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51. 发明申请

US20050002865A1 Diagnostic/therapeutic agents 审中-公开
标题翻译：诊断/治疗剂
公开(公告)号：US20050002865A1
公开(公告)日：2005-01-06
申请号：US10734730
申请日：2003-12-15
申请人： Jo Klaveness , Pal Rongved , Anders Hogset , Helge Tolleshaug , Alan Cuthbertson , Aslak Godal , Lars Hoff , Geir Gogstad , Klaus Bryn , Anne Naevestad , Dagfinn Lovhaug , Halldis Hellebust , Magne Solbakken
发明人： Jo Klaveness , Pal Rongved , Anders Hogset , Helge Tolleshaug , Alan Cuthbertson , Aslak Godal , Lars Hoff , Geir Gogstad , Klaus Bryn , Anne Naevestad , Dagfinn Lovhaug , Halldis Hellebust , Magne Solbakken
IPC分类号： A61K47/48 , A61K49/00 , A61K49/08 , A61K49/18 , A61K49/22 , A61K51/04 , A61K51/08 , A61K51/12
CPC分类号： A61K51/1255 , A61K47/542 , A61K47/62 , A61K47/6925 , A61K49/0002 , A61K49/0043 , A61K49/0047 , A61K49/0054 , A61K49/0056 , A61K49/0058 , A61K49/0091 , A61K49/223 , A61K51/065 , A61K51/1227 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.
摘要翻译：靶向诊断和/或治疗活性剂，例如超声造影剂，其包含在包含含气体或气体产生材料的报道分子的含水载体液体中的悬浮液，所述试剂能够与靶形成至少两种结合对。

52. 发明授权

US06331289B1 Targeted diagnostic/therapeutic agents having more than one different vectors 失效
标题翻译：具有多于一种不同载体的靶向诊断/治疗剂
公开(公告)号：US06331289B1
公开(公告)日：2001-12-18
申请号：US08959206
申请日：1997-10-28
申请人： Jo Klaveness , Pål Rongved , Anders Høgset , Helge Tolleshaug , Alan Cuthbertson , Lars Hoff , Klaus Bryn , Halldis Hellebust , Magne Solbakken
发明人： Jo Klaveness , Pål Rongved , Anders Høgset , Helge Tolleshaug , Alan Cuthbertson , Lars Hoff , Klaus Bryn , Halldis Hellebust , Magne Solbakken
IPC分类号： A61B800
CPC分类号： A61K51/1255 , A61K47/542 , A61K47/62 , A61K47/6925 , A61K49/0002 , A61K49/0043 , A61K49/0047 , A61K49/0054 , A61K49/0056 , A61K49/0058 , A61K49/0091 , A61K49/223 , A61K51/065 , A61K51/1227 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.
摘要翻译：靶向诊断和/或治疗活性剂，例如超声造影剂，其包含在包含含气体或气体产生材料的报道分子的含水载体液体中的悬浮液，所述试剂能够与靶形成至少两种结合对。

53. 发明授权

US06261537B1 Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors 失效
标题翻译：具有偶联至一种或多种载体的微泡的诊断/治疗剂
公开(公告)号：US06261537B1
公开(公告)日：2001-07-17
申请号：US08960054
申请日：1997-10-29
申请人： Jo Klaveness , Pål Rongved , Anders Høgset , Helge Tolleshaug , Anne Nævestad , Halldis Hellebust , Lars Hoff , Alan Cuthbertson , Dagfinn Løvhaug , Magne Solbakken
发明人： Jo Klaveness , Pål Rongved , Anders Høgset , Helge Tolleshaug , Anne Nævestad , Halldis Hellebust , Lars Hoff , Alan Cuthbertson , Dagfinn Løvhaug , Magne Solbakken
IPC分类号： A61B800
CPC分类号： A61K51/1255 , A61K47/542 , A61K47/62 , A61K47/6925 , A61K49/0002 , A61K49/0043 , A61K49/0047 , A61K49/0054 , A61K49/0056 , A61K49/0058 , A61K49/0091 , A61K49/223 , A61K51/088 , A61K51/1227 , Y10S977/928
摘要： Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, having reporters comprising gas-filled microbubbles stabilised by monolayers of film-forming surfactants, the reporter being coupled or linked to at least one vector.
摘要翻译：靶向诊断和/或治疗活性剂，例如超声造影剂，具有包含通过成膜表面活性剂的单层稳定的充气微泡的记者，所述报告基团与至少一个载体偶联或连接。

54. 发明授权

US06235591B1 Method to form gate oxides of different thicknesses on a silicon substrate 失效
标题翻译：在硅衬底上形成不同厚度的栅极氧化物的方法
公开(公告)号：US06235591B1
公开(公告)日：2001-05-22
申请号：US09425904
申请日：1999-10-25
申请人： Narayanan Balasubramanian , Yelehanka Ramachandamurthy Pradeep , Jia Zhen Zheng , Alan Cuthbertson
发明人： Narayanan Balasubramanian , Yelehanka Ramachandamurthy Pradeep , Jia Zhen Zheng , Alan Cuthbertson
IPC分类号： H01L218234
CPC分类号： H01L21/823462
摘要： A method of fabricating gate oxides of different thicknesses has been achieved. Active area isolations are provided in a silicon substrate to define low voltage sections and high voltage sections in the silicon substrate. A sacrificial oxide layer is formed overlying the silicon substrate. A silicon nitride layer is deposited overlying the sacrificial oxide layer. A masking oxide layer is deposited overlying the silicon nitride layer. The masking oxide layer is patterned to form a hard mask overlying the low voltage sections. The silicon nitride layer is etched through where exposed by the hard mask thereby exposing the sacrificial oxide layer overlying the high voltage section. The exposed sacrificial oxide layer and the hard mask are etched away. A thick gate oxide layer is grown overlying the silicon substrate in the high voltage section. The silicon nitride layer is etched away. The sacrificial oxide layer overlying the low voltage section is etched away. A thin gate oxide layer is grown overlying the silicon substrate in the low voltage section, and the integrated circuit device is completed.
摘要翻译：已经实现了制造不同厚度的栅极氧化物的方法。在硅衬底中提供有源区隔离以限定硅衬底中的低电压部分和高压部分。在硅衬底上形成牺牲氧化层。覆盖在牺牲氧化物层上的氮化硅层被沉积。覆盖氮化硅层的掩模氧化物层被沉积。图案化掩模氧化物层以形成覆盖低电压部分的硬掩模。蚀刻氮化硅层，通过硬掩模露出，从而暴露覆盖高压部分的牺牲氧化物层。暴露的牺牲氧化物层和硬掩模被蚀刻掉。在高压部分中生长覆盖硅衬底的厚栅氧化层。蚀刻掉氮化硅层。覆盖低电压部分的牺牲氧化物层被蚀刻掉。在低电压部分中生长覆盖硅衬底的薄栅氧化层，并且完成集成电路器件。

55. 发明授权

US10201625B2 Radiolabelled octreotate analogues as PET tracers 有权
公开(公告)号：US10201625B2
公开(公告)日：2019-02-12
申请号：US14002168
申请日：2012-03-01
申请人： Sajinker Kaur Luthra , Julius Leyton , Eric Ofori Aboagye , Lisa Iddon , Bard Indrevoll , Matthias Eberhard Glaser , Alan Cuthbertson
发明人： Sajinker Kaur Luthra , Julius Leyton , Eric Ofori Aboagye , Lisa Iddon , Bard Indrevoll , Matthias Eberhard Glaser , Alan Cuthbertson
IPC分类号： A61K51/00 , A61M36/14 , A61K51/08 , C07B59/00
摘要： Novel radiotracer(s) for Positron Emission Tomography (PET) imaging are described. Novel radiotracer(s) for Positron Emission Tomography (PET) imaging of neuorendocrine tumors are described. Specifically the present invention describes novel [18F]Fluoroethyltriazol-[Tyr3]Octreotate analogs; in particular those that target somatostatin receptors found on the cell surface of gastroenteropancreatic neuorendocrine tumors. The present invention also describes intermediate(s), precursor(s), pharmaceutical composition(s), methods of making, and methods of use of the novel radiotracer(s).

56. 发明授权

US08568689B1 uPAR-targeting contrast agents 失效
标题翻译： uPAR靶向造影剂
公开(公告)号：US08568689B1
公开(公告)日：2013-10-29
申请号：US11576193
申请日：2005-09-28
申请人： Alan Cuthbertson , Bente E. Arbo
发明人： Alan Cuthbertson , Bente E. Arbo
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K49/0056 , A61K38/10 , A61K49/0032 , A61K51/088
摘要： The invention relates to contrast agents for detection of the Urokinase Plasminogen Activator Receptor (uPAR). More specifically the invention relates to contrast agents comprising a peptidic vector binding to the uPAR, labelled with an imageable moiety.
摘要翻译：本发明涉及用于检测尿激酶纤溶酶原激活因子受体（uPAR）的造影剂。更具体地，本发明涉及包含与uPAR结合的肽载体的造影剂，其用可成像部分标记。

57. 发明授权

US08444955B2 Radiofluorination methods 失效
标题翻译：放射性氟化方法
公开(公告)号：US08444955B2
公开(公告)日：2013-05-21
申请号：US12676427
申请日：2008-09-09
申请人： Alan Cuthbertson , Magne Solbakken , Dag Erlend Olberg
发明人： Alan Cuthbertson , Magne Solbakken , Dag Erlend Olberg
IPC分类号： A61K51/00
CPC分类号： C07B59/008 , A61K51/088 , C07K1/13 , C07K5/0817 , C07K7/56 , C07K14/745
摘要： The invention relates to conjugates of formula (V) or (VI), their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates used in such processes.
摘要翻译：本发明涉及式（Ⅴ）或（Ⅵ）的缀合物，它们作为放射性药物的用途，其制备方法以及在这些方法中使用的合成中间体。

58. 发明授权

US08258101B2 Peptide-based compounds 失效
标题翻译：基于肽的化合物
公开(公告)号：US08258101B2
公开(公告)日：2012-09-04
申请号：US12814621
申请日：2010-06-14
申请人： Alan Cuthbertson
发明人： Alan Cuthbertson
IPC分类号： A61K38/12 , C07K5/12
CPC分类号： C07K14/70546 , A61K51/082 , C07K7/06
摘要： This invention relates to new peptide-based compounds and their use in therapeutically effective treatments as well as for diagnostic imaging techniques. More specifically the invention relates to the use of such peptide-based compounds used as targeting vectors that bind to receptors associated with angiogenesis, in particular the αvβ3 integrin receptor. Such contrast agents may thus be used for diagnosis of for example malignant diseases, heart diseases, inflammation-related diseases, rheumatoid arthritis and Kaposi's sarcoma. Moreover such compounds may also be used in therapeutic treatment of these diseases.
摘要翻译：本发明涉及新的基于肽的化合物及其在治疗有效治疗以及诊断成像技术中的用途。更具体地，本发明涉及用作与血管生成相关的受体结合的靶向载体的这种基于肽的化合物的用途，特别是αv＆bgr 3整合素受体。因此，这样的造影剂可用于诊断例如恶性疾病，心脏病，炎症相关疾病，类风湿性关节炎和卡波西氏肉瘤。此外，这些化合物也可用于治疗这些疾病。

59. 发明授权

US07897142B2 Peptide based-compounds 失效
标题翻译：基于肽的化合物
公开(公告)号：US07897142B2
公开(公告)日：2011-03-01
申请号：US11570156
申请日：2005-06-15
申请人： Alan Cuthbertson , Robert James Nairne
发明人： Alan Cuthbertson , Robert James Nairne
IPC分类号： A61B10/00 , A61B5/00
CPC分类号： A61K49/0056 , A61K49/0032 , C07K5/0817 , C07K5/126 , C07K14/70546 , G01N33/533
摘要： The invention relates to new peptide-based compounds and their use in diagnostic optical imaging techniques. More specifically the invention relates to the use of such peptide-based compounds as targeting vectors that bind to receptors associated with angiogenesis. The compounds are labelled with at least one cyanine dye reporter and may be used as contrast agents in optical imaging in diagnosis of angiogenesis-related diseases.
摘要翻译：本发明涉及新的基于肽的化合物及其在诊断光学成像技术中的应用。更具体地，本发明涉及这种基于肽的化合物作为与血管发生相关的受体结合的靶向载体的用途。该化合物用至少一种花青染料报告物进行标记，并可用作造影剂用于诊断血管发生相关疾病的光学成像。

60. 发明授权

US07776705B2 Method for fabricating a thick copper line and copper inductor resulting therefrom 有权
标题翻译：用于制造由其产生的粗铜线和铜电感器的方法
公开(公告)号：US07776705B2
公开(公告)日：2010-08-17
申请号：US11470552
申请日：2006-09-06
申请人： Isaiah O. Oladeji , Alan Cuthbertson
发明人： Isaiah O. Oladeji , Alan Cuthbertson
IPC分类号： H01L21/20
CPC分类号： H01L21/76885 , H01L21/76834 , H01L23/5227 , H01L23/53238 , H01L28/10 , H01L2924/0002 , H01L2924/00
摘要： A method of forming one or more inductors on a substrate is disclosed. The method includes forming a first dielectric material over the substrate, forming a trench in the first dielectric material, and substantially filling the trench with copper to form the one or more inductors. The first dielectric material is removed and a second dielectric material is formed over the copper. The second dielectric material is removed from an uppermost portion of the copper, thus leaving a portion of the second dielectric material on the sidewalls of the copper.
摘要翻译：公开了一种在衬底上形成一个或多个电感器的方法。该方法包括在衬底上形成第一介电材料，在第一介电材料中形成沟槽，并用铜基本上填充沟槽以形成一个或多个电感器。去除第一电介质材料，并在铜上形成第二电介质材料。第二电介质材料从铜的最上部去除，因此在铜的侧壁上留下一部分第二电介质材料。

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