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51. 发明授权

US08951203B2 Measures of cardiac contractility variability during ischemia 有权
标题翻译：缺血期心脏收缩变异性测量
公开(公告)号：US08951203B2
公开(公告)日：2015-02-10
申请号：US12761018
申请日：2010-04-15
申请人： Abhilash Patangay , Yi Zhang , Aaron Lewicke , Julie A. Thompson
发明人： Abhilash Patangay , Yi Zhang , Aaron Lewicke , Julie A. Thompson
IPC分类号： A61B5/02 , A61N1/00 , A61B5/0452 , A61B5/024 , G06F19/00 , A61B5/021 , A61B7/04 , A61N1/362
CPC分类号： A61B5/0452 , A61B5/021 , A61B5/024 , A61B5/02405 , A61B7/04 , A61B2562/0219 , A61N1/3627 , G06F19/00 , G06F19/3418 , G16H50/30
摘要： Systems and methods include obtaining a measure of cardiac contractility. A cardiac contractility variability is determined from the measure of cardiac contractility. Analyzing the cardiac contractility variability, an indication of cardio-vasculature health is provided.
摘要翻译：系统和方法包括获得心脏收缩力的量度。心肌收缩能力的变化由心脏收缩力的测量确定。分析心脏收缩性变异性，提供心血管系统健康的指征。

52. 发明申请

US20100274141A1 MEASURES OF CARDIAC CONTRACTILITY VARIABILITY DURING ISCHEMIA 有权
标题翻译： ISCHEMIA期间心脏适应症变异性的措施
公开(公告)号：US20100274141A1
公开(公告)日：2010-10-28
申请号：US12761018
申请日：2010-04-15
申请人： Abhilash Patangay , Yi Zhang , Aaron Lewicke , Julie A. Thompson
发明人： Abhilash Patangay , Yi Zhang , Aaron Lewicke , Julie A. Thompson
IPC分类号： A61B5/021 , A61B5/02
CPC分类号： A61B5/0452 , A61B5/021 , A61B5/024 , A61B5/02405 , A61B7/04 , A61B2562/0219 , A61N1/3627 , G06F19/00 , G06F19/3418 , G16H50/30
摘要： Systems and methods include obtaining a measure of cardiac contractility. A cardiac contractility variability is determined from the measure of cardiac contractility. Analyzing the cardiac contractility variability, an indication of cardio-vasculature health is provided.
摘要翻译：系统和方法包括获得心脏收缩力的量度。心肌收缩能力的变化由心脏收缩力的测量确定。分析心脏收缩性变异性，提供心血管系统健康的指征。

53. 发明授权

US09597029B2 System and method for remotely evaluating patient compliance status 有权
公开(公告)号：US09597029B2
公开(公告)日：2017-03-21
申请号：US11820798
申请日：2007-06-19
申请人： Abhilash Patangay , Shelley Marie Cazares
发明人： Abhilash Patangay , Shelley Marie Cazares
IPC分类号： A61B5/00 , G06F19/00 , A61N1/00 , A61B5/16 , A61N1/372
CPC分类号： A61B5/16 , A61B5/0002 , A61B5/165 , A61B5/4833 , A61B5/686 , A61B5/74 , A61N1/372 , G06F19/00 , G06F19/34 , G06F19/3418 , G06F19/3475
摘要： A system and method for remotely evaluating patient compliance status is presented. Compliance to a course of treatment is periodically checked through qualitative inquiry of a patient under remote management. Physiometry of the patient, that indicates emotional state, is remotely monitored contemporaneously with the qualitative state. Patient status is evaluated, including at least one of corroborating the compliance and identifying an emotional imbalance, based upon the indicated emotional state of the patient.

54. 发明授权

US08597197B2 Monitoring of heart sounds 有权
标题翻译：心音监听
公开(公告)号：US08597197B2
公开(公告)日：2013-12-03
申请号：US13491848
申请日：2012-06-08
申请人： Abhilash Patangay , Jeffrey E. Stahmann , Robert J. Sweeney
发明人： Abhilash Patangay , Jeffrey E. Stahmann , Robert J. Sweeney
IPC分类号： A61B5/02
CPC分类号： A61B5/025 , A61B5/0031 , A61B5/0205 , A61B5/029 , A61B5/0295 , A61B5/0402 , A61B5/053 , A61B5/0816 , A61B5/103 , A61B7/00 , A61B7/04 , A61N1/36521 , A61N1/36542 , A61N1/36578
摘要： A system comprises an implantable medical device (IMD) including an implantable heart sound sensor circuit configured to produce an electrical heart sound signal representative of a heart sound of a subject and a processor circuit. The processor circuit is coupled to the heart sound sensor circuit and includes a detection circuit, a heart sound feature circuit and a trending circuit. The detection circuit configured to detect a physiologic perturbation and the heart sound feature circuit is configured to identify a heart sound feature in the electrical signal. The processor circuit is configured to trigger the heart sound feature circuit in relation to a detected physiologic perturbation. The trending circuit is configured to trend the heart sound feature in relation to a recurrence of the physiologic perturbation. The processor circuit is configured to declare a change in a physiologic condition of the patient according to the trending.
摘要翻译：一种系统包括可植入医疗装置（IMD），其包括可植入的心音传感器电路，该可植入心音传感器电路被配置为产生代表对象的心脏声音的电心脏心音信号和处理器电路。处理器电路耦合到心脏声音传感器电路，并且包括检测电路，心脏声音特征电路和趋势电路。被配置为检测生理扰动的检测电路和心音特征电路被配置为识别电信号中的心音特征。处理器电路被配置为相对于检测到的生理扰动触发心音特征电路。趋势电路被配置为相对于生理扰动的复发趋向心音特征。处理器电路被配置为根据趋势来声明患者的生理状况的变化。

55. 发明申请

US20120157864A1 CARDIAC DECOMPENSATION DETECTION USING MULTIPLE SENSORS 有权
标题翻译：使用多个传感器的心脏分解检测
公开(公告)号：US20120157864A1
公开(公告)日：2012-06-21
申请号：US13324174
申请日：2011-12-13
申请人： Pramodsingh Hirasingh Thakur , Abhilash Patangay
发明人： Pramodsingh Hirasingh Thakur , Abhilash Patangay
IPC分类号： A61B5/02
CPC分类号： A61B5/0538 , A61B5/036 , A61B5/0809 , A61N1/36521 , A61N1/36535 , G06F19/00
摘要： Physiological data, such as thoracic impedance data, can be obtained over a first time window to establish a baseline, or can be used to form one or more data clusters. Additional physiological data, such as thoracic impedance test data acquired over a later time window, can be obtained and compared to the baseline or data clusters to determine an indication of worsening heart failure. In an example, a quantitative attribute of one or more data clusters can be monitored and used to provide an indication of worsening heart failure. A posture discrimination metric can be obtained, such as using the physiological data obtained over the first time window. The additional physiological data, such as can be obtained over a second time window, can be compared to the posture discrimination metric to provide a patient posture status.
摘要翻译：可以在第一时间窗口中获得诸如胸部阻抗数据的生理数据以建立基线，或者可以用于形成一个或多个数据簇。可以获得额外的生理数据，例如在稍后时间窗口上获取的胸部阻抗测试数据，并与基线或数据簇进行比较，以确定心脏衰竭恶化的指示。在一个示例中，可以监视一个或多个数据集群的定量属性并用于提供恶化的心力衰竭的指示。可以获得姿势辨别度量，例如使用在第一时间窗口中获得的生理数据。可以将诸如在第二时间窗口上获得的附加生理数据与姿势辨别度量进行比较以提供患者姿势状态。

56. 发明授权

US09713432B2 Wide QRS detector 有权
公开(公告)号：US09713432B2
公开(公告)日：2017-07-25
申请号：US13472563
申请日：2012-05-16
申请人： Abhilash Patangay , Shibaji Shome , Pramodsingh Hirasingh Thakur , Dan Li , Stevens L. Martin
发明人： Abhilash Patangay , Shibaji Shome , Pramodsingh Hirasingh Thakur , Dan Li , Stevens L. Martin
IPC分类号： A61B5/0472 , A61B5/0452 , A61B5/00 , A61N1/362 , A61N1/365 , A61N1/37
CPC分类号： A61B5/0472 , A61B5/0031 , A61B5/0452 , A61B5/7239 , A61N1/3627 , A61N1/36507 , A61N1/37
摘要： A system comprises a cardiac signal sensing circuit and a processor circuit. To detect a QRS duration, the processor circuit determines an isoelectric amplitude value of the cardiac signal segment, identifies a time where the cardiac signal segment amplitude deviates from the first isoelectric amplitude value by a specified threshold deviation value as a Q time, determines an isoelectric value time after the determined maxima and minima times that the cardiac signal segment returns to the same or a different isoelectric amplitude value, identifies a time that follows both the determined maxima and minima times and precedes the isoelectric value time as an S time, wherein the cardiac signal segment amplitude at the identified S time satisfies a specified amplitude change criterion from an isoelectric amplitude value, and determines a time duration of the QRS complex in the cardiac signal segment using the identified Q and S times.

57. 发明授权

US08602996B2 Integrating device-based sensors and bedside biomarker assays to detect worsening heart failure 有权
标题翻译：整合基于装置的传感器和床旁生物标志物检测以检测恶化的心力衰竭
公开(公告)号：US08602996B2
公开(公告)日：2013-12-10
申请号：US13118932
申请日：2011-05-31
申请人： Pramodsingh Hirasingh Thakur , Abhilash Patangay , Craig Stolen , Timothy Meyer
发明人： Pramodsingh Hirasingh Thakur , Abhilash Patangay , Craig Stolen , Timothy Meyer
IPC分类号： A61B5/02
CPC分类号： A61B5/0205 , A61B5/0022 , A61B5/0031 , A61B5/02 , A61B5/08 , A61B7/00 , A61B2505/07 , A61N1/3627 , A61N1/36521 , A61N1/3702 , A61N1/37258 , G06F19/00
摘要： Devices and methods for improving the sensitivity and specificity of heart failure (HF) detection are described. The devices and methods can detect a HF status such as using physiological sensor data and external biomarker assays. An apparatus can comprise ambulatory physiological sensors that can provide a first HF status indicator and a second HF status indicator to a user. An external biomarker sensor can provide an amount of a biomarker present, such as an assay for B-type natriuretic peptide (BNP), which provides information about HF status. A processor circuit can switch from a first HF detection mode to a second detection mode such as in response to the information from the biomarker sensor. The first detection mode can detect HF status using the first HF status indicator, and the second detection mode can detect HF status using the second HF status indicator. The second detection mode can have a higher specificity than the first detection mode.
摘要翻译：描述了用于改善心力衰竭（HF）检测的灵敏度和特异性的装置和方法。设备和方法可以检测HF状态，例如使用生理传感器数据和外部生物标志物测定。装置可以包括可向用户提供第一HF状态指示符和第二HF状态指示符的动态生理传感器。外部生物标志物传感器可以提供一定量的存在的生物标志物，例如提供关于HF状态的信息的B型利尿钠肽（BNP）的测定。处理器电路可以从第一HF检测模式切换到第二检测模式，例如响应于来自生物标志物传感器的信息。第一检测模式可以使用第一HF状态指示器检测HF状态，第二检测模式可以使用第二HF状态指示器检测HF状态。第二检测模式可以具有比第一检测模式更高的特异性。

58. 发明授权

US08211034B2 Monitoring of heart sounds 有权
标题翻译：心音监听
公开(公告)号：US08211034B2
公开(公告)日：2012-07-03
申请号：US11777739
申请日：2007-07-13
申请人： Abhilash Patangay , Jeffrey E. Stahmann , Robert J. Sweeney
发明人： Abhilash Patangay , Jeffrey E. Stahmann , Robert J. Sweeney
IPC分类号： A61B5/02
CPC分类号： A61B5/025 , A61B5/0031 , A61B5/0205 , A61B5/029 , A61B5/0295 , A61B5/0402 , A61B5/053 , A61B5/0816 , A61B5/103 , A61B7/00 , A61B7/04 , A61N1/36521 , A61N1/36542 , A61N1/36578
摘要： This document discusses, among other things, a system comprising an implantable medical device (IMD) including an implantable heart sound sensor circuit configured to produce an electrical heart sound signal representative of a heart sound of a subject and a processor circuit. The processor circuit is coupled to the heart sound sensor circuit and includes a detection circuit, a heart sound feature circuit and a trending circuit. The detection circuit configured to detect a physiologic perturbation and the heart sound feature circuit is configured to identify a heart sound feature in the electrical signal. The processor circuit is configured to trigger the heart sound feature circuit in relation to a detected physiologic perturbation. The trending circuit is configured to trend the heart sound feature in relation to a recurrence of the physiologic perturbation. The processor circuit is configured to declare a change in a physiologic condition of the patient according to the trending.
摘要翻译：本文件尤其涉及一种包括可植入医疗装置（IMD）的系统，该可植入医疗装置（IMD）包括可植入的心音传感器电路，该可植入心音传感器电路被配置为产生代表对象的心脏声音的电心脏心音信号和处理器电路。处理器电路耦合到心脏声音传感器电路，并且包括检测电路，心脏声音特征电路和趋势电路。被配置为检测生理扰动的检测电路和心音特征电路被配置为识别电信号中的心音特征。处理器电路被配置为相对于检测到的生理扰动触发心音特征电路。趋势电路被配置为相对于生理扰动的复发趋向心音特征。处理器电路被配置为根据趋势来声明患者的生理状况的变化。

59. 发明申请

US20120029362A1 APNEA TYPE DETERMINING APPARATUS AND METHOD 有权
标题翻译： APNEA型确定装置和方法
公开(公告)号：US20120029362A1
公开(公告)日：2012-02-02
申请号：US13172332
申请日：2011-06-29
申请人： Abhilash Patangay , Yachuan Pu
发明人： Abhilash Patangay , Yachuan Pu
IPC分类号： A61B5/08 , A61N1/36 , A61B5/0205
CPC分类号： A61B5/4818 , A61B5/0205 , A61B5/021 , A61B5/0538 , A61B5/0809 , A61B5/113 , A61B5/1135 , A61B5/4836 , A61B5/686 , A61B5/7264 , A61B5/7282 , A61B7/003 , A61N1/05 , A61N1/0526 , A61N1/0548 , A61N1/3601 , A61N1/3611
摘要： An apnea classification system provides for apnea monitoring and differentiation based on several sleep apnea related parameters for diagnostic and therapeutic purposes. Monitoring of such sleep apnea related parameters allows the apnea classification system to differentiate among the different types of apnea and hypopnea and to identify an occurrence of periodic respiration. This information may then be used to determine the best method of therapy, or adjust current therapy parameters to more effectively treat a subject.
摘要翻译：呼吸暂停分类系统基于几种睡眠呼吸暂停相关参数进行呼吸暂停监测和分化，用于诊断和治疗目的。监测这种睡眠呼吸暂停相关参数允许呼吸暂停分类系统区分不同类型的呼吸暂停和呼吸不足，并确定周期性呼吸的发生。然后可以使用该信息来确定最佳治疗方法，或调整当前治疗参数以更有效地治疗受试者。

60. 发明授权

US07976470B2 Apnea type determining apparatus and method 有权
标题翻译：呼吸暂停型确定装置及方法
公开(公告)号：US07976470B2
公开(公告)日：2011-07-12
申请号：US12700942
申请日：2010-02-05
申请人： Abhilash Patangay , Yachuan Pu
发明人： Abhilash Patangay , Yachuan Pu
IPC分类号： A61B5/08
CPC分类号： A61B5/0205 , A61B5/4818 , A61B5/7264 , A61N1/3601
摘要： An apnea classification system provides for apnea monitoring and differentiation based on several sleep apnea related parameters for diagnostic and therapeutic purposes. Monitoring of such sleep apnea related parameters allows the apnea classification system to differentiate among the different types of apnea. This information may then be used to determine the best method of therapy, or adjust current therapy parameters to more effectively treat a subject.
摘要翻译：呼吸暂停分类系统基于几种睡眠呼吸暂停相关参数进行呼吸暂停监测和分化，用于诊断和治疗目的。监测这种睡眠呼吸暂停相关参数可以使呼吸暂停分类系统区分不同类型的呼吸暂停。然后可以使用该信息来确定最佳治疗方法，或调整当前治疗参数以更有效地治疗受试者。

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