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1. 发明授权

US5648212A Detection of inherited and somatic mutations of APC gene in colorectal cancer of humans 失效
标题翻译：检测人类结肠直肠癌APC基因的遗传和体细胞突变
公开(公告)号：US5648212A
公开(公告)日：1997-07-15
申请号：US289548
申请日：1994-08-12
申请人： Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip John Hedge , Geoff Joslyn , Kenneth Kinzler , Alexander Markham , Yusuke Nakamura , Andrew Thliveris , Bert Vogelstein , Raymond L. White
发明人： Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip John Hedge , Geoff Joslyn , Kenneth Kinzler , Alexander Markham , Yusuke Nakamura , Andrew Thliveris , Bert Vogelstein , Raymond L. White
IPC分类号： C07K14/47 , C07K14/82 , C07K16/32 , C12N5/12 , C12N15/12 , C12Q1/68 , C07H21/04 , C07H21/02 , C12P19/34
CPC分类号： C07K14/47 , C07K14/82 , C12Q1/68 , C12Q1/6827 , C12Q1/6886 , A01K2217/05 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , Y10S530/828
摘要： Methods are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. APC is a tumor suppressor.
摘要翻译：提供了用于评估人类组织和身体样品中APC基因突变的方法。家族性腺瘤性息肉病患者以及散发性结肠直肠癌患者发现APC突变。 APC在大多数正常组织中表达。 APC是一种肿瘤抑制因子。

2. 发明授权

US5783666A APC (adenomatous polyosis coli) protein 失效
标题翻译： APC（腺瘤性多发性大肠杆菌）蛋白
公开(公告)号：US5783666A
公开(公告)日：1998-07-21
申请号：US452655
申请日：1995-05-25
申请人： Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip John Hedge , Geoff Joslyn , Kenneth Kinzler , Alexander Fred Markham , Yusuke Nakamura , Andrew Thliveris , Bert Vogelstein , Raymond L. White
发明人： Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip John Hedge , Geoff Joslyn , Kenneth Kinzler , Alexander Fred Markham , Yusuke Nakamura , Andrew Thliveris , Bert Vogelstein , Raymond L. White
IPC分类号： C07K14/47 , C07K14/82 , C07K16/32 , C12N5/12 , C12N15/12 , C12Q1/68
CPC分类号： C07K14/47 , C07K14/82 , C12Q1/68 , C12Q1/6827 , C12Q1/6886 , A01K2217/05 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , Y10S530/828
摘要： A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.
摘要翻译：公开了一种称为APC的人类基因。提供了用于评估人类组织和身体样品中APC基因突变的方法和试剂盒。家族性腺瘤性息肉病患者以及散发性结肠直肠癌患者发现APC突变。 APC在大多数正常组织中表达。这些结果表明APC是肿瘤抑制因子。

3. 发明授权

US06413727B1 Diagnosis for mutant APC by immunoassay 失效
标题翻译：通过免疫测定法诊断突变体APC
公开(公告)号：US06413727B1
公开(公告)日：2002-07-02
申请号：US08449731
申请日：1995-05-25
申请人： Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip John Hedge , Geoff Joslyn , Kenneth Kinzler , Alexander Fred Markham , Yusuke Nakamura , Andrew Thliveris , Bert Vogelstein , Raymond L. White
发明人： Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip John Hedge , Geoff Joslyn , Kenneth Kinzler , Alexander Fred Markham , Yusuke Nakamura , Andrew Thliveris , Bert Vogelstein , Raymond L. White
IPC分类号： G01N33574
CPC分类号： C07K14/47 , A01K2217/05 , C07K14/82 , C12Q1/68 , C12Q1/6827 , C12Q1/6886 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , Y10S530/828
摘要： A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.
摘要翻译：公开了一种称为APC的人类基因。提供了用于评估人类组织和身体样品中APC基因突变的方法和试剂盒。家族性腺瘤性息肉病患者以及散发性结肠直肠癌患者发现APC突变。 APC在大多数正常组织中表达。这些结果表明APC是肿瘤抑制因子。

4. 发明授权

US5691454A APC antibodies 失效
标题翻译： APC抗体
公开(公告)号：US5691454A
公开(公告)日：1997-11-25
申请号：US452654
申请日：1995-05-25
申请人： Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip John Hedge , Geoff Joslyn , Kenneth Kinzler , Alexander Fred Markham , Yusuke Nakamura , Andrew Thliveris , Bert Vogelstein , Raymond L. White
发明人： Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip John Hedge , Geoff Joslyn , Kenneth Kinzler , Alexander Fred Markham , Yusuke Nakamura , Andrew Thliveris , Bert Vogelstein , Raymond L. White
IPC分类号： C07K14/47 , C07K14/82 , C07K16/32 , C12N5/12 , C12N15/12 , C12Q1/68
CPC分类号： C07K14/47 , C07K14/82 , C12Q1/68 , C12Q1/6827 , C12Q1/6886 , A01K2217/05 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , Y10S530/828
摘要： A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.
摘要翻译：公开了一种称为APC的人类基因。提供了用于评估人类组织和身体样品中APC基因突变的方法和试剂盒。家族性腺瘤性息肉病患者以及散发性结肠直肠癌患者发现APC突变。 APC在大多数正常组织中表达。这些结果表明APC是肿瘤抑制因子。

5. 发明授权

US6114124A Detection of APC proteins 失效
标题翻译：检测APC蛋白
公开(公告)号：US6114124A
公开(公告)日：2000-09-05
申请号：US450582
申请日：1995-05-25
申请人： Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip John Hedge , Geoff Joslyn , Kenneth Kinzler , Alexander Fred Markham , Yusuke Nakamura , Andrew Thliveris , Bert Vogelstein , Raymond L. White
发明人： Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip John Hedge , Geoff Joslyn , Kenneth Kinzler , Alexander Fred Markham , Yusuke Nakamura , Andrew Thliveris , Bert Vogelstein , Raymond L. White
IPC分类号： C07K14/47 , C07K14/82 , C07K16/32 , C12N5/12 , C12N15/12 , C12Q1/68 , G01N33/53 , G01N33/48 , G01N33/574
CPC分类号： C07K14/47 , C07K14/82 , C12Q1/68 , C12Q1/6827 , C12Q1/6886 , A01K2217/05 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , Y10S530/828
摘要： A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.
摘要翻译：公开了一种称为APC的人类基因。提供了用于评估人类组织和身体样品中APC基因突变的方法和试剂盒。家族性腺瘤性息肉病患者以及散发性结肠直肠癌患者发现APC突变。 APC在大多数正常组织中表达。这些结果表明APC是肿瘤抑制因子。

6. 发明授权

US5352775A APC gene and nucleic acid probes derived therefrom 失效
标题翻译： APC基因和衍生自其的核酸探针
公开(公告)号：US5352775A
公开(公告)日：1994-10-04
申请号：US741940
申请日：1991-08-08
申请人： Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip J. Hedge , Geoff Joslyn , Kenneth Kinzler , Alexander F. Markham , Yusuke Nakamura , Andrew Thliveris , Bert Vogelstein , Raymond L. White
发明人： Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip J. Hedge , Geoff Joslyn , Kenneth Kinzler , Alexander F. Markham , Yusuke Nakamura , Andrew Thliveris , Bert Vogelstein , Raymond L. White
IPC分类号： C07K14/47 , C07K14/82 , C07K16/32 , C12N5/12 , C12N15/12 , C12Q1/68 , C07H21/00
CPC分类号： C07K14/47 , C07K14/82 , C12Q1/68 , C12Q1/6827 , C12Q1/6886 , A01K2217/05 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , Y10S530/828
摘要： A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.
摘要翻译：公开了一种称为APC的人类基因。提供了用于评估人类组织和身体样品中APC基因突变的方法和试剂盒。家族性腺瘤性息肉病患者以及散发性结肠直肠癌患者发现APC突变。 APC在大多数正常组织中表达。这些结果表明APC是肿瘤抑制因子。

7. 再颁专利

USRE38916E1 APC Antibodies 有权
标题翻译： APC抗体
公开(公告)号：USRE38916E1
公开(公告)日：2005-12-06
申请号：US09442489
申请日：1999-11-18
申请人： Bert Vogelstein , Kenneth W. Kinzler , Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip John Hedge , Geoff Joslyn , Alexander Fred Markham , Yusuka Nakamura , Andrew Thilveris , Raymond L. White
发明人： Bert Vogelstein , Kenneth W. Kinzler , Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip John Hedge , Geoff Joslyn , Alexander Fred Markham , Yusuka Nakamura , Andrew Thilveris , Raymond L. White
IPC分类号： C07K14/47 , C07K16/32 , C12N5/12 , C12N15/12
CPC分类号： C07K14/47
摘要： A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.
摘要翻译：公开了一种称为APC的人类基因。提供了用于评估人类组织和身体样品中APC基因突变的方法和试剂盒。家族性腺瘤性息肉病患者以及散发性结肠直肠癌患者发现APC突变。 APC在大多数正常组织中表达。这些结果表明APC是肿瘤抑制因子。

8. 再颁专利

USRE36713E APC gene and nucleic acid probes derived therefrom 失效
标题翻译： APC基因和衍生自其的核酸探针
公开(公告)号：USRE36713E
公开(公告)日：2000-05-23
申请号：US726870
申请日：1996-10-04
申请人： Bert Vogelstein , Kenneth W. Kinzler , Hans Albertson , Rakesh Anand , Mary Carlson , Joanna Groden , Philip John Hedge , Geoff Joslyn , Alexander Fred Markham , Yusuke Nakamura , Andrew Thliveris , Raymond White
发明人： Bert Vogelstein , Kenneth W. Kinzler , Hans Albertson , Rakesh Anand , Mary Carlson , Joanna Groden , Philip John Hedge , Geoff Joslyn , Alexander Fred Markham , Yusuke Nakamura , Andrew Thliveris , Raymond White
IPC分类号： C07K14/47 , C07K14/82 , C07K16/32 , C12N5/12 , C12N15/12 , C12Q1/68 , C07K14/435
CPC分类号： C07K14/47 , C07K14/82 , C12Q1/68 , C12Q1/6827 , C12Q1/6886 , A01K2217/05 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , Y10S530/828
摘要： A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in hum tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as wel as in sporadic colorectal cancer patents. APC is expressed in most normal tissue. These results suggest that APC is a tumor suppressor.
摘要翻译：公开了一种称为APC的人类基因。提供了方法和试剂盒，用于评估嗡嗡声组织和身体样品中APC基因的突变。在家族性腺瘤性息肉病患者中发现APC突变与散发性结肠直肠癌专利一样。 APC在大多数正常组织中表达。这些结果表明APC是肿瘤抑制因子。

9. 再颁专利

USRE40948E1 APC antibodies 有权
标题翻译： APC抗体
公开(公告)号：USRE40948E1
公开(公告)日：2009-10-27
申请号：US09983543
申请日：2001-10-24
申请人： Bert Vogelstein , Kenneth W. Kinzler , Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip Hedge , Geoff Joslyn , Alexander Fred Markham , Yusuke Nakumura , Andrew Thliveris , Raymond White
发明人： Bert Vogelstein , Kenneth W. Kinzler , Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip Hedge , Geoff Joslyn , Alexander Fred Markham , Yusuke Nakumura , Andrew Thliveris , Raymond White
IPC分类号： C07K16/30 , A61K39/395
摘要： A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.
摘要翻译：公开了一种称为APC的人类基因。提供了用于评估人类组织和身体样品中APC基因突变的方法和试剂盒。家族性腺瘤性息肉病患者以及散发性结肠直肠癌患者发现APC突变。 APC在大多数正常组织中表达。这些结果表明APC是肿瘤抑制因子。

10. 发明授权

US5824501A Nucleic acids of the bloom's syndrome gene 失效
标题翻译：绽放综合征基因的核酸
公开(公告)号：US5824501A
公开(公告)日：1998-10-20
申请号：US559303
申请日：1995-11-15
申请人： Nathan A. Ellis , James German , Joanna Groden
发明人： Nathan A. Ellis , James German , Joanna Groden
IPC分类号： A61K48/00 , C12N9/90 , C12N15/12 , C12Q1/68 , C07H21/04 , C12N15/00 , C12N15/63
CPC分类号： C12Q1/6883 , C12N9/90 , A01K2217/05 , A01K2217/072 , A01K2267/0306 , A61K48/00 , C12Q2600/154 , C12Q2600/156
摘要： The present invention provides a method for diagnosing BS as well as determining whether a subject is a carrier of a mutated BLM gene. The present invention also provides one or more single-stranded nucleic acid probes and antibodies which may be formulated in kits, and used for diagnosing BS or determining whether a subject is a carrier of a mutated BLM gene. In addition, the present invention provides a method for treating or preventing the onset of BS in a subject in need of such treatment or prevention, as well as vectors and stem cells useful for such treatment or prevention. The present invention also provides a purified and isolated nucleic acid encoding an enzymatically active BLM protein, a vector comprising this nucleic acid, a cell stably transformed with this vector, as well as a method for producing recombinant, enzymatically active BLM protein. A purified, enzymatically active BLM protein is also provided by the present invention. Finally, the present invention provides a vector, an embryonic stem cell, and a non-human, transgenic animal, each of which comprises a mutated BLM gene, as well as a method for producing the non-human, transgenic animal.
摘要翻译：本发明提供了用于诊断BS以及确定受试者是否是突变的BLM基因的载体的方法。本发明还提供一种或多种单链核酸探针和抗体，其可以配制在试剂盒中，并用于诊断BS或确定受试者是否是突变的BLM基因的载体。此外，本发明提供了治疗或预防需要这种治疗或预防的受试者以及可用于这种治疗或预防的载体和干细胞的BS发病的方法。本发明还提供了编码酶活性BLM蛋白质的纯化和分离的核酸，包含该核酸的载体，用该载体稳定转化的细胞，以及用于产生重组酶活性BLM蛋白质的方法。纯化的酶活性BLM蛋白也由本发明提供。最后，本发明提供载体，胚胎干细胞和非人转基因动物，其中每一种都包含突变的BLM基因，以及用于生产非人转基因动物的方法。

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