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51. 发明申请

US20060025405A1 Modified pyrimidine glucocorticoid receptor modulators 有权
标题翻译：改性嘧啶糖皮质激素受体调节剂
公开(公告)号：US20060025405A1
公开(公告)日：2006-02-02
申请号：US11174096
申请日：2005-06-29
申请人： Robin Clark , Nicolas Ray , Karen Williams , Peter Crackett , Gwen Hickin , David Clark
发明人： Robin Clark , Nicolas Ray , Karen Williams , Peter Crackett , Gwen Hickin , David Clark
IPC分类号： A61K31/513 , A61K31/551 , C07D403/02
CPC分类号： C07D239/545 , A61K31/506 , A61K31/513 , A61K31/551 , C07D401/04 , C07D403/04
摘要： The present invention provides a novel class of modified pyrimidine compounds and compositions and methods of using the compounds as glucocorticoid receptor modulators.
摘要翻译：本发明提供了一类新颖的改良嘧啶化合物及其组合物和使用该化合物作为糖皮质激素受体调节剂的方法。

52. 发明申请

US20050124332A1 Mobile device programming system and method 审中-公开
标题翻译：移动设备编程系统及方法
公开(公告)号：US20050124332A1
公开(公告)日：2005-06-09
申请号：US10786961
申请日：2004-02-25
申请人： David Clark , Nathan Marion
发明人： David Clark , Nathan Marion
IPC分类号： G06F9/445 , H04L12/28 , H04L12/56 , H04M1/725 , H04M3/42 , H04W8/24 , H04W72/04 , H04M3/00 , H04Q7/20
CPC分类号： G06F8/65 , H04M1/72525 , H04M1/72547 , H04M3/42178 , H04W8/24 , H04W8/245 , H04W24/02
摘要： A method of updating a mobile device includes receiving at a mobile device resource requirements data for an update from an update management computing device, determining whether the mobile device has associated update resources to meet the resource requirements, allocating update resources to the mobile device if the mobile device does not have update resources to meet the resource requirements, transmitting from the mobile device to the update management computing device update request data requesting update data, and receiving at the mobile device the update data from the update management computing device in response to the transmitted update request data.
摘要翻译：一种更新移动设备的方法包括在移动设备处接收来自更新管理计算设备的用于更新的资源需求数据，确定移动设备是否具有相关联的更新资源以满足资源需求，如果移动设备没有更新资源以满足资源需求，从移动设备向请求更新数据的更新管理计算设备更新请求数据进行发送，并且响应于所述更新管理计算设备在移动设备处接收来自更新管理计算设备的更新数据发送更新请求数据。

53. 发明申请

US20050110614A1 Identification coding schemes for modulated reflectance systems 有权
标题翻译：调制反射系统的识别编码方案
公开(公告)号：US20050110614A1
公开(公告)日：2005-05-26
申请号：US10723073
申请日：2003-11-25
申请人： Don Coates , Scott Briles , Daniel Neagley , David Platts , David Clark
发明人： Don Coates , Scott Briles , Daniel Neagley , David Platts , David Clark
IPC分类号： G06K19/067 , G08B13/14 , H04B20060101 , H04Q5/22
CPC分类号： G06K19/0672
摘要： An identifying coding apparatus employing modulated reflectance technology involving a base station emitting a RF signal, with a tag, located remotely from the base station, and containing at least one antenna and predetermined other passive circuit components, receiving the RF signal and reflecting back to the base station a modulated signal indicative of characteristics related to the tag.
摘要翻译：一种采用调制反射技术的识别编码装置，其包括发射RF信号的基站，具有远离基站的标签，并且包含至少一个天线和预定的其它无源电路部件，接收RF信号并反射回到基站指示与标签相关的特征的调制信号。

54. 发明申请

US20050048069A1 Methods and compositions for modulating immunity 失效
标题翻译：用于调节免疫力的方法和组合物
公开(公告)号：US20050048069A1
公开(公告)日：2005-03-03
申请号：US10850562
申请日：2004-05-21
申请人： Reginald Gorczynski , David Clark
发明人： Reginald Gorczynski , David Clark
IPC分类号： A61K38/00 , A61K48/00 , C07K14/705 , C07K16/28 , A61K39/00
CPC分类号： C07K14/70503 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K16/2803 , C07K2319/00 , C07K2319/30
摘要： Methods and compositions for inducing immune suppression are disclosed. The methods involve administering an effective amount of a CD200 protein or a nucleic acid encoding a CD200 protein. The methods are useful in preventing graft rejection, fetal loss, autoimmune disease, and allergies. Methods and compositions for preventing immune suppression are also disclosed. The methods involve administering an effective amount of an agent that inhibits CD200. Such methods are useful in treating cancer.
摘要翻译：公开了诱导免疫抑制的方法和组合物。所述方法包括施用有效量的CD200蛋白或编码CD200蛋白的核酸。该方法可用于预防移植物排斥，胎儿丧失，自身免疫性疾病和过敏。还公开了用于预防免疫抑制的方法和组合物。所述方法包括施用有效量的抑制CD200的药剂。这些方法可用于治疗癌症。

55. 发明申请

US20050044586A1 Genetic elements conferring flower petal-specific transgene expression 失效
标题翻译：赋予花瓣特异性转基因表达的遗传元件
公开(公告)号：US20050044586A1
公开(公告)日：2005-02-24
申请号：US10889684
申请日：2004-07-13
申请人： David Clark , Harry Klee , Kenichi Shibuya , Holly Loucas
发明人： David Clark , Harry Klee , Kenichi Shibuya , Holly Loucas
IPC分类号： A01H1/00 , C07K14/415 , C12N20060101 , C12N5/04 , C12N5/10 , C12N15/82
CPC分类号： C12N15/823
摘要： The present invention provides recombinant promoters that drive tissue-specific expression, and transgenes comprising such recombinant promoters. Specifically, the invention provides transgenes comprising a recombinant promoter that drives tissue-specific expression of a heterologous nucleic acid molecule in a floral organ. The invention also provides methods for using such transgenes to produce a protein in a host cell or transgenic plant. The invention further provides methods for producing a transgenic plant that produces, for example, longer-lasting flowers, better fragrance, or better or longer-lasting color as compared to a wild type plant.
摘要翻译：本发明提供驱动组织特异性表达的重组启动子和包含这种重组启动子的转基因。具体地，本发明提供了转基因，其包含驱动花器官中的异源核酸分子的组织特异性表达的重组启动子。本发明还提供了使用这种转基因在宿主细胞或转基因植物中产生蛋白质的方法。本发明还提供了与野生型植物相比，生产转基因植物的方法，该转基因植物产生例如持久的花，更好的香味或更好或更持久的颜色。

56. 发明申请

US20050026290A1 Inhibiting gene expression with dsRNA 审中-公开
标题翻译：用dsRNA抑制基因表达
公开(公告)号：US20050026290A1
公开(公告)日：2005-02-03
申请号：US10631718
申请日：2003-08-01
申请人： Joseph Ciardi , Kenichi Shibuya , Holly Loucas , David Clark
发明人： Joseph Ciardi , Kenichi Shibuya , Holly Loucas , David Clark
IPC分类号： C12N15/82 , A01H1/00
CPC分类号： C12N15/8249 , C12N15/8218
摘要： The present invention relates to the altering or controlling inhibition of gene expression in a cell using a methodology involving a dsRNA. The use of the method in plants and plant cells has been found to be particularly beneficial. For example the inhibition of a hormone signaling gene in a plant, such as the EIN2 gene, permits the modulating of flower longevity in the selected plant. This is accomplished by using our RNAi technology in inhibiting the expression of an ethylene-modulated gene or an ethylene signaling gene in plants and plant cells. This method provides for the use of RNAi technology in inhibiting the expression of a hormone signaling gene in a plant, particularly in the floral parts of a plant. Thus, one can modulate flower longevity in a plant.
摘要翻译：本发明涉及使用涉及dsRNA的方法改变或控制细胞中基因表达的抑制。已经发现在植物和植物细胞中使用该方法是特别有益的。例如，抑制植物中的激素信号基因，例如EIN2基因，允许调节所选择的植物中的花的寿命。这是通过使用我们的RNAi技术在植物和植物细胞中抑制乙烯调节基因或乙烯信号基因的表达来实现的。该方法提供了使用RNAi技术来抑制植物中特别是植物的花卉部位中激素信号基因的表达。因此，可以调节植物中的花卉寿命。

57. 发明授权

US06501852B1 Method and component for serialization of images 失效
标题翻译：图像序列化的方法和组件
公开(公告)号：US06501852B1
公开(公告)日：2002-12-31
申请号：US09265754
申请日：1999-03-10
申请人： David Clark , Andrew John Smith
发明人： David Clark , Andrew John Smith
IPC分类号： G06K900
CPC分类号： G06F8/00 , Y10S707/99944 , Y10S707/99945
摘要： Java™ Development Toolkit version 1.1.x (JDK) does not support the serialization of images. JDK on the other hand allows primitive data types to be serialized. This means that an application developer can design an application so that any primitive data type objects, including objects comprising primitive data type components, can be written to a file or another area of memory, before an application closes. When the application re-opens, the primitive data types can be de-serialized and so recovered and the application can continue as if it had never closed with the exception that image objects will not have been recovered. The invention discloses a component for a development kit comprising means for converting an image object into a primitive data type object and means for serializing that object so that the object can be made persistent. In a preferred embodiment, the component converts an image object to an array of integers representing the image pixels; creates a color table of unique integers from the integer array; converts each integer in the integer array into an index into the color table; and zip compresses the combined color table and array of indices before serialization.
摘要翻译： Java（TM）开发工具包版本1.1.x（JDK）不支持图像序列化。另一方面，JDK允许原始数据类型被序列化。这意味着应用程序开发人员可以设计应用程序，以便在应用程序关闭之前，可以将任何包含原始数据类型组件的对象的原始数据类型对象写入文件或其他存储器区域。当应用程序重新打开时，原始数据类型可以被解除序列化，因此恢复，并且应用程序可以继续，就像它从未关闭，但是图像对象不会被恢复。本发明公开了一种用于开发套件的组件，其包括用于将图像对象转换为原始数据类型对象的装置，以及用于对该对象进行序列化以使对象可以持久化的装置。在优选实施例中，组件将图像对象转换为表示图像像素的整数数组; 从整数数组创建唯一整数的颜色表; 将整数数组中的每个整数转换为颜色表中的索引; 并且zip在序列化之前压缩组合的颜色表和索引数组。

58. 外观设计

USD460085S1 Articulated telehandler 失效
标题翻译：铰接式伸缩臂叉装机
公开(公告)号：USD460085S1
公开(公告)日：2002-07-09
申请号：US29141638
申请日：2001-05-10
申请人： William E. Crookes , Aris G. Nichols , Bengt A. Nestell , David Clark , Rene Laberheim , Ernst Simon
设计人： William E. Crookes , Aris G. Nichols , Bengt A. Nestell , David Clark , Rene Laberheim , Ernst Simon

59. 发明授权

US5993628A Electrophoresis method and apparatus for separating bio-organic molecules 失效
标题翻译：用于分离生物有机分子的电泳方法和设备
公开(公告)号：US5993628A
公开(公告)日：1999-11-30
申请号：US62381
申请日：1998-04-17
申请人： Barton G. Selby , Johan Goudberg , Binh Vo , David Clark
发明人： Barton G. Selby , Johan Goudberg , Binh Vo , David Clark
IPC分类号： G01N27/447 , G01N27/26
CPC分类号： G01N27/44743
摘要： The present invention relates to the electrophoretic separation of bio-organic molecules using a slab gel electrophoresis apparatus having a pair of spaced, confronting plates defining a multi-lane separation zone adapted to hold a separation medium and an upper loading zone. In one aspect of the invention, at least one of the plates is shaped to provide an expanded loading zone. The plate-to-plate distance within the expanded loading zone is greater than the plate-to-plate width within the separation zone. In another aspect of the invention, a comb is provided with each tooth having a gradual taper beginning at a support member and extending along most of the tooth's longitudinal axis, and a sharp taper beginning immediately beyond the gradual taper and extending to the end of the tooth. In a related aspect of the invention, a method is provided wherein a comb is inserted into the loading zone so that the teeth penetrate an upper portion of the separation medium, thereby forming a series of fluid-tight, elongate sample-loading apertures of substantially rectangular cross-section having a plate-to-plate width greater than that of the inter-plate distance in the separation zone.
摘要翻译：本发明涉及使用板式凝胶电泳装置的生物有机分子的电泳分离，所述板式凝胶电泳装置具有限定适于保持分离介质和上装载区的多通道分离区的一对间隔开的面对板。在本发明的一个方面中，至少一个板被成形为提供一个膨胀的加载区。扩展加载区内的板间距离大于分离区内的板对板宽度。在本发明的另一方面，梳子具有每个齿具有从支撑构件开始并且沿着该齿的纵向轴线的大部分延伸的渐变锥形的逐渐渐缩锥形，以及紧接着逐渐变细并且延伸至齿。在本发明的相关方面，提供了一种方法，其中将梳子插入装载区域中，使得齿穿透分离介质的上部，由此形成一系列流体密封的细长的样品加载孔，其基本上矩形横截面的板对板宽度大于分离区中的板间距离。

60. 发明授权

US5529075A Fixation device and method for repair of pronounced hallux valgus 失效
标题翻译：固定装置和修复拇指外翻的方法
公开(公告)号：US5529075A
公开(公告)日：1996-06-25
申请号：US304167
申请日：1994-09-12
申请人： David Clark
发明人： David Clark
IPC分类号： A61B17/68 , A61B17/86 , A61B19/00
CPC分类号： A61B17/68 , A61B17/683 , A61B2017/565 , A61B2017/868 , Y10S606/908 , Y10S606/916
摘要： A method is described to repair hallux valgus which involves a medial incision as the primary incision, mechanical stabilization of the first and second metatarsals during and after a proximal chevron osteotomy of the first metatarsal shaft, reorientation of the metatarsal segments to compensate for hallux valgus, and stabilization of the reoriented metatarsal during healing by insertion of a fixation device which may be removed later with little trauma to surrounding tissues. The fixation device comprises an elongated, relatively rigid stabilizing member of biocompatible material sized to pass from the medial side of the first metatarsal through the first and second metatarsals and out the lateral side of the second metatarsal, and two retainer members cooperating with the segments of the stabilizing member, medial to the first metatarsal and lateral to the second, adapted to prevent migration of the stabilizing member as the wound is healing.
摘要翻译：描述了一种方法来修复拇趾外翻，其包括内侧切口作为主要切口，在第一跖骨轴的近端人字形截骨期间和之后的第一和第二跖骨的机械稳定性，跖骨段的重新定向以补偿拇趾外翻，并且通过插入固定装置在愈合期间稳定重新定向的跖骨，该固定装置可稍后被移除，对周围组织几乎没有创伤。固定装置包括细长的相对刚性的生物相容性材料的稳定构件，其大小适于从第一跖骨的内侧穿过第一和第二跖骨并从第二跖骨的外侧穿过，以及两个保持构件与第所述稳定构件在所述第一跖骨的内侧和所述第二跖侧的内侧适于在伤口愈合时防止所述稳定构件的移动。

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