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1. 发明授权

US07569682B2 Brachyspira hyodysenteriae vaccine 失效
标题翻译：猪链球菌疫苗
公开(公告)号：US07569682B2
公开(公告)日：2009-08-04
申请号：US11833632
申请日：2007-08-03
申请人： Ben Adler , Paul Antony Cullen , Scott Adam James Coutts , Dieter Mark Bulach , Ruud Philip Antoon Maria Segers
发明人： Ben Adler , Paul Antony Cullen , Scott Adam James Coutts , Dieter Mark Bulach , Ruud Philip Antoon Maria Segers
IPC分类号： C07H21/00
CPC分类号： C07K14/20 , A61K39/00 , A61K2039/505 , A61K2039/523 , A61K2039/53
摘要： The present invention relates to nucleic acid sequences encoding a 30 kD Brachyspira hyodysenteriae lipoprotein and to parts of such nucleic acid sequences that encode an immunogenic fragment of such lipoproteins, and to DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof. The invention also relates to a 30 kD Brachyspira hyodysenteriae lipoprotein and immunogenic parts thereof encoded by such sequences. Furthermore, the present invention relates to vaccines comprising such nucleic acid sequences and parts thereof, DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof, lipoproteins or immunogenic parts thereof and antibodies against such lipoproteins or immunogenic parts thereof. Also, the invention relates to the use of said lipoproteins in vaccines and for the manufacture of vaccines. Moreover, the invention relates to the use of said nucleic acid sequences, lipoproteins or antibodies for diagnostic or vaccination purposes. Finally the invention relates to diagnostic kits comprising such a nucleic acid, lipoprotein or antibodies against such lipoprotein.
摘要翻译：本发明涉及编码30kD猪链球菌血脂性脂蛋白的核酸序列以及编码这种脂蛋白的免疫原性片段的这些核酸序列的部分以及DNA片段，重组DNA分子，活重组载体和包含该核酸的宿主细胞酸序列或其部分。本发明还涉及由这样的序列编码的30kD猪链球菌脂蛋白及其免疫原性部分。此外，本发明涉及包含此类核酸序列及其部分的DNA疫苗，DNA片段，重组DNA分子，活重组载体和包含此类核酸序列或其部分的宿主细胞，脂蛋白或其免疫原性部分和针对此类脂蛋白的抗体或其免疫原性部分。此外，本发明还涉及所述脂蛋白在疫苗中的用途以及制造疫苗。此外，本发明涉及所述核酸序列，脂蛋白或抗体用于诊断或疫苗接种目的的用途。最后，本发明涉及包含这种核酸，脂蛋白或抗这种脂蛋白的抗体的诊断试剂盒。

2. 发明申请

US20090017048A1 Novel Brachyspira hyodysenteriae vaccine 审中-公开
标题翻译：新型短螺旋体猪链球菌疫苗
公开(公告)号：US20090017048A1
公开(公告)日：2009-01-15
申请号：US12047188
申请日：2008-03-12
申请人： Ben Adler , Paul Antony Cullen , Scott Adam James Coutts , Dieter Mark Bulach , Ruud Philip Antoon Maria Segers
发明人： Ben Adler , Paul Antony Cullen , Scott Adam James Coutts , Dieter Mark Bulach , Ruud Philip Antoon Maria Segers
IPC分类号： A61K39/02 , C07H21/04 , A61P31/04 , C12N5/06
CPC分类号： C07K14/20 , A61K39/00 , A61K2039/505 , A61K2039/523 , A61K2039/53
摘要： The present invention relates to nucleic acid sequences encoding a 61 kD and a 20 kD Brachyspira hyodysenteriae lipoprotein and to parts of such nucleic acid sequences that encode an immunogenic fragment of such lipoproteins, and to DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof. The invention also relates to a 61 kD and a 20 kD Brachyspira hyodysenteriae lipoprotein and immunogenic parts thereof encoded by such sequences. Furthermore, the present invention relates to vaccines comprising such nucleic acid sequences and parts thereof, DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof, lipoproteins or immunogenic parts thereof and antibodies against such lipoproteins or immunogenic parts thereof. Also, the invention relates to the use of said lipoproteins in vaccines and for the manufacture of vaccines. Moreover, the invention relates to the use of said nucleic acid sequences, lipoproteins or antibodies for diagnostic or vaccination purposes. Finally the invention relates to diagnostic kits comprising such a nucleic acid, lipoprotein or antibodies against such lipoprotein.
摘要翻译：本发明涉及编码61kD和20kD猪链霉菌血脂蛋白脂蛋白的核酸序列以及编码这种脂蛋白的免疫原性片段的这些核酸序列的部分，以及DNA片段，重组DNA分子，活重组载体和宿主包含这样的核酸序列的细胞或其部分。本发明还涉及由这样的序列编码的61kD和20kD猪链球菌脂蛋白及其免疫原性部分。此外，本发明涉及包含此类核酸序列及其部分的DNA疫苗，DNA片段，重组DNA分子，活重组载体和包含此类核酸序列或其部分的宿主细胞，脂蛋白或其免疫原性部分和针对此类脂蛋白的抗体或其免疫原性部分。此外，本发明还涉及所述脂蛋白在疫苗中的用途以及制造疫苗。此外，本发明涉及所述核酸序列，脂蛋白或抗体用于诊断或疫苗接种目的的用途。最后，本发明涉及包含这种核酸，脂蛋白或抗这种脂蛋白的抗体的诊断试剂盒。

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