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51. 发明授权

US07749506B2 Proteins derived from white spot syndrome virus and uses thereof 失效
标题翻译：衍生自白点综合征病毒的蛋白质及其用途
公开(公告)号：US07749506B2
公开(公告)日：2010-07-06
申请号：US11737227
申请日：2007-04-19
申请人： Maria Cornelia Wilhelmina van Hulten , Justinus Maria Vlak
发明人： Maria Cornelia Wilhelmina van Hulten , Justinus Maria Vlak
IPC分类号： A61K39/12 , C07K14/00 , C12P21/04 , C07H21/04
CPC分类号： C07K14/005 , A61K2039/525 , C12N2710/14143 , C12N2710/18022
摘要： Embodiments of the present invention generally relate to proteins derived from white spot syndrome virus, nucleic acid sequences encoding them, and their use in the manufacture of a vaccine for prophylaxis and/or treatment of white spot syndrome in crustaceans.
摘要翻译：本发明的实施方案一般涉及来源于白点综合征病毒的蛋白质，编码它们的核酸序列及其在制备用于预防和/或治疗甲壳类动物白斑综合征的疫苗中的用途。

52. 发明申请

US20100136090A1 Helically-Shaped Drug Delivery System 审中-公开
标题翻译：螺旋形药物输送系统
公开(公告)号：US20100136090A1
公开(公告)日：2010-06-03
申请号：US12594169
申请日：2007-11-19
申请人： Marc-Antoine Driancourt , Wouter De Graff , Laura Buttafoco , Fabrice Payot , Harm Veenstra , René Willem Joris Voss
发明人： Marc-Antoine Driancourt , Wouter De Graff , Laura Buttafoco , Fabrice Payot , Harm Veenstra , René Willem Joris Voss
IPC分类号： A61K31/567 , A61F6/14 , A61K31/56 , A61P15/00 , A61P15/18
CPC分类号： A61K9/0036 , A61K31/575 , A61K47/32
摘要： The present invention relates to a helically-shaped medicated veterinary system suitable for delivery of a drug to the vaginal cavity of a female non-human mammal and to a method of manufacture. The drug delivery system is helically-shaped and comprises a three layered polymer fibre. The polymer fibre comprises a polymer core, a polymer intermediate layer comprising a drug, and a polymer skin. The medicated system provides a controlled delivery of drug to the vaginal cavity of the mammal. The present invention also relates to a process of making the springs.
摘要翻译：本发明涉及一种适合于将药物递送至女性非人哺乳动物的阴道腔的螺旋形药物兽医系统及其制造方法。药物递送系统是螺旋形的并且包括三层聚合物纤维。聚合物纤维包括聚合物芯，包含药物的聚合物中间层和聚合物皮肤。药物系统提供药物到哺乳动物的阴道腔的受控递送。本发明还涉及制造弹簧的方法。

53. 发明申请

US20100111997A1 Multi component vaccine containing clostridial and non-clostridial organisms in a low dose 审中-公开
标题翻译：含有低剂量梭菌和非梭菌生物的多组分疫苗
公开(公告)号：US20100111997A1
公开(公告)日：2010-05-06
申请号：US12684335
申请日：2010-01-08
申请人： Richard E. Parizek , Lonny E. Vlieger , Sharon A. Bryant , Stuart K. Nibbelink , Michael J. McGinley
发明人： Richard E. Parizek , Lonny E. Vlieger , Sharon A. Bryant , Stuart K. Nibbelink , Michael J. McGinley
IPC分类号： A61K39/116
CPC分类号： A61K39/08 , A61K39/102 , Y02A50/489 , A61K2300/00
摘要： Disclosed herein is a multicomponent low dose vaccine comprising a safe and immunogenically effective combination of a protective antigen component or components of clostridial organism, a protective antigen component of a non-clostridial organism and an adjuvant.
摘要翻译：本文公开了一种多组分低剂量疫苗，其包含保护性抗原成分或梭菌生物的组分，非梭菌生物的保护性抗原成分和佐剂的安全和免疫有效组合。

54. 发明授权

US07638131B2 Coccidiosis poultry vaccine 失效
标题翻译：球虫病家禽疫苗
公开(公告)号：US07638131B2
公开(公告)日：2009-12-29
申请号：US11743402
申请日：2007-05-02
申请人： Jacobus Johannes Kok , Paul van den Boogaart , Arnodus Nicolaas Vermeulen
发明人： Jacobus Johannes Kok , Paul van den Boogaart , Arnodus Nicolaas Vermeulen
IPC分类号： A61K39/00 , A61K39/38 , A61K39/002 , A61K39/012 , A61K38/00 , A61K38/16 , A01N37/18 , C07K14/00 , C07K17/00 , C07K1/00
CPC分类号： A61K39/012 , A61K38/00 , A61K39/00 , A61K2039/51 , A61K2039/53 , C07K14/455 , C07K16/20 , C12N9/0006
摘要： This invention relates to novel Eimeria proteins with immunogenic properties as well as to DNA sequences encoding these proteins. These proteins can be administered to poultry thereby protecting the birds against coccidiosis. In addition the DNA encoding these proteins can be used for the preparation of a vector vaccine against coccidiosis.
摘要翻译：本发明涉及具有免疫原性的新颖艾美球虫蛋白以及编码这些蛋白质的DNA序列。这些蛋白质可以施用于家禽，从而保护鸟类免于球虫病。此外，编码这些蛋白质的DNA可用于制备针对球虫病的载体疫苗。

55. 发明授权

US07601804B2 Streptococcus uberis protein, nucleic acid sequence encoding the same and its use in a mastitis vaccine 失效
标题翻译：乳房链球菌蛋白，编码相同的核酸序列及其在乳腺炎疫苗中的应用
公开(公告)号：US07601804B2
公开(公告)日：2009-10-13
申请号：US10524198
申请日：2003-08-06
申请人： Petrus Johannes Maria Nuijten , Selma Marianne Hensen
发明人： Petrus Johannes Maria Nuijten , Selma Marianne Hensen
IPC分类号： C07K1/00 , G01N33/569
CPC分类号： C07K14/315 , A61K39/00
摘要： The present invention relates to nucleic acid sequences encoding a 22.5 kD Streptococcus uberis protein and to parts of such nucleic acid sequences that encode an immunogenic fragment of such proteins, and to DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof. The invention also relates to a 22.5 kD Streptococcus uberis protein and immunogenic parts thereof encoded by such sequences. Furthermore, the present invention relates to vaccines comprising such nucleic acid sequences and parts thereof, DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof, proteins or immunogenic parts thereof and antibodies against such proteins or immunogenic parts thereof. Also, the invention relates to the use of said proteins in vaccines and for the manufacture of vaccines. Moreover, the invention relates to the use of said nucleic acid sequences, proteins or antibodies for diagnostic or vaccination purposes. Finally the invention relates to diagnostic kits comprising such a nucleic acid, protein or antibodies against such protein.
摘要翻译：本发明涉及编码22.5kD乳房链球菌蛋白质的核酸序列和编码这种蛋白质的免疫原性片段的这些核酸序列的部分，以及DNA片段，重组DNA分子，活重组载体和包含该核酸的宿主细胞酸序列或其部分。本发明还涉及由这样的序列编码的22.5kD乳房链球菌蛋白及其免疫原性部分。此外，本发明涉及包含此类核酸序列及其部分的DNA疫苗，DNA片段，重组DNA分子，活重组载体和包含此类核酸序列或其部分的宿主细胞，蛋白质或其免疫原性部分和针对此类蛋白质的抗体或其免疫原性部分。此外，本发明涉及所述蛋白质在疫苗中的用途以及制造疫苗。此外，本发明涉及用于诊断或疫苗接种目的的所述核酸序列，蛋白质或抗体的用途。最后，本发明涉及包含这种核酸，蛋白质或抗这种蛋白质的抗体的诊断试剂盒。

56. 发明授权

US07601500B2 Prime-boost vaccine for the protection of equines against viral infection 有权
标题翻译：用于保护马免受病毒感染的Prime-boost疫苗
公开(公告)号：US07601500B2
公开(公告)日：2009-10-13
申请号：US11743492
申请日：2007-05-02
申请人： Saskia van de Zande
发明人： Saskia van de Zande
IPC分类号： C12Q1/68
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5254 , A61K2039/545 , A61K2039/552 , A61K2039/55511 , A61K2039/55577 , C12N2760/16134
摘要： It has been found that adequate protection against viral infection in equines can be achieved when vaccination with a live viral vaccine (prime) is followed by vaccination with an inactivated vaccine (boost) for the same virus, wherein the two shots are given no longer than 8 weeks apart.The invention therefore provides a method for vaccination of equines against infection with an equine viral pathogen, wherein an animal is first vaccinated with a (prime) vaccine comprising an attenuated form of the pathogen, followed by a vaccination with a (boost) vaccine comprising the same pathogen in inactivated form, and wherein the boost vaccine is administered no longer than eight weeks after the prime vaccine.The method of the invention is especially useful for vaccination against viral infections such as infections with EIV and/or EHV-1/EHV-4.Especially for EIV, it has been found that when equines are vaccinated with such a prime-boost vaccine regimen according to the invention, the equines are protected against clinical signs after a challenge with a virulent EIV.
摘要翻译：已经发现，当用活病毒疫苗（初始）接种疫苗之后，用相同病毒的灭活疫苗（增强）接种疫苗后，可以实现对马中的病毒感染的充分保护，其中两次照射不再相隔8周。因此，本发明提供了一种针对马病毒病原体感染马的疫苗接种方法，其中动物首先用包含减毒形式的病原体的（初级）疫苗接种疫苗，然后用（加强）疫苗接种疫苗，其包含相同的灭活形式的病原体，并且其中所述加强疫苗在所述主要疫苗之后不超过8周施用。本发明的方法对于针对病毒感染例如EIV和/或EHV-1 / EHV-4感染是特别有用的。特别是对于EIV，已经发现，当使用根据本发明的初始 - 加强疫苗方案接种马时，在用有毒EIV攻击后，马被保护免受临床症状。

57. 发明申请

US20090238844A1 Porcine reproductive and respiratory syndrome virus strains and compositions 失效
标题翻译：猪繁殖与呼吸综合征病毒株及组成
公开(公告)号：US20090238844A1
公开(公告)日：2009-09-24
申请号：US11719715
申请日：2005-11-09
申请人： Richard A. Hesse
发明人： Richard A. Hesse
IPC分类号： A61K39/12 , C12N7/00 , A61P31/12
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5254 , A61K2039/552 , C12N7/00 , C12N2770/10022 , C12N2770/10034 , C12N2770/10061
摘要： This invention relates to two attenuated strains of porcine reproductive and respiratory syndrome virus (PRRSV) and immunogenic compositions comprising one or more strains of attenuated porcine reproductive and respiratory syndrome virus (PRRSV).
摘要翻译：本发明涉及猪繁殖和呼吸综合征病毒（PRRSV）的两种减毒菌株和包含一种或多种减毒猪繁殖与呼吸综合征病毒（PRRSV）菌株的免疫原性组合物。

58. 发明授权

US07514547B2 Helicobacter felis vaccine 失效
标题翻译：幽门螺杆菌疫苗
公开(公告)号：US07514547B2
公开(公告)日：2009-04-07
申请号：US09904994
申请日：2001-07-13
申请人： Johannes Gerardus Kusters , Giovanni Cattoli
发明人： Johannes Gerardus Kusters , Giovanni Cattoli
IPC分类号： A61K39/00
CPC分类号： C12N9/80 , A61K39/00 , C07K14/205
摘要： The present invention relates to novel Helicobacter felis urease subunit polypeptides and to nucleic acid sequences encoding these subunit polypeptides, to DNA fragments and recombinant DNA molecules comprising the nucleic acid sequences encoding these subunit polypeptides, to live recombinant carriers and to host cells comprising nucleic acid sequences encoding these subunit polypeptides. Also, the invention relates to the subunit polypeptides for use in vaccines and the use in the manufacturing thereof, to vaccines comprising said subunit polypeptides and to methods for the preparation of such vaccines. Furthermore, the invention relates to diagnostic methods for the detection of Helicobacter felis specific nucleic acid sequences, Helicobacter felis antigenic material and to antibodies against Helicobacter felis.
摘要翻译：本发明涉及新颖的幽门螺杆菌脲酶亚基多肽和编码这些亚单位多肽的核酸序列，涉及包含编码这些亚单位多肽的核酸序列的DNA片段和重组DNA分子，以及包含核酸序列的宿主细胞编码这些亚基多肽。此外，本发明还涉及用于疫苗的亚单位多肽及其制备中使用的疫苗，包括所述亚单位多肽的疫苗以及制备这种疫苗的方法。此外，本发明涉及用于检测幽门螺杆菌特异性核酸序列，幽门螺杆菌抗原物质和针对幽门螺杆菌抗体的诊断方法。

59. 发明授权

US07491401B2 Lawsonia intracellularis vaccine 失效
标题翻译：细胞内毒素疫苗
公开(公告)号：US07491401B2
公开(公告)日：2009-02-17
申请号：US11180997
申请日：2005-07-13
申请人： Antonius Arnoldus Christiaan Jacobs , Paul Vermeij
发明人： Antonius Arnoldus Christiaan Jacobs , Paul Vermeij
IPC分类号： A61K39/02 , C07H21/04 , C12P21/04
CPC分类号： C07K14/205 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/195
摘要： The present invention relates i.a. to nucleic acid sequences encoding novel Lawsonia intracellularis proteins. It furthermore relates to DNA fragments, recombinant DNA molecules and live recombinant carriers comprising these sequences. Also it relates to host cells comprising such nucleic acid sequences, DNA fragments, recombinant DNA molecules and live recombinant carriers. Moreover, the invention relates to proteins encoded by these nucleotide sequences. The invention also relates to vaccines for combating Lawsonia intracellularis infections and methods for the preparation thereof. Finally the invention relates to diagnostic tests for the detection of Lawsonia intracellularis DNA, the detection of Lawsonia intracellularis antigens and of antibodies against Lawsonia intracellularis.
摘要翻译：本发明涉及到涉及编码新的细胞内劳森氏菌蛋白质的核酸序列。此外，它还涉及包含这些序列的DNA片段，重组DNA分子和活重组载体。此外，它涉及包含这种核酸序列的宿主细胞，DNA片段，重组DNA分子和活重组载体。此外，本发明涉及由这些核苷酸序列编码的蛋白质。本发明还涉及用于防治细胞内劳森氏菌感染的疫苗及其制备方法。最后本发明涉及检测细胞内劳森氏菌DNA，检测细胞内劳森氏菌抗原和针对细胞内劳森氏菌的抗体的诊断试验。

60. 发明申请

US20090017048A1 Novel Brachyspira hyodysenteriae vaccine 审中-公开
标题翻译：新型短螺旋体猪链球菌疫苗
公开(公告)号：US20090017048A1
公开(公告)日：2009-01-15
申请号：US12047188
申请日：2008-03-12
申请人： Ben Adler , Paul Antony Cullen , Scott Adam James Coutts , Dieter Mark Bulach , Ruud Philip Antoon Maria Segers
发明人： Ben Adler , Paul Antony Cullen , Scott Adam James Coutts , Dieter Mark Bulach , Ruud Philip Antoon Maria Segers
IPC分类号： A61K39/02 , C07H21/04 , A61P31/04 , C12N5/06
CPC分类号： C07K14/20 , A61K39/00 , A61K2039/505 , A61K2039/523 , A61K2039/53
摘要： The present invention relates to nucleic acid sequences encoding a 61 kD and a 20 kD Brachyspira hyodysenteriae lipoprotein and to parts of such nucleic acid sequences that encode an immunogenic fragment of such lipoproteins, and to DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof. The invention also relates to a 61 kD and a 20 kD Brachyspira hyodysenteriae lipoprotein and immunogenic parts thereof encoded by such sequences. Furthermore, the present invention relates to vaccines comprising such nucleic acid sequences and parts thereof, DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof, lipoproteins or immunogenic parts thereof and antibodies against such lipoproteins or immunogenic parts thereof. Also, the invention relates to the use of said lipoproteins in vaccines and for the manufacture of vaccines. Moreover, the invention relates to the use of said nucleic acid sequences, lipoproteins or antibodies for diagnostic or vaccination purposes. Finally the invention relates to diagnostic kits comprising such a nucleic acid, lipoprotein or antibodies against such lipoprotein.
摘要翻译：本发明涉及编码61kD和20kD猪链霉菌血脂蛋白脂蛋白的核酸序列以及编码这种脂蛋白的免疫原性片段的这些核酸序列的部分，以及DNA片段，重组DNA分子，活重组载体和宿主包含这样的核酸序列的细胞或其部分。本发明还涉及由这样的序列编码的61kD和20kD猪链球菌脂蛋白及其免疫原性部分。此外，本发明涉及包含此类核酸序列及其部分的DNA疫苗，DNA片段，重组DNA分子，活重组载体和包含此类核酸序列或其部分的宿主细胞，脂蛋白或其免疫原性部分和针对此类脂蛋白的抗体或其免疫原性部分。此外，本发明还涉及所述脂蛋白在疫苗中的用途以及制造疫苗。此外，本发明涉及所述核酸序列，脂蛋白或抗体用于诊断或疫苗接种目的的用途。最后，本发明涉及包含这种核酸，脂蛋白或抗这种脂蛋白的抗体的诊断试剂盒。

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