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51. 发明授权

US08318508B2 Patterning with compositions comprising lipid 有权
标题翻译：用包含脂质的组合物进行图案化
公开(公告)号：US08318508B2
公开(公告)日：2012-11-27
申请号：US12213301
申请日：2008-06-17
申请人： Chad A. Mirkin , Ling Huang , Rafael Vega , Steven Lenhert
发明人： Chad A. Mirkin , Ling Huang , Rafael Vega , Steven Lenhert
IPC分类号： G01N1/00
CPC分类号： C09D11/03 , B01J19/0046 , B01J2219/00382 , B01J2219/00387 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00648 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2219/00734 , B82Y30/00 , C09D11/30 , C40B50/14 , Y10T428/24802 , Y10T436/143333 , Y10T436/25 , Y10T436/2575
摘要： Better patterning methods, including for better methods for forming biomolecular arrays, including a method comprising: providing a tip and a substrate surface, disposing a patterning composition at the end of the tip, depositing at least some of the patterning composition from the tip to the substrate surface to form a deposit disposed on the substrate surface, wherein the patterning composition comprises at least one lipid, optionally at least one solvent, and at least one patterning species different from the lipid and the optional solvent. The lipid can be a phospholipid such as DOPC. The patterning species can be an oligonucleotide or a protein. Microarrays and nanoarrays can be prepared including nanoscale resolution of deposits. The lipid can activate patterning or increase the rate of patterning. Simplified tip preparation can be achieved. Nanoscopic, SPM, and AFM tips can be used.
摘要翻译：更好的图案化方法，包括用于形成生物分子阵列的更好的方法，包括一种方法，包括：提供尖端和基底表面，在尖端的末端设置图案化组合物，将至少一些图案化组合物从尖端沉积到衬底表面以形成设置在衬底表面上的沉积物，其中所述图案化组合物包含至少一种脂质，任选的至少一种溶剂和至少一种不同于脂质和任选溶剂的图案化物种。脂质可以是磷脂如DOPC。图案化物质可以是寡核苷酸或蛋白质。可以制备微阵列和纳米阵列，包括沉积物的纳米级分辨率。脂质可以激活图案化或增加图案化速率。可以实现简化的尖端准备。可以使用纳米镜，SPM和AFM提示。

52. 发明申请

US20120297509A1 MASSIVELY PARALLEL LITHOGRAPHY WITH TWO-DIMENSIONAL PEN ARRAYS 审中-公开
标题翻译：具有两维笔阵列的大规模并行平版印刷
公开(公告)号：US20120297509A1
公开(公告)日：2012-11-22
申请号：US13530006
申请日：2012-06-21
申请人： Chad A. Mirkin , Khalid Salaita , Yuhuang Wang , Joseph S. Fragala , Raymond R. Shile
发明人： Chad A. Mirkin , Khalid Salaita , Yuhuang Wang , Joseph S. Fragala , Raymond R. Shile
IPC分类号： G01Q70/16 , B82Y40/00
CPC分类号： G03F7/0002
摘要： Massive parallel printing of structures and nanostructures at high speed with high resolution and high quality using two dimensional arrays comprising cantilevers and tip-based transfer of material to a surface. The array is designed so only tips touch the surface. This can be accomplished by long tips and bent cantilevers and alignment. An article comprising: a two-dimensional array of a plurality of cantilevers, wherein the array comprises a plurality of base rows, each base row comprising a plurality of cantilevers, wherein each of the cantilevers comprise tips at the cantilever end away from the base, wherein the number of cantilevers is greater than 250, and wherein the tips have an apex height relative to the cantilever of at least four microns, and a support for the array. Combinatorial arrays and bioarrays can be prepared. The arrays can be manufactured by micromachining methods.
摘要翻译：以高分辨率和高质量高结构和纳米结构的大规模平行印刷，使用二维阵列，其包括悬臂和基于尖端的材料转移到表面。该阵列设计为只有尖端触摸表面。这可以通过长尖端和弯曲的悬臂和对准来实现。一种制品，包括：多个悬臂的二维阵列，其中所述阵列包括多个基列，每个基列包括多个悬臂，其中每个所述悬臂包括远离所述基座的所述悬臂端处的尖端，其中所述悬臂的数量大于250，并且其中所述尖端具有相对于至少四微米的所述悬臂的顶点高度，以及所述阵列的支撑。可以制备组合阵列和生物阵列。阵列可以通过微加工方法制造。

53. 发明申请

US20120244230A1 POLYVALENT POLYNUCLEOTIDE NANOPARTICLE CONJUGATES AS DELIVERY VEHICLES FOR A CHEMOTHERAPEUTIC AGENT 审中-公开
标题翻译：多价多核苷酸纳米粒子作为化学药剂的交付车辆
公开(公告)号：US20120244230A1
公开(公告)日：2012-09-27
申请号：US13393454
申请日：2010-09-01
申请人： Chad A. Mirkin , David A. Giljohann , Weston L. Daniel , Stephen J. Lippard , Shanta Dhar
发明人： Chad A. Mirkin , David A. Giljohann , Weston L. Daniel , Stephen J. Lippard , Shanta Dhar
IPC分类号： C07H21/00 , C12N5/02 , A61P35/00 , C07H21/04 , C07H21/02 , A61K33/24 , C07K2/00 , B82Y5/00
CPC分类号： B82Y5/00 , A61K47/6923
摘要： The present invention is directed to compositions and methods of delivering a chemotherapeutic agent via a polynueleotide-functionalized nanoparticle (PN-NP).
摘要翻译：本发明涉及通过多核苷酸官能化的纳米颗粒（PN-NP）递送化学治疗剂的组合物和方法。

54. 发明授权

US08220317B2 Massively parallel lithography with two-dimensional pen arrays 失效
标题翻译：大尺寸平行光刻与二维笔阵列
公开(公告)号：US08220317B2
公开(公告)日：2012-07-17
申请号：US11690738
申请日：2007-03-23
申请人： Chad A. Mirkin , Khalid Salaita , Yuhuang Wang , Joseph S. Fragala , Raymond R. Shile
发明人： Chad A. Mirkin , Khalid Salaita , Yuhuang Wang , Joseph S. Fragala , Raymond R. Shile
IPC分类号： G01B5/28
CPC分类号： G03F7/0002
摘要： Massive parallel printing of structures and nanostructures at high speed with high resolution and high quality using two dimensional arrays comprising cantilevers and tip-based transfer of material to a surface. The array is designed so only tips touch the surface. This can be accomplished by long tips and bent cantilevers and alignment. An article comprising: a two-dimensional array of a plurality of cantilevers, wherein the array comprises a plurality of base rows, each base row comprising a plurality of cantilevers, wherein each of the cantilevers comprise tips at the cantilever end away from the base, wherein the number of cantilevers is greater than 250, and wherein the tips have an apex height relative to the cantilever of at least four microns, and a support for the array. Combinatorial arrays and bioarrays can be prepared. The arrays can be manufactured by micromachining methods.
摘要翻译：以高分辨率和高质量高结构和纳米结构的大规模平行印刷，使用二维阵列，其包括悬臂和基于尖端的材料转移到表面。该阵列设计为只有尖端触摸表面。这可以通过长尖端和弯曲的悬臂和对准来实现。一种制品，包括：多个悬臂的二维阵列，其中所述阵列包括多个基列，每个基列包括多个悬臂，其中每个所述悬臂包括远离所述基座的所述悬臂端处的尖端，其中所述悬臂的数量大于250，并且其中所述尖端具有相对于至少四微米的所述悬臂的顶点高度，以及所述阵列的支撑。可以制备组合阵列和生物阵列。阵列可以通过微加工方法制造。

55. 发明申请

US20120167262A1 SILICON PEN NANOLITHOGRAPHY 有权
标题翻译：硅笔笔纳米尺度
公开(公告)号：US20120167262A1
公开(公告)日：2012-06-28
申请号：US13375361
申请日：2010-06-04
申请人： Chad A. Mirkin , Wooyoung Shim , Adam B. Braunschweig , Xing Liao , Jinan Chai , Jong Kuk Lim , Gengfeng Zheng , Zijian Zheng
发明人： Chad A. Mirkin , Wooyoung Shim , Adam B. Braunschweig , Xing Liao , Jinan Chai , Jong Kuk Lim , Gengfeng Zheng , Zijian Zheng
IPC分类号： G01Q70/14 , G01Q70/16
CPC分类号： G03F7/0002 , B81B2203/0361 , B81B2207/056 , B81C1/00111 , B81C1/0046 , B81C2201/0154 , B81C2201/0185 , B82Y10/00 , B82Y40/00 , Y10S977/732
摘要： Disclosed are methods of lithography using a tip array having a plurality of pens attached to a backing layer, where the tips can comprise a metal, metalloid, and/or semi-conducting material, and the backing layer can comprise an elastomeric polymer. The tip array can be used to perform a lithography process in which the tips are coated with an ink (e.g., a patterning composition) that is deposited onto a substrate upon contact of the tip with the substrate surface. The tips can be easily leveled onto a substrate and the leveling can be monitored optically by a change in light reflection of the backing layer and/or near the vicinity of the tips upon contact of the tip to the substrate surface.
摘要翻译：公开了使用具有连接到背衬层的多个笔的尖端阵列的光刻方法，其中尖端可以包括金属，准金属和/或半导电材料，并且背衬层可以包括弹性体聚合物。尖端阵列可用于执行光刻工艺，其中尖端涂覆有当尖端与衬底表面接触时沉积到衬底上的油墨（例如，图案化组合物）。尖端可以容易地平整到基底上，并且可以通过背衬层的光反射的变化和/或在尖端与基底表面接触时靠近尖端附近来光学地监测流平。

56. 发明申请

US20120141731A1 FABRICATION OF MICROSTRUCTURES AND NANOSTRUCTURES USING ETCHING RESIST 审中-公开
标题翻译：使用蚀刻电阻制造微结构和纳米结构
公开(公告)号：US20120141731A1
公开(公告)日：2012-06-07
申请号：US11958350
申请日：2007-12-17
申请人： Chad A. Mirkin , Ling Huang , Raymond Sanedrin
发明人： Chad A. Mirkin , Ling Huang , Raymond Sanedrin
IPC分类号： B32B3/00 , H01L21/306 , B44C1/22 , C23F1/00 , B82Y40/00
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y30/00 , B82Y40/00 , C23F1/02 , C23F1/14 , Y10T428/24355
摘要： Nanostructures and microstructures are formed by patterning methods such as Dip Pen Nanolithography (DPN) or microcontact printing of organic molecules functioning as a resist on a substrate followed by an etching step. The etch resist is a patterning composition and can contain on a substrate including polyethylene glycol (PEG). Positive and negative etch methods can be used.
摘要翻译：纳米结构和微结构通过诸如Dip Pen Nanoithography（DPN）的图案化方法或用作基底上的抗蚀剂的有机分子的微接触印刷形成，然后进行蚀刻步骤。抗蚀剂是图案化组合物，并且可以包含在包含聚乙二醇（PEG）的基材上。可以使用正和负蚀刻方法。

57. 发明授权

US08192794B2 Massively parallel lithography with two-dimensional pen arrays 失效
标题翻译：大尺寸平行光刻与二维笔阵列
公开(公告)号：US08192794B2
公开(公告)日：2012-06-05
申请号：US12000456
申请日：2007-12-12
申请人： Chad A. Mirkin , Peng Sun , Yuhuang Wang , Steven Lenhert
发明人： Chad A. Mirkin , Peng Sun , Yuhuang Wang , Steven Lenhert
IPC分类号： B05D5/00 , G01N1/28
CPC分类号： G03F7/0002 , G01Q80/00
摘要： Massive parallel printing of structures and nanostructures, including lipids, at high speed with high resolution and high quality using two dimensional arrays comprising cantilevers and tip-based transfer of material to a surface. The invention provides a nanolithographic method comprising (1) providing a two-dimensional array of a plurality of cantilevers, wherein the array comprises a plurality of base rows, each base row comprising a plurality of cantilevers extending from the base row, wherein each of the cantilevers comprising tips at the cantilever end away from the base row; wherein the two dimensional array has a support; (2) providing a patterning composition, wherein the composition comprises one or more lipids; (3) providing a substrate; (4) coating the tips of the cantilevers with the patterning composition; and (5) depositing at least some of the patterning composition from the tips to the substrate surface.
摘要翻译：使用包括悬臂和基于尖端的材料转移到表面的二维阵列，以高分辨率和高质量的高速大规模平行印刷结构和纳米结构，包括脂质。本发明提供一种纳米光刻方法，其包括（1）提供多个悬臂的二维阵列，其中所述阵列包括多个基列，每个基行包括从所述基列延伸的多个悬臂，其中，悬臂包括远离基座的悬臂端的尖端; 其中所述二维阵列具有支撑; （2）提供图案化组合物，其中所述组合物包含一种或多种脂质; （3）提供基板; （4）用图案化组合物涂覆悬臂的尖端; 和（5）将至少一些图案化组合物从尖端沉积到基底表面。

58. 发明申请

US20120097058A1 Multiplexed Biomolecule Arrays Made By Polymer Pen Lithography 审中-公开
标题翻译：由聚合物笔平版印刷制成的复用生物分子阵列
公开(公告)号：US20120097058A1
公开(公告)日：2012-04-26
申请号：US13263760
申请日：2010-04-23
申请人： Chad A. Mirkin , Fengwei Huo , Zijian Zheng , Louise R. Giam , Weston L. Daniel
发明人： Chad A. Mirkin , Fengwei Huo , Zijian Zheng , Louise R. Giam , Weston L. Daniel
IPC分类号： B41F33/00 , B42D15/00
CPC分类号： B01J19/0046 , B01J2219/00387 , B01J2219/00533 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00626 , B01J2219/00637 , B01J2219/00662 , B01J2219/00725 , B81C1/00206
摘要： Methods of patterning multiple biomolecules on a surface are disclosed. The method includes inking a polymer pen array, where tips are inked with selected inks comprising the biomolecules, and transferring the biomolecules to a surface using a polymer pen lithography technique. Methods of using the multiple patterned biomolecules on a surface are also disclosed.
摘要翻译：公开了在表面上构图多个生物分子的方法。该方法包括着墨聚合物笔阵列，其中尖端用包含生物分子的所选油墨着墨，并使用聚合物笔光刻技术将生物分子转移到表面。还公开了在表面上使用多个图案化的生物分子的方法。

59. 发明申请

US20120006674A1 ENERGY TRANSFER THROUGH SURFACE PLASMON RESONANCE EXCITATION ON MULTISEGMENTED NANOWIRES 审中-公开
标题翻译：通过表面等离子体共振激发在多种纳米级纳米粒子上的能量转移
公开(公告)号：US20120006674A1
公开(公告)日：2012-01-12
申请号：US13037942
申请日：2011-03-01
申请人： Chad A. Mirkin , Wei Wei , Lidong Qin , Can Xue , Jill E. Millstone , Xiaoyang Xu
发明人： Chad A. Mirkin , Wei Wei , Lidong Qin , Can Xue , Jill E. Millstone , Xiaoyang Xu
IPC分类号： C01B21/36 , C01B13/00 , C07D301/03 , C01B31/18 , C01B31/20
CPC分类号： B01J35/004 , B01J23/42 , B01J23/48 , B01J23/50 , B01J23/52 , B01J35/06 , B82Y20/00 , B82Y30/00 , B82Y40/00 , C01B3/042 , Y02E60/364 , Y02P20/134
摘要： Disclosed herein is energy transfer on multisegmented nanowires via surface plasmon resonance excitation of visible light, such as solar energy, absorbed by metals sensitive to visible light and transferred to metals insensitive to visible light. The nanowires are prepared with controllable gap sizes between different segments by on-wire lithography (OWL).
摘要翻译：本文公开的是通过对可见光的表面等离子体共振激发（例如由对可见光敏感的金属吸收的太阳能）转移到对可见光不敏感的金属的多分段纳米线的能量转移。通过在线光刻（OWL）在不同的片段之间制备具有可控的间隙尺寸的纳米线。

60. 发明授权

US08012400B2 Surface and site-specific polymerization by direct-write lithography 失效
标题翻译：通过直写光刻技术进行表面和位点特异性聚合
公开(公告)号：US08012400B2
公开(公告)日：2011-09-06
申请号：US11966764
申请日：2007-12-28
申请人： Chad A. Mirkin , Xiaogang Liu , Shouwu Guo
发明人： Chad A. Mirkin , Xiaogang Liu , Shouwu Guo
IPC分类号： B29C35/08
CPC分类号： G03F7/0002 , G01Q80/00 , G03F7/2049 , H01J2237/31738 , Y10S977/857 , Y10S977/882 , Y10S977/897
摘要： Polymeric microstructures and nanostructures can be prepared with use of a tip to pattern a surface. A tip can be used to pattern a structure which can initiate polymerization. The structure can be then exposed to monomer to induce polymerization at the structure. Alternatively, a tip can be used to pattern a surface with a monomer in which the surface is treated with polymerization catalyst so that polymerization occurs at the patterning site. Ring-opening metathesis polymerization can be carried out with use of the tip to control the polymerization. The tip can be a sharp tip as used in for example an atomic force microscope tip. Norbornene types of monomers can be used. Biological macromolecules can be also prepared.
摘要翻译：可以使用尖端来制备聚合物微结构和纳米结构以对表面进行图案化。尖端可用于图案化可引发聚合的结构。然后将该结构暴露于单体以在结构处引发聚合。或者，可以使用尖端来用表面用聚合催化剂处理的单体对表面进行图案化，使得在图案化位点发生聚合。可以使用尖端进行开环易位聚合以控制聚合。尖端可以是例如原子力显微镜尖端中使用的尖锐尖端。可以使用降冰片烯类型的单体。还可制备生物大分子。

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