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41. 发明授权

US06664089B2 38692 and 21117, novel dual specificity phosphatase molecules and uses therefor 失效
公开(公告)号：US06664089B2
公开(公告)日：2003-12-16
申请号：US09816494
申请日：2001-03-23
申请人： Rachel A. Meyers
发明人： Rachel A. Meyers
IPC分类号： C12N916
CPC分类号： C12N9/16 , A61K38/00 , A61K2039/505 , C07K2319/00
摘要： The invention provides isolated nucleic acids molecules, designated 38692 or 21117 nucleic acid molecules, which encode novel dual specificity phosphatase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 38692 or 21117 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 38692 or 21117 gene has been introduced or disrupted. The invention still further provides isolated 38692 or 21117 proteins, fusion proteins, antigenic peptides and anti-38692 or 21117 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

42. 发明授权

US06623947B2 Human glucose-6-phosphatase molecules and uses thereof 失效
公开(公告)号：US06623947B2
公开(公告)日：2003-09-23
申请号：US09874132
申请日：2001-06-04
申请人： Hong Chen
发明人： Hong Chen
IPC分类号： C12N916
CPC分类号： C12N9/16 , A01K2217/05 , A61K38/00
摘要： The invention provides isolated nucleic acids encoding human pancreatic islet-specific glucose-6-phosphatase proteins and nucleic acids having diagnostic, preventive, therapeutic, and other uses. These nucleic acids and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides, and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes, including those which are aberrant in diabetes and other disorders associated with pancreatic dysfunction. The invention includes methods of modulating secretion of pancreatic hormones such as insulin and glucagon, and these methods can be used to alleviate disorders (e.g., diabetes and hyperinsulinemia) associated with aberrant secretion of these hormones.

43. 发明授权

US06610524B2 Thermostable phospholipase A1 mutants and a process for preparing the same 失效
公开(公告)号：US06610524B2
公开(公告)日：2003-08-26
申请号：US09818739
申请日：2001-03-27
申请人： Joon-Shick Rhee , Jae-Kwang Song
发明人： Joon-Shick Rhee , Jae-Kwang Song
IPC分类号： C12N916
CPC分类号： C12N9/18 , C12Y301/01032
摘要： The present invention provides thermostable phospholipase TA3 and TA13 which are mutants of phospholipase A1 involving the hydrolysis/synthesis of phospholipids, the mutated genes encoding the same, microorganisms transformed with recombinant expression vectors comprising the mutated genes and a process for preparing phospholipase A1 mutants therefrom. The process for preparing phospholipase A1 mutant of the invention comprises the steps of: culturing E. coli strain transformed with a recombinant expression vector comprising a gene coding for phospholipase A1 mutant derived from Serratia sp.; and, isolating and purifying phospholipase A1 mutant from the culture. Since phospholipase A1 mutants of the invention have been improved in terms of thermal stability and enzyme activity as well, they can be practically applied to various biological process, pharmaceutics, cosmetics and food industries.

44. 发明授权

US06582948B1 Recombinant kid pregastric esterase and methods for its production and use 有权
公开(公告)号：US06582948B1
公开(公告)日：2003-06-24
申请号：US10043665
申请日：2002-01-14
申请人： Paul L. Bolen , Paul L. Cihak , Lewis G. Scharpf, Jr.
发明人： Paul L. Bolen , Paul L. Cihak , Lewis G. Scharpf, Jr.
IPC分类号： C12N916
CPC分类号： C12N9/20 , A23C19/043 , A61K38/00
摘要： The present invention provides kPGE and derivative polypeptides which are capable of being produced by genetic recombination and used to produce EMCs. This invention further provides nucleic acid sequences encoding kPGE and derivative polypeptides which can be used to create recombinant host cells that express kPGE and derivative polypeptides. A further subject of the present of invention is a fusion polypeptide called polyHis-enterokinase which increases expression of esterases and lipases when fused to the N-terminal of the esterase or lipase. This invention also provides a method for treating animals with an esterase or lipase deficiency by administering rkPGE to the animal in a therapeutically effective amount.

45. 发明授权

US06569659B1 Phytase polypeptides 失效
公开(公告)号：US06569659B1
公开(公告)日：2003-05-27
申请号：US09482558
申请日：2000-01-13
申请人： Soren Flensted Lassen , Lisbeth Bech , Anders Ohmann , Jens Breinholt , Claus Crone Fuglsang , Peter Rahbek Ostergaard
发明人： Soren Flensted Lassen , Lisbeth Bech , Anders Ohmann , Jens Breinholt , Claus Crone Fuglsang , Peter Rahbek Ostergaard
IPC分类号： C12N916
CPC分类号： C12Y301/03026 , A23K20/189 , A23L5/25 , A23L29/06 , A63B57/00 , A63B57/357 , A63B57/40 , C12N9/16 , C12P3/00
摘要： The present invention relates to isolated polypeptides having phytase activity, the corresponding cloned DNA sequences, a process for preparing such polypeptides, and the use thereof for a number of industrial applications. In particular, the invention relates to phytases derived from the phyllum Basidiomycota, phytases of certain consensus sequences and fungal 6-phytases.

46. 发明授权

US06492157B1 DSP-9 dual-specificity phosphatase 失效
标题翻译： DSP-9双特异性磷酸酶
公开(公告)号：US06492157B1
公开(公告)日：2002-12-10
申请号：US09544716
申请日：2000-04-06
申请人： Ralf M. Luche , Bo Wei
发明人： Ralf M. Luche , Bo Wei
IPC分类号： C12N916
CPC分类号： C12Y301/03016 , C12N9/16 , C12Y301/03048
摘要： Compositions and methods are provided for the treatment of conditions associated with cells proliferation, cells differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-9, and polypeptide variants thereof that stimulate dephosphorylation of DSP-9 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-9 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.
摘要翻译：提供组合物和方法用于治疗与细胞增殖，细胞分化和细胞存活相关的病症。特别地，提供了刺激DSP-9底物去磷酸化的双重特异性磷酸酶DSP-9及其多肽变体。多肽可用于例如鉴定抑制DSP-9活性的抗体和其它试剂。多肽和试剂可用于调节细胞增殖，分化和存活。

47. 发明授权

US06440684B1 Methods of identifying modulators of kinesin motor proteins 失效
标题翻译：鉴定驱动蛋白运动蛋白调节剂的方法
公开(公告)号：US06440684B1
公开(公告)日：2002-08-27
申请号：US09592054
申请日：2000-06-12
申请人： Christophe Beraud , Jeffrey T. Finer , Roman Sakowicz , Kenneth W. Wood
发明人： Christophe Beraud , Jeffrey T. Finer , Roman Sakowicz , Kenneth W. Wood
IPC分类号： C12N916
CPC分类号： C12N9/14 , C12N9/16 , C12Q1/34 , G01N33/6893 , G01N2500/00
摘要： The present invention provides high throughput screening systems for identifying compounds useful in the treatment of cellular proliferation disorders. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
摘要翻译：本发明提供用于鉴定可用于治疗细胞增殖障碍的化合物的高通量筛选系统。该方法可以多次同时进行荧光或吸光度读数。

48. 发明授权

US06399346B1 Human kinesin-like protein HsKif16b 失效
标题翻译：人驱动蛋白样蛋白HsKif16b
公开(公告)号：US06399346B1
公开(公告)日：2002-06-04
申请号：US09721832
申请日：2000-11-24
申请人： Christophe Beraud , Richard Freedman
发明人： Christophe Beraud , Richard Freedman
IPC分类号： C12N916
CPC分类号： C12N9/14 , C07K2319/00
摘要： The invention provides isolated nucleic acid and amino acid sequences of HsKif16b, antibodies to HsKif16b, methods of screening for HsKif16b modulators using biologically active HsKif16b, and kits for screening for HsKif16b modulators.
摘要翻译：本发明提供HsKif16b的分离的核酸和氨基酸序列，HsKif16b的抗体，使用生物活性HsKif16b筛选HsKif16b调节剂的方法，以及用于筛选HsKif16b调节剂的试剂盒。

49. 发明授权

US06333184B1 Motor proteins and methods for their use 失效
标题翻译：运动蛋白及其使用方法
公开(公告)号：US06333184B1
公开(公告)日：2001-12-25
申请号：US09718841
申请日：2000-11-22
申请人： Christophe Beraud , Richard Freedman
发明人： Christophe Beraud , Richard Freedman
IPC分类号： C12N916
CPC分类号： C12N9/14
摘要： The invention provides isolated nucleic acid and amino acid sequences of HsKif16a, antibodies to HsKif16a, methods of screening for HsKif16a modulators using biologically active HsKif16a, and kits for screening for HsKif16a modulators.
摘要翻译：本发明提供HsKif16a的分离的核酸和氨基酸序列，HsKif16a的抗体，使用生物活性HsKif16a筛选HsKif16a调节剂的方法，以及用于筛选HsKif16a调节剂的试剂盒。

50. 发明授权

US06331424B1 Motor proteins and methods for their use 失效
标题翻译：运动蛋白及其使用方法
公开(公告)号：US06331424B1
公开(公告)日：2001-12-18
申请号：US09594669
申请日：2000-06-15
申请人： Christophe Beraud , Roman Sakowicz
发明人： Christophe Beraud , Roman Sakowicz
IPC分类号： C12N916
CPC分类号： C12N9/14 , C12Q1/42 , C12Q1/48 , C12Q1/50
摘要： The present invention provides high throughput screening systems for identifying compounds useful in the treatment of cellular proliferation disorders. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
摘要翻译：本发明提供用于鉴定可用于治疗细胞增殖障碍的化合物的高通量筛选系统。该方法可以多次同时进行荧光或吸光度读数。

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