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51. 发明申请

US20080267828A1 Micro-Volume Liquid Ejection System 有权
标题翻译：微量液体喷射系统
公开(公告)号：US20080267828A1
公开(公告)日：2008-10-30
申请号：US11666032
申请日：2004-11-22
申请人： Dong Wang , Kun Zou , Jianxing Ye , Yelei Sun , Hui Zhu , Xianhua Wang , Jing Cheng
发明人： Dong Wang , Kun Zou , Jianxing Ye , Yelei Sun , Hui Zhu , Xianhua Wang , Jing Cheng
IPC分类号： B65D83/00
CPC分类号： B01L3/0265 , B01L2400/0487 , B01L2400/0666 , Y10T436/2575
摘要： The present invention relates to a micro-volume liquid ejection system, including an air pressure module, a micro-ejection unit which is connected with the air pressure module by means of pipes, and a control circuit which is connected with the air pressure module and the micro-ejection unit respectively. In the present invention, due to air is used as the pressure medium, on one hand, as the sample does not contact with the pressure regulating module, the efficiency of cleaning process is improved, on the other hand, the volume of the sample needed in the sample ejecting process is only equal to the cavity-dimension of the micro-ejection unit by not need to fill the whole pipe with liquid. During the sample ejecting process, it is not need to regulate the pressure. After the sample ejecting is finished, the sample can be put into its original place, so as to greatly save the sample. The present invention is connected with the manipulator, so as to sample from the sample plate, eject sample and clean the pipes automatically, and it can also dispense a multiplicity of samples to micro-array substrate conveniently. The present invention can be used for transferring or dispensing the micro volume liquid of nL grade and L grade widely, and all kinds of the micro-volume liquid including biological liquid.
摘要翻译：微体积液体喷射系统技术领域本发明涉及一种微体积液体喷射系统，包括空气压力模块，通过管道与空气压力模块连接的微型喷射单元，以及与气压模块连接的控制电路和微型喷射单元。在本发明中，由于空气被用作压力介质，一方面由于样品不与压力调节模块接触，因此提高了清洗过程的效率，另一方面，样品的体积需要在样品喷射过程中，仅通过不需要用整个管道填充液体就等于微喷射单元的腔体尺寸。在样品喷射过程中，不需要调节压力。样品喷射完成后，样品可以放在原来的位置，大大节省样品。本发明与机械手连接，从样品板上取样，自动排出样品并清洗管道，方便地将多个样品分配给微阵列基板。本发明可广泛用于转移或分配nL级和L级微量液体，以及各种微体积液体，包括生物液体。

52. 发明申请

US20070160984A1 Multiple-property composite beads and preparation and use thereof 审中-公开
标题翻译：多属性复合珠及其制备和应用
公开(公告)号：US20070160984A1
公开(公告)日：2007-07-12
申请号：US11714954
申请日：2007-03-06
申请人： Mingxian Huang , Lei Wu , Xiaobo Wang , Junquan Xu , Guo Tao , Jing Cheng
发明人： Mingxian Huang , Lei Wu , Xiaobo Wang , Junquan Xu , Guo Tao , Jing Cheng
IPC分类号： C12Q1/70 , G01N33/567 , B32B5/16 , G01N33/551
CPC分类号： C40B70/00 , B01J19/0046 , B01J2219/00459 , B01J2219/005 , B01J2219/00545 , B01J2219/00551 , B01J2219/00585 , B01J2219/00596 , B01J2219/00655 , B01J2219/0072 , B01J2219/0074 , B03C1/02 , B03C5/026 , B03C5/028 , B82Y15/00 , C40B40/06 , C40B50/16 , G01N33/54326 , G01N33/588 , Y10S428/90 , Y10T428/2982 , Y10T428/2991 , Y10T428/32
摘要： This invention relates generally to the field of moiety or molecule isolation, detection and manipulation and library synthesis. In particular, the invention provides a bead, which bead comprises: a) a magnetizable substance; and b) an electrically conductive substance or an optical labeling substance. Methods and kits for isolating, detecting and manipulating moieties and synthesizing libraries using the beads are also provided.
摘要翻译：本发明一般涉及部分或分子分离，检测和操作以及文库合成领域。特别地，本发明提供了一种珠，该珠包括：a）可磁化物质; 和b）导电物质或光学标记物质。还提供了用于分离，检测和操作部分并使用珠的合成文库的方法和试剂盒。

53. 发明授权

US07081192B1 Methods for manipulating moieties in microfluidic systems 有权
公开(公告)号：US07081192B1
公开(公告)日：2006-07-25
申请号：US09636104
申请日：2000-08-10
申请人： Xiaobo Wang , Lei Wu , Jing Cheng , Weiping Yang , Junquan Xu
发明人： Xiaobo Wang , Lei Wu , Jing Cheng , Weiping Yang , Junquan Xu
IPC分类号： G01N27/447 , G01N33/48 , C12Q1/00
CPC分类号： G01N33/54386 , B01L3/502761 , B01L2200/0647 , B01L2200/0668 , B01L2300/0816 , B01L2300/0864 , B01L2400/0415 , B01L2400/0424 , B01L2400/043 , B01L2400/0436 , B01L2400/0439 , B01L2400/0454 , B01L2400/0496 , B03C5/028 , B03C2201/26 , G01N27/745 , G01N33/569
摘要： This invention relates generally to the field of moiety or molecule manipulation in a chip format. In particular, the invention provides a method for manipulating a moiety in a microfluidic application, which method comprises: a) coupling a moiety to be manipulated onto surface of a binding partner of said moiety to form a moiety-binding partner complex; and b) manipulating said moiety-binding partner complex with a physical force in a chip format, wherein said manipulation is effected through a combination of a structure that is external to said chip and a structure that is built-in in said chip, thereby said moiety is manipulated.

54. 发明申请

US20060148102A1 Apparatuses and methods for assaying analytes using photoelectrochemical labels 有权
标题翻译：使用光电化学标记分析分析物的装置和方法
公开(公告)号：US20060148102A1
公开(公告)日：2006-07-06
申请号：US10535905
申请日：2003-05-06
申请人： Lianghong Guo , Dong Dong , Dong Zheng , Fuquan Wang , Xiqiang Yang , Jing Cheng
发明人： Lianghong Guo , Dong Dong , Dong Zheng , Fuquan Wang , Xiqiang Yang , Jing Cheng
IPC分类号： G01N33/551
CPC分类号： G01N33/582 , C12Q1/6816 , G01N2458/30 , C12Q2563/113 , C12Q2523/313
摘要： The present invention provides apparatus, kits and methods for assaying analytes using photoelectrochemical molecules as labels. Specifically, the present invention provides a method for assaying an analyte, comprising: a) contacting a sample suspected of containing an analyte with a reactant capable of binding and/or reacting with the analyte under suitable conditions to allow binding of analyte, if present in the sample, to the reactant; and b) assessing binding and/or reacting between the analyte and the reactant to determine presence and/or amount of analyte in the sample, wherein the reactant, analyte, or additional reactant or additional analyte or analyte analog is labeled with a photoelectrochemically active molecule. The assessing step also comprises converting the photoelectrochemically active molecule with light to an excited state in the presence of an electrode, and assessing an electric current generated by an electron transfer between the excited photoelectrochemically active molecule and the electrode.
摘要翻译：本发明提供了使用光电化学分子作为标记来测定分析物的装置，试剂盒和方法。具体地，本发明提供了一种用于分析分析物的方法，其包括：a）在合适的条件下将疑似含有分析物的样品与能够与分析物结合和/或反应的反应物接触，以使分析物（如果存在于样品，反应物; 和b）评估分析物和反应物之间的结合和/或反应以确定样品中分析物的存在和/或量，其中反应物，分析物或附加反应物或其他分析物或分析物类似物用光电化学活性分子标记。评估步骤还包括在电极存在下将光电化学活性分子与光转化为激发态，并评估由激发的光电化学活性分子和电极之间的电子转移产生的电流。

55. 发明申请

US20060141450A1 Magnetism based rapid cell separation 有权
标题翻译：基于磁性的快速细胞分离
公开(公告)号：US20060141450A1
公开(公告)日：2006-06-29
申请号：US10538498
申请日：2002-12-31
申请人： Xu Zhang , Xin Xie , Depu Chen , Weiyang Fei , Jing Cheng
发明人： Xu Zhang , Xin Xie , Depu Chen , Weiyang Fei , Jing Cheng
IPC分类号： C12Q1/70 , G01N33/567 , C12N1/20
CPC分类号： G01N33/54333 , C12N1/02 , C12N7/00 , C12N2760/16051 , C12N2795/14151 , C12Q1/24 , G01N33/54326
摘要： This invention relates generally to the field of. In particular, the invention provides processes and kits for isolating a target cell, cellular organelle or virus from a sample, using inter alia, non- or low-specific binding between a target cell, cellular organelle or virus with a magnetic microbead.
摘要翻译：本发明一般涉及领域。特别地，本发明提供了用于使用靶细胞，细胞器官细胞或病毒与磁性微珠之间的非特异性或低特异性结合从样品中分离靶细胞，细胞器官细胞或病毒的方法和试剂盒。

56. 发明申请

US20060134608A1 Chemically amplified electrochemical detection of affinity reaction 审中-公开
标题翻译：化学扩增电化学检测亲和力反应
公开(公告)号：US20060134608A1
公开(公告)日：2006-06-22
申请号：US10537378
申请日：2003-05-06
申请人： Lianghong Guo , Yuanguang Li , Na Wang , Fuquan Wang , Xiqiang Yang , Jing Cheng
发明人： Lianghong Guo , Yuanguang Li , Na Wang , Fuquan Wang , Xiqiang Yang , Jing Cheng
IPC分类号： C12Q1/70 , C12Q1/68 , G01N33/567
CPC分类号： G01N33/5438 , C12Q1/6825 , G01N27/3277 , G01N33/58 , G01N2458/30
摘要： This invention relates generally to the field of electrochemistry. In particular, the invention provides a method for assaying an analyte, using, inter alia, a reactant capable of binding and/or reacting with an analyte to be analyzed on an oxide electrode and a reducing agent not capable of being oxidized directly by said electrode to generate reduced electrochemically active molecule that participates in oxidation-reduction reactions repeatedly to generate an amplified electrochemical signal to determine presence and/or amount of said analyte in said sample.
摘要翻译：本发明一般涉及电化学领域。特别地，本发明提供了一种用于测定分析物的方法，特别是使用能够在不能被所述电极直接氧化的氧化物电极和还原剂上结合和/或与待分析的分析物反应的反应物以产生重复参与氧化还原反应的还原电化学活性分子以产生放大的电化学信号以确定所述样品中所述分析物的存在和/或量。

57. 发明授权

US06900013B1 Methods and compositions for identifying nucleic acid molecules using nucleolytic activities and hybridization 失效
标题翻译：用核酸分解活性和杂交鉴定核酸分子的方法和组合物
公开(公告)号：US06900013B1
公开(公告)日：2005-05-31
申请号：US09648081
申请日：2000-08-25
申请人： Guoqing Wang , Lei Wu , Xiaobo Wang , Jing Cheng , WeiPing Yang
发明人： Guoqing Wang , Lei Wu , Xiaobo Wang , Jing Cheng , WeiPing Yang
IPC分类号： C07H21/02 , C07H21/04 , C12M1/34 , C12P19/34 , C12Q1/68
CPC分类号： C12Q1/6816 , C07H21/04 , C12Q1/6827 , C12Q1/6837 , C12Q2521/101 , C12Q2533/101 , C12Q2563/107 , C12Q2521/327 , C12Q2537/143 , C12Q2565/501
摘要： The present invention recognizes that identifying genes expressed during developmental processes, stress responses, and disease states can advance understanding of these biological functions, and can contribute to identifying targets for therapeutic drugs. In addition, the present invention recognizes that rapid and reliable profiling of genetic variations, such as mutations and SNPs, is of increasing importance to diagnostics, prognostics, forensics, heredity determinations, and pharmacogenetics. One aspect of the present invention provides a method of identifying one or more nucleic acid molecules that are expressed under a given set of conditions based on their complementarity to known sequences, or one or more mutations or SNPs in a population of nucleic acid molecules. The method includes: contacting at least one probe nucleic acid molecule with a survey population of nucleic acid molecules under conditions that promote nucleic acid hybridization to generate a probe-survey population mixture of nucleic acid molecules, treating the probe-survey population mixture of nucleic acid molecules with a nucleolytic activity, such that nucleolytic activity-sensitive nucleic acid molecules are digested, and contacting the resulting mixture of nucleolytic activity-protected nucleic acid molecules with a solid support comprising one or more attached nucleic acid molecules to generate attached nucleic acid molecule/nucleolytic activity-protected nucleic acid molecule complexes, and identifying one or more of the attached nucleic acid molecules or one or more of the nucleolytic activity-protected nucleic acid molecules in one or more attached nucleic acid molecule/nucleolytic activity-protected nucleic acid molecule complexes.
摘要翻译：本发明认识到，在发育过程，应激反应和疾病状态期间表达的鉴定基因可以促进对这些生物功能的理解，并且可以有助于鉴定治疗药物的靶标。此外，本发明认识到，遗传变异的快速和可靠的分析，例如突变和SNP，对于诊断，预后，取证，遗传测定和药物遗传学是越来越重要的。本发明的一个方面提供了鉴定一种或多种核酸分子的方法，所述核酸分子基于它们与已知序列的互补性或核酸分子群体中的一个或多个突变或SNP在给定条件下表达。该方法包括：在促进核酸杂交以产生核酸分子的探针 - 调查群体混合物的条件下使至少一个探针核酸分子与核酸分子的调查群体接触，处理核酸的探针 - 调查群体混合物具有核分解活性的分子，使得消解活性敏感的核酸核酸分子，并使得到的核分解活性保护的核酸分子的混合物与包含一个或多个连接的核酸分子的固体支持物接触，以产生附着的核酸分子/ 核分解活性保护的核酸分子复合物，以及鉴定一个或多个连接的核酸分子/核酸分解活性保护的核酸分子复合物中所附连的核酸分子或一个或多个核裂解活性保护的核酸分子。

58. 发明授权

US06716642B1 Individually addressable micro-electromagnetic unit array chips in horizontal configurations 有权
标题翻译：水平配置的单独寻址微电磁单元阵列芯片
公开(公告)号：US06716642B1
公开(公告)日：2004-04-06
申请号：US09685410
申请日：2000-10-10
申请人： Lei Wu , Xiaobo Wang , Jing Cheng , Weiping Yang , YuXiang Zhou , LiTian Liu , Junquan Xu
发明人： Lei Wu , Xiaobo Wang , Jing Cheng , Weiping Yang , YuXiang Zhou , LiTian Liu , Junquan Xu
IPC分类号： G01N33543
CPC分类号： B01L3/502792 , B01J19/0046 , B01J2219/00468 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00614 , B01J2219/00619 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00648 , B01J2219/00653 , B01J2219/00655 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/00734 , B01J2219/0074 , B01J2219/00743 , B01L3/5025 , B01L3/502761 , B01L2200/0647 , B01L2200/0668 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2300/0877 , B01L2300/089 , B01L2400/043 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , G01N35/0098 , H01F17/0006
摘要： The present invention provides electromagnetic chips and electromagnetic biochips having arrays of individually addressable micro-electromagnetic units, as well as methods of utilizing these chips for directed manipulation of micro-particles and micro-structures such as biomolecules and chemical reagents.
摘要翻译：本发明提供具有单独寻址的微电磁单元的阵列的电磁芯片和电磁生物芯片，以及利用这些芯片来定向操纵微粒和微结构如生物分子和化学试剂的方法。

59. 发明授权

US06596143B1 Apparatus for switching and manipulating particles and method of use thereof 有权
标题翻译：用于切换和操纵颗粒的装置及其使用方法
公开(公告)号：US06596143B1
公开(公告)日：2003-07-22
申请号：US09678263
申请日：2000-10-03
申请人： Xiao-Bo Wang , Weiping Yang , Junquan Xu , Jing Cheng , Lei Wu
发明人： Xiao-Bo Wang , Weiping Yang , Junquan Xu , Jing Cheng , Lei Wu
IPC分类号： G01N2726
CPC分类号： H02N11/006 , B01D57/02 , B03C5/028 , H02N1/004
摘要： A device acts as a particle switch to transport and/or re-direct microparticles which are in a fluid suspension. The switch comprises at least three structural branches and the branches may be connected at a common junction. Particles can be transported along the branches as a result of the forces generated along that branch. Particles are transported into or out of the particle switch via the ends of the branches. Particles can be switched from one branch into one of the other branches. Depending on the properties of the particles, the transportation mechanism may be traveling-wave-dielectrophoresis or traveling-wave-electrophoresis.
摘要翻译：装置用作颗粒开关以运输和/或重新引导处于流体悬浮液中的微粒。开关包括至少三个结构分支，并且分支可以在公共接头处连接。由于沿该分支产生的力，颗粒可以沿着分支运输。颗粒通过分支的末端被输送进出颗粒开关。颗粒可以从一个分支切换到其他分支之一。根据颗粒的性质，运输机制可以是行波介电电泳或行波电泳。

60. 发明授权

US09327004B2 Topical compositions comprising fermented extracts of traditional chinese medicinal (TCM) ingredients, and methods of making and using same 有权
公开(公告)号：US09327004B2
公开(公告)日：2016-05-03
申请号：US14043021
申请日：2013-10-01
申请人： Jing Cheng , Chia-wen Chen , Steven Francis Schnittger , Ming Lu
发明人： Jing Cheng , Chia-wen Chen , Steven Francis Schnittger , Ming Lu
IPC分类号： A61K36/725 , A61K8/97 , A61K8/99 , A61Q19/00 , A61K36/752 , A61K36/756 , A61K36/804 , A61K36/8998 , A61K36/068 , A61K36/074 , A61K36/076 , A61K36/10 , A61K36/16 , A61K36/185 , A61K36/23 , A61K36/235 , A61K36/236 , A61K36/258 , A61K36/28 , A61K36/41 , A61K36/535 , A61K36/539 , A61K36/65 , A61K36/704 , A61K36/06 , A61K36/69
CPC分类号： A61K36/725 , A61K8/97 , A61K8/99 , A61K36/06 , A61K36/068 , A61K36/074 , A61K36/076 , A61K36/10 , A61K36/16 , A61K36/185 , A61K36/23 , A61K36/235 , A61K36/236 , A61K36/258 , A61K36/28 , A61K36/41 , A61K36/535 , A61K36/539 , A61K36/65 , A61K36/69 , A61K36/704 , A61K36/752 , A61K36/756 , A61K36/804 , A61K36/8998 , A61K2800/85 , A61Q19/00
摘要： The present invention relates to topical compositions containing fermented extracts of Traditional Chinese Medicinal (TCM) ingredients for improving the appearance and skin condition of the user. The topical compositions of the present invention are tailored for different users of different skin compositions according to TCM principles. The fermented TCM extracts are characterized by reduced odor and/or color in comparison with unfermented TCM extracts and are therefore more suitable for use in cosmetic products.

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