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51. 发明授权

US09248131B2 Aquaporin modulators and methods of using them for the treatment of edema and fluid imbalance 有权
标题翻译：水通道蛋白调节剂及其用于治疗水肿和液体不平衡的方法
公开(公告)号：US09248131B2
公开(公告)日：2016-02-02
申请号：US14678818
申请日：2015-04-03
申请人： THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
发明人： Gary A. Flynn , Andrea J. Yool , Elton Rodrigues Migliati , Leslie S. Ritter
IPC分类号： A61K31/54 , A61K31/24 , A61K31/495 , A61K31/5375 , A61K31/341 , A61K31/4402 , A61K31/4409 , A61K31/443 , A61K31/496 , A61K31/196 , A61K31/4406 , C07C311/39 , C07D213/40 , C07D213/75 , C07D239/91 , C07D279/12 , C07D307/52 , C07C311/16 , C07D213/16 , C07D241/04 , C07D265/30 , C07D307/36 , C07D405/06 , C07D405/12 , C07D407/12
CPC分类号： A61K31/54 , A61K31/196 , A61K31/24 , A61K31/341 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/443 , A61K31/495 , A61K31/496 , A61K31/5375 , C07C311/16 , C07C311/39 , C07D213/16 , C07D213/40 , C07D213/75 , C07D239/91 , C07D241/04 , C07D265/30 , C07D279/12 , C07D307/36 , C07D307/52 , C07D405/06 , C07D405/12 , C07D407/12
摘要： Compounds, including 3-carboxy aryl sulfonamide compounds, which agonize or antagonize aquaporin channels and methods of using them to treat disorders or diseases mediated by aquaporins.
摘要翻译：激动或拮抗水通道蛋白通道的化合物，包括3-羧基芳基磺酰胺化合物，以及使用它们治疗由水通道蛋白介导的疾病或疾病的方法。

52. 发明授权

US09233085B1 Topical application of AMPK activators for pharmacological prevention of chronic pain 有权
标题翻译： AMPK激活剂局部应用于慢性疼痛的药理学预防
公开(公告)号：US09233085B1
公开(公告)日：2016-01-12
申请号：US14318245
申请日：2014-06-27
申请人： THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
发明人： Theodore J. Price , Gregory D. Dussor , Dipti Tillu , Bo Lian
IPC分类号： A61K31/155 , A61K31/05 , A61K9/00
CPC分类号： A61K31/155 , A61K9/0014 , A61K31/05 , A61K2300/00
摘要： A topical composition containing an adenosine monophosphate protein kinase (AMPK) activator and methods of administering the AMPK activator for treating acute pain or preventing the development of chronic pain in a subject. The AMPK activator is resveratrol. A second AMPK activator may also be used. The second AMPK activator is metformin. The topical composition may be administered as a gel, ointment, cream, lotion, suspension, liquid, or transdermal patch.
摘要翻译：含有腺苷一磷酸蛋白激酶（AMPK）激活剂的局部组合物和施用AMPK活化剂治疗急性疼痛或预防受试者慢性疼痛发展的方法。 AMPK激活剂是白藜芦醇。也可以使用第二AMPK活化剂。第二种AMPK活化剂是二甲双胍。局部组合物可以作为凝胶，软膏，乳膏，洗剂，悬浮液，液体或透皮贴剂施用。

53. 发明申请

US20150368607A1 METHOD FOR AFFECTING PHENOTYPIC ACTIVITY OF ENDOPHYTIC FUNGI 有权
标题翻译：影响真菌真菌活性的方法
公开(公告)号：US20150368607A1
公开(公告)日：2015-12-24
申请号：US14745365
申请日：2015-06-19
申请人： The Arizona Board of Regents on Behalf of the University of Arizona
发明人： Anne Elizabeth Arnold , Kayla Arendt , David A. Baltrus
IPC分类号： C12N1/14 , C12N1/20 , C12Q1/02
CPC分类号： C12N1/14 , C12N1/20 , C12Q1/26 , C12Q1/34 , G01N33/56961 , G01N2333/37 , G01N2333/942
摘要： Described herein are methods for the alteration and/or transfer of fungal functional traits, e.g., phenotypic activity, via the controlled transfer of endohyphal symbionts, e.g., bacteria, among fungal species. Also described are methods for the identification of endohyphal bacterial symbionts as determinants of cellulase and ligninase activity in fungi, and the use of endohyphal bacterial symbionts to alter the activity, including cellulase and ligninase activities, of the fungi. In particular, the fungi described herein are endophytic fungi, that is, fungi which colonize living, and subsequently senescent, plant tissue.
摘要翻译：本文描述的是通过在真菌物种中受控转移内皮细胞共生体例如细菌来改变和/或转移真菌功能性状，例如表型活性的方法。还描述了用于鉴定末尾真菌细菌共生体作为真菌中纤维素酶和木质素酶活性的决定因素的方法，以及使用内切细菌共生体来改变真菌的活性，包括纤维素酶和木质素酶活性。特别地，本文所述的真菌是内生真菌，即定居于生物的真菌，随后衰老的植物组织。

54. 发明申请

US20150284431A1 MELANOTROPIN LIGANDS FOR SKIN CARE 有权
标题翻译：用于皮肤护理的MELANOTROPIN配方
公开(公告)号：US20150284431A1
公开(公告)日：2015-10-08
申请号：US14300991
申请日：2014-06-10
申请人： THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
发明人： Minying Cai , Victor J. Hruby , Sean Shelby
IPC分类号： C07K7/08
CPC分类号： A61K38/10 , A61K9/00 , A61K9/0014 , A61K9/107 , A61K9/7084 , A61K47/24 , A61L15/00 , C07K7/08 , C07K14/68 , C07K14/685 , C07K14/723
摘要： A MC1R peptide ligand-elastic vesicle complex for preventing skin maladies. The MC1R peptide ligand is modified by coupling the melanocortin 1 receptor (MC1R) ligand to a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, elastic vesicles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The MC1R peptide ligand-elastic vesicle complex is prepared as a patch or viscous emulsion that can be applied to human skin.
摘要翻译：用于预防皮肤疾病的MC1R肽配体弹性囊泡复合物。通过将黑皮质素1受体（MC1R）配体偶联到官能团或连接体（例如点击功能）上来偶联到表面或试剂来修饰MC1R肽配体。修饰的MC1R肽配体可以例如通过与所连接的互补点击功能的点击反应偶联，以形成MC1R靶向的试剂。药物，造影剂，聚合物，颗粒，胶束，弹性囊泡，较大结构的表面或其它部分可以靶向MC1R。制备MC1R肽配体弹性囊泡复合物作为可应用于人皮肤的贴剂或粘稠乳液。

55. 发明申请

US20150238767A1 APPARATUS FOR ELECTRICAL STIMULATION OF CELL AND METHOD OF USE 有权
标题翻译：电刺激细胞的方法及其使用方法
公开(公告)号：US20150238767A1
公开(公告)日：2015-08-27
申请号：US14424966
申请日：2013-08-28
申请人： THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
发明人： Wolfgang Fink , Erich Schmid
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36182 , A61N1/0529 , A61N1/0543 , A61N1/0551 , A61N1/36046 , A61N1/36067 , A61N1/36082 , A61N1/36185
摘要： This invention provides an apparatus for electrically stimulating a cell and a method for using the same. In particular, the apparatus of the invention comprises an array of electrodes and a controller for actuating individual electrodes.
摘要翻译：本发明提供一种用于电刺激细胞的装置及其使用方法。特别地，本发明的装置包括电极阵列和用于致动各个电极的控制器。

56. 发明申请

US20150226845A1 ULTRASONIC/PHOTOACOUSTIC IMAGING DEVICES AND METHODS 审中-公开
标题翻译：超声/摄影成像装置及方法
公开(公告)号：US20150226845A1
公开(公告)日：2015-08-13
申请号：US14533013
申请日：2014-11-04
申请人： The Arizona Board of Regents on behalf of the University of Arizona
发明人： Russell S. Witte , Leonardo Gabriel Montilla , Ragnar Olafsson , Charles M. Ingram , Zhaohui Wang , Robert A. Norwood , Charles Greenlee
IPC分类号： G01S7/52 , A61B5/00 , G01S15/02
CPC分类号： G01S7/52017 , A61B5/0093 , A61B5/0095 , A61B5/7257 , A61B8/08 , A61B8/0825 , G01N21/1702 , G01N29/0672 , G01N29/2418 , G01N2291/02475 , G01S7/52 , G01S15/02
摘要： Devices are disclosed for obtaining data of a sample, particularly data capable of being processed to produce an image of a region of the sample. An exemplary device includes a light-beam source, an acoustic-wave source, an optical element, and an acoustic detector. The optical element is transmissive to a light beam produced by the light-beam source and reflective to acoustic waves produced by the acoustic-wave source. The optical element is situated to direct the transmitted light beam and reflected acoustic wave simultaneously along an optical axis to be incident at a situs in or on a sample to cause the sample to produce acoustic echoes from the incident acoustic waves while also producing photoacoustic waves from the incident light beam photoacoustically interacting with the situs. The acoustic detector is placed to receive and detect the acoustic echoes and the photoacoustic waves from the situs. The acoustic detector can comprise one or more hydrophones exploiting the acousto-electric effect.
摘要翻译：公开了用于获取样本数据的装置，特别是能够被处理以产生样本区域的图像的数据。示例性装置包括光束源，声波源，光学元件和声学检测器。光学元件对由光束源产生的光束是透射的，并且对由声波源产生的声波进行反射。光学元件被定位成沿着光轴同时引导透射光束和反射声波，以入射到样品中或样品上的位置，以使样品从入射的声波产生声学回声，同时还产生来自入射光束与地势光声学相互作用。声学检测器被放置以接收和检测来自地点的声学回波和光声波。声学检测器可以包括利用声电效应的一个或多个水听器。

57. 发明申请

US20150194242A1 Electrostatic Coating with Metallic Nanoparticles by Intrinsic Particle to Surface Interaction 审中-公开
标题翻译：具有金属纳米颗粒的静电涂层通过内在的粒子与表面相互作用
公开(公告)号：US20150194242A1
公开(公告)日：2015-07-09
申请号：US14557957
申请日：2014-12-02
申请人： The Arizona Board of Regents on Behalf of the University of Arizona
发明人： Anthony Joseph MUSCAT , Lance Rex HUBBARD
IPC分类号： H01B13/00
CPC分类号： B22F9/24 , B22F1/0018 , B22F7/04 , B22F7/08 , B22F2009/245 , C25D7/00 , H01L21/288 , H01L21/76873
摘要： Described are methods for forming thin, pinhole-free conformal metal layers on both conducting and non-conducting surfaces. The formed metal films are useful as seed layers for further deposition of metal using conventional techniques like electroplating, and provide specific advantages for non-conducting surfaces, which are otherwise unsuitable for electroplating without the presence of the formed metal films. Unlike electroplating, the disclosed methods, however, do not require the presence of a voltage or external electric field at the surface, but form the metal films through an electroless technique using electrostatic interactions between negatively charged nanoparticles and a positively charged surface. In addition, the disclosed methods are compatible with solution phase processing and, thus, eliminate the need to transfer the surfaces into a vacuum chamber for a chemical or physical vapor deposition to form a metal layer.
摘要翻译：描述了在导电和非导电表面上形成薄的无针孔保形金属层的方法。所形成的金属膜可用作种子层，用于使用诸如电镀之类的常规技术进一步沉积金属，并为非导电表面提供特定的优点，否则不适合电镀而不存在所形成的金属膜。然而，不同于电镀，所公开的方法不需要在表面存在电压或外部电场，而是通过使用带负电荷的纳米颗粒和带正电的表面之间的静电相互作用的无电技术形成金属膜。此外，所公开的方法与溶液相处理兼容，因此不需要将表面转移到用于化学或物理气相沉积的真空室中以形成金属层。

58. 发明申请

US20150184225A1 ELECTROKINETIC POLYMERASE CHAIN REACTION (PCR) DEVICES AND METHODS 审中-公开
标题翻译：电化学聚合酶链反应（PCR）装置和方法
公开(公告)号：US20150184225A1
公开(公告)日：2015-07-02
申请号：US14409992
申请日：2013-06-25
申请人： The Arizona Board of Regents on behalf of the University of Arizona , Genefluidics, Inc.
发明人： Pak Kin Wong , Yi Lu , Tingting Liu , Vincent Gau
IPC分类号： C12Q1/68 , B01L7/00
CPC分类号： C12Q1/686 , B01L3/502761 , B01L7/525 , B01L2200/0668 , B01L2200/10 , B01L2300/0645 , B01L2300/1833 , B01L2400/0415 , B01L2400/0424 , B01L2400/0445 , C12Q2523/307 , C12Q2561/113 , C12Q2565/607
摘要： Described herein are microfluidic diagnostic methods and devices using electrokinetic modules for the isolation of targets (e.g., cells, bacteria, biomolecules) from biological samples, PCR amplification of DNA isolated from the targets, and real-time quantification of the amplified DNA using impedance sensing. Sample preparation, PCR amplification, and impedance sensing are thus performed using a single integrated platform.
摘要翻译：本文描述了使用电动模块用于从生物样品分离靶（例如细胞，细菌，生物分子）的微流体诊断方法和装置，从靶标分离的DNA的PCR扩增，以及使用阻抗感测实时定量扩增的DNA 。因此，使用单个集成平台执行样品制备，PCR扩增和阻抗感测。

59. 发明申请

US20150103140A1 VOLUME HOLOGRAPHIC IMAGING SYSTEM (VHIS) ENDOSCOPE 有权
标题翻译：体积全息成像系统（VHIS）内窥镜
公开(公告)号：US20150103140A1
公开(公告)日：2015-04-16
申请号：US14353148
申请日：2012-10-19
申请人： The Arizona Board of Regents on Behalf of the University of Arizona
发明人： Raymond K. Kostuk , Paul J. Gelsinger-Austin , Johnathan W. Brownlee , Jennifer K. Barton , Erich de Leon , Michael Gordon
IPC分类号： G03H1/00 , G03H1/04 , G02B23/24 , H04N7/18
CPC分类号： G03H1/0005 , A61B1/00163 , G02B23/243 , G02B23/2446 , G02B23/2469 , G03H1/0248 , G03H1/041 , G03H1/0443 , G03H1/0465 , G03H1/28 , G03H2001/005 , G03H2001/0436 , G03H2001/0452 , H04N7/183
摘要： Provided are modular volume holographic imaging system (VHIS) endoscopic systems, comprising: an endoscope attachment module having a microscope objective lens, a single or cascaded compensated relay system configured to preserve an optical wavefront for use with a single or multiplexed volume hologram to select wavefronts originating from different object depths, and a system aperture; and a handle module configured to be reversibly attachable for operative communication with the endoscope attachment module, and having a beam splitter; a relay having adjustable spacing for object space focus compensation, and a single or multiplexed volume hologram suitable in operation to select wavefronts originating from different object depths, and wherein the handle module is further configured for operative communication with an illumination source and imaging optics. Preferably, an illumination module and an imaging module are configured to be in operative, reversibly attachable communication with the handle module. Flexible tip endoscopic embodiments are provided.
摘要翻译：提供的是模块化体积全息成像系统（VHIS）内窥镜系统，包括：具有显微镜物镜的内窥镜附件模块，单个或级联的补偿中继系统，被配置为保留用于单个或复用的体积全息图的光波阵面以选择波前源自不同的物体深度和系统孔径; 以及手柄模块，其被构造成可逆地附接以用于与所述内窥镜附件模块的操作性通信，并且具有分束器; 具有用于对象空间聚焦补偿的可调间隔的继电器，以及适于操作以选择源自不同物体深度的波前的单个或多路复用的体积全息图，并且其中所述手柄模块还被配置用于与照明源和成像光学器件的操作性通信。优选地，照明模块和成像模块被配置为与手柄模块处于可操作的可逆连接的连接。提供柔性尖端内窥镜实施例。

60. 发明授权

US08855903B2 Active traffic and demand management system 有权
标题翻译：主动流量和需求管理系统
公开(公告)号：US08855903B2
公开(公告)日：2014-10-07
申请号：US14256756
申请日：2014-04-18
申请人： The Arizona Board of Regents on behalf of the University of Arizona
发明人： Yi-Chang Chiu
IPC分类号： G06F19/00 , G06Q30/02 , G01C21/34 , G08G1/09
CPC分类号： G08G1/09 , G01C21/3492 , G06Q10/047 , G06Q30/02 , G06Q30/0207 , G08G1/0112 , G08G1/0129 , G08G1/0141 , G08G1/096811 , G08G1/096838 , Y10S430/137
摘要： Systems and methods for providing incentives for the public to travel during time windows and routes that help alleviate traffic congestion. The systems described herein include at least two components: a computer server software system that includes various algorithms and database sub-systems; and a mobile device application. Generally, a user may enter an origin, destination, and preferred time of travel for an intended trip into the mobile device application, which transmits the information to a remote server. The server computes a route for the trip and provides the user with available incentives for traveling the route at one or more departure time windows. The user's mobile device transmits GPS data to the server, which allows the server to verify whether the user has traveled the route during the specified time window. If so, the server then provides the incentive to the user via the user's mobile device or through email.
摘要翻译：提供激励措施的制度和方法，使公众在时间窗口和路线上旅行，有助于减轻交通拥堵。本文描述的系统包括至少两个组件：包括各种算法和数据库子系统的计算机服务器软件系统; 和移动设备应用程序。通常，用户可以输入到移动设备应用程序的预期行程的起始，目的地和优选时间，其将信息发送到远程服务器。服务器计算旅程的路线，并为用户提供在一个或多个出发时间窗口上行驶路线的可用激励。用户的移动设备向服务器发送GPS数据，这允许服务器在指定的时间窗口期间验证用户是否已经行进路线。如果是这样，服务器然后通过用户的移动设备或通过电子邮件向用户提供激励。

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