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1. 发明申请

US20070128262A1 Package containing adhesive patch and method of inhibiting drug migration 审中-公开
标题翻译：含有贴剂的包装和抑制药物迁移的方法
公开(公告)号：US20070128262A1
公开(公告)日：2007-06-07
申请号：US10587660
申请日：2005-01-31
申请人： Satoshi Amano , Sachiko Honma , Tetsuro Tateishi , Naruhito Higo
发明人： Satoshi Amano , Sachiko Honma , Tetsuro Tateishi , Naruhito Higo
IPC分类号： A61K9/70 , A61K31/138
CPC分类号： A61K31/138 , A61L15/58
摘要： The patch-containing pouch 100 of the present invention is a pouch 1 housing in its interior a patch 2 which has a pressure-sensitive adhesive layer 22 laminated on at least one side of a support 21 and has a release film 23 attached to the pressure-sensitive adhesive layer 22, wherein the pressure-sensitive adhesive layer 22 contains a drug represented by general formula (1) or a pharmaceutically acceptable salt thereof, and at least a portion of the inner surface 31a or 31b of the pouch 1 in contact with the patch 2 is made of polyacrylonitrile. [where R represents 2-isopropoxyethoxymethyl, carbamoylmethyl or 2-methoxyethyl.]
摘要翻译：本发明的含有补片的袋100是在其内部容纳有贴片2的袋1，贴片2具有层压在支撑体21的至少一侧上的压敏粘合剂层22，并且具有附接到压力的剥离膜23 敏感性粘合剂层22，其中粘合剂层22含有由通式（1）表示的药物或其药学上可接受的盐，并且袋1的内表面31a或31b的至少一部分在贴片2的接触由聚丙烯腈制成。 [其中R表示2-异丙氧基乙氧基甲基，氨基甲酰基甲基或2-甲氧基乙基]

2. 发明申请

US20070158227A1 Plaster enclosing packaging bag 审中-公开
标题翻译：石膏包装袋
公开(公告)号：US20070158227A1
公开(公告)日：2007-07-12
申请号：US10587834
申请日：2005-01-28
申请人： Satoshi Amano , Sachiko Honma , Tetsuro Tateishi , Naruhito Higo
发明人： Satoshi Amano , Sachiko Honma , Tetsuro Tateishi , Naruhito Higo
IPC分类号： A61B19/02 , B65D73/00 , B65D81/26
CPC分类号： A61K9/7053 , A61J1/00 , A61K9/7061 , A61K31/138 , B65D75/26
摘要： An object of the present invention is to provide a patch-containing packaging pouch which enables stable storage of a patch containing bisoprolol in a pressure-sensitive adhesive layer. A packaged desiccant 1 of the present invention has a packaging pouch 8 composed of a pair of laminated package members 7a and 7b arranged in mutual opposition, and a patch 10 housed in the space within this packaging pouch 8. Patch 10 is provided with a support 12 and a pressure-sensitive adhesive layer 14 laminated substantially over the entire surface of one side of this support 12. In addition, the pressure-sensitive adhesive layer is composed of a pressure-sensitive adhesive composition containing a pressure-sensitive adhesive and bisoprolol or pharmaceutically acceptable salt thereof. Moreover, a packaged desiccant 20 is housed within packaging pouch 8. The relative humidity within packaging pouch 8 is maintained at 25% or less in a patch-containing packaging pouch 1 having this constitution.
摘要翻译：本发明的目的是提供一种能够在压敏粘合剂层中稳定地储存含有比索洛尔的贴剂的贴剂的包装袋。本发明的包装干燥剂1具有由相互相对设置的一对层叠包装构件7a和7b组成的包装袋8和容纳在该包装袋8内的空间中的贴片10。贴片10设置有基本上在该支撑体12的一侧的整个表面上层叠的支撑体12和压敏粘合剂层14。此外，压敏粘合剂层由含有压敏粘合剂和比索洛尔或其药学上可接受的盐的压敏粘合剂组合物组成。此外，包装干燥剂20容纳在包装袋8内。在具有这种结构的贴片包装袋1中，包装袋8内的相对湿度保持在25％以下。

3. 发明申请

US20060240086A1 Adhesive patch 审中-公开
标题翻译：胶贴
公开(公告)号：US20060240086A1
公开(公告)日：2006-10-26
申请号：US10566350
申请日：2004-07-30
申请人： Tetsuro Tateishi , Satoshi Amano , Sachiko Honma , Naruhito Higo
发明人： Tetsuro Tateishi , Satoshi Amano , Sachiko Honma , Naruhito Higo
IPC分类号： A61K9/70 , A61F13/00
CPC分类号： A61K9/7061 , A61K31/138
摘要： An adhesive patch which includes a pressure-sensitive adhesive layer comprising a composition which comprises: bisoprolol and/or a pharmaceutically acceptable salt thereof; and an acrylic polymer obtained by copolymerizing a (meth)acrylic ester with a carboxylated (meth)acrylic acid. The adhesive patch is stable and excellent in penetration through the skin.
摘要翻译：一种粘合贴剂，其包括压敏粘合剂层，其包含组合物，其包含：比索洛尔和/或其药学上可接受的盐; 和通过使（甲基）丙烯酸酯与羧化的（甲基）丙烯酸共聚得到的丙烯酸类聚合物。粘合贴剂稳定且穿透皮肤优异。

4. 发明授权

US08524273B2 Transdermal absorption preparation 有权
标题翻译：透皮吸收制剂
公开(公告)号：US08524273B2
公开(公告)日：2013-09-03
申请号：US12224586
申请日：2007-02-27
申请人： Satoshi Amano , Sachiko Honma , Tetsuro Tateishi , Natsumi Kase
发明人： Satoshi Amano , Sachiko Honma , Tetsuro Tateishi , Natsumi Kase
IPC分类号： A61K47/32 , A61K9/70 , A61K9/14 , A61K31/135 , A61F13/02
CPC分类号： A61K9/7084 , A61K31/138 , A61K31/165
摘要： A transdermal absorption preparation having a support and a pressure-sensitive adhesive layer consisting of multiple layers, wherein the pressure-sensitive adhesive layer comprises a drug-retaining layer containing a drug and an acrylic pressure-sensitive adhesive and a skin adhesion layer containing a styrene-isoprene-styrene block copolymer. This preparation can continuously release bisoprolol at a constant concentration. Moreover, it can be easily produced.
摘要翻译：一种具有支持体和由多层构成的压敏粘合剂层的透皮吸收制剂，其中所述压敏粘合剂层包含含药物的药物保持层和丙烯酸类压敏粘合剂以及含有苯乙烯的皮肤粘附层 - 异戊二烯 - 苯乙烯嵌段共聚物。该制剂可以以恒定的浓度连续释放比索洛尔。此外，它可以容易地生产。

5. 发明申请

US20090068252A1 Transdermal Absorption Preparation 有权
标题翻译：经皮吸收制剂
公开(公告)号：US20090068252A1
公开(公告)日：2009-03-12
申请号：US12224586
申请日：2007-02-27
申请人： Satoshi Amano , Sachiko Honma , Tetsuro Tateishi , Natsumi Kase
发明人： Satoshi Amano , Sachiko Honma , Tetsuro Tateishi , Natsumi Kase
IPC分类号： A61K9/70 , A61K47/32 , A61K31/138 , A61K31/166
CPC分类号： A61K9/7084 , A61K31/138 , A61K31/165
摘要： A transdermal absorption preparation having a support and a pressure-sensitive adhesive layer consisting of multiple layers, wherein the pressure-sensitive adhesive layer comprises a drug-retaining layer containing a drug and an acrylic pressure-sensitive adhesive and a skin adhesion layer containing a styrene-isoprene-styrene block copolymer. This preparation can continuously release bisoprolol at a constant concentration. Moreover, it can be easily produced.
摘要翻译：一种具有支持体和由多层构成的压敏粘合剂层的透皮吸收制剂，其中所述压敏粘合剂层包含含药物的药物保持层和丙烯酸类压敏粘合剂以及含有苯乙烯的皮肤粘附层 - 异戊二烯 - 苯乙烯嵌段共聚物。该制剂可以以恒定的浓度连续释放比索洛尔。此外，它可以容易地生产。

6. 发明申请

US20100227932A1 Patch 审中-公开
标题翻译：补丁
公开(公告)号：US20100227932A1
公开(公告)日：2010-09-09
申请号：US12721814
申请日：2010-03-11
申请人： Satoshi Amano , Sachiko Honma , Tetsuro Tateishi
发明人： Satoshi Amano , Sachiko Honma , Tetsuro Tateishi
IPC分类号： A61K31/135 , A61P9/12
CPC分类号： A61K9/7061 , A61K31/138
摘要： A Bisoprolol patch, wherein the skin penetration rate of Bisoprolol after 24 hours is 15 to 60% of the maximum skin penetration rate thereof, shows a little difference between the maximum level of the concentration in blood and the minimum level thereof in repeated administration and, therefore, scarcely exhibits side effects. Moreover, it achieves the quick development of the drug effect owing to the stabilization of the concentration in blood within a short time.
摘要翻译：比索洛尔贴剂，其中比索洛尔24小时后的皮肤渗透率为其最大皮肤渗透率的15〜60％，在血液中的最大浓度与其重复给药的最低水平之间略有差异，因此，几乎没有副作用。此外，由于血液中的浓度在短时间内稳定，因此药物作用迅速发展。

7. 发明申请

US20090012181A1 Patch 审中-公开
标题翻译：补丁
公开(公告)号：US20090012181A1
公开(公告)日：2009-01-08
申请号：US11814840
申请日：2006-01-16
申请人： Satoshi Amano , Sachiko Honma , Tetsuro Tateishi
发明人： Satoshi Amano , Sachiko Honma , Tetsuro Tateishi
IPC分类号： A61K31/138
CPC分类号： A61K9/7061 , A61K31/138
摘要： A Bisoprolol patch, wherein the skin penetration rate of Bisoprolol after 24 hours is 15 to 60% of the maximum skin penetration rate thereof, shows a little difference between the maximum level of the concentration in blood and the minimum level thereof in repeated administration and, therefore, scarcely exhibits side effects. Moreover, it achieves the quick development of the drug effect owing to the stabilization of the concentration in blood within a short time.
摘要翻译：比索洛尔贴剂，其中比索洛尔24小时后的皮肤渗透率为其最大皮肤渗透率的15〜60％，在血液中的最大浓度与其重复给药的最低水平之间略有差异，因此，几乎没有副作用。此外，由于血液中的浓度在短时间内稳定，因此药物作用迅速发展。

8. 发明申请

US20100003313A1 ADHESIVE SKIN PATCH 审中-公开
标题翻译：粘合皮肤贴
公开(公告)号：US20100003313A1
公开(公告)日：2010-01-07
申请号：US12312025
申请日：2007-10-18
申请人： Makoto Suzuki , Satoshi Amano , Tetsuro Tateishi , Akio Takeuchi
发明人： Makoto Suzuki , Satoshi Amano , Tetsuro Tateishi , Akio Takeuchi
IPC分类号： A61K9/70 , A61K31/343
CPC分类号： A61K31/343 , A61K9/7053 , A61K9/7061
摘要： A plaster including a backing layer and a drug layer laminated on the backing layer, where the drug layer contains an adhesive base and at least one compound selected from the group consisting of citalopram and pharmaceutically acceptable salts thereof, an abundance ratio of the S form being greater than an abundance ratio of the R form.
摘要翻译：一种石膏，其包括层叠在所述背衬层上的背衬层和药物层，其中所述药物层含有粘合剂基质和至少一种选自西酞普兰及其药学上可接受的盐的化合物，S形式的丰度比为大于R形式的丰度比。

9. 发明授权

US08512742B2 Transdermal preparation 有权
标题翻译：透皮制剂
公开(公告)号：US08512742B2
公开(公告)日：2013-08-20
申请号：US13318370
申请日：2010-04-30
申请人： Satoshi Amano , Tomohiro Shinoda , Natsumi Kase
发明人： Satoshi Amano , Tomohiro Shinoda , Natsumi Kase
IPC分类号： A61K9/70
CPC分类号： A61K45/06 , A61K9/7084 , A61K31/138 , A61K31/15 , A61K2300/00
摘要： Provided is a transdermal preparation, which is capable of long-term (1-day to 7-day) release of a basic drug from a preparation, continuously and at a consistent concentration; shows little reduction over time in the drug content, even if multiple drugs are contained in the preparation; and is produced by a simple process. The transdermal preparation comprises a substrate, and an adhesive layer containing a basic drug and a water-soluble polymer.
摘要翻译：提供一种透皮制剂，其能够以连续和一致的浓度从制剂中长期（1至7天）释放碱性药物; 即使制剂中含有多种药物，药物含量随时间推移几乎没有减少; 并通过简单的过程生产。透皮制剂包括底物和含有碱性药物和水溶性聚合物的粘合剂层。

10. 发明申请

US20120315318A1 TRANSDERMAL PREPARATION 有权
标题翻译：变态准备
公开(公告)号：US20120315318A1
公开(公告)日：2012-12-13
申请号：US13580168
申请日：2011-02-24
申请人： Arata Toshimitsu , Satoshi Amano , Kumi Morimoto
发明人： Arata Toshimitsu , Satoshi Amano , Kumi Morimoto
IPC分类号： A61K9/70 , A61K9/00 , A61K31/13
CPC分类号： A61K9/7061 , A61K9/0014 , A61K9/0021
摘要： A transdermal preparation comprising a multivalent metal chloride, a basic drug having an amino group, and an ester group-containing base material, is useful because of its excellent drug content stability.
摘要翻译：包含多价金属氯化物，具有氨基的碱性药物和含酯基的基材的透皮制剂由于其优异的药物含量稳定性是有用的。

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