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51. 发明授权

US08177837B2 Percutaneously deployed vascular valves 有权
标题翻译：经皮部署血管瓣膜
公开(公告)号：US08177837B2
公开(公告)日：2012-05-15
申请号：US13008629
申请日：2011-01-18
申请人： Brian C. Case , Charles W. Agnew , Jacob A. Flagle
发明人： Brian C. Case , Charles W. Agnew , Jacob A. Flagle
IPC分类号： A61F2/24 , A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2002/068 , A61F2002/8483 , A61F2210/0076 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0034 , A61F2230/0095
摘要： Described are percutaneous vascular valves free of attached support structures and deployment systems and methods for providing attachment of the valves within a vascular vessel.
摘要翻译：描述的是没有附接的支撑结构的经皮血管瓣和用于在血管容器内提供阀附件的展开系统和方法。

52. 发明授权

US08157810B2 Prosthesis adapted for placement under external imaging 有权
标题翻译：假体适应放置在外部成像
公开(公告)号：US08157810B2
公开(公告)日：2012-04-17
申请号：US10787307
申请日：2004-02-26
申请人： Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Andrew K. Hoffa , Ray Leonard, II
发明人： Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Andrew K. Hoffa , Ray Leonard, II
IPC分类号： A61F11/00
CPC分类号： A61F2/2475 , A61B90/39 , A61F2/2418 , A61F2230/0026 , A61F2230/0095 , A61F2250/0098
摘要： A expandable prosthesis having an imageable structure comprising one or more elements visually distinguishable by an external (e.g., radiographic or ultrasonic) imaging system, the structure being located about a first axis that corresponds to a structural feature of the prosthesis that is configured to perform a specific function particular to that axis. The imageable structure is configured to assist in the rotational orientation of the prosthesis during placement within the implantation site. In one embodiment, the prosthesis comprises a venous valve that includes imageable elements or structure, such as a pair of radiopaque markers, that defines the orifice of the valve structure such that the orifice can be oriented with a particular anatomical feature under imaging, such as to align the orifice with the long axis of the vessel. In another embodiment, the imageable structure is configured to permit an aperture located about a stent graft to be oriented with a anatomical feature of the vessel, such as a branch vessel opening. The invention includes a method for using imageable structure to confirm that the orientation of the prosthesis within a delivery apparatus is consistent the desired delivery approach to be used.
摘要翻译：一种具有可成像结构的可扩张假体，其包括可由外部（例如，射线照相或超声）成像系统在视觉上区分的一个或多个元件，所述结构围绕与假体的结构特征对应的第一轴定位，所述第一轴构造成执行特定于该轴的特定功能。可成像结构构造成在放置在植入部位期间有助于假体的旋转取向。在一个实施例中，假体包括静脉瓣，其包括可成像元件或结构，例如一对不透射线的标记，其限定瓣膜结构的孔，使得孔可以在成像下具有特定解剖特征，例如以将孔与容器的长轴对准。在另一个实施例中，可成像结构被配置为允许围绕支架移植物定位的孔与容器的解剖特征（例如分支血管开口）定向。本发明包括一种使用可成像结构来确认假体在输送装置内的取向与所要使用的输送方法一致的方法。

53. 发明授权

US07833267B2 Methods and systems for modifying vascular valves 有权
标题翻译：改变血管瓣膜的方法和系统
公开(公告)号：US07833267B2
公开(公告)日：2010-11-16
申请号：US12257720
申请日：2008-10-24
申请人： Jacob A. Flagle , Brian C. Case
发明人： Jacob A. Flagle , Brian C. Case
IPC分类号： A61F2/24
CPC分类号： A61B17/00234 , A61B17/00491 , A61B17/064 , A61B17/122 , A61B18/1492 , A61B2017/00783 , A61F2/06 , A61F2/2475 , Y10S623/904
摘要： Described are methods and systems for modifying vascular valves in order to reduce retrograde blood flow through the valves. Preferred methods include connecting vascular valve leaflets with at least one remodelable material, such that the valve leaflets become fused by the ingrowth of the patient's native tissue. Preferred remodelable materials include collagenous extracellular matrix material, such as small intestine submucosa.
摘要翻译：描述了用于修改血管瓣膜以减少通过瓣膜的逆行血流量的方法和系统。优选的方法包括将血管瓣叶与至少一种可重塑材料连接，使得瓣膜小叶通过患者的天然组织的向内生长而变得熔化。优选的可重塑材料包括胶原细胞外基质材料，例如小肠粘膜下层。

54. 发明申请

US20100063577A1 METHOD OF IMPLANTING A PROSTHETIC VALVE 审中-公开
标题翻译：植入预制阀的方法
公开(公告)号：US20100063577A1
公开(公告)日：2010-03-11
申请号：US12621214
申请日：2009-11-18
申请人： Brian C. Case , Thomas A. Osborne , Jacob A. Flagle , Fred T. Parker
发明人： Brian C. Case , Thomas A. Osborne , Jacob A. Flagle , Fred T. Parker
IPC分类号： A61F2/06 , A61F2/82
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2230/0067 , A61F2230/0078 , A61F2230/008 , A61F2250/0063
摘要： Methods of implanting a prosthetic valve in a body vessel are provided. A first expandable frame member is delivered to and deployed at a point of treatment in a body vessel. A second expandable frame member is delivered to the point of treatment. The second expandable frame member has an attached graft member that forms a valve adapted to permit fluid flow through the body vessel in a first direction and to substantially prevent fluid flow through the body vessel in a second, opposite direction. After deployment of the first expandable frame member, the second expandable frame member is deployed at the point of treatment such that the second frame member is positioned radially inward of the first frame member within said body vessel to form a prosthetic valve.
摘要翻译：提供了将人造瓣植入人体容器中的方法。第一可膨胀框架构件被输送到身体容器中并在其处处被部署。第二可膨胀框架构件被输送到处理点。第二可膨胀框架构件具有附接的移植构件，其形成适于允许流体沿第一方向流过身体容器的阀，并且基本上防止流体沿第二相反方向流过身体容器。在展开第一可膨胀框架构件之后，第二可膨胀框架构件在处理点处展开，使得第二框架构件位于所述主体容器内的第一框架构件的径向内侧以形成人造瓣膜。

55. 发明申请

US20100057201A1 PROSTHETIC VALVE WITH VESSEL ENGAGING MEMBER 审中-公开
标题翻译：具有船舶参与成员的前置阀
公开(公告)号：US20100057201A1
公开(公告)日：2010-03-04
申请号：US12616518
申请日：2009-11-11
申请人： Jacob A. Flagle , Brian C. Case , Andrew K. Hoffa
发明人： Jacob A. Flagle , Brian C. Case , Andrew K. Hoffa
IPC分类号： A61F2/24
CPC分类号： A61F2/2475 , A61F2/07 , A61F2/2412 , A61F2/2418 , A61F2220/0033 , A61F2220/005 , A61F2230/0078
摘要： Medical devices for implantation in a body vessel are provided. Each medical device comprises a main body, a valve, and a vessel engaging member. The vessel engaging member is disposed on an outer surface of the main body. Kits including a plurality of vessel engaging members for use with one or more valve members are also provided. The vessel engaging members have varying radial dimensions, allowing assembly of medical devices having varying radial dimensions. Methods of treating a patient using medical devices according to the invention are also provided.
摘要翻译：提供用于植入体内的医疗装置。每个医疗装置包括主体，阀和容器接合构件。容器接合构件设置在主体的外表面上。还提供了包括与一个或多个阀构件一起使用的多个容器接合构件的套件。容器接合构件具有变化的径向尺寸，允许组装具有变化径向尺寸的医疗装置。还提供了使用根据本发明的医疗装置治疗患者的方法。

56. 发明授权

US07628803B2 Implantable vascular device 有权
公开(公告)号：US07628803B2
公开(公告)日：2009-12-08
申请号：US10642372
申请日：2003-08-15
申请人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
发明人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/24 , A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2002/8483 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0069 , A61F2230/0095
摘要： An valve prosthesis, such as an artificial venous valve, having a support frame and leaf structure comprising one or more leaflets in which the outer edge of each leaflet engages the inner circumference of the bodily passageway along a serpentine path urged against the passageway by an expandable frame, while the inner edges move in response to fluid to restrict retrograde flow. Optionally, one or more elements can extend from the support frame/leaf structure to provide centering support and/or protection from the leaflet adhering to the vessel wall. In one embodiment, the centering support structure comprises a second or third expandable frames attached to and extending from the proximal and/or distal ends of main valve structure and support frame. In another embodiment, one or more support elements extend outward from the valve support frame to engage the vessel wall to provide greater longitudinal stability.

57. 发明授权

US07544207B2 Medical device with bioactive agent 有权
标题翻译：带有生物活性剂的医疗器械
公开(公告)号：US07544207B2
公开(公告)日：2009-06-09
申请号：US11244991
申请日：2005-10-06
申请人： Thomas A. Osborne , Jacob A. Flagle , Brian C. Case , Joseph F. Obermiller , Ram H. Paul
发明人： Thomas A. Osborne , Jacob A. Flagle , Brian C. Case , Joseph F. Obermiller , Ram H. Paul
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0016 , A61F2230/0026 , A61F2230/0067 , A61F2230/008 , A61F2230/0095 , A61F2250/0067
摘要： Medical devices with one or more bioactive agents are provided for regulating fluid flow through a body vessel. Medical devices according to the invention can comprise prosthetic valves that include a bioactive agent.
摘要翻译：提供具有一种或多种生物活性剂的医疗装置用于调节通过身体血管的流体流动。根据本发明的医疗装置可以包括包括生物活性剂的人造瓣膜。

58. 发明授权

US07153324B2 Prosthetic valve devices and methods of making such devices 有权
标题翻译：假体瓣膜装置及其制造方法
公开(公告)号：US07153324B2
公开(公告)日：2006-12-26
申请号：US10909153
申请日：2004-07-30
申请人： Brian C. Case , Jacob A. Flagle
发明人： Brian C. Case , Jacob A. Flagle
IPC分类号： A61F2/06
CPC分类号： A61F2/2412 , A61F2/2415 , A61F2/2418 , A61F2/2475 , A61F2220/0075
摘要： Prosthetic valve devices for implantation in body vessels, and methods of making same, are provided. The device has a main body with first and second ends and defining a lumen, with the second end being inverted into the lumen. A valve is disposed at the second end. In multiple valve devices, valves are disposed at the first and second ends, and individually may be inverted into the lumen. The prosthetic valve devices may further include a support structure such as a stent. Methods of making a prosthetic valve device include providing a main body having first and second ends and defining a lumen, forming a valve at the second end, and inverting the second end into the lumen. Methods may further comprise forming multiple valves and may also include attaching a support structure.
摘要翻译：提供用于植入体内血管的假体瓣膜装置及其制造方法。该装置具有主体，其具有第一和第二端并且限定内腔，其中第二端被倒置成内腔。阀设置在第二端。在多个阀装置中，阀设置在第一和第二端处，并且可以单独地倒置到内腔中。假体瓣膜装置还可以包括诸如支架的支撑结构。制造假体瓣膜装置的方法包括提供具有第一和第二端并限定内腔的主体，在第二端处形成阀，并将第二端翻转成内腔。方法还可以包括形成多个阀并且还可以包括附接支撑结构。

59. 发明授权

US07128759B2 Implantable medical device with constrained expansion 有权
标题翻译：植入式医疗器械具有约束扩张
公开(公告)号：US07128759B2
公开(公告)日：2006-10-31
申请号：US10849639
申请日：2004-05-19
申请人： Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Andrew K. Hoffa , Michael L. Garrison
发明人： Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Andrew K. Hoffa , Michael L. Garrison
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0026 , A61F2230/0095
摘要： Medical devices for implantation in a body vessel are provided. A medical device according to the invention comprises a support structure and one or more graft members comprising a valve portion and a constraining portion. The support structure has a first, unexpanded configuration and a second, expanded configuration. The constraining portion is adapted to substantially prevent the support structure from achieving the second, expanded configuration. The valve portion is adapted to permit fluid flow through a body vessel in a first direction and substantially prevent fluid flow through the vessel in a second, opposite direction.
摘要翻译：提供用于植入体内的医疗装置。根据本发明的医疗装置包括支撑结构和包括阀部分和约束部分的一个或多个移植部件。支撑结构具有第一，未膨胀的构造和第二扩展构型。约束部分适于基本上防止支撑结构实现第二扩张构型。阀部分适于允许流体沿第一方向流过身体容器，并且基本上防止流体沿第二相反方向流过血管。

60. 发明申请

US20120253446A1 Valve Device with Inflatable Chamber 审中-公开
标题翻译：带充气舱的阀门装置
公开(公告)号：US20120253446A1
公开(公告)日：2012-10-04
申请号：US13493563
申请日：2012-06-11
申请人： Thomas A. Osborne , Jacob A. Flagle , John A. Brumleve
发明人： Thomas A. Osborne , Jacob A. Flagle , John A. Brumleve
IPC分类号： A61F2/84 , B21D53/00
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2412 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2230/0026 , A61F2230/0095 , A61F2250/0003 , Y10T29/494
摘要： Prosthetic valve devices for implantation in body vessels are provided. The prosthetic valve device includes at least one flexible member that permits fluid flow in a first direction and substantially prevents fluid flow in a second. The valve device also includes an inflatable chamber at least partially attached to the flexible member. The inflatable chamber is adapted to receive inflating media and is adapted to contact the body vessel. A delivery system is also provided that includes a valve device and a delivery apparatus. The delivery apparatus includes a member adapted for filling the chamber of the valve device with inflating media. A related method of making the valve device is also provided.
摘要翻译：提供用于植入体内血管的假体瓣膜装置。所述人工瓣膜装置包括至少一个柔性构件，其允许流体沿第一方向流动并且基本上防止流体在第二方向流动。阀装置还包括至少部分地附接到柔性构件的可充气室。充气室适于接收充气介质并且适于接触身体容器。还提供了包括阀装置和输送装置的输送系统。输送装置包括适于用充气介质填充阀装置的室的构件。还提供了制造阀装置的相关方法。

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