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51. 发明申请

US20060240419A1 Method of detecting gene polymorphism 审中-公开
标题翻译：检测基因多态性的方法
公开(公告)号：US20060240419A1
公开(公告)日：2006-10-26
申请号：US10514780
申请日：2003-05-16
申请人： Yusuke Nakamura , Akihiro Sekine , Aritoshi Lida , Susumu Saito
发明人： Yusuke Nakamura , Akihiro Sekine , Aritoshi Lida , Susumu Saito
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6858 , C12Q1/6827
摘要： A method for detecting a genetic polymorphism(s), comprising creating oligonucleotide probes and/or oligonucleotide primers so that the probes and/or primers contain a polymorphic site(s) present in a gene encoding a receptor or a sequence complementary thereto or so that the polymorphic site(s) is/are contained in the amplified fragment when at least one of said gene encoding the receptor and said sequence complementary thereto is amplified; and detecting at least one genetic polymorphism in a gene of a subject encoding the receptor using the resultant oligonucleotide probes and/or oligonucleotide primers.
摘要翻译：一种用于检测遗传多态性的方法，包括产生寡核苷酸探针和/或寡核苷酸引物，使得探针和/或引物含有存在于编码受体或与其互补的序列的基因中的多态性位点，或使得当编码受体的所述基因和与其互补的所述序列的至少一个被扩增时，所述多态性位点被包含在扩增的片段中; 并使用得到的寡核苷酸探针和/或寡核苷酸引物检测编码受体的受试者的基因中的至少一个遗传多态性。

52. 发明申请

US20060234230A1 Method of detecting gene polymorphism 审中-公开
标题翻译：检测基因多态性的方法
公开(公告)号：US20060234230A1
公开(公告)日：2006-10-19
申请号：US10516038
申请日：2003-05-29
申请人： Yusuke Nakamura , Akihiro Sekine , Aritoshi Iida , Susumu Saito
发明人： Yusuke Nakamura , Akihiro Sekine , Aritoshi Iida , Susumu Saito
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6818 , C12Q1/6827 , C12Q1/6837 , C12Q1/6883 , C12Q2600/156 , C12Q2561/113
摘要： A method for detecting a genetic polymorphism(s) in a gene encoding cytochrome P450 using as oligonucleotide probes and/or oligonucleotide primers at least one sequence selected from the group consisting of an at least 13 nucleotide sequence within any of the nucleotide sequences as shown in SEQ ID NOS: 1 through 215, said at least 13 nucleotide sequence containing the 21st nucleotide, or a sequence complementary to said at least 13 nucleotide sequence.
摘要翻译：用于使用寡核苷酸探针和/或寡核苷酸引物检测编码细胞色素P450的基因中的遗传多态性的方法，所述寡核苷酸探针和/或寡核苷酸引物至少一个选自下列任一核苷酸序列中的至少13个核苷酸序列的序列，如 SEQ ID NO：1至215，所述至少13个核苷酸序列含有第21个核苷酸，或与所述至少13个核苷酸序列互补的序列。

53. 发明申请

US20060216739A1 Insulin-like growth factor binding protein 失效
标题翻译：胰岛素样生长因子结合蛋白
公开(公告)号：US20060216739A1
公开(公告)日：2006-09-28
申请号：US11396430
申请日：2006-03-30
申请人： Kazuya Yamano , Susumu Sekine , Mitsuo Satoh , Toshio Ota , Akiko Furuya , Kenji Shibata , Yuki Kobayashi , Miho Takebayashi , Yusuke Nakamura , Sumio Sugano
发明人： Kazuya Yamano , Susumu Sekine , Mitsuo Satoh , Toshio Ota , Akiko Furuya , Kenji Shibata , Yuki Kobayashi , Miho Takebayashi , Yusuke Nakamura , Sumio Sugano
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N1/18 , C12N1/21 , C12N5/06 , C07K14/65
CPC分类号： C07K16/26 , A61K38/00 , A61K2039/505 , C07K14/4743 , C07K16/18 , C07K2317/34
摘要： Using the proteins of the present invention, DNAs encoding the proteins, and antibodies recognizing the proteins, detection methods for diseases relating to the novel insulin-like growth factor binding proteins of the present invention, as well as diagnostic agents, preventive agents, and therapeutic agents for diseases relating to the proteins of the present invention can be provided.
摘要翻译：使用本发明的蛋白质，编码蛋白质的DNA和识别蛋白质的抗体，与本发明的新型胰岛素样生长因子结合蛋白相关的疾病的检测方法以及诊断试剂，预防剂和治疗剂可以提供与本发明的蛋白质相关的疾病的药剂。

54. 发明申请

US20060194199A1 Method for diagnosing testicular seminomas 审中-公开
标题翻译：诊断睾丸精原细胞瘤的方法
公开(公告)号：US20060194199A1
公开(公告)日：2006-08-31
申请号：US10529593
申请日：2003-09-12
申请人： Yusuke Nakamura , Toyomasa Katagiri
发明人： Yusuke Nakamura , Toyomasa Katagiri
IPC分类号： C12Q1/68 , A61K48/00
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158
摘要： Objective methods for detecting and diagnosing testicular seminoma (TS) arc described herein. In one embodiment, the diagnostic method involves the determining a expression level of TS -associated gene that discriminate between TS and nomal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of TS, methods of treating TS and method of vaccinating a subject against TS.
摘要翻译：本文描述了用于检测和诊断睾丸精原细胞瘤（TS）弧的客观方法。在一个实施方案中，诊断方法涉及确定区分TS和正常细胞的TS相关基因的表达水平。本发明进一步提供筛选用于治疗TS的治疗剂，治疗TS的方法和接种个体接种TS的方法的方法。

55. 发明申请

US20060111314A1 Method for treating or preventing metastasis of colorectal cancers 审中-公开
标题翻译：治疗或预防结直肠癌转移的方法
公开(公告)号：US20060111314A1
公开(公告)日：2006-05-25
申请号：US10529523
申请日：2003-08-14
申请人： Yusuke Nakamura , Yoichi Furukawa
发明人： Yusuke Nakamura , Yoichi Furukawa
IPC分类号： A61K48/00 , C12Q1/68 , A61K39/395
CPC分类号： A61K38/1709 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , G01N33/57419 , G01N2500/04
摘要： Disclosed are methods of detecting metastasis of colorectal cancer using differentially expressed genes. Also disclosed are methods of identifying agents for treating colorectal cancer or preventing metastasis of colorectal cancer.
摘要翻译：公开了使用差异表达基因检测结肠直肠癌转移的方法。还公开了鉴定用于治疗结肠直肠癌或预防结肠直肠癌转移的药剂的方法。

56. 发明申请

US20050214303A1 Methods for damaging cells using effector functions of anti FAM3D antibodies 审中-公开
标题翻译：使用抗FAM3D抗体的效应子功能破坏细胞的方法
公开(公告)号：US20050214303A1
公开(公告)日：2005-09-29
申请号：US10809821
申请日：2004-03-24
申请人： Yusuke Nakamura , Yataro Daigo
发明人： Yusuke Nakamura , Yataro Daigo
IPC分类号： A61K39/395 , C07K16/30
CPC分类号： C07K16/3023 , A61K2039/505 , C07K2317/732
摘要： The present invention relates to the use of cytoxicity based on the effector function of anti-FAM3D antibodies. Specifically, the present invention provides methods and pharmaceutical compositions that comprise an anti-FAM3D antibody as an active ingredient for damaging FAM3D-expressing cells using antibody effector function. Since FAM3D is strongly expressed in lung cancer cells, the present invention is useful in lung cancer therapies.
摘要翻译：本发明涉及基于抗FAM3D抗体的效应子功能的细胞毒性的用途。具体地说，本发明提供了包含抗FAM3D抗体作为活性成分的方法和药物组合物，用于使用抗体效应子功能损伤表达FAM3D的细胞。由于FAM3D在肺癌细胞中强烈表达，因此本发明可用于肺癌治疗。

57. 发明授权

US5871916A ECDN protein and DNA encoding the same 失效
标题翻译： ECDN蛋白和编码相同的DNA
公开(公告)号：US5871916A
公开(公告)日：1999-02-16
申请号：US649619
申请日：1996-05-02
申请人： Yusuke Nakamura , Hiroko Saito
发明人： Yusuke Nakamura , Hiroko Saito
IPC分类号： A61K38/00 , C07K14/72 , C12N15/12 , C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C07K14/721 , C07K14/72 , A61K38/00
摘要： A DNA encoding a novel steroid hormone receptor-like protein was obtained from a human fetal lung cDNA library, and its structure was determined. Further, the protein encoded by the gene was isolated, identified, and designated as an ECDN protein. Furthermore, a protein encoded by a DNA lacking a part of the above gene was isolated, identified, and designated as an ECDN paucimolecular protein.It was proven that the ECDN paucimolecular protein was expressed in various cancer cells. Therefore, it is expected that it becomes possible to diagnose and treat cancers by analyzing the expression of the ECDN protein and the ECDN paucimolecular protein in a subject tissue. Furthermore, attained to develop novel pharmaceuticals can be developed by finding natural and synthetic compounds capable of binding specifically to the ECDN protein and the ECDN paucimolecular protein.
摘要翻译： PCT No.PCT / JP95 / 01909 Sec。 371日期：1996年5月2日 102（e）日期1996年5月2日PCT提交1995年9月21日PCT公布。公开号WO96 / 09324 日期1996年3月28日从人胎儿肺cDNA文库获得编码新型类固醇激素受体样蛋白的DNA，测定其结构。此外，由该基因编码的蛋白质被分离，鉴定并命名为ECDN蛋白。此外，由缺乏上述基因的一部分的DNA编码的蛋白质被分离，鉴定并命名为ECDN分子蛋白。证明ECDN微囊分子蛋白在各种癌细胞中表达。因此，通过分析对象组织中的ECDN蛋白质和ECDN微分子蛋白质的表达，可以预测癌症的诊断和治疗。此外，通过发现能够特异性结合ECDN蛋白质和ECDN微分子蛋白质的天然和合成化合物，可以开发开发新型药物。

58. 发明授权

US5834245A PRLTS proteins and DNA's encoding the same 失效
标题翻译： PRLTS蛋白和DNA的编码相同
公开(公告)号：US5834245A
公开(公告)日：1998-11-10
申请号：US506864
申请日：1995-07-25
申请人： Yusuke Nakamura , Yoshiyuki Fujiwara
发明人： Yusuke Nakamura , Yoshiyuki Fujiwara
IPC分类号： A61K38/00 , C07K14/82 , C12N15/12 , C12N15/63
CPC分类号： C07K14/82 , A61K38/00
摘要： A gene is provided which is present in the deletion region of a chromosome common in lung cancer, hepatocellular carcinoma and colorectal cancer and encodes a novel protein, a protein encoded by the gene (PRLTS protein), and a method of discriminating tumor cells. With respect to the human chromosome 8, a detailed gene map was prepared, the chromosome of each of lung cancer, hepatocellular carcinoma and colorectal cancer tissues was analyzed, and a gene encoding a novel protein was cloned to thereby determine the structure thereof. A gene analysis was conducted with the use of a DNA probe derived from the above gene, and consequently mutations in the gene were confirmed in the lung cancer, hepatocellular carcinoma and colorectal cancer tissues.
摘要翻译：提供存在于肺癌，肝细胞癌和结肠直肠癌中常见的染色体的缺失区域中的基因，并编码新的蛋白质，由该基因编码的蛋白质（PRLTS蛋白质）和鉴别肿瘤细胞的方法。对于人染色体8，制备了详细的基因图，分析了肺癌，肝细胞癌和结肠直肠癌组织的染色体，克隆了编码新蛋白的基因，从而确定了其结构。使用源自上述基因的DNA探针进行基因分析，因此在肺癌，肝细胞癌和结肠直肠癌组织中证实了基因突变。

59. 发明授权

US5648212A Detection of inherited and somatic mutations of APC gene in colorectal cancer of humans 失效
标题翻译：检测人类结肠直肠癌APC基因的遗传和体细胞突变
公开(公告)号：US5648212A
公开(公告)日：1997-07-15
申请号：US289548
申请日：1994-08-12
申请人： Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip John Hedge , Geoff Joslyn , Kenneth Kinzler , Alexander Markham , Yusuke Nakamura , Andrew Thliveris , Bert Vogelstein , Raymond L. White
发明人： Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip John Hedge , Geoff Joslyn , Kenneth Kinzler , Alexander Markham , Yusuke Nakamura , Andrew Thliveris , Bert Vogelstein , Raymond L. White
IPC分类号： C07K14/47 , C07K14/82 , C07K16/32 , C12N5/12 , C12N15/12 , C12Q1/68 , C07H21/04 , C07H21/02 , C12P19/34
CPC分类号： C07K14/47 , C07K14/82 , C12Q1/68 , C12Q1/6827 , C12Q1/6886 , A01K2217/05 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , Y10S530/828
摘要： Methods are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. APC is a tumor suppressor.
摘要翻译：提供了用于评估人类组织和身体样品中APC基因突变的方法。家族性腺瘤性息肉病患者以及散发性结肠直肠癌患者发现APC突变。 APC在大多数正常组织中表达。 APC是一种肿瘤抑制因子。

60. 发明授权

US5559023A Tumor suppressor gene 失效
标题翻译：肿瘤抑制基因
公开(公告)号：US5559023A
公开(公告)日：1996-09-24
申请号：US384850
申请日：1995-02-07
申请人： Yusuke Nakamura , Takashi Imai
发明人： Yusuke Nakamura , Takashi Imai
IPC分类号： A61K38/00 , C07K14/47 , C07K14/82 , C12N5/10 , C07H21/04
CPC分类号： C07K14/82 , C07K14/4703 , A61K38/00
摘要： A detailed genetic map on human chromosome 11 was prepared. Then, a commonly deleted region on the chromosome in the tumor tissues of patients with multiple endocrine neoplasia type 1 was identified. Further, by linkage analysis of a family line with this disease, a genetic cause for this disease was localized. A gene present in the region common to these observations was cloned and the structure of this gene was determined. Because a protein coded by this DNA is homologous with those of transcriptional factors, it is expected that the above-mentioned gene may be a novel tumor suppressor gene. Further, it is also expected that the above-mentioned gene and a protein coded for thereby may be useful in preparation of a remedy for cancer and a diagnostic drug for cancer.
摘要翻译：准备了人类染色体11上的详细遗传图谱。然后，鉴定了多发性内分泌瘤1型患者肿瘤组织染色体上普遍缺失的一个区域。此外，通过家族系与这种疾病的联系分析，本病的遗传原因是本病。克隆了与这些观察结果共同的区域中存在的基因，并测定了该基因的结构。由于由该DNA编码的蛋白质与转录因子的蛋白质同源，所以预期上述基因可能是新的肿瘤抑制基因。此外，还预期上述基因和由此编码的蛋白质可用于制备癌症治疗剂和癌症诊断药物。

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