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51. 发明授权

US06564805B2 Less-invasive devices and methods for treatment of cardiac valves 失效
公开(公告)号：US06564805B2
公开(公告)日：2003-05-20
申请号：US10198513
申请日：2002-07-18
申请人： Michi E. Garrison , Brian S. Donlon , S. Christopher Daniel , John H. Stevens
发明人： Michi E. Garrison , Brian S. Donlon , S. Christopher Daniel , John H. Stevens
IPC分类号： A61B1900
CPC分类号： A61B17/0057 , A61B17/00234 , A61B17/0218 , A61B17/0293 , A61B17/0467 , A61B17/0469 , A61B17/06061 , A61B17/122 , A61B17/29 , A61B17/2909 , A61B17/3421 , A61B18/1492 , A61B90/36 , A61B90/50 , A61B2017/00053 , A61B2017/00243 , A61B2017/00247 , A61B2017/00575 , A61B2017/00867 , A61B2017/00907 , A61B2017/00946 , A61B2017/0237 , A61B2017/0243 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/0496 , A61B2017/2912 , A61B2017/2926 , A61B2017/2927 , A61B2017/2932 , A61B2017/2943 , A61B2017/306 , A61B2017/308 , A61B2017/3405 , A61B2017/3492 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00291 , A61B2018/00363 , A61B2018/00392 , A61B2018/00577 , A61B2018/00982 , A61B2090/061 , A61B2090/306 , A61F2/2427 , A61F2/2442 , A61F2/2445 , A61F2/2448 , A61F2/2466 , A61F2/2496 , A61F7/10 , A61F2007/0001 , A61F2007/0054 , A61F2007/101 , A61M1/3621 , A61M25/1011 , A61M39/0247 , A61M2025/028 , A61M2039/027 , A61M2039/0279 , A61M2202/047 , A61M2205/3344 , A61M2205/3355 , A61M2205/366
摘要： Devices and methods are provided for less-invasive surgical treatment of cardiac valves whereby the need for a gross thoracotomy or median sternotomy is eliminated. In one aspect of the invention, a delivery system for a cardiac valve prosthesis such as an annuloplasty ring or prosthetic valve includes an elongated handle configured to extend into the heart through an intercostal space from outside of the chest cavity, and a prosthesis holder attached to the handle for releasably holding a prosthesis. The prosthesis holder is attached to the handle in such a way that the holder, prosthesis and handle have a profile with a height smaller than the width of an intercostal space when the adjacent ribs are unretracted, preferably less than about 30 mm. In a further aspect, the invention provides a method for repairing or replacing a heart valve which includes the steps of introducing a prosthesis through an intercostal space and through a penetration in a wall of the heart, and securing the prosthesis to an interior wall of the heart, wherein each step is carried out without cutting, removing, or significantly retracting the ribs or sternum.

52. 发明授权

US06283127B1 Devices and methods for intracardiac procedures 有权
标题翻译：用于心内手术的装置和方法
公开(公告)号：US06283127B1
公开(公告)日：2001-09-04
申请号：US09161190
申请日：1998-09-25
申请人： Wesley D. Sterman , Michi E. Garrison , Hanson S. Gifford, III , John L. Stevens
发明人： Wesley D. Sterman , Michi E. Garrison , Hanson S. Gifford, III , John L. Stevens
IPC分类号： A61B1700
CPC分类号： A61B17/00234 , A61B17/0057 , A61B17/0218 , A61B17/0467 , A61B17/0469 , A61B17/06061 , A61B17/064 , A61B17/068 , A61B17/12013 , A61B17/122 , A61B17/1227 , A61B17/1285 , A61B17/29 , A61B17/2909 , A61B17/30 , A61B17/3403 , A61B18/1442 , A61B18/1492 , A61B90/50 , A61B2017/00243 , A61B2017/00247 , A61B2017/00637 , A61B2017/00663 , A61B2017/0243 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/2943 , A61B2017/306 , A61B2017/3405 , A61B2017/3427 , A61B2017/3492 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00291 , A61B2018/00363 , A61B2018/00392 , A61B2018/00577 , A61B2090/064 , A61F2/2427 , A61F2/2496 , A61M1/3664 , A61M25/0023 , A61M25/0032 , A61M25/1011 , A61M39/0247 , A61M2025/0003 , A61M2025/028 , A61M2025/1052 , A61M2039/027 , A61M2039/0279 , A61M2202/047 , A61M2205/3344 , A61M2205/3355 , A61M2205/366 , A61M2210/127 , A61M2230/005
摘要： The invention provides devices and methods for performing less-invasive surgical procedures within an organ or vessel. In an exemplary embodiment, the invention provides a method of closed-chest surgical intervention within an internal cavity of a patient's heart or great vessel. According to the method, the patient's heart is arrested and cardiopulmonary bypass is established. A scope extending through a percutaneous intercostal penetration in the patient's chest is used to view an internal portion of the patient's chest. An internal penetration is formed in a wall of the heart or great vessel using cutting means introduced through a percutaneous penetration in an intercostal space in the patient's chest. An interventional tool is then introduced, usually through a cannula positioned in a percutaneous intercostal penetration. The interventional tool is inserted through the internal penetration in the heart or great vessel to perform a surgical procedure within the internal cavity under visualization by means of the scope. In a preferred embodiment, a cutting tool is introduced into the patient's left atrium from a right portion of the patient's chest to remove the patient's mitral valve. A replacement valve is then introduced through an intercostal space in the right portion of the chest and through the internal penetration in the heart, and the replacement valve is attached in the mitral valve position.
摘要翻译：本发明提供了用于在器官或血管内执行较少侵入性外科手术的装置和方法。在一个示例性实施例中，本发明提供了一种在患者心脏或大血管的内腔内进行闭胸手术干预的方法。根据该方法，患者的心脏被停止并建立了体外循环。使用延伸穿过患者胸部经皮肋间穿透的范围来观察患者胸部的内部部分。使用通过在患者胸部的肋间空间经皮渗透引入的切割装置在心脏或大容器的壁上形成内部穿透。然后引入介入工具，通常通过定位在经皮肋间穿透中的套管。介入工具通过心脏或大容器中的内部穿透插入，通过范围在可视化的内部空腔内执行外科手术。在优选实施例中，切割工具从患者胸部的右侧部分引入患者的左心房以移除患者的二尖瓣。然后将置换瓣膜通过胸部右侧部分的肋间空间并通过心脏内部穿透引入，置换瓣膜连接于二尖瓣位置。

53. 发明授权

US5980455A Method for manipulating a tissue structure within a thoracic cavity 失效
标题翻译：操纵胸腔内组织结构的方法
公开(公告)号：US5980455A
公开(公告)日：1999-11-09
申请号：US893066
申请日：1997-07-15
申请人： S. Christopher Daniel , Robert K. Deckman , Michi E. Garrison
发明人： S. Christopher Daniel , Robert K. Deckman , Michi E. Garrison
IPC分类号： A61B17/00 , A61B17/02 , A61B17/04 , A61B17/06 , A61B17/28 , A61B17/30 , A61B17/34 , A61B18/14 , A61B19/00 , A61F2/24 , A61F2/958 , A61M1/00 , A61B1/313
CPC分类号： A61M39/0247 , A61B17/00234 , A61B17/0218 , A61B17/0469 , A61B17/06061 , A61B18/1492 , A61B90/50 , A61F2/2427 , A61B17/0467 , A61B17/2909 , A61B17/3417 , A61B2017/00243 , A61B2017/00247 , A61B2017/00349 , A61B2017/0243 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/2943 , A61B2017/2946 , A61B2017/306 , A61B2017/3405 , A61B2017/3425 , A61B2017/3492 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00291 , A61B2018/00363 , A61B2018/00392 , A61B2018/00577 , A61M2025/028 , A61M2039/027 , A61M2039/0279 , A61M2205/3344 , A61M2205/3355 , A61M2205/366 , A61M25/1011
摘要： A method for manipulating a tissue structure within a body cavity provides for retracting and supporting the heart wall to provide access into the heart during a cardiac surgical procedure. In one embodiment of the present invention, a surgical tool support apparatus comprises a base having an atraumatic tissue-engaging surface and an aperture for receiving an elongate tool. The apparatus also has a clamp assembly aligned with the aperture and spaced-apart from a surface of the base opposite to the tissue-engaging surface. The apparatus is particularly useful in maintaining a retracting force on a surgical tool used to manipulate tissue within a body cavity such as the thoracic cavity.
摘要翻译：用于操纵体腔内的组织结构的方法提供回缩和支撑心脏壁以在心脏外科手术过程中提供进入心脏的通路。在本发明的一个实施例中，一种手术工具支撑装置包括具有无创伤组织接合表面的底座和用于接收细长工具的孔。该装置还具有与孔对准并且与基部的与组织接合表面相对的表面间隔开的夹具组件。该装置特别可用于在用于操纵诸如胸腔的体腔内的组织的外科手术工具上保持缩回力。

54. 发明授权

US5885228A Valve sizer and method of use 失效
公开(公告)号：US5885228A
公开(公告)日：1999-03-23
申请号：US646850
申请日：1996-05-08
申请人： Daniel C. Rosenman , Michi E. Garrison , Sean Christopher Daniel
发明人： Daniel C. Rosenman , Michi E. Garrison , Sean Christopher Daniel
IPC分类号： A61F2/24 , A61B5/103
CPC分类号： A61F2/2496 , Y10S623/90
摘要： A valve sizer having a movable element mounted to the distal end of a shaft. A valve sizing portion includes the movable element so that the valve sizing portion may be adjusted to correspond to a number of different available replacement valve sizes. An indicator mounted to the proximal end of the shaft indicates the valve size corresponding to the outer dimension of the valve sizing portion.

55. 发明授权

US5860992A Endoscopic suturing devices and methods 失效
标题翻译：内窥镜缝合装置及方法
公开(公告)号：US5860992A
公开(公告)日：1999-01-19
申请号：US594869
申请日：1996-01-31
申请人： Sean Christopher Daniel , Brian S. Donlon , Michi E. Garrison , Hanson S. Gifford, III , Daniel C. Rosenman , William S. Peters , Robert L. Lathrop, II , George Crothall , James B. Mullin , Gerald R. Anderson , Wiley A. Kittrell
发明人： Sean Christopher Daniel , Brian S. Donlon , Michi E. Garrison , Hanson S. Gifford, III , Daniel C. Rosenman , William S. Peters , Robert L. Lathrop, II , George Crothall , James B. Mullin , Gerald R. Anderson , Wiley A. Kittrell
IPC分类号： A61B17/04 , A61B17/06 , A61F2/24
CPC分类号： A61B17/0491 , A61B17/0469 , A61B17/062 , A61B17/0625 , A61B2017/047 , A61B2017/0472 , A61B2017/061 , A61F2/2409
摘要： The invention provides devices and methods for suture placement while performing less invasive surgical procedures within a body cavity. In an exemplary embodiment, the invention provides for the placement of sutures within the heart or a great vessel that is accessed from outside the closed chest. According to one exemplary method, the patient's heart valve is accessed through an intercostal port in the patient's chest. At least one needle having a suture is then directed into the annulus while visualizing through the port placement of the needle into the annulus. The needle is then passed through the annulus.
摘要翻译：本发明提供了用于缝合放置的装置和方法，同时在体腔内执行较少侵入性的外科手术。在一个示例性实施例中，本发明提供将缝合线放置在心脏内或从封闭胸部外部进入的大容器中。根据一种示例性方法，患者的心脏瓣膜通过患者胸部的肋间端口进入。至少一根具有缝合线的针头然后被引导到环形空间中，同时通过针头插入环形空间的端口可视化。然后针穿过环。

56. 发明授权

US5263963A Expandable cage catheter for repairing a damaged blood vessel 失效
标题翻译：用于修复受损血管的可扩展的笼导管
公开(公告)号：US5263963A
公开(公告)日：1993-11-23
申请号：US682190
申请日：1991-04-08
申请人： Michi E. Garrison , Timothy R. Machold
发明人： Michi E. Garrison , Timothy R. Machold
IPC分类号： A61B19/00 , A61F2/00 , A61F2/06 , A61F2/84 , A61M25/04 , A61M29/00 , A61M29/02
CPC分类号： A61F2/95 , A61M25/04 , A61M29/02 , A61B90/39 , A61F2250/0059 , A61F2250/0098 , A61M2025/0063 , A61M2025/0183 , A61M2025/107
摘要： A vascular catheter having an expandable cage mounted on the distal end of a tubular member which is radially expanded and contracted by means of a control wire which is secured to the distal end of the expandable cage. The control wire extends through a first inner lumen within the tubular member which extends along essentially the entire length thereof. A second inner lumen is provided in the distal portion of the tubular member which has a proximal port at least 15 but not more than 60 cm from the distal end of the catheter and a distal port which opens into the interior of the expandable cage. A guidewire or a low-profile steerable catheter is slidably disposed within the second lumen and a tubular member such as a slightly expanded coil through the expandable cage interior to facilitate the rapid exchange of the catheter. The catheter assembly is particularly adapted to hold open a blood vessel after a vascular procedure therein such as an angioplasty.
摘要翻译：一种血管导管，其具有安装在管状构件的远端上的可膨胀笼，其通过固定到可膨胀笼的远端的控制线径向膨胀和收缩。控制线延伸穿过管状构件内的基本上整个长度延伸的第一内腔。第二内腔设置在管状构件的远端部分中，其具有距离导管的远端至少15个但不超过60cm的近端口以及通向可扩张笼的内部的远端口。引导线或低轮廓可导向导管可滑动地设置在第二腔内，以及管状构件，例如通过可膨胀笼内部的略微膨胀的线圈，以促进导管的快速更换。导管组件特别适用于在其中的血管手术（例如血管成形术）之后保持打开血管。

57. 发明授权

US5002560A Expandable cage catheter with a rotatable guide 失效
标题翻译：具有可旋转导轨的可扩展笼式导管
公开(公告)号：US5002560A
公开(公告)日：1991-03-26
申请号：US404818
申请日：1989-09-08
申请人： Timothy R. Machold , Michi E. Garrison
发明人： Timothy R. Machold , Michi E. Garrison
IPC分类号： A61M25/04 , A61F2/00 , A61F2/90 , A61M29/02
CPC分类号： A61F2/95 , A61F2/90 , A61M29/02 , A61F2002/9517 , A61F2250/0059 , A61F2250/0098
摘要： A steerable vascular catheter having an expandable cage mounted on the distal end of a tubular member which is radially expanded and contracted by means of a guidewire which is disposed within an inner lumen in the tubular member and secured to the distal end of the expandable cage. A helical coil is disposed about the secured to a distal portion of the guidewire which extends out the distal end of the expandable cage facilitate steering the catheter through the patient's coronary anatomy. The catheter assembly is particularly adapted to hold open a blood vessel after a vascular procedure therein such as an angioplasty.

58. 发明授权

US10327790B2 Methods and systems for treatment of acute ischemic stroke 有权
公开(公告)号：US10327790B2
公开(公告)日：2019-06-25
申请号：US13566451
申请日：2012-08-03
申请人： Michi E. Garrison , Tony M. Chou , Gregory M. Hyde , Alan K. Schaer
发明人： Michi E. Garrison , Tony M. Chou , Gregory M. Hyde , Alan K. Schaer
IPC分类号： A61M5/00 , A61B17/22 , A61B17/221 , A61M1/10 , A61M1/36 , A61M1/00 , A61M25/06 , A61M31/00 , A61M25/00 , A61F2/01 , A61B17/3203 , A61M25/01
摘要： Described are methods and systems for transcervical access of the cerebral arterial vasculature and treatment of cerebral occlusions, including ischemic stroke. The methods and devices may include methods and devices which may provide aspiration and passive flow reversal, those which protect the cerebral penumbra during the procedure to minimize injury to brain, as well as distal catheters and devices to remove an occlusion. The methods and devices that provide passive flow reversal may also offer to the user a degree of flow control. Devices and methods which provide a way to securely close the access site in the carotid artery to avoid the potentially devastating consequences of a transcervical hematoma are also described.

59. 发明授权

US08858490B2 Systems and methods for treating a carotid artery 有权
标题翻译：用于治疗颈动脉的系统和方法
公开(公告)号：US08858490B2
公开(公告)日：2014-10-14
申请号：US12834869
申请日：2010-07-12
申请人： Tony M. Chou , Michi E. Garrison , Gregory M. Hyde , Richard Renati , Alan Schaer
发明人： Tony M. Chou , Michi E. Garrison , Gregory M. Hyde , Richard Renati , Alan Schaer
IPC分类号： A61M5/00
CPC分类号： A61F2/954 , A61B17/0057 , A61B17/0218 , A61B17/0469 , A61B17/3207 , A61B2017/0065 , A61B2017/00663 , A61B2017/00668 , A61B2017/00778 , A61B2017/00986 , A61B2017/0472 , A61B2017/22047 , A61B2017/320716 , A61B2017/3482 , A61B2017/3484 , A61F2/013 , A61F2/844 , A61F2/856 , A61F2/90 , A61F2/915 , A61F2/95 , A61F2002/011 , A61F2002/065 , A61F2002/067 , A61F2002/9511 , A61F2002/9517 , A61F2250/0037 , A61M1/3613 , A61M1/3659 , A61M25/04 , A61M25/10 , A61M25/104 , A61M27/00 , A61M27/002 , A61M2025/0681 , A61M2025/1052
摘要： Systems and methods are adapted for treating the carotid artery. The systems include interventional catheters and blood vessel access devices that are adapted for transcervical insertion into the carotid artery. Embodiments of the systems and methods can be used in combination with embolic protection systems including blood flow reversal mechanisms, arterial filters, and arterial occlusion devices.
摘要翻译：系统和方法适用于治疗颈动脉。该系统包括适于宫颈插入颈动脉的介入导管和血管通路装置。系统和方法的实施例可以与包括血流反转机构，动脉过滤器和动脉闭塞装置在内的栓塞保护系统结合使用。

60. 发明授权

US08740834B2 Methods and systems for establishing retrograde carotid arterial blood flow 有权
公开(公告)号：US08740834B2
公开(公告)日：2014-06-03
申请号：US13050855
申请日：2011-03-17
申请人： Enrique Criado , Tony M. Chou , Michi E. Garrison , Gregory M. Hyde , Alan Schaer , Richard Renati
发明人： Enrique Criado , Tony M. Chou , Michi E. Garrison , Gregory M. Hyde , Alan Schaer , Richard Renati
IPC分类号： A61M5/00 , A61F2/06
CPC分类号： A61M1/3655 , A61B8/06 , A61B8/488 , A61B17/12045 , A61B17/12109 , A61B2017/00778 , A61B2017/12127 , A61B2017/320716 , A61F2/82 , A61F2/90 , A61F2/95 , A61F2/954 , A61F2002/065 , A61F2250/0037 , A61M1/34 , A61M1/36 , A61M1/3613 , A61M1/3659 , A61M5/007 , A61M25/10 , A61M29/02 , A61M39/06 , A61M39/22 , A61M2025/1052 , A61M2205/33 , A61M2205/3331 , A61M2205/3334
摘要： Interventional procedures on the carotid arteries are performed through a transcervical access while retrograde blood flow is established from the internal carotid artery to a venous or external location. A system for use in accessing and treating a carotid artery includes an arterial access device, a shunt fluidly connected to the arterial access device, and a flow control assembly coupled to the shunt and adapted to regulate blood flow through the shunt between at least a first blood flow state and at least a second blood flow state. The flow control assembly includes one or more components that interact with the blood flow through the shunt.

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