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51. 发明授权

US08420117B2 Patch formulation for external use 有权
标题翻译：补丁配方外用
公开(公告)号：US08420117B2
公开(公告)日：2013-04-16
申请号：US12831190
申请日：2010-07-06
申请人： Hideharu Chono , Toshiro Yamaguchi , Hisakazu Kurita , Tetsuro Tateishi , Naruhito Higo
发明人： Hideharu Chono , Toshiro Yamaguchi , Hisakazu Kurita , Tetsuro Tateishi , Naruhito Higo
IPC分类号： A61K9/70 , A61K9/14 , A61K31/24 , A61L15/00 , A61L15/16
CPC分类号： A61K9/7053 , A61K47/12
摘要： A patch formulation for external use where a basic drug, an organic acid and an organic acid salt are combined as essential components is disclosed. The basic drug is preferably in the form of its acid addition salt. The organic acid is preferably a carboxylic acid having carbon atoms of 2 to 7, and more preferably at least one acid selected from the group consisting of acetic, lactic, tartaric, citric, malic, benzoic and salicylic acids. The organic acid salt is preferably a metal salt of a carboxylic acid, and more preferably sodium acetate.
摘要翻译：公开了将碱性药物，有机酸和有机酸盐组合为必需成分的外用贴剂。碱性药物优选为其酸加成盐的形式。有机酸优选为碳原子数为2〜7的羧酸，更优选为选自乙酸，乳酸，酒石酸，柠檬酸，苹果酸，苯甲酸和水杨酸中的至少一种酸。有机酸盐优选为羧酸的金属盐，更优选为乙酸钠。

52. 发明授权

US07883719B2 Pasting agent 有权
标题翻译：贴剂
公开(公告)号：US07883719B2
公开(公告)日：2011-02-08
申请号：US10525644
申请日：2003-08-07
申请人： Takeshi Ito , Tetsuro Tateishi , Naruhito Higo
发明人： Takeshi Ito , Tetsuro Tateishi , Naruhito Higo
IPC分类号： A61L15/44 , A61F13/02 , A61K8/02
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/221 , A61K47/12 , A61K47/32
摘要： A patch comprising a backing layer and an adhesive layer disposed on the backing layer and compounded with an adhesive agent and oxybutynin and/or a pharmaceutically acceptable salt thereof, wherein the adhesive agent comprises an acrylic polymer substantially free of both carboxyl group and hydroxyl group and a rubber polymer, in which weight ratio of content of the acrylic polymer to content of the rubber polymer is from 1:4 to 1:19.
摘要翻译：一种贴剂，其包括背衬层和设置在背衬层上并与粘合剂和奥昔布宁和/或其药学上可接受的盐复合的粘合剂层，其中所述粘合剂包含基本上不含羧基和羟基的丙烯酸聚合物，橡胶聚合物，其中丙烯酸类聚合物的含量与橡胶聚合物的含量的重量比为1:4至1:19。

53. 发明授权

US07504114B1 Preparations for percutaneous absorption 有权
标题翻译：经皮吸收制剂
公开(公告)号：US07504114B1
公开(公告)日：2009-03-17
申请号：US09958624
申请日：2000-04-07
申请人： Hisakazu Kurita , Tetsuro Tateishi , Tatsuaki Suzuki , Naruhito Higo
发明人： Hisakazu Kurita , Tetsuro Tateishi , Tatsuaki Suzuki , Naruhito Higo
IPC分类号： A61K9/70 , A61L15/16
CPC分类号： A61K9/7053 , A61K9/0014 , A61K9/7076 , A61K47/12
摘要： Preparations for percutaneous absorption comprising a basic drug or its salt dissolved in a liquid component and having an enhanced percutaneous absorbability and a safety to the skin, i.e., the administration site. The preparations for percutaneous absorption, preferably patches, contain a basic drug or its salt, an organic acid or its salt and a liquid component having a solubility parameter of from 7 to 13 (cal/cm3)1/2 and a have a very excellent skin permeability of the drug.
摘要翻译：用于经皮吸收的制剂，其包含溶解在液体组分中的碱性药物或其盐，并且具有增强的经皮吸收性和对皮肤的安全性，即给药部位。用于经皮吸收的制剂，优选片剂含有碱性药物或其盐，有机酸或其盐和溶解度参数为7至13（cal / cm 3）1/2的液体组分和具有非常优异的药物的皮肤渗透性。

54. 发明授权

US07502654B2 Electrode device having recessed part 失效
标题翻译：具有凹部的电极装置
公开(公告)号：US07502654B2
公开(公告)日：2009-03-10
申请号：US10517535
申请日：2003-06-11
申请人： Kenji Mori , Hiroyuki Maeda , Naruhito Higo , Shuji Sato , Yasushi Fuchita , Tatsuya Ogawa , Saori Takahashi
发明人： Kenji Mori , Hiroyuki Maeda , Naruhito Higo , Shuji Sato , Yasushi Fuchita , Tatsuya Ogawa , Saori Takahashi
IPC分类号： A61N1/00
CPC分类号： A61N1/0492 , A61B2562/187 , A61N1/0424 , A61N1/044 , A61N1/0448
摘要： The invention provides an electrode device that prevents disconnection of an electrode layer effectively by reducing stress at the time when a recess is formed.An electrode device (10) has a protrusion (70), which projects upward, in the part of an outward flange section (110f), other than a recess (60) formed by molding. The protrusion (70) is arranged so as to surround an outer periphery of the recess (60). When the recess (60) is cold-pressed, the protrusion (70) prevents warp (warp waving along a peripheral direction) in the outward flange section (110f) from occurring. Consequently, the protrusion (70) also eases warp of an electrode layer (30) extending on the outward flange section (110f) and prevents disconnection of the electrode layer (30).
摘要翻译：本发明提供一种电极装置，其通过在形成凹部时减少应力来有效地防止电极层的断开。电极装置（10）具有在外部凸缘部（110f）的不同于通过模制形成的凹部（60）的一部分中向上方突出的突起（70）。突出部70配置成包围凹部60的外周。当凹部（60）被冷压时，突起（70）防止在向外的凸缘部（110f）中发生翘曲（沿周向的翘曲）。因此，突起（70）也可以缓和在外侧凸缘部（110f）上延伸的电极层（30）的翘曲，防止电极层（30）断开。

55. 发明申请

US20070184097A1 Adhesive preparations 审中-公开
标题翻译：粘合剂
公开(公告)号：US20070184097A1
公开(公告)日：2007-08-09
申请号：US11725929
申请日：2007-03-20
申请人： Hisakazu Kurita , Tetsuro Tateishi , Hideharu Chono , Naruhito Higo
发明人： Hisakazu Kurita , Tetsuro Tateishi , Hideharu Chono , Naruhito Higo
IPC分类号： A61K31/74
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/135 , A61K31/137 , A61K31/138 , A61K31/14 , A61K31/165 , A61K31/167 , A61K31/215 , A61K31/222 , A61K31/415 , A61K31/433 , A61K31/445 , A61K31/4535 , A61K31/55
摘要： Adhesive preparations with improved percutaneous absorption of physiologically active substances, in particular, matrix adhesive preparations containing a base drug salt and an organic acid salt having an mean diameter of from 0.1 to 100 μm are provided.
摘要翻译：提供具有改善的生理活性物质的经皮吸收的粘合剂制剂，特别是含有基础药物盐和平均直径为0.1至100μm的有机酸盐的基质粘合剂制剂。

56. 发明申请

US20070158227A1 Plaster enclosing packaging bag 审中-公开
标题翻译：石膏包装袋
公开(公告)号：US20070158227A1
公开(公告)日：2007-07-12
申请号：US10587834
申请日：2005-01-28
申请人： Satoshi Amano , Sachiko Honma , Tetsuro Tateishi , Naruhito Higo
发明人： Satoshi Amano , Sachiko Honma , Tetsuro Tateishi , Naruhito Higo
IPC分类号： A61B19/02 , B65D73/00 , B65D81/26
CPC分类号： A61K9/7053 , A61J1/00 , A61K9/7061 , A61K31/138 , B65D75/26
摘要： An object of the present invention is to provide a patch-containing packaging pouch which enables stable storage of a patch containing bisoprolol in a pressure-sensitive adhesive layer. A packaged desiccant 1 of the present invention has a packaging pouch 8 composed of a pair of laminated package members 7a and 7b arranged in mutual opposition, and a patch 10 housed in the space within this packaging pouch 8. Patch 10 is provided with a support 12 and a pressure-sensitive adhesive layer 14 laminated substantially over the entire surface of one side of this support 12. In addition, the pressure-sensitive adhesive layer is composed of a pressure-sensitive adhesive composition containing a pressure-sensitive adhesive and bisoprolol or pharmaceutically acceptable salt thereof. Moreover, a packaged desiccant 20 is housed within packaging pouch 8. The relative humidity within packaging pouch 8 is maintained at 25% or less in a patch-containing packaging pouch 1 having this constitution.
摘要翻译：本发明的目的是提供一种能够在压敏粘合剂层中稳定地储存含有比索洛尔的贴剂的贴剂的包装袋。本发明的包装干燥剂1具有由相互相对设置的一对层叠包装构件7a和7b组成的包装袋8和容纳在该包装袋8内的空间中的贴片10。贴片10设置有基本上在该支撑体12的一侧的整个表面上层叠的支撑体12和压敏粘合剂层14。此外，压敏粘合剂层由含有压敏粘合剂和比索洛尔或其药学上可接受的盐的压敏粘合剂组合物组成。此外，包装干燥剂20容纳在包装袋8内。在具有这种结构的贴片包装袋1中，包装袋8内的相对湿度保持在25％以下。

57. 发明申请

US20070009588A1 Adhesive patch 有权
标题翻译：胶贴
公开(公告)号：US20070009588A1
公开(公告)日：2007-01-11
申请号：US10527710
申请日：2003-09-12
申请人： Takeshi Ito , Tetsuro Tateishi , Naruhito Higo
发明人： Takeshi Ito , Tetsuro Tateishi , Naruhito Higo
IPC分类号： A61K31/445 , A61K9/70
CPC分类号： A61K31/4453 , A61K9/7053 , A61K9/7076
摘要： An adhesive patch for percutaneous fentanyl administration which is easily produced, has long-term continuity, and is excellent in adhesion and conformability to the skin. The adhesive patch comprises a backing layer and a pressure-sensitive adhesive layer formed on one side thereof, wherein the pressure-sensitive adhesive layer comprises fentanyl as an active ingredient, a pressure-sensitive adhesive base, and a tackifier resin, the pressure-sensitive adhesive base comprising polyisobutylene and a styrene/isoprene/styrene block copolymer, the proportion of the polyisobutylene in the adhesive base being, 8 to 15 wt. %, and the ratio of the concentration of the polyisobutylene to that of the styrene/isoprene/styrene block copolymer being from 2/3 to 3/2.
摘要翻译：用于经皮芬太尼给药的粘合贴剂易于生产，具有长期的连续性，并且具有优异的粘附性和对皮肤的适应性。粘合贴剂包括背衬层和在其一侧形成的压敏粘合剂层，其中压敏粘合剂层包含芬太尼作为活性成分，压敏粘合剂基底和增粘树脂，压敏粘合剂层包含聚异丁烯和苯乙烯/异戊二烯/苯乙烯嵌段共聚物的粘合剂基料，粘合剂基质中聚异丁烯的比例为8〜15wt。％，聚异丁烯的浓度与苯乙烯/异戊二烯/苯乙烯嵌段共聚物的浓度的比例为2/3〜3/2。

58. 发明申请

US20060206186A1 Electrode device having recessed part 失效
标题翻译：具有凹部的电极装置
公开(公告)号：US20060206186A1
公开(公告)日：2006-09-14
申请号：US10517535
申请日：2003-06-11
申请人： Kenji Mori , Hiroyuki Maeda , Naruhito Higo , Shuji Sato , Yasushi Fuchita , Tatsuya Ogawa , Saori Takahashi
发明人： Kenji Mori , Hiroyuki Maeda , Naruhito Higo , Shuji Sato , Yasushi Fuchita , Tatsuya Ogawa , Saori Takahashi
IPC分类号： A61N1/04
CPC分类号： A61N1/0492 , A61B2562/187 , A61N1/0424 , A61N1/044 , A61N1/0448
摘要： The invention provides an electrode device that prevents disconnection of an electrode layer effectively by reducing stress at the time when a recess is formed. An electrode device (10) has a protrusion (70), which projects upward, in the part of an outward flange section (110f), other than a recess (60) formed by molding. The protrusion (70) is arranged so as to surround an outer periphery of the recess (60). When the recess (60) is cold-pressed, the protrusion (70) prevents warp (warp waving along a peripheral direction) in the outward flange section (110f) from occurring. Consequently, the protrusion (70) also eases warp of an electrode layer (30) extending on the outward flange section (110f) and prevents disconnection of the electrode layer (30).
摘要翻译：本发明提供一种电极装置，其通过在形成凹部时减少应力来有效地防止电极层的断开。电极装置（10）具有突出部（70），该突起部（70）在除了通过模制形成的凹部（60）之外的向外的凸缘部分（110f）的一部分中向上突出。突出部70配置成包围凹部60的外周。当凹部（60）被冷压时，突起（70）防止在向外的凸缘部（110f）中的翘曲（沿着周向的翘曲）发生。因此，突起（70）还可以缓和在外侧凸缘部（110f）上延伸的电极层（30）的翘曲，并防止电极层（30）断开。

59. 发明申请

US20050260255A1 Adhesive patch 有权
标题翻译：胶贴
公开(公告)号：US20050260255A1
公开(公告)日：2005-11-24
申请号：US10525646
申请日：2003-08-07
申请人： Takaaki Terahara , Kazunosuke Aida , Arata Toshimitsu , Naruhito Higo
发明人： Takaaki Terahara , Kazunosuke Aida , Arata Toshimitsu , Naruhito Higo
IPC分类号： A61K9/70 , A61K31/405 , A61K31/4422 , A61K31/48 , A61K47/06 , A61K47/12 , A61K47/32
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/405 , A61K31/4422 , A61K31/48
摘要： A patch comprising a backing layer and an adhesive layer disposed on the backing layer and compounded with a drug and an adhesive base agent, wherein the adhesive base agent comprises styrene-isoprene-styrene block copolymer, 2-ethylhexyl acrylate—vinyl acetate copolymer and a basic nitrogen-including polymer including a basic nitrogen and having no adhesion property at normal temperature.
摘要翻译：一种贴剂，包括背衬层和设置在背衬层上并与药物和粘合剂基剂复配的粘合剂层，其中所述粘合剂基剂包括苯乙烯 - 异戊二烯 - 苯乙烯嵌段共聚物，丙烯酸2-乙基己酯 - 乙酸乙烯酯共聚物和碱性含氮聚合物，包括碱性氮，并且在常温下不具有附着性。

60. 发明申请

US20050163831A1 Patch for transdermal administration 审中-公开
标题翻译：补片用于透皮给药
公开(公告)号：US20050163831A1
公开(公告)日：2005-07-28
申请号：US11046687
申请日：2005-02-01
申请人： Atsutoshi Ikesue , Norifumi Tateishi , Kengo Uemura , Takaaki Terahara , Naruhito Higo , Michinori Sakai
发明人： Atsutoshi Ikesue , Norifumi Tateishi , Kengo Uemura , Takaaki Terahara , Naruhito Higo , Michinori Sakai
IPC分类号： A61K9/70 , A61K31/42 , A61K31/724 , A61K31/365
CPC分类号： A61K9/7061 , A61K31/42
摘要： A patch for transdermal administration having a sufficiently high transdermal permeation property of a COX-2 inhibitor to exert a superior antiinflammatory effect, the patch for transdermal administration comprising a backing and an adhesive layer which is placed on at least one side of the backing and comprises an adhesive base agent and a drug, wherein the drug is valdecoxib or a pharmaceutically acceptable salt thereof.
摘要翻译：一种用于透皮给药的贴剂，其具有足够高的COX-2抑制剂的透皮渗透性能以发挥优异的抗炎作用，用于透皮给药的贴片包括背衬和粘合剂层，其被放置在背衬的至少一侧上，并且包括粘合剂基剂和药物，其中药物是伐地考昔或其药学上可接受的盐。

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