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41. 发明公开

US20240344091A1 PROCESS AND PLANT 审中-公开
公开(公告)号：US20240344091A1
公开(公告)日：2024-10-17
申请号：US18619150
申请日：2024-03-27
申请人： Cemvita Factory, Inc.
发明人： Zachary Richard BROUSSARD , TJ TIDWELL , Michael SAMUEL , Edward John KOCH , Raja Subramanian RAMANATHAN , Renata Amanda GONÇALVES , Aaron TREVINO , Addien WRAY , Bárbara de Freitas MAGALHÃES , Edris TAHER
IPC分类号： C12P3/00 , C12M1/00
CPC分类号： C12P3/00 , C12M23/52 , C12M41/14
摘要： The present application provides a process and plant for the microbial production of hydrogen from the site of hydrocarbonaceous deposit, the process comprising modifying the composition of the deposit through the introduction into or into the vicinity of the deposit of at least one hydrogen producing microorganism, wherein the at least one hydrogen producing microorganism is provided on site by means of a transportable microbiological incubator, the plant comprising means in the form of a transportable microbiological incubator for generating at least one hydrogen producing microorganism; and means for supplying the at least one at least one hydrogen producing microorganism into the hydrocarbonaceous deposit.

42. 发明公开

US20240344089A1 METHODS FOR PRODUCTION OF BIOPRODUCTS 审中-公开
公开(公告)号：US20240344089A1
公开(公告)日：2024-10-17
申请号：US18634947
申请日：2024-04-14
申请人： SUPERBREWED FOOD INC.
发明人： ALAN KARPOL , AHARON M. EYAL , BRYAN P. TRACY
IPC分类号： C12P1/04 , C12N1/20
CPC分类号： C12P1/04 , C12N1/20
摘要： Provided is a method for producing a bioproduct, comprising culturing at least one target microorganism in a target growth medium comprising cells of a strictly anaerobic bacterium, the cells comprising protein at a crude protein concentration of at least 60 wt % of a total dry weight of the cells, wherein at least 50% of a total number of the cells are dead cells.

43. 发明公开

US20240344038A1 L-ARGININE-GLYCINE AMIDINOTRANSFERASE AND USE THEREOF IN THE PRODUCTION OF GUANIDINOACETIC ACID 审中-公开
公开(公告)号：US20240344038A1
公开(公告)日：2024-10-17
申请号：US18415827
申请日：2024-01-18
申请人： JIANGNAN UNIVERSITY
发明人： Meijuan XU , Zhiming RAO , Yaxin LIAO , Haofei XU , Xian ZHANG , Taowei YANG
IPC分类号： C12N9/10 , C12N15/70 , C12P13/04
CPC分类号： C12N9/1003 , C12N15/70 , C12P13/04 , C12Y201/04001
摘要： The present invention discloses an L-arginine-glycine amidinotransferase and use thereof in the production of guanidinoacetic acid. In the present invention, through combined multi-site amino acid mutation, a technical effect of significantly improved enzyme activity of the mutant AkAGATT225Q/A258P/L278K than that of the wild-type strain is achieved, providing an application value for large-scale production of guanidinoacetic acid in industry. When the L-arginine-glycine amidinotransferase mutant constructed in the present invention is used in the production of guanidinoacetic acid, by optimizing the conversion conditions, the yield of guanidinoacetic acid is up to 21.4 g/L and the conversion rate is 90.4%, after 24 hrs of reaction in a 1 L reaction system. Compared with the production of guanidinoacetic acid with the raw enzyme, the yield is increased by 49.6%.

44. 发明公开

US20240343884A1 INTEGRATED PROCESS FOR THE PURIFICATION OF LEVULINIC ACID FROM TECHNICAL LIGNIN 审中-公开
公开(公告)号：US20240343884A1
公开(公告)日：2024-10-17
申请号：US18620971
申请日：2024-03-28
申请人： Indian Oil Corporation Limited , Department of Biotechnology
发明人： Alok SATLEWAL , Ruchi AGRAWAL , Prakram Singh CHAUHAN , Ravindra KUMAR , Ravi Prakash GUPTA , Sankara Sri Venkata RAMAKUMAR
IPC分类号： C08J11/16 , C07C51/44 , C07C51/47 , C07C51/48 , C07C59/185 , C08J11/10 , C12P7/22
CPC分类号： C08J11/16 , C07C51/44 , C07C51/47 , C07C51/48 , C07C59/185 , C08J11/105 , C12P7/22 , C12P2201/00
摘要： The present invention relates to a novel integrated process to extract and purify levulinic acid (LA) produced from the technical lignin waste (2-G residue) generated after second generation (2-G) ethanol production from biomass. In this process, liquid-liquid extraction was carried out using fusel oil as an organic extractant to yield a LA rich organic phase and an acidic aqueous phase (raffinate). In addition, selected amines improved the LA yields by acting synergistically. Further fractional distillation was carried out to purify LA. The acidic raffinate is recycled back to the reaction in multiple times, which reduce the use of additional catalyst and make the overall process cost effective. The process is very simple and suitable to remove any colour and humins (soluble tar), which would otherwise form a problem in subsequent process step, particularly in distillation. At optimized process conditions 95% LA is recovered with 98% purity.

45. 发明公开

US20240343670A1 PROCESS FOR PRODUCING RECYCLED LACTATE SALT 审中-公开
公开(公告)号：US20240343670A1
公开(公告)日：2024-10-17
申请号：US18293759
申请日：2022-08-02
申请人： TRIPLEW LTD.
发明人： Tal Shapira , Nitsan Papo , Dina Pinsky
IPC分类号： C07C51/41 , C07C51/43 , C12P7/56
CPC分类号： C07C51/412 , C07C51/43 , C12P7/56
摘要： The present invention relates to processes for producing highly pure magnesium L-lactate salt from decomposed organic waste and enriching the enantiomeric purity of recycled lactate salt.

46. 发明公开

US20240336947A1 METHOD TO PRODUCE COLLAGEN AS THERAPEUTICS AND BIOMATERIALS 审中-公开
公开(公告)号：US20240336947A1
公开(公告)日：2024-10-10
申请号：US18626636
申请日：2024-04-04
申请人： University of Kentucky Research Foundation
发明人： Houfu Guo
IPC分类号： C12P21/02 , C12N9/10
CPC分类号： C12P21/02 , C12N9/1051 , C12Y204/01066
摘要： Humans and Acanthamoeba Polyphaga Mimivirus share numerous homologous genes, including collagens and collagen-modifying enzymes. To explore the homology, a genome-wide comparison was performed between human and mimivirus using DELTA-BLAST (Domain Enhanced Lookup Time Accelerated BLAST) and identified 190 new mimiviral proteins that share homology with 1236 human proteins. To gain functional insights into mimiviral proteins, the human protein homologs were organized into Gene Ontology (GO) and REACTOME pathways to build a functional network. Collagen and collagen-modifying enzymes form the largest subnetwork with most nodes. Further analysis of this subnetwork identified a putative collagen glycosyltransferase R699. Protein expression test suggested that R699 is highly expressed in E coli, unlike the human collagen-modifying enzymes. Enzymatic activity assays showed that R699 catalyzes the conversion of galactosyl-hydroxylysine to glucosyl-galactosyl-hydroxylysine on collagen using UDP-glucose as a sugar donor, suggesting R699 is a mimiviral collagen galactosylhydroxylysyl glucosyltransferase (GGT). Structural study of R699 produced the first crystal structure of a collagen GGT with uridine diphosphate glucose (UDP-Glc). Sugar moiety of the UDP-Glc resides in a previously unrecognized pocket. Mn2+ coordination and nucleoside-diphosphate binding site are conserved among GGT family members and critical for R699's collagen GGT activity. To facilitate further analysis of human and mimiviral homologous proteins, we presented an interactive and searchable genome-wide comparison app for quickly browsing of human and Acanthamoeba Polyphaga Mimivirus homologs, which is available at RRID Resource ID: SCR_022140 or guolab.shinyapps.io/app-mimivirus-publication/.

47. 发明公开

US20240336946A1 SOLID-PHASE GLYCAN REMODELING OF GLYCOPROTEINS 审中-公开
公开(公告)号：US20240336946A1
公开(公告)日：2024-10-10
申请号：US18554242
申请日：2022-04-11
申请人： MERCK SHARP & DOHME LLC
发明人： YEN-PANG HSU , BENJAMIN F. MANN , SHUWEN SUN , DEEPTAK VERMA
IPC分类号： C12P21/00
CPC分类号： C12P21/005
摘要： A solid-phase glycan remodeling (SPGR) system for the glycoengineering of glycoproteins to provide glycoprotein compositions comprising particular predominant glycoforms is described.

48. 发明授权

US12110532B2 In vitro glycosylation of proteins and enzymes 有权
公开(公告)号：US12110532B2
公开(公告)日：2024-10-08
申请号：US18170045
申请日：2023-02-16
申请人： Design-Zyme LLC
发明人： Peter Albert Petillo , Dwight O'Dell Deay, III
IPC分类号： C12Q1/00 , C07K1/00 , C07K1/107 , C12N9/02 , C12N9/04 , C12N9/06 , C12P21/00
CPC分类号： C12Q1/005 , C07K1/006 , C07K1/1077 , C12N9/0004 , C12N9/0006 , C12P21/005
摘要： The present invention is broadly concerned with new in vitro glycosylation methods that provide rational approaches for producing glycosylated proteins, and the use of glycosylated proteins. In more detail, the present invention comprises methods of glycosylating a starting protein having an amino sidechain with a nucleophilic moiety, comprising the step of reacting the protein with a carbohydrate having an oxazoline moiety on the reducing end thereof, to covalently bond the amino sidechain of the starting protein with the oxazoline moiety, wherein the glycosylated protein substantially retains the structure and function of the starting protein. Target proteins include oxidase, oxidoreductase and dehydrogenase enzymes. The glycosylated proteins advantageously have molecular weights of at least about 7500 Daltons. In a further embodiment, the present invention concerns the use of glycosylated proteins, fabricated by the methods disclosed herein, in the assembly of amperometric biosensors.

49. 发明授权

US12110529B2 Methods and systems using ionophores to control contamination in fermentation of gaseous substrates 有权
公开(公告)号：US12110529B2
公开(公告)日：2024-10-08
申请号：US16471453
申请日：2017-12-14
申请人： Synata Bio, Inc.
发明人： Jennine B. Terrill
IPC分类号： C12P7/06 , C12M1/00 , C12P7/40
CPC分类号： C12P7/065 , C12M21/12 , C12M43/02
摘要： Provided is a method of anaerobically fermenting a gaseous substrate to form a liquid product, the method comprising: (a) introducing the gaseous substrate into a bio-reactor, the gaseous substrate comprising at least one of the following constituents: carbon monoxide, carbon dioxide, and hydrogen, (b) the bio-reactor comprising a fermentation broth therein, the fermentation broth containing at least two types of microorganisms, one type comprising at least one fermenting species, and the other type comprising at least one competing species; (c) introducing at least one type of ionophore into the reactor, the ionophore having selectivity for preferentially inhibiting the at least one competing species from growing and/or producing an undesired product; and (d) allowing the gaseous substrate to ferment by exposure to the at least one fermenting species, to produce the liquid product and a system for doing the same.

50. 发明授权

US12110512B2 Biocatalysts for ezetimibe synthesis 有权
公开(公告)号：US12110512B2
公开(公告)日：2024-10-08
申请号：US17204189
申请日：2021-03-17
申请人： Codexis Inc.
发明人： Michael A. Crowe , Oscar Alvizo , Behnaz Behrouzian , Yong Koy Bong , Steven J. Collier , Anupam Gohel , Jagadeesh Mavinahalli , Naga K. Modukuru , Emily Mundorff , Derek J. Smith , Shiwei Song , Wan Lin Yeo
IPC分类号： C12N9/00 , C07K14/47 , C12N9/04 , C12P17/10 , A61K38/00 , C12P17/14
CPC分类号： C12N9/0006 , C07K14/47 , C12P17/10 , C12Y101/00 , C12Y101/01184 , A61K38/00 , C12P17/14
摘要： The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.

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