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51. 发明授权

US08703155B2 Method of stabilizing reduced coenzyme q10 有权
标题翻译：稳定还原型辅酶Q10的方法
公开(公告)号：US08703155B2
公开(公告)日：2014-04-22
申请号：US10492122
申请日：2002-10-10
申请人： Takahiro Ueda , Tadao Ono , Mitsutoshi Moro , Shiro Kitamura , Yasuyoshi Ueda
发明人： Takahiro Ueda , Tadao Ono , Mitsutoshi Moro , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： A61K38/43 , A61K9/00
CPC分类号： A61K31/122 , A61K9/4866 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/22 , B01D9/00 , C07C41/26 , C07C41/40 , C07C41/46 , C07C43/23
摘要： The present invention provides a stabilization method, a preservation method and the like method of reduced coenzyme Q10, which is useful as functional nutritive foods, specific health foods and the like. Furthermore, the present invention provides a method for efficiently obtaining reduced coenzyme Q10 of high quality and by a method suitable for a commercial production. It is possible to handle and stably preserve reduced coenzyme Q10 under a condition that oxidation by a molecular oxygen is inhibited by contacting reduced coenzyme Q10 with an ascorbic acid and citric acid or a related compound thereof, and thus a stabilized composition is obtained. Moreover, reduced coenzyme Q10 is converted into a crystalline state in such a condition that the formation of oxidized coenzyme Q10 as a byproduct is minimized by crystallizing reduced coenzyme Q10 in the presence of ascorbic acid or a related compound thereof, etc., and thus a reduced coenzyme Q10 crystal of high quality is produced. Furthermore, by successively crystallizing the generated reduced coenzyme Q10, in the presence of ascorbic acid or related compound thereof after reducing oxidized coenzyme Q10 to reduced coenzyme Q10 using ascorbic acid or a related compound thereof, operations are simplified and minimized, and thus reduced coenzyme Q10 of high quality is produced.
摘要翻译：本发明提供还原型辅酶Q10的稳定化方法，保存方法等，其作为功能性营养食品，特定健康食品等有用。此外，本发明提供了一种有效地获得高质量的还原型辅酶Q10的方法，以及适用于商业生产的方法。在减少的辅酶Q10与抗坏血酸和柠檬酸或其相关化合物接触的条件下，通过分子氧的氧化被抑制的条件下，可以处理和稳定地保持还原型辅酶Q10，从而得到稳定的组合物。此外，将还原型辅酶Q10转化为结晶状态，使得在抗坏血酸或其相关化合物等的存在下使还原型辅酶Q10结晶化，使作为副产物的氧化型辅酶Q10的形成最小化，生产高品质的还原型辅酶Q10晶体。此外，通过使生成的还原型辅酶Q10连续结晶，在使用抗坏血酸或其相关化合物还原氧化型辅酶Q10至还原型辅酶Q10后，在抗坏血酸或其相关化合物的存在下，操作简化并最小化，从而减少了辅酶Q10 生产高品质。

52. 发明授权

US08232389B2 Method for crystallization of azetidinonecarboxylic acid 失效
标题翻译：氮杂环丁烷羧酸结晶方法
公开(公告)号：US08232389B2
公开(公告)日：2012-07-31
申请号：US12308413
申请日：2007-06-13
申请人： Keita Nishino , Teruyoshi Koga , Masafumi Fukae , Yasuyoshi Ueda
发明人： Keita Nishino , Teruyoshi Koga , Masafumi Fukae , Yasuyoshi Ueda
IPC分类号： C07F7/18
CPC分类号： C07F7/1804
摘要： The present invention relates to a method for crystallization of (2R)-2-{(3S,4S)-3-[(1R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-oxoazetidin-4-yl}propionic acid, and is characterized in that crystallization is carried out by mixing a solution containing the compound with a substituted aromatic hydrocarbon solvent and/or a halogenated hydrocarbon solvent. The method can provide a crystal of the compound with a high purity and a high yield while the content of 2S isomer is kept at a low level.
摘要翻译：本发明涉及（2R）-2 - {（3S，4S）-3 - [（1R）-1-（叔丁基二甲基甲硅烷氧基）乙基] -2-氧代氮杂环丁烷-4-基}丙酸其特征在于，通过将含有该化合物的溶液与取代的芳烃溶剂和/或卤代烃溶剂混合来进行结晶。该方法可以提供具有高纯度和高产率的化合物的晶体，而2S异构体的含量保持在低水平。

53. 发明授权

US07253299B2 Process for purifying n2-(1(s)-ethoxycarbonyl-3-phenylpropyl)-n6-thifluoroacetyl-l-lysine 失效
标题翻译：纯化N2-（1（s） - 乙氧基羰基-3-苯基丙基）-n6-三氟乙酰基-1-赖氨酸的方法
公开(公告)号：US07253299B2
公开(公告)日：2007-08-07
申请号：US10432288
申请日：2002-07-10
申请人： Yasuhiro Iida , Hajime Manabe , Yasuyoshi Ueda
发明人： Yasuhiro Iida , Hajime Manabe , Yasuyoshi Ueda
IPC分类号： C07C229/00 , C07C51/42
CPC分类号： C07C231/24 , C07C233/47
摘要： A process for purifying N2-(1(S)-ethoxycarbonyl-3-phenylpropyl)-N6-trifluoroacetyl-L-lysine which comprises subjecting N2-(1(S)-ethoxycarbonyl-3-phenylpropyl)-N6-trifluoroacetyl-L-lysine contaminated with impurities to crystallization from a solvent comprising a water-soluble non-protic organic solvent, thereby removing the impurities into the mother liquor and giving crystals of N2-(1(S)-ethoxycarbonyl-3-phenylpropyl)-N6-trifluoroacetyl-L-lysine, according to which N2-(1(S)-ethoxycarbonyl-3-phenylpropyl)-N6-trifluoroacetyl-L-lysine having a high quality can be obtained in a high yield and a high productivity and which is suitable for practice on an industrial scale.
摘要翻译：一种纯化N 2 - （1（S） - 乙氧基羰基-3-苯基丙基）-N 6 - 三氟乙酰基-L-赖氨酸的方法，其包括使N 2 - 被杂质污染的（1（S） - 乙氧基羰基-3-苯基丙基）-N 6 - 三氟乙酰基-L-赖氨酸从包含水溶性非质子有机物溶剂，从而将杂质除去到母液中，得到N 2 - （1（S） - 乙氧基羰基-3-苯基丙基）-N 6 - 三氟乙酰基-L - 赖氨酸，其中具有高质量的N 2 - （1（S） - 乙氧基羰基-3-苯基丙基）-N 6 - 三氟乙酰基-L-赖氨酸可以是以高产量和高生产率获得，适用于工业规模的实践。

54. 发明授权

US07208639B2 Method of producing reduced coenzyme Q10 as oily product 有权
标题翻译：还原型辅酶Q10作为油性产品的生产方法
公开(公告)号：US07208639B2
公开(公告)日：2007-04-24
申请号：US10483870
申请日：2002-07-15
申请人： Takahiro Ueda , Shiro Kitamura , Yasuyoshi Ueda
发明人： Takahiro Ueda , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： C07C41/18
CPC分类号： C07C41/26 , C07C41/34 , C07C43/23
摘要： The present invention provides a method for obtaining reduced coenzyme Q10 which is useful as an ingredient in foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, drinks, feeds, cosmetics, medicines, remedies, preventive drugs, etc. suited for a commercial scale production in high quality and efficiently.The high-quality oily reduced coenzyme Q10 which has low viscosity and thereby easily handled may be produced by separating an aqueous phase from the reaction mixture obtainable by oily reacting oxidized coenzyme Q10 with a reducing agent in water, or by distilling off an coexisting organic solvent at or above the melting temperature of reduced coenzyme Q10 in concentrating the organic phase containing reduced coenzyme Q10. Moreover, a solution or slurry of reduced coenzyme Q10 may be obtained by adding a desired solvent to the obtained oily product, or a solid of reduced coenzyme Q10 may be produced by contacting the oily product with a seed crystal.
摘要翻译：本发明提供一种用于获得还原型辅酶Q 10的方法，其可用作食品，功能营养食品，特定保健食品，营养补充剂，营养物质，饮料，饲料，化妆品，药物，补救剂中的成分，预防药物等，适用于高质量，高效的商业规模生产。具有低粘度并因此容易处理的高品质油性还原型辅酶Q 10 N可以通过将水相从可通过油性反应氧化型辅酶Q 10 在还原型辅酶Q 10的有机相中浓缩还原型辅酶Q 10的有机相，或者通过在还原型辅酶Q 10的熔解温度下蒸馏掉共存的有机溶剂， >。此外，可以通过向得到的油性产品中加入所需的溶剂，或者可以生产还原型辅酶Q 10的固体来获得还原型辅酶Q 10 N的溶液或浆液通过将油状产物与晶种接触。

55. 发明授权

US07145044B2 Method of producing reduced coenzyme Q10 using solvent with high oxidation-protective effect 有权
标题翻译：使用具有高氧化保护作用的溶剂生产还原型辅酶Q10的方法
公开(公告)号：US07145044B2
公开(公告)日：2006-12-05
申请号：US10483604
申请日：2002-07-15
申请人： Takahiro Ueda , Shiro Kitamura , Yasuyoshi Ueda
发明人： Takahiro Ueda , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： C07C35/18 , C07C50/04 , C12N15/00
CPC分类号： C07C41/26 , C07C41/46 , C07C43/23 , Y10S435/816
摘要： The present invention relates to a method of conveniently and efficiently producing reduced coenzyme Q10 having excellent qualities which is useful in foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, drinks, feeds, animal drugs, cosmetics, medicines, remedies, preventive drugs, etc. This method is suitable for industrial production thereof.In a method of synthesizing reduced coenzyme Q10 by reducing oxidized coenzyme Q10, followed by crystallization, at least one species selected from among hydrocarbons, fatty acid esters, ethers and nitrites is used as a solvent. Thus, the reduced coenzyme Q10 can be protected from oxidation, and as a result, the formation of the oxidized coenzyme Q10 as a by-product can be minimized, thereby giving reduced coenzyme Q10 having excellent qualities.
摘要翻译：本发明涉及一种方便有效地生产具有优良品质的还原型辅酶Q 10的方法，其可用于食品，功能营养食品，特定保健食品，营养补充剂，营养物，饮料，饲料，动物药品，化妆品，药品，补救措施，预防药品等。该方法适用于工业生产。在通过还原氧化型辅酶Q 10 N合成还原型辅酶Q 10的方法中，随后结晶，选自烃，脂肪酸酯，醚和亚硝酸盐中的至少一种用作溶剂。因此，可以防止还原型辅酶Q 10被氧化，结果可以使作为副产物的氧化型辅酶Q 10的形成最小化，从而给出具有优异品质的还原型辅酶Q 10。

56. 发明申请

US20060147542A1 Solid preparation containing reduced coenzyme Q10 and method for producing the same 审中-公开
标题翻译：含有还原型辅酶Q10的固体制剂及其制备方法
公开(公告)号：US20060147542A1
公开(公告)日：2006-07-06
申请号：US11315159
申请日：2005-12-23
申请人： Tadao Ono , Takahiro Ueda , Shiro Kitamura , Yasuyoshi Ueda
发明人： Tadao Ono , Takahiro Ueda , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： A61K38/43 , A61K9/50 , A61K9/16
CPC分类号： A61K9/2054 , A61K9/286 , A61K9/2866
摘要： The present invention has its object to provide a solid preparation containing reduced coenzyme Q10 with high stability by protecting reduced coenzyme Q10 against oxidization to oxidized coenzyme Q10 by molecular oxygen. The present invention provides a solid preparation containing reduced coenzyme Q10 which comprises a solid composition containing reduced coenzyme Q10 coated with at least one coating medium selected from among oil-soluble coating media and water-soluble coating media. The present invention also provides a method for stabilizing a solid preparation containing reduced coenzyme Q10, wherein a solid composition containing reduced coenzyme Q10 is coated with at least one coating medium selected from among oil-soluble coating media and water-soluble coating media to thereby stabilize the resulting solid preparation containing reduced coenzyme Q10.
摘要翻译：本发明的目的是提供一种含有还原型辅酶Q 10的固体制剂，其具有高度的稳定性，通过将还原型辅酶Q 10保护氧化成氧化型辅酶Q 10， / SUB>。本发明提供了含有还原型辅酶Q 10固体制剂，其包含含有还原型辅酶Q 10的固体组合物，所述还原型辅酶包被至少一种选自油溶性涂层介质和水溶性涂料介质。本发明还提供了一种用于稳定含有还原型辅酶Q 10 N的固体制剂的方法，其中含有还原型辅酶Q 10的固体组合物涂覆有至少一种选择的涂层介质从油溶性涂层介质和水溶性涂层介质中，由此使得到的含有还原型辅酶Q 10的固体制剂稳定。

57. 发明授权

US07071349B2 Purification method of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine 失效
标题翻译： N-（1（S） - 乙氧基羰基-3-苯基丙基）-L-丙氨酸的纯化方法
公开(公告)号：US07071349B2
公开(公告)日：2006-07-04
申请号：US10311060
申请日：2002-03-19
申请人： Akira Matsumoto , Michio Nomura , Yoshikazu Kogame , Yasuyoshi Ueda
发明人： Akira Matsumoto , Michio Nomura , Yoshikazu Kogame , Yasuyoshi Ueda
IPC分类号： C07C229/00
CPC分类号： C07C227/42 , C07C229/36
摘要： The present invention is to provide a purification method of obtaining N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine of high quality in good yield with high productivity, which is accordingly suited for commercial scale application.An impurity-contaminated N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine is crystallized from a mixed solvent of alcohol and water in a volume ratio of alcohol/water being 1 to 20 to remove a contaminating impurity into a mother liquor and give crystals of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine.
摘要翻译：本发明提供以高生产率获得高质量的N-（1（S） - 乙氧基羰基-3-苯基丙基）-L-丙氨酸的纯化方法，因此适用于商业规模应用。杂质污染的N-（1（S） - 乙氧基羰基-3-苯基丙基）-L-丙氨酸从酒精和水的混合溶剂中以醇/水的体积比为1至20结晶，以除去污染杂质母液，得到N-（1（S） - 乙氧羰基-3-苯基丙基）-L-丙氨酸晶体。

58. 发明申请

US20050226858A1 Compositions containing reduced coenzyme Q10 and carotenoid 审中-公开
标题翻译：含有还原型辅酶Q10和类胡萝卜素的组合物
公开(公告)号：US20050226858A1
公开(公告)日：2005-10-13
申请号：US11101437
申请日：2005-04-08
申请人： Shiro Kitamura , Takahiro Ueda , Kenji Fujii , Yasuyoshi Ueda
发明人： Shiro Kitamura , Takahiro Ueda , Kenji Fujii , Yasuyoshi Ueda
IPC分类号： A61K31/015 , A61K31/07 , A61K38/43
CPC分类号： A61K31/015 , A61K31/07 , A61K2300/00
摘要： A composition having an antioxidative activity, especially, having a sufficient activity for removing active oxygen and/or free radicals is provided. The composition includes both reduced coenzyme Q10 and a carotenoid, and the activity for removing active oxygen and/or free radicals is synergistically enhanced. A method for removing active oxygen and/or free radicals by using the composition containing both reduced coenzyme Q10 and a carotenoid is also provided.
摘要翻译：提供具有抗氧化活性的组合物，特别是具有足够的活性氧和/或自由基活性的活性。该组合物包括还原型辅酶Q 10和类胡萝卜素，并且促进除去活性氧和/或自由基的活性协同增强。还提供了通过使用含有还原型辅酶Q 10和类胡萝卜素的组合物除去活性氧和/或自由基的方法。

59. 发明授权

US06344572B1 Processes for the preparation of threo-1,2-epoxy-3-amino-4-phenylbutane derivatives 有权
标题翻译：制备苏式-1,2-环氧-3-氨基-4-苯基丁烷衍生物的方法
公开(公告)号：US06344572B1
公开(公告)日：2002-02-05
申请号：US09647340
申请日：2000-11-17
申请人： Katsuji Maehara , Yukinori Tokuda , Hiroshi Murao , Yasuyoshi Ueda
发明人： Katsuji Maehara , Yukinori Tokuda , Hiroshi Murao , Yasuyoshi Ueda
IPC分类号： C07D30102
CPC分类号： C07D301/26 , C07D303/36
摘要： The present invention provides a production method of high quality threo-1,2-epoxy-3-amino-4-phenylbutane derivatives (1) on a commercial scale in a simple, easy and efficient manner and with very high productivity, which comprises treating a threo-1-halo-2-hydroxy-3-amino-4-phenylbutane derivative (2) with a base in a polar organic solvent or a solvent composed of a polar organic solvent and water, and adding the resulting reaction mixture to water to thereby cause the resulting threo-1,2-epoxy-3-amino-4-phenylbutane derivative (1) to crystallize out.
摘要翻译：本发明以简单，容易和有效的方式以非常高的生产率提供了高质量的threo-1,2-epoxy-3-氨基-4-苯基丁烷衍生物（1）的制备方法，其包括处理在极性有机溶剂或由极性有机溶剂和水组成的溶剂中的碱，将苏-1-卤代-2-羟基-3-氨基-4-苯基丁烷衍生物（2）与碱反应，并将得到的反应混合物加入到水从而使得到的所述苏-12-环氧-3-氨基-4-苯基丁烷衍生物（1）结晶出来。

60. 发明授权

US06218552B1 3-phenyl-7-[4-(tetrahydrofurfuryloxy)phenyl]-1,5-dioxa-s-indacene-2,6-dione 失效
标题翻译： 3-苯基-7- [4-（四氢呋喃氧基）苯基] -1,5-二氧杂-s-引丙烯-2,6-二酮
公开(公告)号：US06218552B1
公开(公告)日：2001-04-17
申请号：US08229671
申请日：1994-04-19
申请人： Junichi Sekihachi , Jun Yamamoto , Yasuyoshi Ueda
发明人： Junichi Sekihachi , Jun Yamamoto , Yasuyoshi Ueda
IPC分类号： C07D30777
CPC分类号： C09B67/0025 , C09B57/00 , Y10T428/2913 , Y10T428/2915
摘要： A compound, 3-phenyl-7-[4-(tetrahydrofurfuryloxy)phenyl]-1,5-dioxa-s-indacene-2,6-dione, which has a structure of crystals exhibiting the strongest peak at an angle of diffraction, 2&thgr;, of 4.7°, among peaks appearing within the range of not smaller than 3° of 2&thgr;, in an X-ray diffraction using a Cu-K&agr;-ray. The compound gives dyed or printed products having deep and brilliant tint of colors with excellent fastnesses, when applied to hydrophobic fiber materials, particularly, polyester fiber materials.
摘要翻译：具有在衍射角呈现最强峰的结晶结构的化合物3-苯基-7- [4-（四氢呋喃氧基）苯基] -1,5-二氧杂-s-引丙烯-2,6-二酮，在使用Cu-Kalpha射线的X射线衍射中，出现在不大于3θ的范围内的峰之间的4.7°的2θ。当应用于疏水性纤维材料，特别是聚酯纤维材料时，该化合物产生具有优异坚牢度的深色和辉煌色彩的染色或印刷产品。

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