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51. 发明授权

US5531734A Method of altering composition of nutritional product during enteral tube feeding 失效
标题翻译：改变肠管喂养期间营养产品组成的方法
公开(公告)号：US5531734A
公开(公告)日：1996-07-02
申请号：US372408
申请日：1995-01-13
申请人： Ronita K. Geckle , Terrence B. Mazer , Joseph E. Walton , Carl J. Piontek , Susan B. Duel , Andre Daab-Krzykowski , Mark A. McCamish , Robert L. Joseph , William G. Pierson
发明人： Ronita K. Geckle , Terrence B. Mazer , Joseph E. Walton , Carl J. Piontek , Susan B. Duel , Andre Daab-Krzykowski , Mark A. McCamish , Robert L. Joseph , William G. Pierson
IPC分类号： A61J15/00 , A61K9/22 , A61M5/00 , A61M5/14 , A61M31/00
CPC分类号： A61M31/002 , A61J15/0026 , A61J15/0069 , A61M5/007 , A61M5/1407 , A61J15/00
摘要： A method is disclosed for modifying a liquid enteral nutritional product during delivery thereof from a supply container to a feeding tube delivering the nutritional product to the gastrointestinal tract of a patient. During enteral tube feeding the nutritional product passes through a formulation chamber, e.g., a drip chamber, having located therein at least one controlled release dosage form unit containing at least one beneficial agent. The beneficial agent may be selected from nutrients, medicaments, probiotics, or diagnostic agents or mixtures thereof, and any such together with a physiologically acceptable marker dye in controlled release dosage form and/or the same or different additional beneficial agent not in controlled release dosage form. Controlled release dosage forms may be of a conventional sustained release type or an osmotically driven delivery device.
摘要翻译：公开了一种用于在将液体肠内营养产品从供应容器输送到将营养产品输送到患者的胃肠道的进料管中时，用于改变液体肠内营养产品的方法。在肠管喂养期间，营养产品通过配制室，例如滴注室，其中至少含有至少一种含有至少一种有益剂的控释剂型单元。有益药物可以选自营养物，药物，益生菌或诊断剂或其混合物，以及任何这些与控制释放剂型中的生理学上可接受的标记染料和/或不是控制释放剂量的相同或不同的附加有益剂形成。受控释放剂型可以是常规的缓释型或渗透驱动的输送装置。

52. 发明授权

US5531682A Apparatus for adding marker dye to nutritional product during enternal tube feeding 失效
标题翻译：在内管喂养期间添加标记染料至营养产品的装置
公开(公告)号：US5531682A
公开(公告)日：1996-07-02
申请号：US372266
申请日：1995-01-13
申请人： Terrence B. Mazer , Joseph E. Walton , Ronita K. Geckle , Carl J. Piontek , Susan B. Duel , Andre Daab-Krzykowski , Robert L. Joseph , William G. Pierson , Thomas D. Loughrin , Thomas W. Osip
发明人： Terrence B. Mazer , Joseph E. Walton , Ronita K. Geckle , Carl J. Piontek , Susan B. Duel , Andre Daab-Krzykowski , Robert L. Joseph , William G. Pierson , Thomas D. Loughrin , Thomas W. Osip
IPC分类号： A61J15/00 , A61M5/00 , A61M5/14 , A61M5/168 , A61M31/00 , G01N27/327 , A61M37/00
CPC分类号： A61M31/002 , A61J15/0026 , A61J15/0069 , A61M5/007 , A61M5/1407 , A61J15/00 , G01N33/02
摘要： An apparatus is useful for dye marking a liquid enteral nutritional product during delivery thereof from a supply container to a feeding tube delivering the nutritional product to the gastrointestinal tract of a patient. A formulation chamber, such as a drip chamber, is connectable to the supply container. At least one sustained release reservoir containing a physiologically acceptable marker dye is positioned within the formulation chamber, or if not, is included as part of a kit. The sustained release reservoir may be in the form of a coated tablet, osmotically driven device, coated capsule, microencapsulated microspheres, agglomerated molecular sieving material, or chopped hollow fibers having permeable walls. A liquid communication means connects the formulation chamber to the feeding tube of a patient. The marker dye may be a colorant dye or a fluorescing dye or a mixture thereof. In using the apparatus for dye marking the nutritional product is flowed through the apparatus and a feeding tube to enter the gastrointestinal tract of a patient.
摘要翻译：一种装置可用于将液体肠内营养产品在从供应容器输送到将营养产品输送到患者的胃肠道的喂食管中时进行标记。诸如滴水室的配制室可连接到供应容器。包含生理上可接受的标记染料的至少一个持续释放储存器位于制剂室内，或者如果不包含，则作为试剂盒的一部分。持续释放储存器可以是包衣片剂，渗透驱动装置，包衣胶囊，微囊化微球，聚集分子筛材料或具有可渗透壁的切碎中空纤维的形式。液体连通装置将制剂室连接到患者的进料管。标记染料可以是着色剂染料或荧光染料或其混合物。在使用染色标记设备时，营养产品流过设备和进料管进入患者的胃肠道。

53. 发明授权

US5376393A Removal of phosphorous from mammalian milk using ion exchange 失效
标题翻译：使用离子交换从哺乳动物奶中去除磷
公开(公告)号：US5376393A
公开(公告)日：1994-12-27
申请号：US200061
申请日：1994-02-22
申请人： Christy A. Nardelli , Terrence B. Mazer , Arthur J. C. L. Hogarth , John D. Suh , Leona M. Pickett , Harold W. Keller , William J. Nelson
发明人： Christy A. Nardelli , Terrence B. Mazer , Arthur J. C. L. Hogarth , John D. Suh , Leona M. Pickett , Harold W. Keller , William J. Nelson
IPC分类号： A23C9/146 , A23C7/04
CPC分类号： A23C9/146
摘要： A novel process for the removal of phosphorous from mammalian milk, preferably bovine skim milk, has been developed. The process involves passage of the milk at an elevated temperature through a Type I or Type II macroporous or gel type strong base ion exchange material in the chloride or carbonate form. The weak base anion sites inherent to the ion exchange material have been neutralized. The ion exchange material can easily be regenerated.
摘要翻译：已经开发了从哺乳动物乳，优选牛脱脂乳中去除磷的新方法。该方法包括在升高的温度下通过具有氯或碳酸盐形式的I型或II型大孔或凝胶型强碱离子交换材料。离子交换材料固有的弱碱阴离子位点已被中和。离子交换材料可以容易地再生。

54. 发明授权

US5322357A Apparatus for blending a powder with a liquid 失效
标题翻译：用于将粉末与液体混合的装置
公开(公告)号：US5322357A
公开(公告)日：1994-06-21
申请号：US77158
申请日：1993-06-14
申请人： Terrence B. Mazer
发明人： Terrence B. Mazer
IPC分类号： B01F5/16 , B01F7/04
CPC分类号： B01F5/16
摘要： An apparatus has the capacity to satisfactorily blend a liquid with a powder and pump the resultant viscous slurry in a single stage operation. The apparatus has a vertically oriented drive shaft with a bladed impeller attached to the drive shaft. A housing surrounds a mixing chamber in which the impeller is located. The lower end of a powder inlet tube is disposed in very close proximity to the highest vertical extent of the impeller blades. A liquid enters the mixing chamber exterior of the powder inlet tube. The resultant slurry leaves the mixing chamber via a slurry discharge port.
摘要翻译：一种装置具有令人满意地将液体与粉末混合的能力，并且在单级操作中泵送所得到的粘稠浆料。该装置具有垂直定向的驱动轴，叶片叶片连接到驱动轴上。壳体围绕叶轮所在的混合室。粉末入口管的下端设置在非常接近叶轮叶片的最高垂直范围。液体进入粉末入口管外部的混合室。所得浆料通过浆料排出口离开混合室。

55. 发明授权

US5248804A Separation of phytate from plant protein using ion exchange 失效
标题翻译：使用离子交换从植物蛋白中分离植酸盐
公开(公告)号：US5248804A
公开(公告)日：1993-09-28
申请号：US986651
申请日：1992-12-08
申请人： Christy A. Nardelli , Terrence B. Mazer , Arthur J. C. L. Hogarth , John D. Suh , Andre Daab-Krzykowski , Leona M. Pickett , Harold W. Keller , William J. Nelson
发明人： Christy A. Nardelli , Terrence B. Mazer , Arthur J. C. L. Hogarth , John D. Suh , Andre Daab-Krzykowski , Leona M. Pickett , Harold W. Keller , William J. Nelson
IPC分类号： A23J1/14
CPC分类号： A23J1/14
摘要： A novel process for the removal of phytate from protein using ion exchange has been developed. The process involves the upflow passage of a protein slurry at an elevated temperature through a strong base anion exchanger in the chloride form. The weak base anion sites inherent to the resin have been converted to the free base form. The anion exchange material can easily be regenerated. The process can be used on-line, yields phytate removal of greater than 90%, has high (greater than 90%) protein recovery, is cost-effective, and is environmentally friendly.
摘要翻译：已经开发了使用离子交换从蛋白质中去除植酸盐的新方法。该方法包括蛋白质浆液在升高的温度下通过氯离子形式的强碱阴离子交换剂。树脂固有的弱碱阴离子位点已经转化为游离碱形式。阴离子交换材料可以容易地再生。该过程可以在线使用，产生植酸盐去除率大于90％，具有高（大于90％）的蛋白质回收率，具有成本效益，是环保的。

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