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51. 发明授权

US5565085A Method for quantifying specific compound 失效
标题翻译：定量化合物的方法
公开(公告)号：US5565085A
公开(公告)日：1996-10-15
申请号：US428040
申请日：1995-04-25
申请人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai , Haruhiro Tsutsumi , Hideyuki Baba , Yoshinobu Tokuno
发明人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai , Haruhiro Tsutsumi , Hideyuki Baba , Yoshinobu Tokuno
IPC分类号： G01N27/416 , C12Q1/00 , G01N27/30 , G01N27/327 , G01N27/26
CPC分类号： C12Q1/001 , Y10S435/817
摘要： A biosensor for quantifying a specific compound has a reaction layer containing at least an enzyme, and an electrode system having a working electrode and a counter electrode formed on an insulating base plate; the biosensor detects the specific compound contained in a sample on the basis of an electrochemical response. In quantifying, the working electrode and the counter electrode are short-circuited before the voltage is applied therebetween. The short-circuiting eliminates measuring errors that may occur due to nonuniform dissolution of the reaction layer in a sample, and achieves highly reliable quantification of a specific compound.
摘要翻译：用于定量特定化合物的生物传感器具有至少含有酶的反应层和在绝缘基板上形成有工作电极和对电极的电极系统; 生物传感器基于电化学响应来检测样品中包含的特定化合物。在量化之前，工作电极和对电极在施加电压之前短路。短路消除了由于反应层在样品中的不均匀溶解而可能发生的测量误差，并且实现了特定化合物的高度可靠的定量。

52. 发明授权

US5320732A Biosensor and measuring apparatus using the same 失效
标题翻译：生物传感器和使用其的测量装置
公开(公告)号：US5320732A
公开(公告)日：1994-06-14
申请号：US75859
申请日：1993-06-11
申请人： Shiro Nankai , Mariko Kawaguri , Toshihiko Yoshioka , Haruhiro Tsutsumi , Minoru Fukuda
发明人： Shiro Nankai , Mariko Kawaguri , Toshihiko Yoshioka , Haruhiro Tsutsumi , Minoru Fukuda
IPC分类号： G01N27/28 , G01N33/487 , G01N27/26
CPC分类号： G01N27/3272
摘要： The subject invention provides a simple sensor and an easy to handle biosensor measuring apparatus for the purpose of making measurements easily, rapidly and with high accuracy for specific components within a biological specimen such as blood.The biosensor of the subject invention is provided with a protrusion or a depression in a portion of a base having at least a measurement electrode and an opposing electrode. Also, the biosensor measuring apparatus is so configurated to have a mating means in the main body of the measuring apparatus freely supporting this biosensor to contact the said sensor's protrusion or depression, and further having the activating switch of the driving power supply located in this mating means.By means of these, it is possible to prevent wasteful measuring operations, as noted in the prior art biosensors, such as inserting the sensor backwards and making measurements with the sensor inserted backwards.
摘要翻译：本发明提供了一种简单的传感器和易于处理的生物传感器测量装置，用于容易，快速且高度精确地测量诸如血液的生物样本内的特定组分的目的。本发明的生物传感器在至少具有测量电极和相对电极的基部的一部分中设置有突起或凹陷。此外，生物传感器测量装置被配置为具有在测量装置的主体中具有自由支撑该生物传感器的配合装置以接触所述传感器的突起或凹陷，并且还具有位于该配合中的驱动电源的启动开关手段。通过这些，可以防止浪费的测量操作，如现有技术的生物传感器中所述，例如向后插入传感器并且使传感器向后插入进行测量。

53. 发明授权

US4376689A Coenzyme immobilized electrode 失效
标题翻译：辅酶固定电极
公开(公告)号：US4376689A
公开(公告)日：1983-03-15
申请号：US321326
申请日：1981-11-13
申请人： Kenichi Nakamura , Shiro Nankai , Takashi Iijima
发明人： Kenichi Nakamura , Shiro Nankai , Takashi Iijima
IPC分类号： C12Q1/00 , C12Q1/26
CPC分类号： C12Q1/005 , Y10S435/817
摘要： Improvements in a coenzyme electrode used to electrochemically measure the activity of enzyme or substrate concentration of the enzyme easily. The coenzyme is immobilized, without using a semipermeable membrane, on the electron collector directly with the chemical bond, particularly the covalent bond, whereby the activity of the oxide-reductase requiring the coenzyme can be measured. In addition, the oxide-reductase requiring the coenzyme is also immobilized together with such immobilized coenzyme to improve the characteristics of the conventional enzyme-coenzyme immobilized electrode.
摘要翻译：用于电化学测量酶活性或酶底物浓度的辅酶电极的改进容易。辅酶不用半透膜即可直接用化学键，特别是共价键直接固定在电子收集器上，从而可以测量需要辅酶的氧化还原酶的活性。此外，需要辅酶的氧化还原酶也与这样的固定化辅酶一起固定，以改善常规的酶 - 辅酶固定化电极的特性。

54. 发明申请

US20050203707A1 Data measuring device, healthcare data acquiring system, and healthcare data acquiring method 审中-公开
标题翻译：数据测量装置，保健数据采集系统，医疗数据采集方法
公开(公告)号：US20050203707A1
公开(公告)日：2005-09-15
申请号：US10509728
申请日：2003-08-08
申请人： Hiroshi Tsutsui , Yasuhiro Mori , Hirosi Yamamoto , Shiro Nankai , Nobuyuki Shigetoh , Tatsurou Kawamura
发明人： Hiroshi Tsutsui , Yasuhiro Mori , Hirosi Yamamoto , Shiro Nankai , Nobuyuki Shigetoh , Tatsurou Kawamura
IPC分类号： A61B5/00 , G06F19/00
CPC分类号： G16H10/40 , A61B5/14532
摘要： The data measuring unit 11 measures a subject's blood and urine, and acquires numerical data (S501). The communication control unit 12 transmits the acquired numerical data to the data management apparatus 20 (S502). The overall control unit 14 receives the numerical data from the data measuring apparatus 10 (S503), and analyzes the content of the received numerical data (S504). The overall control unit 14 selects calibration curve data based on the above mentioned analysis result (S505), and calculates health care data (S506). Furthermore, the overall control unit 14 directs the communication control unit 13 to transmit the calculated health care data to the data measuring apparatus 10 (S507). The data measuring apparatus 10 receives the health care data from the data management apparatus 20 (S508).
摘要翻译：数据测量单元11测量受试者的血液和尿液，并获取数字数据（S 501）。通信控制单元12将获取的数字数据发送到数据管理装置20（步骤502）。总体控制单元14从数据测量装置10接收数字数据（S 503），并分析接收数字数据的内容（S 504）。总体控制单元14基于上述分析结果选择校准曲线数据（S 505），并计算保健数据（S 506）。此外，总体控制单元14引导通信控制单元13将计算出的医疗保健数据发送到数据测量装置10（S 507）。数据测量装置10从数据管理装置20接收保健数据（S 508）。

55. 发明授权

US06885196B2 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US06885196B2
公开(公告)日：2005-04-26
申请号：US10220153
申请日：2001-07-17
申请人： Yuko Taniike , Shin Ikeda , Shiro Nankai
发明人： Yuko Taniike , Shin Ikeda , Shiro Nankai
IPC分类号： C12Q1/00 , A61B5/05
CPC分类号： G01N27/3272 , C12Q1/005 , C12Q1/006
摘要： A highly sensitive biosensor that uses a smaller amount of sample for measurement is described. The biosensor includes a first insulating base plate having a working electrode, a second insulating base plate having a counter electrode opposed to the working electrode, and a reagent layer containing at least an oxidoreductase. The biosensor further includes a sample supply pathway formed between the first and second insulating base plates, where the working electrode, counter electrode and reagent layer are exposed to an inside of the sample supply pathway, and the distance between the working electrode and the counter electrode is 150 μm or less.
摘要翻译：描述了使用较少量的样品进行测量的高灵敏度生物传感器。生物传感器包括具有工作电极的第一绝缘基板，具有与工作电极相对的反电极的第二绝缘基板和至少含有氧化还原酶的试剂层。生物传感器还包括形成在第一和第二绝缘基板之间的样品供给路径，其中工作电极，对电极和试剂层暴露于样品供应路径的内部，并且工作电极和对电极之间的距离是150mam以下。

56. 发明授权

US06790327B2 Device and method for determining the concentration of a substrate 有权
标题翻译：用于确定底物浓度的装置和方法
公开(公告)号：US06790327B2
公开(公告)日：2004-09-14
申请号：US10023734
申请日：2001-12-21
申请人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
发明人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： C12Q1/004
摘要： An apparatus for determining the concentration of a substrate in a sample solution using an electrode system comprising a working electrode, a counter electrode, and a reaction layer which contains at least an oxidoreductase and an electron mediator and is formed on the electrode system to electrochemically measure a reduced amount of the electron mediator resulting from enzyme reaction in the reaction layer, wherein a third electrode is formed as an interfering substance detecting electrode. A current flowing between the counter electrode and the third electrode is measured which is taken as a positive error. Subsequently, voltage application between the counter electrode and the third electrode is released and a voltage for oxidizing the reduced form electron mediator is applied between the working electrode and the counter electrode to measure a current flowing between the two electrodes.
摘要翻译：一种用于使用包括工作电极，对电极和至少包含氧化还原酶和电子介体的反应层的电极系统来确定样品溶液中基底的浓度的装置，并且形成在电极系统上以电化学测量在反应层中由酶反应产生的电子介体的量减少，其中形成第三电极作为干扰物质检测电极。测量在对电极和第三电极之间流动的电流，其被认为是正误差。随后，释放对电极和第三电极之间的电压施加，并且在工作电极和对电极之间施加用于氧化还原形式的电子介体的电压，以测量在两个电极之间流动的电流。

57. 发明授权

US06471839B1 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US06471839B1
公开(公告)日：2002-10-29
申请号：US09572797
申请日：2000-05-17
申请人： Tomohiro Yamamoto , Toshihiko Yoshioka , Shiro Nankai
发明人： Tomohiro Yamamoto , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： C12Q1/004 , C12Q1/005
摘要： The present invention provides a biosensor which enables quick measurement and is excellent in storage characteristic. This biosensor comprises an electrically insulating base plate on which an electrode system having at least a measuring electrode and a counter electrode is formed, a cover member which is integrated to the base plate so as to form a sample solution supply path for supplying a sample solution to the electrode system between the cover member and the base plate, and a carrier composed of fiber supporting a reagent containing at least an oxidoreductase, and the carrier is placed in the sample solution supply path. Preferably, the carrier is constituted at least of two carrier pieces and each carrier piece supports a different reagent.
摘要翻译：本发明提供一种生物传感器，其能够快速测量并且具有优异的储存特性。该生物传感器包括电绝缘基板，其上形成有至少具有测量电极和对电极的电极系统，盖构件，其与基板一体地形成用于提供样品溶液的样品溶液供应路径涉及覆盖构件和基板之间的电极系统，以及由支撑含有至少一种氧化还原酶的试剂的纤维构成的载体，载体被放置在样品溶液供给路径中。优选地，载体至少由两个载体片构成，并且每个载体片支撑不同的试剂。

58. 再颁专利

USRE37002E Lipid-dispersed solution, production thereof and use in determining lipid levels 失效
标题翻译：脂质分散溶液，其生产和用于确定脂质水平
公开(公告)号：USRE37002E
公开(公告)日：2000-12-26
申请号：US327019
申请日：1999-06-07
申请人： Tomohiro Yamamoto , Toshihiko Yoshioka , Shiro Nankai
发明人： Tomohiro Yamamoto , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N33/92 , G01N33/96 , B01J13/00 , C12Q1/60
CPC分类号： G01N33/96 , G01N33/92 , G01N2800/044 , Y10S516/928 , Y10T436/104165
摘要： .[.There is disclosed an aqueous dispersed solution as a standard solution for determining lipid levels, having a dispersion form and a particle size, which are similar to those of serum lipids. A lipid-dispersed solution is obtained by evaporating an organic solvent from a mixture prepared by adding cholesterol, a phospholipid, a bile acid or bile acid salt, and a neutral lipid and/or a cholesterol ester in the organic solvent, swelling the resultant thin-film like mixture with water or buffer heated at a temperature higher than a phase transition temperature of the lecithin, and then dispersing the solution by a physical shear force. There can be easily obtained a solution having a cholesterol concentration of about less than 1,000 mg/dl, which is extremely stable and can be stored for a long period of time..]. .Iadd.There is disclosed an aqueous dispersed solution as a standard solution for determining lipid levels, having a dispersion form and a particle size, which are similar to those of serum lipids. A lipid-dispersed solution is obtained by evaporating an organic solvent from a mixture prepared by adding cholesterol, a phospholipid, a bile acid or bile acid salt, and a neutral lipid and/or a cholesterol ester in the organic solvent, swelling the resultant thin-film like mixture with water or buffer heated at a temperature higher than a phase transition temperature of the lecithin, and then dispersing the solution by a physical shear force. These can be easily obtained a solution having a cholesterol concentration of about less than 1,000 mg/dl, which is extremely stable and can be stored for a long period of time. The lipid dispersed solution is used as a standard solution in calibrating a device for performing enzymatic lipid level determination, and the calibrated device is used to determine the lipid level (e.g. cholesterol) in a solution.
摘要翻译：公开了水分散溶液作为用于测定脂质水平的标准溶液，具有与血清脂质相似的分散体形式和粒径。通过将有机溶剂从通过在有机溶剂中加入胆固醇，磷脂，胆汁酸或胆汁酸盐和中性脂质和/或胆固醇酯制备的混合物蒸发而获得脂质分散溶液，将所得薄片在与高于卵磷脂相变温度的温度下加热的水或缓冲液混合，然后通过物理剪切力分散溶液。可以容易地获得胆固醇浓度大约小于1,000mg / dl的溶液，其非常稳定并且可以长期储存。]公开了作为确定脂质的标准溶液的水性分散溶液水平，具有与血清脂质相似的分散体形式和粒径。通过将有机溶剂从通过在有机溶剂中加入胆固醇，磷脂，胆汁酸或胆汁酸盐和中性脂质和/或胆固醇酯制备的混合物蒸发而获得脂质分散溶液，将所得薄片在与高于卵磷脂相变温度的温度下加热的水或缓冲液混合，然后通过物理剪切力分散溶液。这些可以容易地获得胆固醇浓度大约小于1,000mg / dl的溶液，其非常稳定并且可以长期储存。脂质分散溶液用作校准用于进行酶脂质水平测定的装置的标准溶液，并且校准的装置用于测定溶液中的脂质水平（例如胆固醇）。

59. 发明授权

US5985130A Method for quantifying substrate 失效
标题翻译：定量底物的方法
公开(公告)号：US5985130A
公开(公告)日：1999-11-16
申请号：US834829
申请日：1997-04-03
申请人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
发明人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N27/327 , C12Q1/00 , G01N27/416 , G01N27/49 , G01N27/26
CPC分类号： C12Q1/001 , G01N27/3273
摘要： The present invention provides a method for quantifying a substrate having improved measurement accuracy and measurement sensitivity. According to the method for quantifying the substrate of the present invention, a constant voltage is applied to an electrode system, between a working electrode and a counter electrode, via a resistor connected in series with the electrode system after placing a sample solution containing the substrate on the electrode system, so as to oxidize an electron acceptor, which has been reduced by an enzyme reaction of the substrate, thereby determining a concentration of the substrate included in the sample solution based on an oxidizing current flowing in the course of oxidation.
摘要翻译：本发明提供了一种用于量化具有改进的测量精度和测量灵敏度的衬底的方法。根据本发明的基板的定量化方法，在放置含有基板的样品溶液之后，通过与电极系统串联连接的电阻器将恒定电压施加到工作电极与对电极之间的电极系统在电极系统上，以通过基板的酶反应而还原的电子受体氧化，从而基于在氧化过程中流动的氧化电流来确定样品溶液中包含的底物的浓度。

60. 发明授权

US5650062A Biosensor, and a method and a device for quantifying a substrate in a sample liquid using the same 失效
标题翻译：生物传感器，以及使用其进行样品液体中的基板的定量的方法和装置
公开(公告)号：US5650062A
公开(公告)日：1997-07-22
申请号：US526557
申请日：1995-09-12
申请人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai , Haruhiro Tsutsumi , Hideyuki Baba , Yoshinobu Tokuno , Syoji Miyazaki
发明人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai , Haruhiro Tsutsumi , Hideyuki Baba , Yoshinobu Tokuno , Syoji Miyazaki
IPC分类号： C12Q1/00 , G01N27/26
CPC分类号： C12Q1/001 , Y10S435/817
摘要： The biosensor of this invention can quantify a substrate in a sample liquid by electrochemically measuring the amount of an electron acceptor that has been reduced by electrons generated in a reaction between the substrate and an oxidoreductase. The biosensor has an electrically insulating substrate and an electrode system formed on the substrate including a working electrode, a counter electrode and a third electrode used for detecting a liquid junction. The third electrode can be used merely for detecting a liquid junction, or can be used as both a reference electrode and a liquid junction detecting electrode.
摘要翻译：本发明的生物传感器可以通过电化学测量由底物和氧化还原酶之间的反应中产生的电子而减少的电子受体的量来量化样品液体中的底物。生物传感器具有电绝缘基板和形成在基板上的电极系统，该基板包括工作电极，对电极和用于检测液体接合点的第三电极。第三电极可以仅用于检测液体接点，也可以用作参考电极和液体接点检测电极。

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