07K16/24 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/19 , C12P21/02 , C12R1/19 , C12R1/91 , G01N33/564 , G01N33/574 , G01N33/68
CPC分类号： C07K16/24 , A61K38/00 , A61K2039/505 , C07K14/523 , G01N33/564 , G01N33/57426 , G01N33/6863 , G01N2333/52
摘要： Human Ckβ-9 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Ckβ-9 polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Diagnostic assays are also disclosed which detect the presence of mutations in the Ckβ-9 coding sequence and over-expression of the Ckβ-9 protein.
摘要翻译：公开了人Ckbeta-9多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。还公开了利用这种Ckbeta-9多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。还公开了抗这些多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。还公开了诊断测定法，其检测Ckbeta-9编码序列中突变的存在和Ckbeta-9蛋白的过表达。

55. 发明授权

US06936688B2 Human chemokine beta-10 mutant polypeptides 失效
标题翻译：人趋化因子β-10突变体多肽
公开(公告)号：US06936688B2
公开(公告)日：2005-08-30
申请号：US10125451
申请日：2002-04-19
申请人： Henrik S. Olsen , Haodong Li , Mark D. Adams , Solange H. L. Gentz , Ralph Alderson , Yuling Li , David Parmelee , John R. White , Edward R. Appelbaum
发明人： Henrik S. Olsen , Haodong Li , Mark D. Adams , Solange H. L. Gentz , Ralph Alderson , Yuling Li , David Parmelee , John R. White , Edward R. Appelbaum
IPC分类号： A61K38/19 , C07H21/04 , C07K14/52 , C12N5/06 , C12N5/10 , C12N15/19 , C12N15/63 , C12P21/02
CPC分类号： C07K14/523 , A61K38/00 , C07K2319/00
摘要： Human chemokine Beta-10 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.
摘要翻译：公开了人趋化因子β-10多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。还公开了利用这种趋化因子多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。还公开了抗这种趋化因子多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧和骨髓衰竭的治疗剂的用途。

56. 发明授权

US06673344B1 Antibodies to human CK&bgr;-10/MCP-4 失效
标题翻译：人类CKbeta-10 / MCP-4的抗体
公开(公告)号：US06673344B1
公开(公告)日：2004-01-06
申请号：US09717209
申请日：2000-11-22
申请人： Haodong Li , Mark Adams , Solange Hanschke Lima , Ralph Alderson , Yuling Li , David Parmelee , John White , Edward Appelbaum
发明人： Haodong Li , Mark Adams , Solange Hanschke Lima , Ralph Alderson , Yuling Li , David Parmelee , John White , Edward Appelbaum
IPC分类号： A61K39395
CPC分类号： C07K14/52 , C07K14/523 , Y10S930/14
摘要： Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.
摘要翻译：公开了人趋化因子多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。还公开了利用这种趋化因子多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。还公开了抗这种趋化因子多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧和骨髓衰竭的治疗剂的用途。

57. 发明授权

US06576745B1 Human cystatin F antibodies 有权
标题翻译：人类半胱氨酸蛋白酶抑制剂F抗体
公开(公告)号：US06576745B1
公开(公告)日：2003-06-10
申请号：US09528436
申请日：2000-03-17
申请人： Haodong Li , Guo-Liang Yu , Reiner L. Gentz , Jian Ni
发明人： Haodong Li , Guo-Liang Yu , Reiner L. Gentz , Jian Ni
IPC分类号： C07K1600
CPC分类号： C07K14/8139 , A61K38/00 , C07K2319/00
摘要： The invention relates to Cystatin F polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译：本发明涉及半胱氨酸蛋白酶抑制剂F多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

58. 发明授权

US06518046B1 Human chemokine &bgr;-9 失效
标题翻译：人趋化因子β-9
公开(公告)号：US06518046B1
公开(公告)日：2003-02-11
申请号：US08793381
申请日：1997-05-19
申请人： Haodong Li , Mark D. Adams
发明人： Haodong Li , Mark D. Adams
IPC分类号： C12N1500
CPC分类号： C07K16/24 , A61K38/00 , A61K2039/505 , C07K14/523 , G01N33/564 , G01N33/57426 , G01N33/6863 , G01N2333/52
摘要： The present invention relates to Human Ck&bgr;-9 polypeptides and DNA (RNA) encoding such chemolcine polypeptides. Moreover, a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Ck&bgr;-9 polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune diseases, fibrotic disorders, wound healing and psoriasis. Antagonists against such polypeptides and their use as a therapeutic agent to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective disease, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Diagnostic assays are also disclosed which detect the presence of mutations in the Ck&bgr;-9 coding sequence and over-expression of the Ck&bgr;-9 protein.
摘要翻译：本发明涉及人Ckbeta-9多肽和编码这种趋化因子多肽的DNA（RNA）。此外，公开了通过重组技术生产这种多肽的方法。还公开了利用这种Ckbeta-9多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。还公开了抗这些多肽的拮抗剂及其作为治疗剂治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的用途。还公开了诊断测定法，其检测Ckbeta-9编码序列中突变的存在和Ckbeta-9蛋白的过表达。

59. 发明授权

US06413933B1 Growth factor HTTER36 失效
标题翻译：生长因子HTTER36
公开(公告)号：US06413933B1
公开(公告)日：2002-07-02
申请号：US09357905
申请日：1999-07-21
申请人： Daniel R. Soppet , Haodong Li
发明人： Daniel R. Soppet , Haodong Li
IPC分类号： A61K3818
CPC分类号： C07K14/495 , A61K48/00 , C12N2799/026
摘要： The present invention discloses Growth Factor HTTER36 polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating cellular growth and differentiation, bone formation and wound healing. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia and to prevent the formation of extracellular matrix molecules in the liver and lung. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.
摘要翻译：本发明公开了生长因子HTTER36多肽和编码这种多肽的多核苷酸。还提供了通过重组技术和包括刺激细胞生长和分化，骨形成和伤口愈合的多肽的治疗用途产生此类多肽的方法。还公开了抗这种多肽的拮抗剂及其作为治疗性肿瘤的治疗剂的用途，并且防止在肝脏和肺中形成细胞外基质分子。还公开了用于检测本发明多肽的改变水平的诊断测定和编码本发明多肽的核酸序列中的突变。

60. 发明授权

US06174995B1 Human chemokines, CK&bgr;4 and CK&bgr;10/MCP-4 失效
标题翻译：人类趋化因子，CKbeta4和CKbeta10 / MCP-4
公开(公告)号：US06174995B1
公开(公告)日：2001-01-16
申请号：US08613822
申请日：1996-02-23
申请人： Haodong Li , Mark Adams , Solange Hanschke Lima , Ralph Alderson , Yuling Li , David Parmelee , John White , Edward Applebaum
发明人： Haodong Li , Mark Adams , Solange Hanschke Lima , Ralph Alderson , Yuling Li , David Parmelee , John White , Edward Applebaum
IPC分类号： C07K1452
CPC分类号： C07K14/52 , C07K14/523 , Y10S930/14
摘要： Human chemokine polypeptides and DNA/(RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.
摘要翻译：公开了人类趋化因子多肽和编码这种趋化因子多肽的DNA /（RNA）和通过重组技术产生此类多肽的方法。还公开了利用这种趋化因子多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。还公开了抗这种趋化因子多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧和骨髓衰竭的治疗剂的用途。

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