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51. 发明申请

US20080268497A1 TREATMENT SOLUTION, METHOD FOR PRETREATMENT, METHOD FOR ACQUIRING INFORMATION AND METHOD FOR DETECTION 有权
标题翻译：治疗方案，预处理方法，获取信息的方法和检测方法
公开(公告)号：US20080268497A1
公开(公告)日：2008-10-30
申请号：US12098822
申请日：2008-04-07
申请人： Hiroyuki Hashimoto , Manabu Komatsu , Satoru Hatakeyama
发明人： Hiroyuki Hashimoto , Manabu Komatsu , Satoru Hatakeyama
IPC分类号： G01N1/30 , C12Q1/00
CPC分类号： G01N33/6848 , B82Y15/00 , G01N33/54313
摘要： The present invention intends to provide a high sensitivity method for identifying the type of a protein contained in each cell with a diameter of ten to several tens μm and a sample treatment solution required for it. The above is achieved by three steps of (1) treating a slice of a diseased tissue with an aqueous solution containing gold particles and a digestive enzyme, and digesting restrictively a protein of interest, (2) measuring a 2-dimensional distribution of fragmented peptides by TOF-SIMS, and (3) visualizing a 2-dimensional distribution of the target protein in the slice of the diseased tissue using the results of the proteome analysis and by means of a numerical analysis.
摘要翻译：本发明旨在提供用于鉴定直径为10至数十微米的每个电池中所含的蛋白质的类型的高灵敏度方法和所需的样品处理溶液。上述通过以下三个步骤实现：（1）用含有金颗粒和消化酶的水溶液处理患病组织的切片，并限制性地消化目的蛋白质，（2）测量片段肽的2维分布通过TOF-SIMS，以及（3）使用蛋白质组分析的结果并通过数值分析来显现病变组织切片中靶蛋白的二维分布。

52. 发明申请

US20080090267A1 METHOD FOR TREATING LIVING SAMPLES AND ANALYZING THE SAME 有权
标题翻译：用于处理生活样品和分析样品的方法
公开(公告)号：US20080090267A1
公开(公告)日：2008-04-17
申请号：US11867276
申请日：2007-10-04
申请人： Manabu Komatsu , Hiroyuki Hashimoto , Kazuhiro Ban , Yohei Murayama
发明人： Manabu Komatsu , Hiroyuki Hashimoto , Kazuhiro Ban , Yohei Murayama
IPC分类号： C12Q1/02
CPC分类号： G01N33/5082 , G01N35/1002 , G01N2035/1041
摘要： A method is provided by which a reagent is provided to a living sample, including contacting a thin-film containing a porous body with a living sample containing cells or tissues, and discharging a solution containing at least one or more reagents to a non-contact side of the thin-film by ink-jet to provide the solution to the specific area of the living sample through pores on the thin-film, wherein the smaller diameter of the pores on the porous body relative to the diameter of cells in the living sample enables the reagent to be provided to each individual cell separately. According to this method, the reagent and the reaction product can be fixed while maintaining positioning information of the target substance in the living sample, as a pretreatment for analyzing with high positioning accuracy the target substance in each individual cell in the living sample.
摘要翻译：提供了一种将试剂提供给活体样品的方法，包括使含有多孔体的薄膜与含有细胞或组织的活体样品接触，并将含有至少一种或多种试剂的溶液排出至非接触通过喷墨使薄膜的一侧通过薄膜上的孔提供到活体样品的特定区域的溶液，其中多孔体上的孔的直径相对于活体中细胞的直径较小样品使得可以分别向每个单独的细胞提供试剂。根据该方法，可以在维持活体样品中的目标物质的定位信息的同时固定试剂和反应产物，作为用于以高定位精度分析活体样品中各个细胞中的目标物质的预处理。

53. 发明申请

US20070262306A1 Semiconductor device having microstructure and method of manufacturing microstructure 审中-公开
标题翻译：具有显微组织和制造微结构的方法的半导体器件
公开(公告)号：US20070262306A1
公开(公告)日：2007-11-15
申请号：US11826647
申请日：2007-07-17
申请人： Naoki Ikeuchi , Hiroyuki Hashimoto
发明人： Naoki Ikeuchi , Hiroyuki Hashimoto
IPC分类号： H01L23/58 , B81C3/00
CPC分类号： B81B7/0048 , B81B2201/0235 , B81B2201/0257 , B81C99/004 , B81C2201/019 , G01P15/0802 , G01P15/123 , G01P15/18 , G01P2015/0842 , H01L2224/48091 , H01L2224/73265 , H01L2924/10158 , Y10T29/49004 , H01L2924/00014
摘要： A semiconductor device having a microstructure and a method of manufacturing a microstructure are provided, suppressing any change of characteristics in a wafer state caused in an assembly step. Specifically, a wafer where a plurality of microstructure chips are formed and a dummy wafer are attached to each other using an adhesive layer. As to an MEMS device, a cut dummy wafer is used as a mount for a chip and the dummy wafer and a housing member are attached to each other. Thus, the dummy wafer absorbs any stress or the like applied from below when the housing member is used for packaging.
摘要翻译：提供了具有微细结构的半导体器件和制造微结构的方法，抑制了在组装步骤中引起的晶片状态的特性变化。具体地，使用粘合剂层将形成有多个微结构芯片的晶片和虚设晶片彼此附接。对于MEMS器件，使用切割的虚设晶片作为芯片的安装座，并且虚设晶片和壳体构件彼此附接。因此，当外壳构件用于包装时，虚设晶片吸收从下方施加的任何应力等。

54. 发明授权

US07254240B2 Active noise control system 失效
标题翻译：主动噪声控制系统
公开(公告)号：US07254240B2
公开(公告)日：2007-08-07
申请号：US11407247
申请日：2006-04-20
申请人： Toshio Inoue , Hisashi Sano , Akira Takahashi , Kenichi Terai , Hiroyuki Hashimoto , Isao Kakuhari
发明人： Toshio Inoue , Hisashi Sano , Akira Takahashi , Kenichi Terai , Hiroyuki Hashimoto , Isao Kakuhari
IPC分类号： A61F11/06
CPC分类号： G10K11/178
摘要： An active noise control system is capable of canceling out noise in the passenger compartment of a vehicle based on low-frequency road noise. The active noise control system has a feed-forward control unit for being supplied with reference signals highly correlated to noise from a noise source and generating a noise cancellation signal which is out of phase to noise in the passenger compartment of the vehicle, and a canceling sound generating unit disposed in the passenger compartment for generating a noise canceling sound in response to the noise cancellation signal from said feed-forward control unit. The active noise control system also has microphones for generating reference signals which are positioned respectively near the base of the front seat, near the center of a roof, and within a trunk compartment, i.e., respectively at vibrational antinodes of a primary or secondary acoustic normal mode of the passenger compartment in the longitudinal direction thereof. Output signals from the microphones are supplied as the reference signals.
摘要翻译：主动噪声控制系统能够基于低频道路噪声消除车辆乘客舱内的噪声。主动噪声控制系统具有前馈控制单元，用于提供与来自噪声源的噪声高度相关的参考信号，并产生噪声消除信号，该噪声消除信号在车辆的乘客舱中相位相差，并且取消发声单元，其布置在所述乘客室中，用于响应于来自所述前馈控制单元的噪声消除信号产生噪声消除声音。主动噪声控制系统还具有用于产生参考信号的麦克风，它们分别位于靠近屋顶的中心附近，并且位于屋顶的中心附近，并且位于主干室内，即分别位于主声级或次级声学法线的振动波腹乘客舱的纵向的模式。来自麦克风的输出信号作为参考信号提供。

55. 发明授权

US07188031B1 Method for acquiring information of a biochip using time of flight secondary ion mass spectrometry and an apparatus for acquiring information for the application thereof 有权
标题翻译：使用飞行时间二次离子质谱法获取生物芯片的信息的方法和用于获取其应用信息的装置
公开(公告)号：US07188031B1
公开(公告)日：2007-03-06
申请号：US10601777
申请日：2003-06-24
申请人： Tadashi Okamoto , Hiromitsu Takase , Hiroyuki Hashimoto
发明人： Tadashi Okamoto , Hiromitsu Takase , Hiroyuki Hashimoto
IPC分类号： G01N33/48 , G01R23/02 , C12Q1/00 , C12M1/34
CPC分类号： G01N23/2258 , H01J49/16 , H01J49/40
摘要： A measurement method is provided, which enables to obtain a two-dimensional image with better quantitative-ability by suppressing the influence of the charge-up, when the two-dimensional secondary ion image is obtained for a biological material fixed on a substrate having a high resistivity by utilizing a TOF-SIMS method in a certain wide area. A two-dimensional image having considerably high positioning resolution-ability can be obtained by the procedure in which the pulsed primary ion beam is irradiated at a spot, and the pulse-wise spot-applications of the primary ion beam and the simultaneous detection of the secondary ion generated from the irradiated primary ion beam proceed along with a discontinuous scanning pattern, and eventually the results of these secondary ion measurements are reconstructed into a two-dimensional image in line with the aforementioned discontinuous scanning pattern.
摘要翻译：提供了一种测量方法，其能够通过抑制电荷的影响来获得具有更好的定量能力的二维图像，当获得固定在具有在某一广泛领域利用TOF-SIMS方法具有高电阻率。具有相当高的定位分辨能力的二维图像可以通过脉冲一次离子束在一个点照射的过程和一次离子束的脉冲点应用和同时检测从照射的一次离子束产生的二次离子与不连续扫描图案一起进行，最终将这些二次离子测量的结果重建为与上述不连续扫描图案一致的二维图像。

56. 发明申请

US20060215998A1 Content playback unit and electronic device 有权
公开(公告)号：US20060215998A1
公开(公告)日：2006-09-28
申请号：US11357058
申请日：2006-02-21
申请人： Hiroyuki Hashimoto
发明人： Hiroyuki Hashimoto
IPC分类号： H04N7/00
CPC分类号： H04N5/9206 , H04N5/93 , H04N7/17318 , H04N21/4325 , H04N21/47202 , H04N21/8455
摘要： A content playback unit includes a content management mechanism that plays back a plurality of contents in a predetermined order to display their images on an image display device. The content management mechanism manages the contents by adding numerical information indicative of scheduled playback time to the contents.

57. 发明授权

US07062049B1 Active noise control system 失效
公开(公告)号：US07062049B1
公开(公告)日：2006-06-13
申请号：US09522178
申请日：2000-03-09
申请人： Toshio Inoue , Hisashi Sano , Akira Takahashi , Kenichi Terai , Hiroyuki Hashimoto , Isao Kakuhari
发明人： Toshio Inoue , Hisashi Sano , Akira Takahashi , Kenichi Terai , Hiroyuki Hashimoto , Isao Kakuhari
IPC分类号： A61F11/06
CPC分类号： G10K11/178
摘要： An active noise control system is capable of canceling out noise in the passenger compartment of a vehicle based on low-frequency road noise. The active noise control system has a feed-forward control unit for being supplied with reference signals highly correlated to noise from a noise source and generating a noise cancellation signal which is out of phase to noise in the passenger compartment of the vehicle, and a canceling sound generating unit disposed in the passenger compartment for generating a noise canceling sound in response to the noise cancellation signal from said feed-forward control unit. The active noise control system also has microphones for generating reference signals which are positioned respectively near the base of the front seat, near the center of a roof, and within a trunk compartment, i.e., respectively at vibrational antinodes of a primary or secondary acoustic normal mode of the passenger compartment in the longitudinal direction thereof. Output signals from the microphones are supplied as the reference signals.

58. 发明授权

US06495211B2 Process for producing a substrate and plating apparatus 有权
标题翻译：制造基板和电镀装置的方法
公开(公告)号：US06495211B2
公开(公告)日：2002-12-17
申请号：US09882016
申请日：2001-06-18
申请人： Masahiro Iba , Hisashi Wakako , Kazuhisa Sato , Hiroyuki Hashimoto , Yasuo Doi
发明人： Masahiro Iba , Hisashi Wakako , Kazuhisa Sato , Hiroyuki Hashimoto , Yasuo Doi
IPC分类号： B05D310
CPC分类号： H05K3/187 , H01L21/288 , H01L21/67028 , H01L2224/13099 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01015 , H01L2924/01029 , H01L2924/01033 , H01L2924/01046 , H01L2924/01075 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/014 , H01L2924/14 , H01L2924/15787 , H05K3/244 , H01L2924/00
摘要： A process for producing a substrate 1 having a base-metal plating layer, which includes an immersion step for immersing the substrate 1 in a plating solution contained in a plating tank 33, to thereby form a base-metal plating layer; a washing step for removing the substrate 1 from the plating tank 33, transferring the substrate 1 to a washing tank, and washing the substrate 1; and a cooling step for applying a cooling liquid to the substrate 1 during at least a portion of the period during which the substrate is transferred to a position where the washing step is carried out after completing the immersion step, to thereby cool the substrate 1. An apparatus for carrying out the above process is also disclosed.
摘要翻译：一种具有基底金属镀层的基板1的制造方法，其包括将基板1浸渍在镀槽33中所含的镀液中的浸渍工序，从而形成基底金属镀层; 洗涤步骤，用于从电镀槽33去除衬底1，将衬底1转移到洗涤槽中，并洗涤衬底1; 以及在完成浸渍步骤之后将衬底转移到进行洗涤步骤的位置的至少一部分时间内将冷却液施加到衬底1从而冷却衬底1的冷却步骤。还公开了一种用于执行上述过程的装置。

59. 再颁专利

USRE37896E1 Solution for fabrication of electron-emitting devices, manufacture method of electron-emitting devices, and manufacture method of image-forming apparatus 有权
公开(公告)号：USRE37896E1
公开(公告)日：2002-10-29
申请号：US09456302
申请日：1999-12-08
申请人： Yoshinori Tomida , Hiroyuki Hashimoto
发明人： Yoshinori Tomida , Hiroyuki Hashimoto
IPC分类号： B05D512
CPC分类号： H01J9/027 , C23C18/1216 , C23C18/1295 , H01J1/316 , H01J2201/3165
摘要： In a solution for forming electron-emitting regions of electron-emitting devices, the solution contains a metal carboxylate expressed by the following general formula (I), an organic solvent and/or , and water; (R(COO)k)mM (I) where k=numeral from 1 to 4 , m=a numeral from 1 to 4, and R=CnX2n+1−k R=CnX2n+2−k where X=a hydrogen or halogen (total number of hydrogen and halogen atoms is 2n+1) , n=an integer from 0 to 30, and M=a metal, wherein the organic solvent is a carboxylic ester having the same carboxylic group as R(COO)k expressed in the general formula (I). In a manufacture method of electron-emitting devices each provided between electrodes with a conductive film including an electron-emitting region, a process of forming the conductive film includes a step of coating and calcining the above solution. An image-forming apparatus is manufactured by using the electron-emitting devices. Variations in sheet resistance values of electron-emitting region-forming thin films and characteristics of the electron-emitting devices are reduced.

60. 发明授权

US06192704B1 Absorber of absorption system refrigerator 失效
标题翻译：吸收系统冰箱吸收器
公开(公告)号：US06192704B1
公开(公告)日：2001-02-27
申请号：US09381700
申请日：1999-09-23
申请人： Naoki Hiro , Yoshio Ozawa , Kenji Nasako , Hiroyuki Hashimoto
发明人： Naoki Hiro , Yoshio Ozawa , Kenji Nasako , Hiroyuki Hashimoto
IPC分类号： F25B1512
CPC分类号： B01D53/18 , F25B37/00 , F25B2500/01 , F28D3/00
摘要： The absorber for use in absorption chillers of the present invention comprises a plurality of cooling water pipes 2 extending horizontally in the interior of the absorber chamber. A plurality of flat heat transfer plates 1 are spaced apart from one another and arranged horizontally in a vertical position, and the plurality of cooling water pipes 2 extend through these heat transfer plates 1 perpendicular thereto. The pitch Pd of the plates 1 is 3 to 15 mm. Each heat transfer plate 1 is integrally formed on its upper end face with an absorbent receptacle 10 V-shaped in cross section and extending longitudinally of the upper end face. The bottom portion of the receptacle 10 is formed with two rows of absorbent holes 11 positioned upwardly of respective surfaces of the plate 1. The holes 11 of each row are spaced apart from one another longitudinally of the plate 1 and each have an outlet adjoining the surface of the plate 1. This enables an absorber to have a higher absorbing capacity than conventional absorbers.
摘要翻译：用于本发明的吸收式制冷机的吸收器包括在吸收室的内部水平延伸的多个冷却水管2。多个扁平传热板1彼此间隔开并且在竖直位置上水平布置，并且多个冷却水管2穿过与其垂直的这些传热板1。板1的间距Pd为3〜15mm。每个传热板1在其上端面上一体地形成有横截面为V形的吸收容器，并且在上端面的纵向延伸。容器10的底部形成有两排位于板1的相应表面向上的吸收孔11.每排的孔11彼此间隔开板1的纵向，并且每个具有出口这使得吸收体具有比常规吸收体更高的吸收能力。

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