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51. 发明授权

US07797119B2 Apparatus and method for rangings and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands 有权
标题翻译：用于低相干干涉测量LCI和光学相干断层扫描的脉冲和降噪的装置和方法通过光谱带的并行检测
公开(公告)号：US07797119B2
公开(公告)日：2010-09-14
申请号：US11956129
申请日：2007-12-13
申请人： Johannes F. de Boer , Guillermo J. Tearney , Brett Eugene Bouma
发明人： Johannes F. de Boer , Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： G01R35/00
CPC分类号： G01B9/02007 , A61B5/0059 , A61B5/0066 , A61B5/7257 , G01B9/02008 , G01B9/0201 , G01B9/02032 , G01B9/02044 , G01B9/02045 , G01B9/02079 , G01B9/0209 , G01B9/02091 , G01B2290/45 , G01N21/4795
摘要： Apparatus and method for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source is split into N spectral bands. The N spectral bands are individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band is detected by a separate photo detector and amplified. For each spectral band the signal is band pass filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is reduced by a factor equal to the number of spectral bands. The signal remains the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.
摘要翻译：通过检测并行的一组光谱带来增加光学相干断层扫描和低相干干涉测量（“LCI”）信号的灵敏度的装置和方法，每个频带是光频率的唯一组合。 LCI宽带宽源分为N个频谱带。 N个光谱带被单独检测和处理，以使信噪比增加N倍。每个光谱带由单独的光检测器检测并被放大。对于每个光谱带，信号通过模拟电子装置在信号带周围进行带通滤波，并且被数字化，或者，信号可以被数字化并且在软件中进行带通滤波。结果，对信号的散粒噪声贡献减小了等于光谱带数的因子。信号保持不变。喷射噪声的降低增加了系统的动态范围和灵敏度。

52. 发明授权

US07643153B2 Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands 有权
标题翻译：低相干干涉测量和降噪的装置和方法LCI和光学相干断层扫描OCT信号通过光谱带的并行检测
公开(公告)号：US07643153B2
公开(公告)日：2010-01-05
申请号：US11956079
申请日：2007-12-13
申请人： Johannes F. de Boer , Guillermo J. Tearney , Brett Eugene Bouma
发明人： Johannes F. de Boer , Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： G01B9/02 , G01B11/02
CPC分类号： G01N21/4795 , A61B5/0059 , A61B5/0066 , A61B5/7257 , G01B9/02044 , G01B9/02079 , G01B9/0209 , G01B9/02091 , G01B2290/45
摘要： Apparatus, method, logic arrangement and storage medium are provided for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source can be split into N spectral bands. The N spectral bands can be individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band may be detected by a separate photo detector and amplified. For each spectral band, the signal can be band pass filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is likely reduced by a factor equal to the number of spectral bands, while the signal amplitude can remain the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.
摘要翻译：提供装置，方法，逻辑布置和存储介质，用于通过检测光谱带的并行组来提高光学相干断层扫描和低相干干涉测量（“LCI”）信号的检测灵敏度，每个频带是光频率的唯一组合。 LCI宽带宽源可以分为N个光谱带。可以单独地检测和处理N个频谱带，以使信噪比增加N倍。每个频谱带可以由单独的光检测器检测并被放大。对于每个光谱带，信号可以通过模拟电子装置在信号带周围进行带通滤波，并被数字化，或者，信号可以被数字化并且在软件中进行带通滤波。结果，对信号的散粒噪声贡献可能降低等于光谱带数的因子，而信号幅度可以保持相同。喷射噪声的降低增加了系统的动态范围和灵敏度。

53. 发明授权

US07630083B2 Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands 有权
标题翻译：低相干干涉测量和降噪的装置和方法LCI和光学相干断层扫描OCT信号通过光谱带的并行检测
公开(公告)号：US07630083B2
公开(公告)日：2009-12-08
申请号：US11955834
申请日：2007-12-13
申请人： Johannes F. de Boer , Guillermo J. Tearney , Brett Eugene Bouma
发明人： Johannes F. de Boer , Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： G01B11/02 , G01B9/02
CPC分类号： G01B9/02007 , A61B5/0059 , A61B5/0066 , A61B5/7257 , G01B9/02008 , G01B9/0201 , G01B9/02032 , G01B9/02044 , G01B9/02045 , G01B9/02079 , G01B9/0209 , G01B9/02091 , G01B2290/45 , G01N21/4795
摘要： Apparatus and method for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source is split into N spectral bands. The N spectral bands are individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band is detected by a separate photo detector and amplified. For each spectral band the signal is band pass filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is reduced by a factor equal to the number of spectral bands. The signal remains the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.
摘要翻译：通过检测并行的一组光谱带来增加光学相干断层扫描和低相干干涉测量（“LCI”）信号的灵敏度的装置和方法，每个频带是光频率的唯一组合。 LCI宽带宽源分为N个频谱带。 N个光谱带被单独检测和处理，以使信噪比增加N倍。每个光谱带由单独的光检测器检测并被放大。对于每个光谱带，信号通过模拟电子装置在信号带周围进行带通滤波，并且被数字化，或者，信号可以被数字化并且在软件中进行带通滤波。结果，对信号的散粒噪声贡献减小了等于光谱带数的因子。信号保持不变。喷射噪声的降低增加了系统的动态范围和灵敏度。

54. 发明申请

US20090027689A1 METHOD AND APPARATUS FOR PERFORMING OPTICAL IMAGING USING FREQUENCY-DOMAIN INTERFEROMETRY 有权
标题翻译：使用频域干涉法进行光学成像的方法和装置
公开(公告)号：US20090027689A1
公开(公告)日：2009-01-29
申请号：US12139314
申请日：2008-06-13
申请人： Seok-Hyun Yun , Brett Eugene Bouma , Guillermo J. Tearney , Johannes Fitzgerald De Boer
发明人： Seok-Hyun Yun , Brett Eugene Bouma , Guillermo J. Tearney , Johannes Fitzgerald De Boer
IPC分类号： G01B11/02
CPC分类号： H01S5/5045 , A61B5/0059 , A61B5/0066 , A61B5/7257 , G01B9/02002 , G01B9/02004 , G01B9/02043 , G01B9/02075 , G01B9/02081 , G01B9/02083 , G01B9/02084 , G01B9/0209 , G01B9/02091 , G01B2290/45 , G01B2290/70 , G01J3/02 , G01J3/0208 , G01J3/021 , G01J3/0218 , G01J3/0264 , G01J3/453 , G01J9/0215 , G01N21/4795 , G02B6/3604 , G02B26/12 , G02B27/48 , G02F1/093 , G02F1/11 , H01S3/0071 , H01S3/0078 , H01S3/08009 , H01S3/08063 , H01S3/105 , H01S3/1068 , H01S5/0071 , H01S5/0078 , H01S5/1025 , H01S5/14 , H01S5/141 , H01S5/146
摘要： An apparatus and method are provided. In particular, at least one first electro-magnetic radiation may be provided to a sample and at least one second electro-magnetic radiation can be provided to a non-reflective reference. A frequency of the first and/or second radiations varies over time. An interference is detected between at least one third radiation associated with the first radiation and at least one fourth radiation associated with the second radiation. Alternatively, the first electro-magnetic radiation and/or second electro-magnetic radiation have a spectrum which changes over time. The spectrum may contain multiple frequencies at a particular time. In addition, it is possible to detect the interference signal between the third radiation and the fourth radiation in a first polarization state. Further, it may be preferable to detect a further interference signal between the third and fourth radiations in a second polarization state which is different from the first polarization state. The first and/or second electro-magnetic radiations may have a spectrum whose mean frequency changes substantially continuously over time at a tuning speed that is greater than 100 Tera Hertz per millisecond.
摘要翻译：提供了一种装置和方法。特别地，可以向样品提供至少一个第一电磁辐射，并且可以向非反射参考提供至少一个第二电磁辐射。第一和/或第二辐射的频率随时间变化。在与第一辐射相关联的至少一个第三辐射与与第二辐射相关联的至少一个第四辐射之间检测到干扰。或者，第一电磁辐射和/或第二电磁辐射具有随时间变化的光谱。频谱可以在特定时间包含多个频率。此外，可以在第一偏振状态下检测第三辐射与第四辐射之间的干涉信号。此外，可能优选在与第一偏振状态不同的第二偏振态中检测第三和第四辐射之间的另外的干扰信号。第一和/或第二电磁辐射可以具有在每毫秒大于100Tera赫兹的调谐速度下，其平均频率随时间而基本连续变化的频谱。

55. 发明申请

US20080287808A1 APPARATUS, PROBE AND METHOD FOR PROVIDING DEPTH ASSESSMENT IN AN ANATOMICAL STRUCTURE 审中-公开
标题翻译：在解剖结构中提供深度评估的装置，探针和方法
公开(公告)号：US20080287808A1
公开(公告)日：2008-11-20
申请号：US11854199
申请日：2007-09-12
申请人： Guillermo J Tearney , Brett Eugene Bouma
发明人： Guillermo J Tearney , Brett Eugene Bouma
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/445 , A61B2562/0242
摘要： Apparatus and method can be provided for obtaining information regarding at least one portion of an anatomical structure. For example, using at least one first arrangement, it is possible to forward at least one first electromagnetic radiation to the at least one portion. In addition, using at least one second arrangement, it is possible to detect at least one second electromagnetic radiation from the sample, the second electromagnetic radiation being related to the first electromagnetic radiation. The second arrangement can be used to obtain data associated with the second electromagnetic radiation at a plurality of integration times. Further, with at least one third arrangement, it is possible to determine at least one motion characteristic as a function of depth within the portion using the second electromagnetic radiation. The motion characteristic can be determined by obtaining data associated with the second electromagnetic radiation. The data can be speckle data detected by the second arrangement. In addition, using the third arrangement, it is possible to determine optical properties of the portion based on the data. Furthermore, with a fourth arrangement, it is possible to receive the first electromagnetic radiation and generate a plurality of third electromagnetic radiations to irradiate multiple points on the portion. The second arrangement can be used to detect the second electromagnetic radiation from the sample based on the third electromagnetic radiations, and the third arrangement can also be used to determine a plurality of motion characteristics as a function of depth for a plurality of location of the at least one portion as a function of the second electromagnetic radiation.
摘要翻译：可以提供装置和方法来获得关于解剖结构的至少一部分的信息。例如，使用至少一个第一布置，可以将至少一个第一电磁辐射转发到至少一个部分。另外，使用至少一个第二布置，可以检测来自样品的至少一个第二电磁辐射，第二电磁辐射与第一电磁辐射有关。第二布置可以用于在多个积分时间获得与第二电磁辐射相关联的数据。此外，利用至少一个第三布置，可以使用第二电磁辐射来确定作为深度的函数的至少一个运动特性。可以通过获得与第二电磁辐射相关联的数据来确定运动特性。数据可以是由第二布置检测到的斑点数据。另外，使用第三布置，可以基于数据来确定该部分的光学特性。此外，通过第四布置，可以接收第一电磁辐射并产生多个第三电磁辐射以照射该部分上的多个点。第二布置可以用于基于第三电磁辐射来检测来自样本的第二电磁辐射，并且第三布置还可以用于确定多个运动特性作为对于多个位置的at的深度的函数作为第二电磁辐射的函数的至少一部分。

56. 发明申请

US20080262359A1 SYSTEM AND METHOD PROVIDING INTRACORONARY LASER SPECKLE IMAGING FOR THE DETECTION OF VULNERABLE PLAQUE 审中-公开
标题翻译：系统和方法提供用于检测易受伤害的PLAQUE的激光雷射成像
公开(公告)号：US20080262359A1
公开(公告)日：2008-10-23
申请号：US12058279
申请日：2008-03-28
申请人： Guillermo J. Tearney , Seemantini N. Nadkarni , Brett Eugene Bouma
发明人： Guillermo J. Tearney , Seemantini N. Nadkarni , Brett Eugene Bouma
IPC分类号： A61B5/00
CPC分类号： G02B6/06 , A61B1/00096 , A61B1/00167 , A61B5/0066 , A61B5/0084 , A61B5/7285 , G02B6/32
摘要： Apparatus and method according to an exemplary embodiment of the present invention can be provided for analyzing tissue. For example, the apparatus can include at least one first arrangement configured to illuminate at least one anatomical structure with at least one of at least one electro-magnetic radiation. The apparatus can also include at least one second arrangement that may include at least two wave-guiding arrangements associated with one another that are configured to receive a further electro-magnetic radiation reflected from the tissue and transmit at least one speckle pattern associated with the further electro-magnetic radiation. The wave-guiding arrangements may be structured so as to reduce crosstalk therebetween.
摘要翻译：可以提供根据本发明的示例性实施例的装置和方法来分析组织。例如，该装置可以包括配置成用至少一个电磁辐射中的至少一个照射至少一个解剖结构的至少一个第一配置。该装置还可以包括至少一个第二布置，其可以包括彼此相关联的至少两个波导装置，其被配置为接收从组织反射的另外的电磁辐射，并且传输与另外的相关联的至少一个散斑图案电磁辐射。波导装置可以被构造成减小它们之间的串扰。

57. 发明授权

US09968245B2 Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample, and effecting such portion(s) 有权
公开(公告)号：US09968245B2
公开(公告)日：2018-05-15
申请号：US13614459
申请日：2012-09-13
申请人： Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin
发明人： Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin
IPC分类号： A61B1/07 , A61B5/00 , A61B18/22 , A61B17/00
CPC分类号： A61B1/07 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B18/22 , A61B2017/00061
摘要： Exemplary apparatus and process can be provided for imaging information associated with at least one portion of a sample. For example, (i) first different wavelengths of at least one first electro-magnetic radiation can be provided within a first wavelength range provided on the portion of the sample so as to determine at least one first transverse location of the portion, and (ii) second different wavelengths of at least one second electro-magnetic radiation within a second wavelength range can be provided on the portion so as to determine at least one second transverse location of the portion. The first and second ranges can east partially overlap on the portion. Further, a relative phase between at least one third electro-magnetic radiation electro-magnetic radiation being returned from the sample and at least one fourth electro-magnetic radiation returned from a reference can be obtained to determine a relative depth location of the portion.

58. 发明授权

US09510758B2 Apparatus, systems and methods for measuring blood pressure within at least one vessel 有权
标题翻译：用于测量至少一个血管内的血压的装置，系统和方法
公开(公告)号：US09510758B2
公开(公告)日：2016-12-06
申请号：US13283143
申请日：2011-10-27
申请人： William C. Warger, II , Simon C. Schlachter , Joseph Gardecki , Brett Eugene Bouma , Guillermo J. Tearney
发明人： William C. Warger, II , Simon C. Schlachter , Joseph Gardecki , Brett Eugene Bouma , Guillermo J. Tearney
IPC分类号： A61B6/00 , A61B5/021 , A61B5/00 , A61B5/1455 , A61B5/0205 , A61B3/14 , A61B5/02 , A61B5/12 , A61B5/20
CPC分类号： A61B5/021 , A61B3/14 , A61B5/0066 , A61B5/02007 , A61B5/02055 , A61B5/12 , A61B5/14558 , A61B5/202 , A61B5/4064 , A61B5/407 , A61B5/42 , A61B2576/00
摘要： Exemplary apparatus and method for obtaining information for at least one structure can be provided. For example, it is possible to forward at least one first electro-magnetic radiation to the at least one structure which is external from the apparatus. At least one second electro magnetic radiation provided from the at least one structure (which is based on the first electro-magnetic radiation(s)) can be detected. It is also possible to determine at least one characteristic of the structure(s) based on the second electro-magnetic radiation(s), and obtain data relating to a pressure of at least one portion of the structure(s) based on the characteristic(s).
摘要翻译：可以提供用于获得至少一个结构的信息的示例性装置和方法。例如，可以将至少一个第一电磁辐射转发到从装置外部的至少一个结构。可以检测从至少一个结构（其基于第一电磁辐射）提供的至少一个第二电磁辐射。也可以基于第二电磁辐射来确定结构的至少一个特性，并且基于特性获得与结构的至少一部分的压力有关的数据（s）。

59. 发明授权

US09254102B2 Method and apparatus for imaging of vessel segments 有权
公开(公告)号：US09254102B2
公开(公告)日：2016-02-09
申请号：US13226274
申请日：2011-09-06
申请人： Guillermo J. Tearney , Milen Shishkov , Brett Eugene Bouma
发明人： Guillermo J. Tearney , Milen Shishkov , Brett Eugene Bouma
IPC分类号： A61B6/00 , A61B5/00 , A61B5/02
CPC分类号： A61B5/6852 , A61B5/0062 , A61B5/0066 , A61B5/0084 , A61B5/02007
摘要： An apparatus, method and software arrangement for imaging a surface of a structure that is in contact with an opaque fluid is provided. The apparatus includes an article of manufacture (e.g., a housing), a fluid delivery arrangement and an imaging arrangement. The housing includes an aperture formed in the article of manufacture. The fluid delivery arrangement is configured to deliver a volume of substantially transparent fluid to the aperture formed in the housing. The imaging arrangement is configured to image the surface of the structure using an imaging modality after the volume of the transparent fluid is delivered to the aperture, wherein the imaging arrangement and/or the article of manufacture is translated along the surface of the structure while imaging the surface of the structure.

60. 发明授权

US09254089B2 Apparatus and methods for facilitating at least partial overlap of dispersed ration on at least one sample 有权
标题翻译：用于促进至少一个样品上的分散比例的至少部分重叠的装置和方法
公开(公告)号：US09254089B2
公开(公告)日：2016-02-09
申请号：US13054015
申请日：2009-07-14
申请人： Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin , Dongkyun Kang
发明人： Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin , Dongkyun Kang
IPC分类号： G01J3/02 , A61B5/00 , G01N21/47 , G02B23/24 , G01J3/18
CPC分类号： A61B1/00172 , A61B1/04 , A61B5/0062 , A61B5/0066 , A61B5/0075 , A61B5/0084 , G01J3/0218 , G01J3/0256 , G01J3/18 , G01N21/4795 , G02B23/2423 , G02B23/2469
摘要： Exemplary embodiments of apparatus and method according to the present disclosure are provided. For example, an apparatus for providing electromagnetic radiation to a structure can be provided. The exemplary apparatus can include a first arrangement having at least two wave-guides which can be configured to provide there through at least two respective electromagnetic radiations with at least partially different wavelengths from one another. The exemplary apparatus can also include a dispersive second arrangement structured to receive the electro-magnetic radiations and forward at least two dispersed radiations associated with the respective electro-magnetic radiations to at least one section of the structure. The wave-guide(s) can be structured and/or spatially arranged with respect to the dispersive arrangement to facilitate at least partially overlap of the dispersed radiations on the structure. In addition, another arrangement can be provided which can include at least two further wave-guides which can be configured to receive the electro-magnetic radiations from the dispersive arrangement. Each of the further wave-guides can be structured and/or spatially arranged with respect to the dispersive arrangement to facilitate a receipt of a different one of the such electro-magnetic radiations as a function of wavelengths thereof.
摘要翻译：提供了根据本公开的设备和方法的示例性实施例。例如，可以提供用于向结构提供电磁辐射的装置。示例性装置可以包括具有至少两个波导的第一装置，所述至少两个波导可被配置成通过至少两个具有彼此具有至少部分不同波长的相应电磁辐射来提供波导。示例性装置还可以包括分散第二装置，其被构造为接收电磁辐射，并将与各个电磁辐射相关联的至少两个分散的辐射转发到该结构的至少一个部分。波导可以相对于分散布置被构造和/或空间布置，以促进结构上分散的辐射的至少部分重叠。此外，可以提供另外的布置，其可以包括至少两个另外的波导，其可被配置为从分散布置接收电磁辐射。每个其它波导可以相对于色散装置构造和/或空间布置，以便于接收这样的电磁辐射中不同的一个作为其波长的函数。

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