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51. 发明授权

US6020206A Homocysteine assay 失效
标题翻译：同型半胱氨酸测定
公开(公告)号：US6020206A
公开(公告)日：2000-02-01
申请号：US99588
申请日：1998-06-18
申请人： Chandra Vargeese , Sumedha Jayasena , Nebojsa Janjic
发明人： Chandra Vargeese , Sumedha Jayasena , Nebojsa Janjic
IPC分类号： G01N33/68
CPC分类号： G01N33/68 , G01N33/6815
摘要： This invention pertains to methods of determining the presence and/or quantity of homocysteine in a sample containing other thiol-containing compounds. The methods of this invention involve modifying the homocysteine to facilitate the separation of homocysteine from cysteine. An assay protocol comprises adjusting the conditions of the sample suspected of containing homocysteine so that homocysteine forms homocysteine thiolactone, separating the homocysteine thiolactone from free thiol-containing compounds present in the sample, including cysteine, reconverting the homocysteine thiolactone to homocysteine, and determining the presence and/or quantity of homocysteine in the sample by conventional means.
摘要翻译：本发明涉及确定含有其它含硫醇化合物的样品中同型半胱氨酸的存在和/或量的方法。本发明的方法涉及修饰同型半胱氨酸以促进半胱氨酸与半胱氨酸的分离。测定方案包括调整怀疑含有同型半胱氨酸的样品的条件，使得同型半胱氨酸形成同型半胱氨酸硫内酯，将同型半胱氨酸硫内酯与存在于样品中的游离含硫醇化合物（包括半胱氨酸）分离，将同型半胱氨酸硫内酯重新转化为同型半胱氨酸，和/或样品中同型半胱氨酸的量。

52. 发明授权

US08895241B2 Aptamers for clostridium difficile diagnostics 有权
标题翻译：艰难梭菌诊断的适配者
公开(公告)号：US08895241B2
公开(公告)日：2014-11-25
申请号：US13417035
申请日：2012-03-09
申请人： Urs Ochsner , Evaldas Katilius , Nebojsa Janjic
发明人： Urs Ochsner , Evaldas Katilius , Nebojsa Janjic
IPC分类号： C12Q1/68 , C12N15/115 , C07H21/02 , C07H21/04
CPC分类号： G01N33/573 , C12N15/115 , C12N2310/16 , G01N2333/91102
摘要： The present disclosure relates generally to the field of nucleic acids and, more particularly, to aptamers capable of binding to toxins produced by Clostridium difficile; diagnostic kits and methods comprising such aptamers; and methods of making and using such aptamers.
摘要翻译：本公开一般涉及核酸领域，更具体地涉及能够结合艰难梭菌产生的毒素的适体; 包括这种适体的诊断试剂盒和方法; 以及制造和使用这些适体的方法。

53. 发明授权

US08431376B2 Bacterial replication systems and methods 有权
标题翻译：细菌复制系统和方法
公开(公告)号：US08431376B2
公开(公告)日：2013-04-30
申请号：US11568286
申请日：2005-04-26
申请人： Thale Cross Jarvis , Charles S. McHenry , Nebojsa Janjic , Garry Dallmann , James M. Bullard , Stacie Bell , Glenn Sanders , Frank Dean
发明人： Thale Cross Jarvis , Charles S. McHenry , Nebojsa Janjic , Garry Dallmann , James M. Bullard , Stacie Bell , Glenn Sanders , Frank Dean
IPC分类号： C12N9/00
CPC分类号： C07K14/21 , C07K14/195 , C07K14/31 , C12N15/63 , C12N15/69 , C12N15/70
摘要： Reconstituted bacterial replication assemblies and methods for their use are provided.
摘要翻译：提供重组的细菌复制组件及其使用方法。

54. 发明授权

US07994192B2 Substituted thienopyridone compounds with antibacterial activity 有权
标题翻译：取代的具有抗菌活性的噻吩并吡酮化合物
公开(公告)号：US07994192B2
公开(公告)日：2011-08-09
申请号：US11853314
申请日：2007-09-11
申请人： Joseph Guiles , Xicheng Sun , Nebojsa Janjic , Sarah Strong
发明人： Joseph Guiles , Xicheng Sun , Nebojsa Janjic , Sarah Strong
IPC分类号： A01N43/42 , A61K31/44 , A61K31/47 , C07D491/02 , C07D498/02 , C07D471/02 , C07D515/02 , C07D215/00
CPC分类号： C07D409/12 , C07D495/04
摘要： Novel bicyclic heteroaromatic compounds are provided that are inhibitors of bacterial methionyl tRNA synthetase (MetRS). Compounds of the invention generally have a left hand side chroman group or left hand side tetrahydroquinoline group and a right hand side thienopyridone group. Also disclosed are methods for their preparation and their use in therapy as antibacterial agents, particularly as anti-Clostridium difficile agents.
摘要翻译：提供了新的双环杂芳族化合物，其是细菌甲硫氨酰tRNA合成酶（MetRS）的抑制剂。本发明的化合物通常具有左侧苯并二氢吡喃基或左手四氢喹啉基和右手侧噻吩并吡喃酮基。还公开了它们的制备方法及其在治疗中的用途，作为抗菌剂，特别是作为抗艰难梭菌试剂。

55. 发明申请

US20120231467A1 Aptamers for C. Difficile Diagnostics 有权
标题翻译：适用于C. Difficile诊断
公开(公告)号：US20120231467A1
公开(公告)日：2012-09-13
申请号：US13417035
申请日：2012-03-09
申请人： Urs Ochsner , Evaldas Katilius , Nebojsa Janjic
发明人： Urs Ochsner , Evaldas Katilius , Nebojsa Janjic
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： G01N33/573 , C12N15/115 , C12N2310/16 , G01N2333/91102
摘要： The present disclosure relates generally to the field of nucleic acids and, more particularly, to aptamers capable of binding to toxins produced by Clostridium difficile; diagnostic kits and methods comprising such aptamers; and methods of making and using such aptamers.
摘要翻译：本公开一般涉及核酸领域，更具体地涉及能够结合艰难梭菌产生的毒素的适体; 包括这种适体的诊断试剂盒和方法; 以及制备和使用这些适体的方法。

56. 发明申请

US20050124562A1 Bis-quinazoline compounds for the treatment of bacterial infections 审中-公开
标题翻译：双喹唑啉化合物用于治疗细菌感染
公开(公告)号：US20050124562A1
公开(公告)日：2005-06-09
申请号：US10948110
申请日：2004-09-23
申请人： Joseph Guiles , Garry Dallmann , Nebojsa Janjic , Charles McHenry , Xicheng Sun , Ming Tregay
发明人： Joseph Guiles , Garry Dallmann , Nebojsa Janjic , Charles McHenry , Xicheng Sun , Ming Tregay
IPC分类号： A01N43/54 , A61K20060101 , A61K31/517 , A61K31/7072 , C07D239/00 , C07D401/00 , C07D403/00 , C07D413/00 , C07D417/00 , C07D471/00 , C07D487/00 , C07D491/00 , C07D43/02
CPC分类号： C07D239/94 , C07D403/04
摘要： Bis-quinazoline compounds based on the compound (3,4-Dihydro-quinazolin-2-yl)-quinazolin-2-yl-amine, and methods of use of the compounds as inhibitors of bacterial DNA polymerase holoenzymes and in the treatment of bacterial infections are described.
摘要翻译：基于化合物（3,4-二氢 - 喹唑啉-2-基） - 喹唑啉-2-基胺的双喹唑啉化合物，以及这些化合物作为细菌DNA聚合酶全酶抑制剂的用途和用于治疗细菌的方法描述感染。

57. 发明授权

US06677146B1 Thermophilic polymerase III holoenzyme 有权
标题翻译：嗜热聚合酶III全酶
公开(公告)号：US06677146B1
公开(公告)日：2004-01-13
申请号：US09818780
申请日：2001-03-28
申请人： Nebojsa Janjic , James M. Bullard , Charles S. McHenry , Vladimir Kery
发明人： Nebojsa Janjic , James M. Bullard , Charles S. McHenry , Vladimir Kery
IPC分类号： C12N912
CPC分类号： C12N9/1247 , C07K16/40 , C12N9/1252 , C12Q1/48 , Y02A50/52 , Y02A50/57
摘要： The present invention relates to gene and amino acid sequences encoding DNA polymerase III holoenzyme subunits and structural genes from thermophilic organisms. In particular, the present invention provides DNA polymerase III holoenzyme subunits and accessory proteins of T. thermophilus. The present invention also provides antibodies, primers, probes, and other reagents useful to identify DNA polymerase III molecules.
摘要翻译：本发明涉及编码DNA聚合酶III全酶亚基的基因和氨基酸序列以及嗜热生物的结构基因。特别地，本发明提供嗜热链球菌的DNA聚合酶III全酶亚基和辅助蛋白。本发明还提供用于鉴定DNA聚合酶III分子的抗体，引物，探针和其它试剂。

58. 发明授权

US08697720B2 Substituted phenylether-thienopyridone compounds with antibacterial activity 有权
标题翻译：取代的苯基醚 - 噻吩并吡酮化合物具有抗菌活性
公开(公告)号：US08697720B2
公开(公告)日：2014-04-15
申请号：US11853589
申请日：2007-09-11
申请人： Joseph Guiles , Xicheng Sun , Nebojsa Janjic , Sarah Strong
发明人： Joseph Guiles , Xicheng Sun , Nebojsa Janjic , Sarah Strong
IPC分类号： A01N43/42 , A61K31/44 , C07D513/02 , C07D515/02 , C07D215/00
CPC分类号： C07D495/04
摘要： Novel bicyclic heteroaromatic compounds are provided that are inhibitors of bacterial methionyl tRNA synthetase (MetRS). Compounds of the invention generally have a left hand side phenylether constituent and a right hand side thienopyridone constituent. Also disclosed are methods for their preparation and their use in therapy as antibacterial agents, particularly as anti-Clostridium difficile agents.
摘要翻译：提供了新的双环杂芳族化合物，其是细菌甲硫氨酰tRNA合成酶（MetRS）的抑制剂。本发明的化合物通常具有左手侧苯醚组分和右手侧噻吩并吡啶酮组分。还公开了它们的制备方法及其在治疗中的用途，作为抗菌剂，特别是作为抗艰难梭菌试剂。

59. 发明授权

US08658670B2 Methods and compounds for treatment of clostridium based infection 有权
标题翻译：用于治疗基于梭状芽胞杆菌感染的方法和化合物
公开(公告)号：US08658670B2
公开(公告)日：2014-02-25
申请号：US11853636
申请日：2007-09-11
申请人： Joseph Guiles , Xicheng Sun , Nebojsa Janjic , Sarah Strong
发明人： Joseph Guiles , Xicheng Sun , Nebojsa Janjic , Sarah Strong
IPC分类号： A01N43/42 , A61K31/44 , A01N43/90 , A61K31/47 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02
CPC分类号： A61K31/4365 , A61K31/4709 , C07D405/12 , C07D495/04
摘要： Methionyl tRNA synthetase inhibitors (MetRS) are provided for use in therapy as antibacterial agents in Clostridium based infection.
摘要翻译：甲硫氨酸tRNA合成酶抑制剂（MetRS）被提供用于治疗作为基于Clostridium的感染中的抗菌剂。

60. 发明申请

US20110275794A1 5-POSITION MODIFIED PYRIMIDINES AND THEIR USE 审中-公开
标题翻译： 5位改性吡啶并及其用途
公开(公告)号：US20110275794A1
公开(公告)日：2011-11-10
申请号：US13085256
申请日：2011-04-12
申请人： John Rohloff , Nebojsa Janjic , Jeffrey D. Carter , Catherine Fowler
发明人： John Rohloff , Nebojsa Janjic , Jeffrey D. Carter , Catherine Fowler
IPC分类号： C07H21/04 , C07H19/10 , C07H19/073
CPC分类号： C07H19/10 , C07H19/06 , C07H21/04 , C12N15/115 , C12N2310/335
摘要： The present disclosure relates to the field of nucleic acid chemistry, specifically to 5-position modified uridines as well as phosphoramidite and triphosphate derivatives thereof. The present disclosure also relates to methods of making and using the same.
摘要翻译：本公开内容涉及核酸化学领域，特别涉及5-位修饰的尿苷以及其亚磷酰胺和三磷酸衍生物。本公开还涉及制备和使用该方法。

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