专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

51. 发明申请

US20060228744A1 Differentiating homozygous, heterozygous and wild-type alleles using a multiplexed hybridization-mediated assay 有权
公开(公告)号：US20060228744A1
公开(公告)日：2006-10-12
申请号：US11439697
申请日：2006-05-23
申请人： Ghazala Hashmi , Michael Seul
发明人： Ghazala Hashmi , Michael Seul
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6883 , C12Q1/6809 , C12Q1/6827 , C12Q1/6837 , C12Q2600/156 , C12Q2600/16 , Y10S436/80 , Y10S436/805 , Y10T436/143333 , C12Q2565/543 , C12Q2563/107 , C12Q2565/501
摘要： Described are methods of assay design and assay image correction, useful for multiplexed genetic screening for mutations and polymorphisms, including CF-related mutants and polymorphs, using an array of probe pairs (in one aspect, where one member is complementary to a particular mutant or polymorphic allele and the other member is complementary to a corresponding wild type allele), with probes bound to encoded particles (e.g., beads) wherein the encoding allows identification of the attached probe. The methods relate to avoiding cross-hybridization by selection of probes and amplicons, as well as separation of reactions of certain probes and amplicons where a homology threshold is exceeded. Methods of correcting a fluorescent image using a background map, where the particles also contain an optical encoding system, are also disclosed.

52. 发明申请

US20060228740A1 Light-controlled electrokinetic assembly of particles near surfaces 有权
公开(公告)号：US20060228740A1
公开(公告)日：2006-10-12
申请号：US11436717
申请日：2006-05-17
申请人： Michael Seul
发明人： Michael Seul
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： C40B50/18 , B01J19/0046 , B01J2219/00432 , B01J2219/00448 , B01J2219/00468 , B01J2219/005 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , C12Q1/6825 , C12Q1/6837 , C40B60/14 , C12Q2565/501 , C12Q2563/155 , C12Q2565/607
摘要： A method and apparatus for the manipulation of colloidal particles and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components.

53. 发明授权

US07083914B2 Color-encoding and in-situ interrogation of matrix-coupled chemical compounds 有权
标题翻译：基质偶联化合物的颜色编码和原位询问
公开(公告)号：US07083914B2
公开(公告)日：2006-08-01
申请号：US09448420
申请日：1999-11-22
申请人： Michael Seul , Richard H. Ebright
发明人： Michael Seul , Richard H. Ebright
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/543 , A61K38/00
CPC分类号： C40B20/04 , B01J19/0046 , B01J2219/00459 , B01J2219/005 , B01J2219/00545 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , C40B30/04 , C40B40/06 , C40B40/10 , C40B50/04 , C40B50/16 , C40B70/00 , G01N21/29 , G01N21/64 , G01N21/6458 , G01N33/54313 , G01N33/582 , G01N33/6845 , G01N2021/1765
摘要： A method and apparatus for the physico-chemical encoding of a collection of beaded resin (“beads”) to determine the chemical identity of bead-anchored compounds by in-situ interrogation of individual beads. The present invention provides method and apparatus to implement color-coding strategies in applications and including the ultrahigh-throughput screening of bead-based combinatorial compounds libraries as well as multiplexed diagnostic and environmental testing and other biochemical assays.
摘要翻译：用于物理化学编码串珠树脂（“珠粒”）的方法和装置，以通过单独珠粒的原位询问来确定珠状锚定化合物的化学特性。本发明提供了在应用中实现颜色编码策略的方法和装置，并且包括基于珠的组合化合物文库的超高通量筛选以及多重诊断和环境测试以及其他生物化学测定。

54. 发明授权

US07057704B2 System and method for programmable illumination pattern generation 有权
标题翻译：用于可编程照明图案生成的系统和方法
公开(公告)号：US07057704B2
公开(公告)日：2006-06-06
申请号：US10098604
申请日：2002-03-16
申请人： Michael Seul , Chiu Wo Chau
发明人： Michael Seul , Chiu Wo Chau
IPC分类号： G03B27/42 , G03B27/72
CPC分类号： G01N21/6456 , B01L3/502761 , B01L2200/0668 , B01L2300/089 , B01L2400/0415 , G01N21/6428 , G01N21/6452 , G01N2021/6463 , G01N2021/6478
摘要： An apparatus providing programmable illumination pattern generation for the manipulation of colloidal particulates and biomolecules in suspension between electrodes, is disclosed. The apparatus implements LEAPS (Light-controlled electrokinetic assembly of particles near surfaces), which relies on: AC electric field-induced assembly of particles: the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The apparatus generates patterns of illumination and projects them on to planar surfaces. i.e., a LEAPS electrode. This enables the creation of patterns using graphical design or drawing software on a personal computer and the projection of said patterns, or sequences of patterns (“time-varying patterns”), onto the interface using a liquid crystal display (LCD) panel and an optical design which images the LCD panel onto the surface of interest, to provide for arrangements and assembly of particles in such patterns.
摘要翻译：公开了一种提供用于在电极之间悬浮的胶体颗粒和生物分子的操作的可编程照明图案生成的装置。该装置实现LEAPS（表面附近的颗粒的光控电动组装），其依赖于：AC电场引起的颗粒组装：电解质/氧化硅/硅界面的图案化以对组装过程施加空间控制; 并通过外部照明实现对装配过程的实时控制。该设备产生照明模式并将它们投影到平面上。即LEAPS电极。这使得能够使用个人计算机上的图形设计或绘图软件来创建图案，并且使用液晶显示器（LCD）面板将所述图案或图案序列（“时变图案”）投影到界面上将LCD面板成像到感兴趣的表面上的光学设计，以提供这种图案中的颗粒的布置和装配。

55. 发明申请

US20060025930A1 Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification 有权
标题翻译：多重探针 - 目标相互作用模式的自动分析：模式匹配和等位基因识别
公开(公告)号：US20060025930A1
公开(公告)日：2006-02-02
申请号：US10909638
申请日：2004-08-02
申请人： Xiongwu Xia , Michael Seul
发明人： Xiongwu Xia , Michael Seul
IPC分类号： G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： C12Q1/6827 , G06F19/18 , G06F19/22
摘要： Disclosed are methods and algorithms (and their implementation) supporting the automated analysis and interactive review and refinement (“redaction”) of the analysis within an integrated software environment, for automated allele assignments. The implementation, preferably with a software system and a program referred to as the Automated Allele Assignment (“AAA”) program, provides a multiplicity of functionalities including: data management by way of an integrated interface to a portable database to permit visualizing, importing, exporting and creating customizable summary reports; system configuration (“Set-up”) including user authorization, training set analysis and probe masking; Pattern Analysis including string matching and probe flipping; and Interactive Redaction combining real-time database computations and “cut-and-paste” editing, generating “warning” statements and supporting annotation. It also includes a thresholding function, a method of setting thresholds, a method of refining thresholds by matching an experimental binary string (“reaction pattern”) setting for that probe, probe masking of signals produced by probes which do not contribute significantly to discriminating among alleles.
摘要翻译：公开的方法和算法（及其实现）支持在集成软件环境中进行自动化等位基因分配的自动分析和交互式审查和细化（“编辑”）分析。优选地使用软件系统和称为自动等位基因分配（“AAA”）程序的程序的实现提供了多种功能，包括：通过与便携式数据库的集成接口的数据管理，以允许可视化，导入，出口和创建可定制的汇总报告; 系统配置（“设置”），包括用户授权，训练集分析和探测屏蔽; 模式分析包括字符串匹配和探针翻转; 和Interactive Redaction将实时数据库计算和“剪切和粘贴”编辑相结合，生成“警告”语句和支持注释。它还包括阈值功能，设置阈值的方法，通过匹配用于该探针的实验二进制串（“反应模式”）设置来精确化阈值的方法，探针对由探针产生的信号进行探针掩蔽，所述探针不对显着区别于等位基因

56. 发明申请

US20050069956A1 Color-encoding and in-situ interrogation of matrix-coupled chemical compounds 审中-公开
标题翻译：基质偶联化合物的颜色编码和原位询问
公开(公告)号：US20050069956A1
公开(公告)日：2005-03-31
申请号：US10901864
申请日：2004-07-29
申请人： Michael Seul
发明人： Michael Seul
IPC分类号： B01J19/00 , C07B61/00 , C40B40/06 , C40B40/10 , C40B70/00 , G01N33/53 , G01N33/543 , G01N33/567
CPC分类号： B01J19/0046 , B01J2219/00459 , B01J2219/005 , B01J2219/00545 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B70/00
摘要： Disclosed is a method for the physico-chemical encoding of a collection of beaded resin (“beads”) allowing determination of the chemical identity of bead-anchored compounds, following identification of beads bearing compounds of interest in an assay, by in-situ interrogation of individual beads, which does not require isolation of the beads of interest. These methods can be used to implement color-coding strategies in applications and including the ultrahigh-throughput screening of bead-based combinatorial compounds libraries as well as multiplexed diagnostic and environmental testing aid other biochemical assays.
摘要翻译：公开了一种用于物理化学编码珠粒树脂（“珠粒”）的集合的方法，其通过原位询问在鉴定在化验中带有感兴趣化合物的珠子之后，确定珠状锚定化合物的化学特性的单个珠粒，其不需要分离感兴趣的珠粒。这些方法可用于实现应用中的颜色编码策略，包括基于珠的组合化合物文库的超高通量筛选，以及多种诊断和环境测试辅助其他生物化学测定。

57. 发明公开

US20240273103A1 System and Methods for Invoking Pattern Matching to Query Tabular Data Collections 审中-公开
公开(公告)号：US20240273103A1
公开(公告)日：2024-08-15
申请号：US18440694
申请日：2024-02-13
申请人： Michael Seul
发明人： Michael Seul
IPC分类号： G06F16/2455 , G06F16/2453 , G06F16/248
CPC分类号： G06F16/2456 , G06F16/24537 , G06F16/24544 , G06F16/248
摘要： Disclosed is a method for querying by pattern matching a relational data store, including a collection of records having a preset number of attributes, wherein the representation of the content of a structured or unstructured data source also encodes the structure of the data source, and including these steps:

providing at least one query comprising at least a find- and a where-clause, wherein the where-clause comprises one or more query patterns, and the find-clause specifies a subset of attributes optionally including aliases thereof; executing the query by:

applying predicates in the one or more query patterns to identify a subset of matching or non-matching records;
forming the intersection of the two or more subsets of records for two or more patterns;
in accordance with the find-clause, selecting specified attributes and applying any aliases; and

thereby identifying the subset of records satisfying constraints expressed in the query patterns.

58. 发明授权

US09428799B2 Method for determining an allele profile of nucleic acid 有权
标题翻译：确定核酸等位基因谱的方法
公开(公告)号：US09428799B2
公开(公告)日：2016-08-30
申请号：US13190147
申请日：2011-07-25
申请人： Michael Seul
发明人： Michael Seul
IPC分类号： G01N33/48 , C12Q1/68 , G06F19/20
CPC分类号： C12Q1/6858 , G06F19/20 , C12Q2535/125 , C12Q2537/143 , C12Q2563/149 , C12Q2563/179
摘要： A method of identifying alleles of polymorphic sites in a plurality of nucleic acid samples including the steps of determining a source tag sharing number “d” for each of the alleles; performing a first reaction in a plurality of pools of the alleles to be identified to produce reaction products including a source tag identifying said each pool; pooling the pools to provide pooled pools; for each of the alleles to be identified, performing a second reaction using said reaction products to produce allele-specific second reaction products comprising a marker tag and a derived source tag; identifying said allele-specific second reaction products to identify the alleles. If “d” is equal to or larger than a maximum pool size, the first reaction may not be performed. Alleles may be binned together. A microparticle comprising one or more capture probes each comprising an oligonucleotide complementary to a subsequence of a target polynucleotide.
摘要翻译：一种鉴定多个核酸样品中多态位点的等位基因的方法，包括确定每个等位基因的源标签共有数“d”的步骤; 在要识别的等位基因的多个池中进行第一反应以产生包括识别所述每个池的源标签的反应产物; 集中池塘提供池池; 对于待鉴定的每个等位基因，使用所述反应产物进行第二反应以产生包含标记标签和衍生源标签的等位基因特异性第二反应产物; 识别所述等位基因特异性第二反应产物以鉴定等位基因。如果“d”等于或大于最大池大小，则可能不执行第一反应。等位基因可以合并在一起。一种包含一种或多种捕获探针的微粒，每个捕获探针包含与靶多核苷酸的亚序列互补的寡核苷酸。

59. 发明授权

US09082145B2 Web-hosted engine for continuously improving the identification of safer products for administration 有权
标题翻译：网站引擎，用于不断改进更安全的产品识别管理
公开(公告)号：US09082145B2
公开(公告)日：2015-07-14
申请号：US14309850
申请日：2014-06-19
申请人： Michael Seul
发明人： Michael Seul
IPC分类号： G01N33/46 , G06Q30/06 , G06F19/00 , G06Q30/00 , C40B20/04 , C40B50/10 , C40B50/16 , G06G7/48
CPC分类号： G06Q30/0631 , B01J2219/00576 , B01J2219/00592 , B01J2219/00722 , B01J2219/00725 , C40B20/04 , C40B50/10 , C40B50/16 , G06F19/34 , G06F19/3456 , G06Q30/018 , G06Q2220/10 , G16H10/60 , G16H50/30
摘要： Genetic information relating to clinically significant attributes are generated as unique molecular signatures, which are provided to a subscriber to be carried as a card or in another form, including for display by a subscriber's computer or smart-phone or PDA. The signature is periodically updated as new clinically significant attributes become known. The process of updating the signature and using it to obtain suitable products (which don't have an unacceptable risk of generating an adverse reaction or outcome) is also described.
摘要翻译：生成与临床重要属性相关的遗传信息，作为独特的分子标记产生，其被提供给用户作为卡或另一形式携带，包括由用户的计算机或智能手机或PDA显示。当新的临床重要属性变得已知时，签名被定期更新。还描述了更新签名并使用其获得合适产品（其不具有产生不利反应或结果的不可接受的风险）的过程。

60. 发明申请

US20130029857A1 METHOD FOR DETERMINING AN ALLELE PROFILE OF NUCLEIC ACID 有权
标题翻译：用于确定核酸的等位基因的方法
公开(公告)号：US20130029857A1
公开(公告)日：2013-01-31
申请号：US13190147
申请日：2011-07-25
申请人： Michael Seul
发明人： Michael Seul
IPC分类号： C40B30/04 , C40B30/10 , C07H21/00 , C40B30/00
CPC分类号： C12Q1/6858 , G06F19/20 , C12Q2535/125 , C12Q2537/143 , C12Q2563/149 , C12Q2563/179
摘要： A method of identifying alleles of polymorphic sites in a plurality of nucleic acid samples including the steps of determining a source tag sharing number “d” for each of the alleles; performing a first reaction in a plurality of pools of the alleles to be identified to produce reaction products including a source tag identifying said each pool; pooling the pools to provide pooled pools; for each of the alleles to be identified, performing a second reaction using said reaction products to produce allele-specific second reaction products comprising a marker tag and a derived source tag; identifying said allele-specific second reaction products to identify the alleles. If “d” is equal to or larger than a maximum pool size, the first reaction may not be performed. Alleles may be binned together. A microparticle comprising one or more capture probes each comprising an oligonucleotide complementary to a subsequence of a target polynucleotide.
摘要翻译：一种确定多个核酸样品中多态性位点的等位基因的方法，包括以下步骤：确定每个等位基因的源标签共享数d; 在要识别的等位基因的多个池中进行第一反应以产生包括识别所述每个池的源标签的反应产物; 集中池塘提供池池; 对于待鉴定的每个等位基因，使用所述反应产物进行第二反应以产生包含标记标签和衍生源标签的等位基因特异性第二反应产物; 识别所述等位基因特异性第二反应产物以鉴定等位基因。如果d等于或大于最大池大小，则可能不执行第一反应。等位基因可以合并在一起。一种包含一种或多种捕获探针的微粒，每个捕获探针包含与靶多核苷酸的亚序列互补的寡核苷酸。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式