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51. 发明申请

US20060106046A1 Melanin-concentrating hormone receptor antagonists containing piperidine derivatives as the active ingredient 失效
标题翻译：黑色素浓缩激素受体拮抗剂含有哌啶衍生物作为活性成分
公开(公告)号：US20060106046A1
公开(公告)日：2006-05-18
申请号：US10544261
申请日：2004-02-09
申请人： Minoru Moriya , Toshihiro Sakamoto , Makoto Ishikawa , Akio Kanatani , Takehiro Fukami
发明人： Minoru Moriya , Toshihiro Sakamoto , Makoto Ishikawa , Akio Kanatani , Takehiro Fukami
IPC分类号： A61K31/4747 , A61K31/4545 , C07D471/10 , C07D401/02
CPC分类号： C07D401/04 , A61K31/438 , A61K31/4439 , A61K31/445 , C07D211/26 , C07D491/10
摘要： The invention provides melanin-concentrating hormone receptor antagonists containing as the active ingredient piperidine derivatives represented by the general formula [I]: [wherein R1 is hydrogen, hydroxyl, lower alkyl, or the like; R2, R3a, R3b, R4a, R4b, R5a, R5b and R6 each stands for hydrogen, halogen, or the like; W1 and W2 each independently stands for —O—, —CH2—, or the like; Y1, Y2, Y3 and Y4 stand for —CH—, —CF—, —N—, or the like; Z stands for lower alkyl, an aliphatic heterocyclic group, or the like; Ar is a mono- or bi-cyclic aliphatic heterocycle or an aromatic heterocycle; and n is an integer of 1 to 8]. The compounds act as antagonist against melanin-concentrating hormone receptor and are useful as drugs for central diseases, circulatory diseases, or metabolic diseases.
摘要翻译：本发明提供了含有作为活性成分的通式[I]表示的哌啶衍生物的黑色素浓缩激素受体拮抗剂：其中R 1是氢，羟基，低级烷基等; R 2，R 3，R 3b，R 4a，R 4b，R 4b， R 5a，R 5b和R 6各自代表氢，卤素等; W 1和W 2各自独立地代表-O-，-CH 2 - 等; Y 1，Y 2，Y 3和Y 4代表-CH - ， - CF - ， - N-等; Z代表低级烷基，脂族杂环基等; Ar是单环或双环脂族杂环或芳族杂环; n为1〜8的整数]。该化合物作为拮抗黑素浓缩激素受体的拮抗剂，可用作中枢疾病，循环系统疾病或代谢疾病的药物。

52. 发明授权

US6090054A Ultrasonic wave cosmetic device 失效
标题翻译：超声波化妆品装置
公开(公告)号：US6090054A
公开(公告)日：2000-07-18
申请号：US97113
申请日：1998-06-12
申请人： Hiroyuki Tagishi , Toshihiro Sakamoto , Kazuyasu Ikadai
发明人： Hiroyuki Tagishi , Toshihiro Sakamoto , Kazuyasu Ikadai
IPC分类号： A61H23/02 , A61H1/00
CPC分类号： A61H23/0245 , A61H2201/0176
摘要： An improved ultrasonic wave cosmetic device which is able to protect skin against burns. The ultrasonic wave cosmetic device for treating skin includes a probe head having a skin contact metal surface for contacting the skin to transmit an ultrasonic wave thereto, an ultrasonic wave vibration element for vibrating at an ultrasonic wave frequency in response to an output signal from an ultrasonic wave oscillation circuit, and a temperature sensor mounted in a manner directly contacting a side surface of the ultrasonic wave vibration element and a surface opposite the skin contact metal surface for detecting the temperature of the probe head. The temperature sensor feeds back signals to the oscillation circuit which terminates the oscillation output signal when the probe head gets too hot.
摘要翻译：一种改进的超声波化妆品，能够保护皮肤免受灼伤。用于治疗皮肤的超声波化妆品装置包括具有皮肤接触金属表面的探针头，用于接触皮肤以传送超声波，超声波振动元件，响应于来自超声波的输出信号以超声波频率振动波振荡电路和以与超声波振动元件的侧面直接接触的方式安装的温度传感器和与皮肤接触金属表面相对的表面，用于检测探头的温度。温度传感器将信号反馈到振荡电路，当探针头太热时终止振荡输出信号。

53. 发明授权

US5502015A Infrared transmitting barium fluoride sintered body 失效
标题翻译：红外透射钡氟化物烧结体
公开(公告)号：US5502015A
公开(公告)日：1996-03-26
申请号：US389420
申请日：1995-02-16
申请人： Kenichiro Shibata , Akihito Fujii , Toshihiro Sakamoto
发明人： Kenichiro Shibata , Akihito Fujii , Toshihiro Sakamoto
IPC分类号： C04B35/553
CPC分类号： C04B35/553
摘要： The present invention provides an infrared ray transmitting material, even large-sized one being manufacturable at a low price, consisting of a polycrystal not liable to cleavage, which makes only a slight absorption of infrared rays all over the region of 8-11 .mu.m wave lengths, thus being highly transmissive. The material is a polycrystalline barium fluoride sintered body excellent in transmission to infrared region of 8-11 .mu.m wave lengths, one that is most excellent in the infrared transmission being produced by a method comprising the hot press sintering and the HIP treatment in combination, one that gives somewhat inferior transmission but which is low-priced by a method comprising the CIP molding and the normal pressure sintering in combination, and one that regarded as intermediate between the aforementioned two by a method comprising the CIP molding, normal-pressure sintering and the HIP treatment in combination, in all cases entirely without addition of any binder or sintering aid.
摘要翻译：本发明提供一种红外线透射材料，即使是大尺寸的也可以以低价格制造，由不易裂开的多晶体组成，仅在8-11μm的区域内仅有轻微的红外线吸收波长，因此是高度透射的。该材料是通过包含热压烧结和HIP处理的方法制造的红外线透过率最高的8-11μm波长的透射率优异的多晶氟化钡烧结体，通过包括CIP成型和常压烧结的方法组合的方法，通过包括CIP成型，常压烧结和在所有情况下，组合的HIP处理完全不添加任何粘合剂或烧结助剂。

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