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51. 发明申请

US20090326039A1 INHIBITORS FOR THE SOLUBLE EPOXIDE HYDROLASE 有权
标题翻译：可溶性环氧化物水解物的抑制剂
公开(公告)号：US20090326039A1
公开(公告)日：2009-12-31
申请号：US12396391
申请日：2009-03-02
申请人： Bruce D. Hammock , In-Hae Kim , Christophe Morisseau , Takaho Watanabe , John W. Newman
发明人： Bruce D. Hammock , In-Hae Kim , Christophe Morisseau , Takaho Watanabe , John W. Newman
IPC分类号： C12N9/99 , A61K31/17 , A61K31/215 , A61K31/195 , A61K31/401 , C12Q1/34
CPC分类号： C07C275/26 , C07C275/30 , C07C275/42 , C07C311/04 , C07C311/05 , C07C311/51 , C07C323/59 , C07C2601/02 , C07C2601/14 , C07C2603/74 , C07D207/16 , C07D233/24 , C07D233/64
摘要： Inhibitors of the soluble epoxide hydrolase (sEH) are provided that incorporate multiple pharmacophores and are useful in the treatment of diseases.
摘要翻译：提供了可溶性环氧化物水解酶（sEH）的抑制剂，其包含多个药效团并且可用于治疗疾病。

52. 发明申请

US20090215894A1 INHIBITION OF PHOSPHATASE ACTIVITY OF SOLUBLE EPOXIDE HYDROLASE AMINO TERMINUS AND USES THEREOF 审中-公开
标题翻译：可溶性环氧化物水解酶氨基末端磷酸酶活性的抑制及其用途
公开(公告)号：US20090215894A1
公开(公告)日：2009-08-27
申请号：US12063573
申请日：2006-08-14
申请人： Bruce D. Hammock , Christophe Morisseau , John W. Newman
发明人： Bruce D. Hammock , Christophe Morisseau , John W. Newman
IPC分类号： A61K31/20 , C12N9/99 , A61K31/10 , C07C309/00
CPC分类号： A61K31/285 , C07C305/06 , C07C305/10
摘要： Inhibitors of the phosphatase activity of soluble epoxide hydrolase (sEH) are provided and are useful for in the treatment of diseases. These Inhibitors are based on derivatives of various epoxide hydrolase substrates that mimic the enzyme substrate so that there Is stable Interaction with the enzyme catalytic site. These inhibitors are potentially useful for the treatment of hypertension, vascular inflammation, renal inflammation, and lung disease.
摘要翻译：提供可溶性环氧化物水解酶（sEH）的磷酸酶活性的抑制剂，可用于治疗疾病。这些抑制剂基于模拟酶底物的各种环氧化物水解酶底物的衍生物，使得与酶催化位点具有稳定的相互作用。这些抑制剂可用于治疗高血压，血管炎症，肾脏炎症和肺部疾病。

53. 发明申请

US20080234755A1 CRANIOSPINAL FUSION METHOD AND APPARATUS 有权
标题翻译： CRANIOSPINAL FUSION方法和装置
公开(公告)号：US20080234755A1
公开(公告)日：2008-09-25
申请号：US11832646
申请日：2007-08-01
申请人： Fraser Cummins Henderson , John W. Newman
发明人： Fraser Cummins Henderson , John W. Newman
IPC分类号： A61B17/70 , A61B17/56 , A61B17/58
CPC分类号： A61B17/8071 , A61B17/7055 , A61B17/80 , A61B17/8085 , A61B17/8891 , A61B2017/00004 , Y10S606/902 , Y10S606/903
摘要： A method for effecting reduction, stabilization and enhancement of fusion of the human cranio-cervical junction, which may be performed in order to relieve mechanical stresses imparted to the spinal cord and brainstem as a result of an abnormal clivo-axial angle, includes steps of achieving the correct craniocervical relationship, of effecting a fusion of a first portion of a bone forming material based structural member to a human cranium, and effecting fusion of a second portion of the bone forming material based structural member to a least one portion of a human cervical spine. Fusion of the bone forming material based structural member to the human cranium may be promoted through the use of plate member that is shaped to define a graft accommodation space between the plate member and the cranium.
摘要翻译：包括以下步骤：用于减轻，稳定和增强人类颅颈交界处融合的方法，所述方法可以执行以减轻由于异常的轴向角度而施加给脊髓和脑干的机械应力实现正确的颅颈关系，实现基于骨形成材料的结构构件的第一部分与人颅骨的融合，并且将骨形成材料基结构构件的第二部分熔化到人的至少一部分颈椎。可以通过使用成形为在板构件和颅骨之间限定移植物容纳空间的板构件来促进基于骨形成材料的结构构件与人颅骨的融合。

54. 发明授权

US07235773B1 Method and apparatus for image signal compensation of dark current, focal plane temperature, and electronics temperature 有权
标题翻译：图像信号补偿暗电流，焦平面温度和电子温度的方法和装置
公开(公告)号：US07235773B1
公开(公告)日：2007-06-26
申请号：US11104206
申请日：2005-04-12
申请人： John W. Newman
发明人： John W. Newman
IPC分类号： H04N5/911 , H04N9/64
CPC分类号： H04N5/361 , H04N5/372 , H04N5/37206
摘要： A system and method for calibration and compensation of a visual sensor system. The visual sensor system includes dark pixels adjacent active pixels on a CCD imaging array, which provide dark current data corresponding to image response data. Concurrently, the temperature of the focal plane of the CCD is measured by one or more temperature sensors disposed on the array. Concurrently, the temperature of a circuit board including a processor is measured by one or more temperature sensors arranged on the circuit board. The image response data, dark current data, and circuit board and focal plane temperatures are used to compensate the image response data.
摘要翻译：一种用于校准和补偿视觉传感器系统的系统和方法。视觉传感器系统包括邻近CCD成像阵列上的有源像素的暗像素，其提供对应于图像响应数据的暗电流数据。同时，通过设置在阵列上的一个或多个温度传感器来测量CCD的焦平面的温度。同时，包括处理器的电路板的温度由布置在电路板上的一个或多个温度传感器测量。图像响应数据，暗电流数据以及电路板和焦平面温度用于补偿图像响应数据。

55. 发明授权

US6092414A Method for analyzing a separation in a deformable structure 失效
标题翻译：用于分析可变形结构中的分离的方法
公开(公告)号：US6092414A
公开(公告)日：2000-07-25
申请号：US345158
申请日：1999-06-30
申请人： John W. Newman
发明人： John W. Newman
IPC分类号： G01B9/025 , G01B11/16 , G01M17/02 , G01M17/00
CPC分类号： G01M17/027 , G01B11/162 , G01B9/025
摘要： A deformable structure is subjected to a plurality of reduced pressures, causing a bulge in the surface of the deformable structure above a separation in the deformable structure. The cross sectional area of the bulge is measured for each reduced pressure in a plane parallel to the surface of the deformable structure. When the cross sectional area of the bulge does not increase with a reduction in the pressure, the cross sectional area of the bulge approximates the area of the separation. The depth of the separation is calculated using the change in cross sectional area of the bulge per change in pressure.
摘要翻译：可变形结构经受多个减压，使可变形结构的表面中的凸起高于可变形结构中的分离。在与可变形结构的表面平行的平面中的每个减压测量凸起的横截面面积。当凸起的横截面积不随着压力的降低而增加时，凸起的横截面积近似于分离的面积。使用每压力变化的凸起的横截面积的变化来计算分离的深度。

56. 发明授权

US5405391A Fusion stabilization chamber 失效
标题翻译：融合稳定室
公开(公告)号：US5405391A
公开(公告)日：1995-04-11
申请号：US18373
申请日：1993-02-16
申请人： Fraser C. Hednerson , Rebecca S. Henderson , John W. Newman
发明人： Fraser C. Hednerson , Rebecca S. Henderson , John W. Newman
IPC分类号： A61B17/86 , A61F2/00 , A61F2/28 , A61F2/30 , A61F2/44
CPC分类号： A61F2/4455 , A61F2/44 , A61B17/86 , A61F2002/2835 , A61F2002/30153 , A61F2002/30158 , A61F2002/30271 , A61F2002/3028 , A61F2002/30373 , A61F2002/30377 , A61F2002/30433 , A61F2002/30507 , A61F2002/3055 , A61F2002/30576 , A61F2002/30601 , A61F2002/30787 , A61F2002/30909 , A61F2002/4475 , A61F2220/0025 , A61F2220/0033 , A61F2220/0041 , A61F2230/0019 , A61F2230/0026 , A61F2230/0063 , A61F2230/0082 , Y10S606/907 , Y10T403/32491
摘要： A fusion stabilization chamber stabilizes the spine following removal of one or more vertebrae, and facilitates bone growth. The chamber includes two hollow members, preferably having slightly trapezoidal cross-sections, which slide relative to each other in a telescoping manner. The hollow members preferably have walls made of a metal mesh. Barrel vaults attached to the hollow members form guides for screws which can attach the chamber to the vertebrae adjacent the corpectomy site. Because of its adjustability, the chamber can fit a wide variety of corpectomy sites. One can fill the chamber with bone material, which can eventually fuse to the adjacent bone. A pair of stabilizing plates prevents the surgeon from pushing the chamber too far towards the spinal cord. The chamber eliminates the need to maintain a large and costly inventory of screws, and neurosurgeons can learn to use it quickly and easily.
摘要翻译：融合稳定室在移除一个或多个椎骨后稳定脊柱，并促进骨骼生长。该腔室包括两个中空构件，优选地具有稍微梯形的横截面，其以伸缩方式相对于彼此滑动。中空构件优选具有由金属网制成的壁。连接到中空构件的桶形突起形成用于螺钉的引导件，其可以将腔室附接到邻近椎骨切除部位的椎骨。由于其可调性，腔室可以适应各种各样的椎骨切除部位。人们可以用骨材料填充房间，骨材料最终可以融化到相邻的骨头。一对稳定板防止外科医生将腔室推向太远的脊髓。该腔室不需要维护大量和昂贵的螺钉库存，神经外科医生可以快速轻松地学习使用它。

57. 发明授权

US4806113A High voltage connector for x-ray equipment 失效
标题翻译：用于x射线设备的高压连接器
公开(公告)号：US4806113A
公开(公告)日：1989-02-21
申请号：US815849
申请日：1986-01-03
申请人： Edward T. Rate, Jr. , John W. Newman , Robert W. Meade
发明人： Edward T. Rate, Jr. , John W. Newman , Robert W. Meade
IPC分类号： H01R13/533 , H01R13/11 , H01R13/53 , H01R13/631 , H01R13/22
CPC分类号： H01R13/631 , H01R13/53
摘要： A high voltage electrical connector set includes a male plug portion and a female receptacle portion. Projecting male contacts are received by female contacts including resilient electrically conductive portions which ensure a secure contact even if the plug and receptacle are somewhat misaligned or incompletely engaged.
摘要翻译：高压电连接器组包括阳插头部分和阴插座部分。突出阳触头由阴触头接收，包括弹性导电部分，即使插头和插座有点不对准或不完全接合，也确保了牢固的接触。

58. 发明授权

US4752899A Condition monitoring system for locomotives 失效
标题翻译：机车状态监测系统
公开(公告)号：US4752899A
公开(公告)日：1988-06-21
申请号：US790480
申请日：1985-10-23
申请人： John W. Newman , John Tyson, II , Thomas Gluyas
发明人： John W. Newman , John Tyson, II , Thomas Gluyas
IPC分类号： G01F23/00 , G06F17/40 , G06F15/20
CPC分类号： G01F23/0069 , G01F23/0076
摘要： The present invention is a system for monitoring and displaying a measured parameter in each of a series of similar modules. In one embodiment, the invention can be used to monitor a parameter or condition, such as the amount of fuel in a tank, in each of a plurality of coupled locomotives. The parameter is measured by an analog or digital sensor, the output of which is connected to a microprocessor. Each locomotive in the train has such a microprocessor, and each microprocessor is programmed in substantially the same way. The microprocessors in the several locomotives are programmed to communicate with each other, and to determine which one is in the lead locomotive, and what signals are being received from which microprocessor. The value of the measured parameters for any of the locomotives of the train can therefore be displayed by the microprocessor in the lead locomotive. The programming of the microprocessors is such that the system will work regardless of the arrangement of the locomotives.
摘要翻译：本发明是用于在一系列类似的模块中的每一个中监视和显示测量参数的系统。在一个实施例中，本发明可以用于监测多个耦合的机车中的每一个中的参数或状况，例如罐中的燃料量。该参数由模拟或数字传感器测量，其输出连接到微处理器。列车中的每个机车具有这样的微处理器，并且每个微处理器以基本上相同的方式被编程。几台机车中的微处理器被编程为相互通信，并且确定哪个机车在哪个机车中，以及从哪个微处理器接收什么信号。因此，列车的任何机车的测量参数的值可以由微机在铅机车中显示。微处理器的编程使得系统将工作，而不管机车的布置。

59. 发明授权

US4497789A Process for the manufacture of carbon fibers 失效
标题翻译：碳纤维制造工艺
公开(公告)号：US4497789A
公开(公告)日：1985-02-05
申请号：US446535
申请日：1982-12-03
申请人： William R. Sawran , Frank H. Turrill , John W. Newman , Norman W. Hall
发明人： William R. Sawran , Frank H. Turrill , John W. Newman , Norman W. Hall
IPC分类号： C10C3/00 , D01F9/155 , D01F9/32 , D01F9/14
CPC分类号： D01F9/155 , C10C3/002 , D01F9/322
摘要： Disclosed herein is an improved pitch for making readily stabilizable, substantially nonmesophasic carbon fibers. The pitch has a softening point of about 250.degree. C. (480.degree. F.) or above and is produced from an unoxidized thermal petroleum pitch by selectively reducing or eliminating a portion of the low molecular weight materials in a very short period of time so that the tendency to produce mesophase pitch is eliminated or reduced and so that the chemical integrity of the components of the higher molecular weight fractions is preserved as much as possible. Also disclosed is a method of producing carbon fibers therefrom and rovings or mats from such fibers.
摘要翻译：本文公开了用于制备容易稳定的，基本上非中性的碳纤维的改进沥青。沥青具有约250℃（480°F）或更高的软化点，并通过在非常短的时间内选择性还原或除去一部分低分子量材料而由未氧化的热石油沥青生产，因此消除或减少产生中间相沥青的趋势，并且尽可能地保持较高分子量级分的组分的化学完整性。还公开了从这种纤维生产碳纤维的方法和粗纱或垫子。

60. 发明授权

US4283952A Flaw detecting device and method 失效
标题翻译：缺陷检测装置及方法
公开(公告)号：US4283952A
公开(公告)日：1981-08-18
申请号：US40678
申请日：1979-05-21
申请人： John W. Newman
发明人： John W. Newman
IPC分类号： G01N29/04 , G01N29/11 , G01N29/30 , G01N29/34 , G01N29/46 , G01N29/48 , G01H13/00
CPC分类号： G01N29/48 , G01N29/11 , G01N29/30 , G01N29/348 , G01N29/46 , G01N2291/044
摘要： The method and apparatus of the invention simultaneously induces the same variable frequency mechanical vibrations in a test part and a standard. The vibrations of the two are converted to signals which are either displayed for comparison purposes or automatically analyzed for differences. Advantageously, the signals are electrical signals providing spectra which are analyzed for differences in amplitudes produced by the signals. Where the parts are separately supported, they are held with substantially the same force and are maintained against the vibration inducing mechanism with the same force. Where accelerometers are used, they are held with substantially the same force against the vibrating parts.
摘要翻译：本发明的方法和装置在测试部件和标准中同时引起相同的变频机械振动。两者的振动被转换成为了比较目的而显示的信号或者被自动分析的信号。有利的是，这些信号是提供频谱的电信号，其被分析为信号产生的幅度差。在零件分开支撑的情况下，它们以大致相同的力保持，并以相同的力保持抵靠振动诱导机构。在使用加速度计的情况下，它们以与振动部件基本相同的力保持。

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