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51. 发明授权

US5322836A Bioactive agents, compositions and materials comprising said bioactive agents 失效
标题翻译：包含所述生物活性剂的生物活性剂，组合物和材料
公开(公告)号：US5322836A
公开(公告)日：1994-06-21
申请号：US917693
申请日：1991-03-06
申请人： Mamoru Tomita , Seiichi Shimamura , Yasuo Fukuwatari , Hiroshi Miyakawa , Hitoshi Saito
发明人： Mamoru Tomita , Seiichi Shimamura , Yasuo Fukuwatari , Hiroshi Miyakawa , Hitoshi Saito
IPC分类号： A61K38/16 , A23C9/123 , A23K1/16 , A23L1/30 , A61K38/00 , A61P1/12 , C07K14/79 , C12N1/20 , C12N1/38 , C12R1/01 , A61K37/14 , A23C9/12 , A23C17/00
CPC分类号： C12N1/38 , A23C9/1234 , A23K20/147 , C07K14/79 , A61K38/00 , Y10S530/832
摘要： Bioactive agents, having growth-promoting activity upon Bifidobacteria, consisting of one or more lactoferrin-compounds selected from the group consisting of bovine lactoferrin, bovine apolactoferrin and bovine Fe-lactoferrin, which can be used as it is as agents to promote proliferation of Bifidobacteria both in vivo and in vitro, and as additives to prepare compositions, materials and products to afford growth-promoting activity thereto, and to improve survivability of Bifidobacteria, if contained therein.
摘要翻译：由双歧杆菌生长促进活性的生物活性剂，由一种或多种选自牛乳铁蛋白，牛非球蛋白铁和牛铁铁乳蛋白的乳铁蛋白化合物组成，可作为促进双歧杆菌增殖的药剂以及用作制备组合物，材料和产品以提供生长促进活性的添加剂，以及如果其中包含双歧杆菌的生存能力的添加剂。

52. 发明授权

US5279847A Methods for producing emulsions, low-fat spread and oil-in-water-in-oil type spread 失效
标题翻译：生产乳液，低脂肪散布和油包水型散布的方法
公开(公告)号：US5279847A
公开(公告)日：1994-01-18
申请号：US683182
申请日：1991-04-11
申请人： Shigeo Okonogi , Ryo Kato , Yuzo Asano , Hiroya Yuguchi , Renzo Kumazawa , Kazuyoshi Sotoyama , Kiyotaka Takahashi , Masahisa Fujimoto
发明人： Shigeo Okonogi , Ryo Kato , Yuzo Asano , Hiroya Yuguchi , Renzo Kumazawa , Kazuyoshi Sotoyama , Kiyotaka Takahashi , Masahisa Fujimoto
IPC分类号： A23D7/00 , A23D7/015 , A23D7/02 , A23D7/04 , B01F3/08 , A23C15/02
CPC分类号： B01F5/0476 , A23D7/001 , A23D7/015 , A23D7/02 , A23D7/04 , B01F3/0811 , B01F2003/0838 , B01F2215/0014 , B01F2215/0031
摘要： A method for producing an emulsion by dispersing a liquid to form a dispersed phase into a liquid to form a continuous phase through a microporous membrane, in which:(a) a W/O type emulsion is produced by dispersing an aqueous phase at low pressure into a fatty phase through a hydrophilic microporous membrane previously treated with the fatty phase;(b) an 01/W/02 type emulsion is produced by dispersing an O/W type emulsion at low pressure into the fatty phase (02) through the same microporous membrane as (a) above;(c) an O/W type emulsion is produced by dispersing a fatty phase containing a hydrophobic emulsifying agent into an aqueous phase through a hydrophilic microporous membrane. Furthermore, methods for producing a low-fat spread and an oil-in-water-in-oil type spread by rapidly cooling a emulsion to plasticize and kneading, in which:(d) a W/O type emulsion for low-fat spread is prepared by dispersing an aqueous phase into a fatty phase through a microporous membrane:(e) an 01/W/02 type emulsion for an oil-in-water-in-oil type spread is prepared by dispersing an 01/W type emulsion into a fatty phase (02) through the same membrane as (d) above.
摘要翻译：一种通过将液体分散形成液体以通过微孔膜形成连续相来制备乳液的方法，其中：（a）通过在低压下分散水相制备W / O型乳液通过预先用脂肪相处理的亲水性微孔膜进入脂肪相; （b）通过与上述（a）相同的微孔膜将O / W型乳液低压分散到脂肪相（O 2）中来制备01 / W / 02型乳液; （c）通过将含有疏水性乳化剂的脂肪相通过亲水性微孔膜向水相中分散而制造O / W型乳液。此外，通过快速冷却乳液进行塑化和捏合，生产低脂肪铺展和油包水包油型的方法，其中：（d）用于低脂肪铺展的W / O型乳液通过微孔膜将水相分散在脂肪相中制备：（e）通过将01 / W型乳液分散在油/油包水型撒布中，制备01 / W / 02型乳液通过与上述（d）相同的膜进入脂肪相（02）。

53. 发明授权

US5214028A Lactoferrin hydrolyzate for use as an antibacterial agent and as a tyrosinase inhibition agent 失效
标题翻译：用作抗菌剂和作为酪氨酸酶抑制剂的LACTOFERRIN水解产物
公开(公告)号：US5214028A
公开(公告)日：1993-05-25
申请号：US634763
申请日：1990-12-27
申请人： Mamoru Tomita , Kouzou Kawase , Yoshitaka Tamura , Mitsunori Takase , Hiroshi Miyakawa , Koji Yamauchi , Hitoshi Saito , Hiroaki Abe , Seiichi Shimamura , Susumu Kobayashi
发明人： Mamoru Tomita , Kouzou Kawase , Yoshitaka Tamura , Mitsunori Takase , Hiroshi Miyakawa , Koji Yamauchi , Hitoshi Saito , Hiroaki Abe , Seiichi Shimamura , Susumu Kobayashi
IPC分类号： A01N63/02 , A23J3/32 , A23J3/34 , A23L3/3526 , A61K8/64 , A61K38/01 , A61Q19/02
CPC分类号： A61Q17/005 , A01N63/02 , A23J3/32 , A23J3/343 , A23L3/3526 , A61K38/40 , A61K8/64 , A61Q19/02 , A61K2800/782
摘要： Lactoferrin hydrolyzates, having a decomposition rate between 6%-20% as measured by formol titration, for use as an antibacterial agent and which have remarkly more potent activity than unhydrolyzed lactoferrin; and lactoferrin hydrolyzates, having a decomposition rate between 4-50% as measured by formol titration, for use as a tyrosinase inhibition agent, are obtainable by conventional methods for hydrolysis with acids or enzymes, and are stable to heating.

54. 发明授权

US4591571A Fine carrier particles sensitized with acylated antibody for antigen detection 失效
标题翻译：用酰化抗体敏化用于抗原检测的细载体颗粒
公开(公告)号：US4591571A
公开(公告)日：1986-05-27
申请号：US601522
申请日：1984-04-18
申请人： Morio Kuboyama , Yoshitsugu Harada , Akio Kawashiri , Eiji Takahashi
发明人： Morio Kuboyama , Yoshitsugu Harada , Akio Kawashiri , Eiji Takahashi
IPC分类号： A61K39/44 , G01N33/531 , G01N33/543 , G01N33/546
CPC分类号： G01N33/54393 , G01N33/531 , Y10S436/825
摘要： Reagents for detecting antigen contained in body fluid or urine according to the immunological agglutination or agglutination inhibition reaction and comprising an antibody adsorbed on fine carrier particle to be sensitized as an effective constituent, and is characterized by acylating said antibody.Owing to such acylation, the reagent can correctly detect antigen without any influence of substance contained in sample which has inevitably caused nonspecific agglutination reaction according to the prior art.
摘要翻译：根据免疫凝集或凝集抑制反应检测体液或尿中含有的抗原的试剂，其含有被吸附在敏化剂作为有效成分的细载体颗粒上的抗体，其特征在于酰化所述抗体。由于这样的酰化，试剂可以正确检测抗原，而不受样品中所含物质的任何影响，根据现有技术不可避免地引起非特异性凝集反应。

55. 发明授权

US4588595A Culture containing a viable cell mass of Bifidobacteria and lactic acid bacteria 失效
标题翻译：含有双歧杆菌和乳酸菌的活细胞块的培养物
公开(公告)号：US4588595A
公开(公告)日：1986-05-13
申请号：US547827
申请日：1983-11-02
申请人： Shigeo Okonogi , Takuji Kawashima , Tsutomu Kudo , Hiroya Yuguchi , Akinori Hiramatsu , Susumu Teraguchi , Tomoko Yaeshima
发明人： Shigeo Okonogi , Takuji Kawashima , Tsutomu Kudo , Hiroya Yuguchi , Akinori Hiramatsu , Susumu Teraguchi , Tomoko Yaeshima
IPC分类号： A23C9/12 , A23C9/123 , C12N1/20 , C12R1/01 , C12R1/225 , C12R1/46 , A23C9/127 , A23C23/00
CPC分类号： A23C9/1234 , A23C9/1238 , C12N1/20 , Y10S435/885
摘要： A culture containing a viable mass of Bifodobacteria and lactic acid bacteria is obtained by incubating separately or together microorganisms of the genus Bifidobacterium and Lactobacillus, and the species Streptococcus thermophilus in a medium containing milk as the main ingredient. The Streptococcus thermophilus is a strain having high oxygen uptake. When incubated separately, the microorganisms are mixed together after incubating. In the presence of the high oxygen uptake Streptococcus thermophilus, a high survival fraction of the Bifidobacteria is obtained when the culture is stored under aerobic conditions. The culture is useful in preparing food, medicine or feed.
摘要翻译：通过将含有双歧杆菌属和乳杆菌属的微生物和嗜热链球菌属物种在含有乳作为主要成分的培养基中分别或一起孵育来获得含有双歧杆菌和乳酸菌的活体的培养物。嗜热链球菌是具有高氧摄取的菌株。孵育后，将微生物混合在一起。在高吸氧链嗜热链球菌的存在下，当培养物在有氧条件下储存时，获得双歧杆菌的高存活率。该文化对于准备食物，药物或饲料是有用的。

56. 发明授权

US4230697A Virus-inactivated HGI-glycoprotein capable of stimulating proliferation and differentiation of human granulocyte, process for preparing same and leukopenia curative containing same 失效
标题翻译：能够刺激人粒细胞增殖和分化的病毒灭活的HGI-糖蛋白，其制备方法和含有其的白细胞减少症
公开(公告)号：US4230697A
公开(公告)日：1980-10-28
申请号：US37515
申请日：1979-05-09
申请人： Masayuki Nishida , Satoshi Funakoshi , Katsuhiro Ogasa , Morio Kuboyama , Nobuya Yanai , Muneo Yamada
发明人： Masayuki Nishida , Satoshi Funakoshi , Katsuhiro Ogasa , Morio Kuboyama , Nobuya Yanai , Muneo Yamada
IPC分类号： A61K35/22 , A61K38/00 , C07K14/52 , A61K37/00 , C07C103/52
CPC分类号： A61K35/22 , C07K14/52 , A61K38/00 , Y10S530/83 , Y10S530/834 , Y10S530/851
摘要： A colony-stimulating factor having definite physical and chemical properties and a function of stimulating activity on human bone marrow cells to proliferate and differentiate, thereby forming granulocyte colonies, is obtained from human urine by concentrating the urine with respect to proteins contained therein by adsorption chromatography with silica gel, salting out with ammonium sulfate and other means, then removing impurities by adsorption on cation exchanger, and further purifying by ion exchanging chromatography on anion exchanger, gel filtrating chromatography with highly crosslinked gels, affinity chromatography with sugar affinitive adsorbents and electrophoresis. This substance is stable in the presence of a stabilizer such as albumin or urinary proteins, against heat-treatment of virus-inactivation and can be used as a leukopenia curative which is precluded from fear of virus-infection.
摘要翻译：具有确定的物理和化学性质以及刺激人骨髓细胞活性增殖和分化，从而形成粒细胞集落的功能的集落刺激因子通过浓缩尿液相对于其中所含蛋白质的吸附色谱从人尿中获得用硅胶盐析，用硫酸铵等方法盐析，然后通过阳离子交换器上的吸附除去杂质，进一步通过阴离子交换柱上的离子交换色谱，高度交联凝胶的凝胶过滤色谱，糖亲和性吸附剂的亲和层析和电泳进行纯化。这种物质在稳定剂如白蛋白或尿蛋白存在下是稳定的，用于病毒灭活的热处理，并且可以用作免于病毒感染的白细胞减少症治疗剂。

57. 发明授权

US4057655A Process for preparing a lactulose-containing powder for feed 失效
标题翻译：用于制备含有乳果糖的粉末用于饲料的方法
公开(公告)号：US4057655A
公开(公告)日：1977-11-08
申请号：US702680
申请日：1976-07-06
申请人： Katsuto Okada , Katsuhiro Ogasa , Mamoru Tomita
发明人： Katsuto Okada , Katsuhiro Ogasa , Mamoru Tomita
IPC分类号： C13K13/00 , A23K1/08
CPC分类号： C13K13/005 , Y10S426/807
摘要： A process for preparing a free-flowing lactulose-containing powder from a solution containing lactose, by adding calcium hydroxide to the solution to adjust the pH of said solution to from 9.4 to 11.2; heating the resulting solution so that the pH is reduced to from 7.5 to 9.0; the homogenizing, concentrating and drying.
摘要翻译：通过向溶液中加入氢氧化钙以将所述溶液的pH调节至9.4至11.2，由含有乳糖的溶液制备含自由流动含乳果糖的粉末的方法; 加热所得溶液使pH降至7.5至9.0; 均质，浓缩和干燥。

58. 发明授权

US3895651A Compound aseptic valve 失效
标题翻译：复合无菌阀
公开(公告)号：US3895651A
公开(公告)日：1975-07-22
申请号：US47061874
申请日：1974-05-16
申请人： MORINAGA MILK INDUSTRY CO LTD
发明人： OKADA KATSUTO , ISHIBASHI AKICHIKA , WATANABE HIROTAKA
IPC分类号： F16K1/44 , F16K31/122 , F16K1/00
CPC分类号： F16K31/1225 , F16K1/446 , Y10T137/4245 , Y10T137/8704 , Y10T137/87121 , Y10T137/87981
摘要： A compound aseptic double valve prevents doubly the passage of fluid between two ports spaced from each other. More particularly, the valve is highly aseptic and capable of providing a sealing and it is thus well suited for use in manufacturing and processing machinery or plants where food or beverage products are handled. The valve comprises a first valve member, a second auxiliary valve member mounted on a first valve shaft for actuating the first valve member, a second sleevelike valve shaft mounted on the first valve shaft to actuate the second auxiliary valve member on the first valve shaft, a second driving source provided independently of a driving source for actuating the first valve shaft and adapted to move the second auxiliary valve member and the second valve shaft on the first valve shaft in a direction which closes the valve, a valve seat for each of the first and second valve members to come into contact therewith, the valve seats being located in the same valve housing to provide a double sealing, and a bellows for sealing within the valve housing those portions of the first and second valve shafts which are moved in and out of the valve housing.
摘要翻译：复合无菌双重阀阻止流体在两个彼此间隔开的端口之间的通过。更具体地，该阀是高度无菌的并且能够提供密封，因此其非常适合用于制造和加工其中处理食品或饮料产品的机械或设备。阀包括第一阀构件，安装在用于致动第一阀构件的第一阀轴上的第二辅助阀构件，安装在第一阀轴上以致动第一阀轴上的第二辅助阀构件的第二套筒阀轴，独立于用于致动第一阀轴的驱动源设置的第二驱动源，并且适于在关闭阀的方向上移动第一阀轴上的第二辅助阀构件和第二阀轴;阀座，第一和第二阀构件与其接触，阀座位于相同的阀壳体中以提供双重密封，并且用于在阀内密封的波纹管容纳在第一和第二阀轴中移动的那些部分，离开阀门外壳。

59. 发明授权

US3850406A Double sealing valve 失效
标题翻译：双重密封阀
公开(公告)号：US3850406A
公开(公告)日：1974-11-26
申请号：US38177673
申请日：1973-07-23
申请人： MORINAGA MILK INDUSTRY CO LTD
发明人： OKADA K , YAMANAMI S , ISHIBASHI A , WATANABE H
IPC分类号： F16K1/44 , F16K11/16 , F16K31/122 , F16K1/06
CPC分类号： F16K11/161 , F16K31/122
摘要： A double sealing valve is provided which prevents the passage of fluid doubly and which is particularly well suited for use in manufacturing and processing machinery or plants where food or beverage products are handled. The valve comprises a valve head or valve seal adapted to be pressed against a valve seat as is the case with an ordinary valve, and a piston mounted on a shaft for actuating the valve seal, wherein a portion of a valve body is formed into a constricted cylindrical shape so that the piston slides in contact therewith, whereby a first seal is provided by the contact between the valve seal and the valve seat and a second seal is provided by the contact between the piston and the cylindrical portion of the valve body.
摘要翻译：提供双重密封阀，其防止流体双重通过，并且特别适合用于制造和加工处理食品或饮料产品的机械或设备。该阀包括适于与普通阀的情况一样按压在阀座上的阀头或阀密封件，以及安装在用于致动阀密封件的轴上的活塞，其中阀体的一部分形成为收缩的圆柱形状使得活塞与其接触，从而通过阀密封件和阀座之间的接触提供第一密封，并且通过活塞与阀体的圆柱形部分之间的接触提供第二密封。

60. 发明授权

US3816174A Process for preparing a lactulose syrup 失效
标题翻译：制备乳酸菌SYRUP的方法
公开(公告)号：US3816174A
公开(公告)日：1974-06-11
申请号：US25416972
申请日：1972-05-17
申请人： MORINAGA MILK INDUSTRY CO LTD
发明人： NAGASAWA T , OBAYASHI T , MIZOTA T , TOMITA M , TAMURA Y
IPC分类号： A23L1/09 , A23L1/236 , C13K13/00 , C07C49/18
CPC分类号： C13K13/005 , A23L27/33 , A23L29/30
摘要： A lactulose syrup containing more than 80 percent lactulose in total solid content, is produced in an industrially acceptable manner by admixing an aqueous solution of lactose with an aqueous solution of sodium hydroxide containing less than 0.54 percent sodium hydroxide based on the quantity of lactose, heating said mixed solution to a temperature of above 70*C. to isomerize the lactose, and thereafter concentrating lactulose from the reaction liquid.
摘要翻译：以工业上可接受的方式，通过将乳糖水溶液与含有少于0.54％氢氧化钠的氢氧化钠水溶液混合，以乳糖的量，加热量为基准，生产含有超过80％乳果糖的总固体含量的乳果糖糖浆将所述混合溶液加热到70℃以上的温度，使乳糖异构化，然后从反应液中浓缩乳果糖。

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