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51. 发明授权

US07736847B2 Methods of treating and preventing neurological symptoms caused by avian reovirus and novel associated characteristics 失效
标题翻译：治疗和预防禽呼肠孤病毒引起的神经症状及新型相关特征的方法
公开(公告)号：US07736847B2
公开(公告)日：2010-06-15
申请号：US10526706
申请日：2003-10-09
申请人： Saskia van de Zande , Rudolf George Hein , Donald Eugene Roessler , Gwenllyan F. Slacum , Karen L. Jensen , Phyllis A. Lynch
发明人： Saskia van de Zande , Rudolf George Hein , Donald Eugene Roessler , Gwenllyan F. Slacum , Karen L. Jensen , Phyllis A. Lynch
IPC分类号： C12Q1/70 , A61K39/15
CPC分类号： C12N7/00 , A61K39/12 , A61K39/15 , A61K2039/5252 , A61K2039/5254 , A61K2039/545 , C12N2720/12034
摘要： Embodiments of the present invention generally relate to novel methods for the treatment and/or prevention of neurological symptoms caused by an avian reovirus, enteric reovirus strain (ERS), and associated characteristics. Other embodiments generally comprise an immunogenic composition or vaccine comprising an ERS for the treatment and/or prevention of neurological symptoms.
摘要翻译：本发明的实施方案通常涉及用于治疗和/或预防由禽呼肠孤病毒，肠道呼肠孤病毒毒株（ERS）引起的神经症状以及相关特征的新方法。其他实施方案通常包含免疫原性组合物或疫苗，其包含用于治疗和/或预防神经症状的ERS。

52. 发明申请

US20100022490A1 Zilpaterol Enantiomer Compositions and Methods of Making and Using Such Compositions 有权
标题翻译：齐帕特罗对映体组合物和制备和使用这些组合物的方法
公开(公告)号：US20100022490A1
公开(公告)日：2010-01-28
申请号：US12373221
申请日：2007-07-10
申请人： Christian Miculka , Thorsten Meyer , Christopher Kern , Serge Francois Droux
发明人： Christian Miculka , Thorsten Meyer , Christopher Kern , Serge Francois Droux
IPC分类号： A61K31/55 , C07D487/04 , A61K31/566 , A61P43/00
CPC分类号： C07D487/06 , A23K20/137 , A23K50/10
摘要： This invention is directed generally to zilpaterol enantiomer compositions and, in particular, to compositions comprising the 6R,7R zilpaterol enantiomer. This invention is also directed to processes for making such compositions; methods for using such compositions to, for example, increase the rate of weight gain, improve feed efficiency, and/or increase carcass leanness in livestock, poultry, and/or fish; and uses of such compositions to make medicaments. This invention is further directed to methods for determining the absolute configurations of zilpaterol enantiomers.
摘要翻译：本发明一般涉及齐伐他醇对映异构体组合物，尤其涉及包含6R，7R齐伐他醇对映异构体的组合物。本发明还涉及制备这种组合物的方法; 使用这种组合物的方法例如可以增加家畜，家禽和/或鱼中的体重增加率，提高饲料效率和/或增加胴体瘦身; 以及这些组合物的用途来制备药物。本发明进一步涉及确定齐勒特罗对映异构体的绝对构型的方法。

53. 发明申请

US20090232846A1 Pestivirus mutant for use in a vaccine 有权
标题翻译：用于疫苗的瘟病毒突变体
公开(公告)号：US20090232846A1
公开(公告)日：2009-09-17
申请号：US12441169
申请日：2007-09-20
申请人： Martin Beer , Ilona Reimann , Patricia Koenig
发明人： Martin Beer , Ilona Reimann , Patricia Koenig
IPC分类号： A61K39/12 , C12N7/01
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5254 , A61K2039/552 , C12N2770/24334 , C12N2770/24362
摘要： The present invention comprises new pestivirus mutants, characterized in that the mutants are based on a cp strain of the virus wherein part of the gene sequence encoding the Npro region is deleted, except that the deleted part does not encompass the coding sequence for the N-terminal twelve amino acids of the Npro protein. Preferably the pestivirus is the Bovine Viral Diarrhea Virus (BVDV). It was found that a mutant according to the invention is a safe and efficient vaccine candidate.
摘要翻译：本发明包括新的瘟病毒突变体，其特征在于，突变体是基于病毒的cp株，其中缺失部分编码Npro区的基因序列除了缺失的部分不包含N-末端的编码序列外， Npro蛋白的末端十二个氨基酸。优选地，瘟病毒是牛病毒性腹泻病毒（BVDV）。发现根据本发明的突变体是安全有效的疫苗候选物。

54. 发明申请

US20090181906A1 Combination Therapies using Melengestrol Acetate and Zilpaterol or its Salts 有权
标题翻译：联合治疗使用醋酸米那司他酸和齐帕特罗或其盐
公开(公告)号：US20090181906A1
公开(公告)日：2009-07-16
申请号：US12327885
申请日：2008-12-04
申请人： Mary Irene Wray , Damon Edward Bradley , Melissa A. Petersen , Auddie Sharp , Celia Shelton , Jayden Lloyd Montgomery
发明人： Mary Irene Wray , Damon Edward Bradley , Melissa A. Petersen , Auddie Sharp , Celia Shelton , Jayden Lloyd Montgomery
IPC分类号： A61K31/7048 , A61K31/57
CPC分类号： A61K31/57 , A23K20/137 , A23K20/168 , A23K20/20 , A23K50/10 , A23K50/30 , A23K50/75 , A23K50/80 , A61K31/55 , A61K2300/00
摘要： This invention generally relates to a method for promoting growth and increasing feed utilization efficiency in animals, and, more specifically, to combinations comprising zilpaterol (and salts thereof) and melengestrol acetate. Included within this invention are treatment methods comprising the administration of such combinations to animals, compositions comprising such combinations, uses of such combinations to prepare medicaments, and kits for using such combinations.
摘要翻译：本发明一般涉及一种用于促进动物生长和提高饲料利用效率的方法，更具体地说，涉及包含齐伐他醇（及其盐）和醋酸烯雌酚的组合。本发明包括包括向动物施用这种组合的治疗方法，包含这种组合的组合物，这种组合的用途来制备药物，以及使用这些组合的试剂盒。

55. 发明申请

US20090053262A1 Combination vaccine for poultry 失效
标题翻译：禽类联合疫苗
公开(公告)号：US20090053262A1
公开(公告)日：2009-02-26
申请号：US10582315
申请日：2004-12-21
申请人： Antonius Arnoldus Christiaan Jacobs , Paul Cornelius Maria van Empel , Petrus Johannes Maria Nuijten
发明人： Antonius Arnoldus Christiaan Jacobs , Paul Cornelius Maria van Empel , Petrus Johannes Maria Nuijten
IPC分类号： A61K39/00
CPC分类号： A61K39/02 , A61K39/0216 , A61K39/12 , A61K2039/522 , A61K2039/5254 , A61K2039/544 , A61K2039/552 , A61K2039/70 , C12N2760/18134 , C12N2770/20034
摘要： The present invention relates to a combination vaccine for the protection of poultry against Ornithobacterium rhinotracheale, to the use of a live over-attenuated Ornithobacterium rhinotracheale strain and a live attenuated poultry virus for the manufacturing of such a combination vaccine, to methods for the preparation of said combination vaccine and to vaccination kits for the immunization of poultry against Ornithobacterium rhinotracheale.
摘要翻译：本发明涉及一种用于保护禽类免受鸟氨酸鼻杆菌的组合疫苗，使用活的过度减毒的鼻咽嗜血杆菌菌株和活的减毒家禽病毒用于制造这种组合疫苗，用于制备所述组合疫苗和针对鸟类鼻气管炎免疫家禽的接种试剂盒。

56. 发明申请

US20090042815A1 Macrolide Synthesis Process and Solid-State Forms 有权
标题翻译：大环内酯合成过程和固态形式
公开(公告)号：US20090042815A1
公开(公告)日：2009-02-12
申请号：US11828404
申请日：2007-07-26
申请人： Fritz Blatter , Meinrad Brenner , Monika Brink , Kerstin Fleischhauer , Guixian Hu , Hans Peter Niedermann , Timo Rager , Tanja Schweisel , Stephan Veit , Ralf Warrass , Heinz-Jorg Wennesheimer
发明人： Fritz Blatter , Meinrad Brenner , Monika Brink , Kerstin Fleischhauer , Guixian Hu , Hans Peter Niedermann , Timo Rager , Tanja Schweisel , Stephan Veit , Ralf Warrass , Heinz-Jorg Wennesheimer
IPC分类号： A61K31/7048 , C07H17/08 , A61P11/00
CPC分类号： C07H17/08
摘要： This invention relates to a method for making macrolides, and, in particular, a method for making optionally substituted 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide and derivatives thereof, as well as uses of macrolides to make medicaments, methods of treatment using macrolides, and methods for making intermediates that, inter alia, may be used to make macrolides. This invention also relates to solvated and non-solvated crystalline forms of 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide, as well as methods for making such crystalline forms, medicaments comprising (or derived from) such crystalline forms, methods for making medicaments comprising (or derived from) such crystalline forms, methods of treatment using such crystalline forms, and kits comprising such crystalline forms.
摘要翻译：本发明涉及一种制备大环内酯类的方法，特别涉及制备任选取代的20,23-二哌啶基-5-O-碳霉糖基 - 太乐内酯及其衍生物的方法，以及大环内酯类制备药物的用途，方法使用大环内酯的处理，以及制备中间体的方法，其特别可用于制备大环内酯。本发明还涉及20,23-二哌啶基-5-O-碳霉糖基 - 太乐内酯的溶剂化和非溶剂化结晶形式，以及制备这种结晶形式的方法，包含（或衍生自）这种结晶形式的药物，制造包含（或衍生自）这种结晶形式的药物，使用这种结晶形式的治疗方法，以及包含这种结晶形式的试剂盒。

57. 发明授权

US07479284B2 Babesia canis vaccine 失效
标题翻译：巴西犬疫苗
公开(公告)号：US07479284B2
公开(公告)日：2009-01-20
申请号：US11249112
申请日：2005-10-11
申请人： Theodorus Petrus Maria Schetters , Bernard Pierre Dominique Carcy , Pascal Robert Drakulovski , Andre Francois Gorenflot
发明人： Theodorus Petrus Maria Schetters , Bernard Pierre Dominique Carcy , Pascal Robert Drakulovski , Andre Francois Gorenflot
IPC分类号： A61K39/018 , C07H21/04 , C12P21/04 , C12N15/09
CPC分类号： C07K14/44 , A61K39/00
摘要： The present invention relates to nucleic acid sequences encoding novel Babesia canis associated proteins and to cDNA fragments, recombinant DNA molecules and live recombinant carriers comprising these sequences. Furthermore, the invention relates to host cells comprising such nucleic acid sequences, cDNA fragments, recombinant DNA molecules and live recombinant carriers. Also, the invention relates to proteins encoded by these nucleotide sequences, to vaccines for combating Babesia canis infections comprising these proteins or genetic material encoding these proteins and methods for the preparation of vaccines. Another embodiment of the invention relates to these Babesia canis associated proteins for use in vaccines and to the use of the Babesia canis associated proteins in the manufacture of vaccines. Finally the invention relates to diagnostic tools for the detection of Babesia canis associated nucleic acid sequences, for the detection of Babesia canis associated antigens and for the detection of antibodies against Babesia canis associated antigenic material.
摘要翻译：本发明涉及编码新型贝叶斯相关蛋白的核酸序列和涉及包含这些序列的cDNA片段，重组DNA分子和活重组载体的核酸序列。此外，本发明涉及包含这种核酸序列的宿主细胞，cDNA片段，重组DNA分子和活重组载体。此外，本发明涉及由这些核苷酸序列编码的蛋白质，用于对抗包含这些蛋白质的巴贝虫感染疫苗或编码这些蛋白质的遗传物质的疫苗和用于制备疫苗的方法。本发明的另一个实施方案涉及用于疫苗的这些巴贝氏菌相关蛋白质以及在疫苗制造中使用巴贝氏杆菌相关蛋白质。最后，本发明涉及用于检测巴贝虫相关核酸序列的诊断工具，用于检测巴贝虫相关抗原和用于检测针对巴贝虫相关抗原物质的抗体。

58. 发明授权

US07462359B2 Neospora vaccines 失效
标题翻译：新孢子虫疫苗
公开(公告)号：US07462359B2
公开(公告)日：2008-12-09
申请号：US11119474
申请日：2005-04-28
申请人： Leszek J. Choromanski , Karen K. Brown
发明人： Leszek J. Choromanski , Karen K. Brown
IPC分类号： A61K39/02
CPC分类号： C12R1/90 , A61K39/002
摘要： A Neospora caninum vaccine comprising tissue culture grown Neospora and methods of making and using said vaccines. Neospora caninum vaccines described include those containing whole Neospora tachyzoites, extracts of Neospora tachyzoites and protective antigen subunits of Neospora tachyzoites. The vaccines of this invention may be in a liquid or lyophilized form.
摘要翻译：包含组织培养生长的新孢子虫的新孢子虫疫苗以及制备和使用所述疫苗的方法。描述的新孢子虫疫苗包括含有全新孢子虫速殖子，新孢子虫速殖子的提取物和新孢子虫速殖子的保护性抗原亚单位的疫苗。本发明的疫苗可以是液体或冻干形式。

59. 发明授权

US07435422B2 Non-animal origin stabilizers and processes for producing the same 失效
标题翻译：非动物来源的稳定剂及其制备方法
公开(公告)号：US07435422B2
公开(公告)日：2008-10-14
申请号：US11031026
申请日：2005-01-07
申请人： R. Monty Warthen , Christopher P. Gully
发明人： R. Monty Warthen , Christopher P. Gully
IPC分类号： A61K39/10
CPC分类号： A61K9/19
摘要： Embodiments of the present invention generally comprise stabilizers for biological products that are free from animal origin excipients/components, such stabilizers functioning well in lyophilization procedures.
摘要翻译：本发明的实施方案通常包含不含动物来源的赋形剂/组分的生物制品的稳定剂，这些稳定剂在冻干程序中很好地起作用。

60. 发明申请

US20080248061A1 Pcv-2 Vaccine 审中-公开
标题翻译： Pcv-2疫苗
公开(公告)号：US20080248061A1
公开(公告)日：2008-10-09
申请号：US12066090
申请日：2006-09-08
申请人： Frank Roerink , Peter van Woensel
发明人： Frank Roerink , Peter van Woensel
IPC分类号： A61K39/00 , A61P37/00
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5256 , A61K2039/545 , A61K2039/55 , A61K2039/552 , A61K2039/55511 , A61K2039/55566 , C12N7/00 , C12N15/86 , C12N2710/14143 , C12N2750/10034
摘要： The present invention relates to a vaccine against porcine circovirus type 2 (PCV-)2 and a method for the manufacture of such a vaccine, for protecting piglets against PCV-2 infection.It has been found that a vaccine comprising at least 20 microgram/dose of ORF-2 protein of porcine circovirus type 2 (PCV-2 is capable of eliciting a protective immune response against PCV-2 (and thus against PMWS) even when they have a relatively high titer of MDA against PCV-2.A vaccine according to the invention may contain a recombinant ORF-2 protein, wherein said recombinant protein is preferably produced by way of expression from a baculovirus expression vector in insect cells, said baculovirus expression vector containing the PCV-2 ORF-2 gene sequence under control of a suitable promoter.
摘要翻译：本发明涉及一种针对猪圆环病毒2型（PCV-）2的疫苗和一种用于制造这种疫苗的方法，用于保护小猪免受PCV-2感染。已经发现，包含至少20微克/剂量的2型猪圆环病毒的ORF-2蛋白质的疫苗（PCV-2能够引起对PCV-2的保护性免疫应答（并因此对抗PMWS），即使它们具有根据本发明的疫苗可以含有重组ORF-2蛋白质，其中所述重组蛋白质优选通过在昆虫细胞中从杆状病毒表达载体表达而产生，所述杆状病毒表达载体在合适的启动子控制下含有PCV-2 ORF-2基因序列。

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