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51. 发明授权

US6047390A Multiple context software analysis 失效
标题翻译：多重上下文软件分析
公开(公告)号：US6047390A
公开(公告)日：2000-04-04
申请号：US995359
申请日：1997-12-22
申请人： Farooq Butt , Roger Smith , Katherine E. Stewart
发明人： Farooq Butt , Roger Smith , Katherine E. Stewart
IPC分类号： G06F11/34 , G06F11/36 , G06F11/00
CPC分类号： G06F11/3612 , G06F11/3466 , G06F11/3636 , G06F11/3644 , G06F11/3495
摘要： A method for multiple context analysis of software applications in a multiprocessing (22, 23), multithreaded computer environment utilizes instrumentation code inserted (54, 55) into the applications. For each execution (67) of the application (60), a context set is selected (62). Execution of the instrumented code (67) provides information for analysis in an instrumentation buffer (82) addressed by a reserved register (80) or buffer pointer. The operating system is responsible for providing in the reserved register (80) the address of the instrumentation buffer (82) appropriate for each instrumented context executed. When the application (60) is done with an instrumentation buffer (82), the buffer may be processed by filter software (68). The combination of using a reserved register (80) and allowing the operating system to keep track of relevant context switches allows applications to be instrumented (54, 55) for various context sets without the necessity of modifying (53) or recompiling (52) the application software (60).
摘要翻译：多处理（22,23）多线程计算机环境中软件应用程序的多重上下文分析方法使用插入（54,55）的测试代码。对于应用（60）的每个执行（67），选择上下文集（62）。检测代码（67）的执行提供了在由保留寄存器（80）或缓冲指针寻址的检测缓冲器（82）中进行分析的信息。操作系统负责在保留寄存器（80）中提供适用于执行的每个仪器化上下文的仪表缓冲器（82）的地址。当应用（60）用仪器缓冲器（82）完成时，缓冲器可以由滤波器软件（68）处理。使用保留寄存器（80）并允许操作系统跟踪相关上下文切换的组合允许对各种上下文集进行应用程序的检测（54,55），而不需要修改（53）或重新编译（52）应用软件（60）。

52. 发明授权

US4885950A Bevel gear backlash and clutch device 失效
标题翻译：锥齿轮齿隙和离合器装置
公开(公告)号：US4885950A
公开(公告)日：1989-12-12
申请号：US326778
申请日：1989-03-20
申请人： Roger Smith
发明人： Roger Smith
IPC分类号： F16H57/022 , F16H57/12
CPC分类号： F16H57/12 , F16H2057/0221 , F16H2057/127 , Y10T74/19623 , Y10T74/19665 , Y10T74/19688
摘要： An antibacklash beveled gear drive is disclosed. The drive is constructed adjust for intial misalignment and subsequent wear. One of the gears is journaled on a driven shaft and has a biasing means which bump the gears into engagement.
摘要翻译：公开了一种防间隙斜齿轮传动装置。驱动器被构造为调整初始偏移和随后的磨损。一个齿轮在从动轴上记录并具有将齿轮碰撞的偏置装置。

53. 发明申请

US20220282607A1 MODULAR SOLUTION MINING SYSTEM AND METHODS 有权
公开(公告)号：US20220282607A1
公开(公告)日：2022-09-08
申请号：US17687089
申请日：2022-03-04
申请人： Max Maxwell , Major Patterson , Roger Smith
发明人： Max Maxwell , Major Patterson , Roger Smith
IPC分类号： E21B43/28 , E21B43/14 , E21B43/30
摘要： A modular solution mining method may include the steps of: providing an injection wellbore, the injection wellbore including a horizontal injection portion, in which the horizontal injection portion includes a toe end and heel end; providing a production wellbore, in which the production wellbore includes a horizontal production portion that is proximate to the toe end; injecting a solvent into the horizontal injection portion; generating a turbulent solvent flow proximate to the toe end to generate a mineral solution and an initial cavern proximate to the horizontal production portion; and motivating the mineral solution from the initial cavern, into the horizontal production portion, and to a surface location. Optionally, the method may include the step of repositioning the turbulent solvent flow to be closer to heel ends to generate mineral solution and subsequent caverns further from horizontal production wellbore.

54. 发明授权

US08580798B2 Substituted pyrimidine derivatives useful in the treatment of cancer and other disorders 失效
标题翻译：可用于治疗癌症和其他疾病的取代嘧啶衍生物
公开(公告)号：US08580798B2
公开(公告)日：2013-11-12
申请号：US12158524
申请日：2006-12-20
申请人： Roger Smith , Jacques Dumas , Gan Wang , Wendy Lee , Karl Miranda
发明人： Roger Smith , Jacques Dumas , Gan Wang , Wendy Lee , Karl Miranda
IPC分类号： C07D401/12 , A61K31/506
CPC分类号： C07D401/12
摘要： Substituted pyrimidine derivatives of formula (I), salts, metabolites, prodrugs and diastereoisomeric forms (both isolated stereoisomers and mixtures of stereoisomers) thereof (wherein A=pyrimidine) pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with other active ingredients, e.g., cytotoxic therapies.
摘要翻译：式（I）的取代的嘧啶衍生物，其盐，代谢物，前药和非对映异构体形式（分离的立体异构体和立体异构体的混合物）（其中A =嘧啶）含有这些化合物的药物组合物以及这些化合物或组合物用于治疗增殖和血管生成障碍，作为唯一的药剂或与其它活性成分组合，例如细胞毒性疗法。

55. 发明申请

US20110118302A1 PREPARATION AND USE OF BIPHENYL-4-YL-CARBONYLAMINO ACID DERIVATIVES FOR THE TREATMENT OF OBESITY 审中-公开
标题翻译：联苯胺-4-甲酰氨基酸衍生物用于治疗肥胖症的制备和使用
公开(公告)号：US20110118302A1
公开(公告)日：2011-05-19
申请号：US12836035
申请日：2010-07-14
申请人： Roger Smith , Stephen J. O'Connor , Philip Coish , Derek Lowe , Roger B. Clark , Jeffrey Stebbins , Ann-Marie Campbell , Christiana Akuche , Tatiana Shelekhin
发明人： Roger Smith , Stephen J. O'Connor , Philip Coish , Derek Lowe , Roger B. Clark , Jeffrey Stebbins , Ann-Marie Campbell , Christiana Akuche , Tatiana Shelekhin
IPC分类号： A61K31/437 , A61K31/428 , A61P3/04 , A61P3/10 , A61P3/00 , A61P3/08 , A61P9/10 , A61P9/00 , A61P9/12
CPC分类号： C07D235/30 , C07D263/58 , C07D277/82 , C07D513/04
摘要： This invention relates to certain biphenyl-4-yl carbonylamino acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
摘要翻译：本发明涉及某些联苯-4-基羰基氨基酸化合物，组合物和治疗或预防肥胖症及相关疾病的方法。

56. 发明申请

US20100160371A1 INHIBITION OF P38 KINASE ACTIVITY BY ARYL UREAS 审中-公开
标题翻译： ARYL URAAS对P38激酶活性的抑制作用
公开(公告)号：US20100160371A1
公开(公告)日：2010-06-24
申请号：US12619913
申请日：2009-11-17
申请人： Gerald RANGES , William Scott , Michael Bombara , Deborah Rauner , Aniko Redman , Roger Smith , Holger Paulsen , David Gunn , Jinshan Chen , Joel Renick
发明人： Gerald RANGES , William Scott , Michael Bombara , Deborah Rauner , Aniko Redman , Roger Smith , Holger Paulsen , David Gunn , Jinshan Chen , Joel Renick
IPC分类号： A61K31/381 , A61K31/341 , A61K31/40 , A61K31/433 , A61K31/47 , A61K31/404 , A61P29/00 , A61P37/00 , A61P19/10 , A61P11/06
CPC分类号： A61K31/4709 , A61K31/341 , A61K31/381 , A61K31/40 , A61K31/4025 , A61K31/433 , Y02A50/401 , Y02A50/411 , Y02A50/414
摘要： This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases other than cancer and proteolytic enzyme mediated diseases other than cancer, and pharmaceutical compositions for use in such therapy.
摘要翻译：本发明涉及一组芳基脲在治疗癌症以外的细胞因子介导的疾病和除了癌症以外的蛋白水解酶介导的疾病以及用于这种治疗的药物组合物中的用途。

57. 发明申请

US20100150863A1 HYDROXY METHYL PHENYL PYRAZOLYL UREA COMPOUND USEFUL IN TREATMENT OF CANCER 审中-公开
标题翻译：用于治疗癌症的羟基甲基苯基吡唑啉酮尿素化合物
公开(公告)号：US20100150863A1
公开(公告)日：2010-06-17
申请号：US12520618
申请日：2007-12-20
申请人： Roger Smith , Dhanapalan Nagarathnam
发明人： Roger Smith , Dhanapalan Nagarathnam
IPC分类号： A61K38/20 , C07D401/12 , A61K31/4439 , A61P35/00 , A61P35/02 , A61K31/4375 , A61K38/21 , A61K39/395 , A61K31/566
CPC分类号： C07D401/12
摘要： The compound 4-{4-[({3-tert-Butyl-1-[3-(hydroxymethyl)phenyl]-1H-pyrazol-5-yl}-carbamoyl)amino]-3-chlorohenoxy}-N-methylpyridine-2-carboxamide and alternatives forms thereof (e.g., salts, hydrates, solvates, prodrugs, polymorphs and metabolites); pharmaceutical compositions which contain them and methods for treating cancer using them.
摘要翻译：化合物4- {4 - [（{3-叔丁基-1- [3-（羟甲基）苯基] -1H-吡唑-5-基} - 氨基甲酰基）氨基] -3-氯苯氧基} -N-甲基吡啶 - （例如盐，水合物，溶剂合物，前药，多晶型物和代谢物）; 含有它们的药物组合物和使用它们治疗癌症的方法。

58. 发明申请

US20100040439A1 SLIDE PROCESSING APPARATUS AND METHOD 有权
标题翻译：滑动加工设备和方法
公开(公告)号：US20100040439A1
公开(公告)日：2010-02-18
申请号：US12440444
申请日：2007-09-08
申请人： John Temple , Ian Kerrod , Alan Prile , Roger Smith , Stephen Hankey
发明人： John Temple , Ian Kerrod , Alan Prile , Roger Smith , Stephen Hankey
IPC分类号： B65H1/00
CPC分类号： G01N1/312 , G01N35/00029 , G01N35/00871 , G01N2001/315 , G01N2035/00079 , G01N2035/00089 , G01N2035/00138 , G01N2035/0462 , G01N2035/0493
摘要： The present invention is concerned with a basket processing apparatus that includes a basket storage portion in a form of a horizontal load rail (2). A plurality of slide storage baskets (4) can be located in series on the rail (2). Each basket is “side loading” and the side loading aperture of each basket can be selectively covered by a slide retaining bar (6). When the baskets (4) are placed on the load rail (2) (e.g. by hooking or clipping the baskets onto the rail), the basket can be moved along the horizontal rail by a basket moving means. The arrangement of the rail and the basket moving means is such that the baskets can be pushed together and move as a “train”. Baskets moved to the pick-up end (12) of the rail can then be removed from the rail and processed. A vertical lift mechanism can be used to remove the basket and transport it to a processing device, for example a coverslipper.
摘要翻译：本发明涉及一种篮子处理装置，其包括水平承载轨道（2）形式的篮子储存部分。可以在轨道（2）上串联设置多个滑动存放篮（4）。每个篮子是“侧面装载”，并且每个篮子的侧面装载孔可以被滑动保持杆（6）选择性地覆盖。当篮子（4）放置在承载轨道（2）上（例如通过将篮子钩住或夹住轨道）时，篮子可以通过篮子移动装置沿着水平轨道移动。轨道和篮子移动装置的布置使得篮子可以一起推动并作为“列车”移动。移动到轨道的拾取端（12）的篮子然后可以从轨道移除并被处理。可以使用垂直提升机构来移除篮子并将其运送到处理装置，例如盖玻片。

59. 发明申请

US20090253762A1 PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY 失效
公开(公告)号：US20090253762A1
公开(公告)日：2009-10-08
申请号：US12206721
申请日：2008-09-08
申请人： Roger Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
发明人： Roger Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
IPC分类号： A61K31/428 , C07D277/82 , C07D413/02 , A61K31/416 , A61K31/423 , C07D405/02
CPC分类号： C07D263/58 , C07D235/30 , C07D263/60 , C07D277/42 , C07D277/58 , C07D277/82 , C07D405/12 , C07D413/12 , C07D417/12
摘要： This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.

60. 发明申请

US20080214545A1 Substituted Pyrazolyl Urea Derivatives Useful in the Treatment of Cancer 失效
标题翻译：用于治疗癌症的替代吡唑基脲衍生物
公开(公告)号：US20080214545A1
公开(公告)日：2008-09-04
申请号：US11579093
申请日：2005-05-02
申请人： Wendy Lee , Gaetan Ladouceur , Jacques Dumas , Roger Smith , Shihong Ying , Gan Wang , Zhi Chen , Qingjie Liu , Holia Hatoum Mokdad
发明人： Wendy Lee , Gaetan Ladouceur , Jacques Dumas , Roger Smith , Shihong Ying , Gan Wang , Zhi Chen , Qingjie Liu , Holia Hatoum Mokdad
IPC分类号： A61K31/5377 , C07D401/12 , C07D413/14 , A61P35/02 , A61P35/00 , A61K31/4439
CPC分类号： C07D401/12 , C07D405/14
摘要： The present invention relates to compounds of formula (I), pharmaceutical compositions which contain them and methods for treating cancer using compounds of formula (I).
摘要翻译：本发明涉及式（I）化合物，含有它们的药物组合物和使用式（I）化合物治疗癌症的方法。

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