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41. 发明申请

US20030203046A1 Solutions and aerosols of metal-containing compounds 有权
标题翻译：含金属化合物的溶液和气溶胶
公开(公告)号：US20030203046A1
公开(公告)日：2003-10-30
申请号：US10364983
申请日：2003-02-12
发明人： Robert E. Burrell , Scott H. Gillis , Paul Schechter , John B. Wright , Kan Lam , Hua Qing Yin , Antony G. Naylor , Peter H. Moxham
IPC分类号： A61K033/38 , A61K033/26 , A61K033/24 , A61K033/04
CPC分类号： A61K9/0024 , A61K8/19 , A61K9/0019 , A61K9/0078 , A61K9/14 , A61K9/1682 , A61K9/51 , A61K9/7007 , A61K9/7023 , A61K31/28 , A61K33/24 , A61K33/38 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K2800/413 , A61L15/46 , A61L17/145 , A61L27/30 , A61L29/10 , A61L31/082 , A61L2300/104 , A61L2300/404 , A61L2300/606 , A61L2300/63 , A61Q17/005 , A61Q19/00 , B82Y5/00 , Y10S514/858 , Y10S514/859 , Y10S514/865 , Y10S514/886 , Y10S514/887 , Y10S514/936 , Y10S514/937 , Y10S514/938 , Y10S514/946 , Y10S514/964 , A61K2300/00
摘要： Solutions and aerosols of metal-containing compounds are disclosed. Methods of preparing and using the solutions and aerosols, particularly in the treatment of a subject having a condition, are also disclosed. The metal-containing material can be, for example, an antimicrobial material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, and/or an MMP modulating material. In certain embodiments, the metal-containing material is an atomically disordered, silver-containing material.
摘要翻译：公开了含金属化合物的溶液和气溶胶。还公开了制备和使用溶液和气溶胶的方法，特别是用于治疗患有病症的受试者。含金属材料可以是例如抗微生物材料，抗菌材料，抗炎材料，抗真菌材料，抗病毒材料，抗癌材料，原凋亡物质和 /或MMP调节材料。在某些实施方案中，含金属的材料是原子上无序的含银材料。

42. 发明申请

US20030199484A1 Method for the treatment of urinary incontinence 失效
公开(公告)号：US20030199484A1
公开(公告)日：2003-10-23
申请号：US10394038
申请日：2003-03-21
发明人： Frank S. Caruso
IPC分类号： A61K031/56 , A61K031/485 , A61K031/353 , A61K031/137
CPC分类号： A61K31/00 , A61K31/485 , A61K31/565 , Y10S514/963 , Y10S514/964 , A61K31/46 , A61K31/445 , A61K31/35 , A61K31/335 , A61K31/215 , A61K31/135 , A61K2300/00
摘要： Urinary incontinence is alleviated in a mammal by administering to the mammal a urinary incontinence alleviating amount of dextromethorphan, dextrorphan, their mixtures and/or pharmaceutically acceptable salts, alone or in combination with a pharmacologically active agent such as an anticholinergic, sympathomimetic, tricyclic antidepressant, antispasmodic, direct-acting smooth muscle relaxant, estrogen, compound having estrogen-like activity, or any combination of the foregoing.

43. 发明授权

US06620814B2 Sustained release ranolazine formulations 有权
公开(公告)号：US06620814B2
公开(公告)日：2003-09-16
申请号：US10256993
申请日：2002-09-27
申请人： Andrew A. Wolff , Fiona Baker , John Langridge
发明人： Andrew A. Wolff , Fiona Baker , John Langridge
IPC分类号： A61K31495
CPC分类号： A61K9/2846 , A61K9/2027 , A61K9/205 , A61K9/2054 , A61K9/2077 , A61K9/2866 , A61K31/495 , A61K31/496 , Y10S514/964
摘要： A sustained release ranolazine formulation contains an intimate mixture of ranolazine and a partially neutralized pH-dependent binder to form a film that is mostly insoluble in aqueous media below pH 4.5 and soluble in aqueous media above pH 4.5. The formulation is suitable for twice daily administration of ranolazine and is useful for controlling the rate of dissolution of ranolazine, and to maintain human plasma ranolazine levels at between 550 and 7500 ng base/mL.

44. 发明申请

US20030165571A1 Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles 失效
公开(公告)号：US20030165571A1
公开(公告)日：2003-09-04
申请号：US10359226
申请日：2003-02-06
申请人： Alkermes Controlled Therapeutics Inc. II
发明人： Jean Mesens , Michael E. Rickey , Thomas J. Atkins
IPC分类号： A61K031/519 , A61K009/14
CPC分类号： A61K9/0024 , A61K9/1647 , A61K31/505 , A61K31/517 , A61K31/519 , Y10S514/962 , Y10S514/963 , Y10S514/964 , Y10S514/965
摘要： Sustained-release microparticle composition. The microparticle composition can be formulated to provide multi-phasic release. In one aspect, the composition includes microparticles having more than one rate of release. In another aspect, the composition includes microparticles that exhibit diffusional release and microparticles that exhibit biodegradation release.

45. 发明申请

US20030096024A1 Methods and compositions for the treatment of benign prostatic hypertrophy 失效
标题翻译：用于治疗良性前列腺肥大的方法和组合物
公开(公告)号：US20030096024A1
公开(公告)日：2003-05-22
申请号：US09992433
申请日：2001-11-16
发明人： Sikander Randhava , Surjit Randhava , Sarabjit Randhava
IPC分类号： A61K035/78
CPC分类号： A61K9/5057 , A61K9/4816 , A61K9/4891 , A61K9/5047 , A61K36/185 , A61K36/28 , A61K36/53 , A61K36/534 , A61K36/81 , A61K36/889 , Y10S514/963 , Y10S514/964 , A61K2300/00
摘要： This invention relates to a composition for use in treating benign prostatic hyperplasia including a saw palmetto extract provided in an oral controlled release formulation which allows release of active ingredients in the intestinal tract and which allows the maintenance of therapeutic levels of active agents in the bloodstream for prolonged periods of time. This invention also relates to a composition for improving the efficacy of a saw palmetto extract, a method of treating benign prostatic hypertrophy, and a method of improving the efficacy of a saw palmetto extract treatment.
摘要翻译：本发明涉及一种用于治疗良性前列腺增生的组合物，其包括在口服控制释放制剂中提供的锯棕榈提取物，其允许在肠道中释放活性成分，并且其允许维持血流中的治疗水平的活性剂延长的时间。本发明还涉及用于提高锯棕榈提取物的效力的组合物，治疗良性前列腺肥大的方法，以及提高锯叶棕提取物治疗效果的方法。

46. 发明申请

US20030059440A1 Composition and method for moisturizing nasal tissue 审中-公开
标题翻译：用于保湿鼻组织的组合物和方法
公开(公告)号：US20030059440A1
公开(公告)日：2003-03-27
申请号：US10243637
申请日：2002-09-13
发明人： Tim Clarot , Charles Hensley
IPC分类号： A61K035/78 , A61K035/80 , A61K031/355
CPC分类号： A61K9/0043 , A61K31/315 , A61K47/02 , A61K47/10 , A61K47/183 , A61K47/186 , A61K47/22 , A61K47/46 , Y10S514/944 , Y10S514/964
摘要： An improved composition and method for moisturizing a nasal membrane are disclosed. The composition includes a viscous carrier and one or more moisturizing agents disposed with the carrier. The composition is applied to a portion of a nasal membrane using a spray, a swab applicator, or a similar application device.
摘要翻译：公开了改进的用于保湿鼻膜的组合物和方法。该组合物包括一个粘性载体和一个或多个与载体一起设置的保湿剂。使用喷雾器，拭子涂抹器或类似的施加装置将组合物施加到鼻膜的一部分上。

47. 发明授权

US06517868B2 Amino acid modulated extended release dosage form 有权
公开(公告)号：US06517868B2
公开(公告)日：2003-02-11
申请号：US09997377
申请日：2001-11-30
申请人： A. Reza Fassihi , Thomas Dürig
发明人： A. Reza Fassihi , Thomas Dürig
IPC分类号： A61K926
CPC分类号： A61K9/2077 , A61K9/2013 , A61K9/205 , Y10S514/96 , Y10S514/961 , Y10S514/964 , Y10S514/965
摘要： Disclosed herein is a tableted oral extended release dosage form comprising a plurality of granules of an effective amount of a pharmaceutically active compound, at least one amino acid, and an intragranular polymer in which the granule is dispersed within a hydrophilic extragranular polymer matrix which is more rapidly hydrating than the intragranular polymer. The amino acid is selected for hydropathy characteristics depending on solubility characteristics of the active compound.

48. 发明申请

US20030012814A1 Levofloxacin antibiotic product, use and formulation thereof 有权
标题翻译：左氧氟沙星抗生素产品，其使用和制剂
公开(公告)号：US20030012814A1
公开(公告)日：2003-01-16
申请号：US10027366
申请日：2001-12-20
发明人： Edward M. Rudnic , James D. Isbister , Donald J. Treacy JR. , Sandra E. Wassink
IPC分类号： A61K031/496 , A61K009/22
CPC分类号： A61K9/2081 , A61K9/1635 , A61K9/1652 , A61K9/5026 , A61K9/5084 , A61K31/00 , A61K31/4164 , A61K31/43 , A61K31/7048 , A61K45/06 , Y10S514/964 , A61K2300/00
摘要： An antibiotic product, in particular levofloxacin, is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antibiotic product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosage form, as well as two or more delayed release dosage forms, with each of the dosage forms having a different release profile, wherein each reaches a Cmax at different times.
摘要翻译：抗生素产品，特别是左氧氟沙星，由至少三种剂型形成，每种剂量形式具有不同的释放特征，抗生素产品的C max在少于约十二小时内达到。在一个实施方案中，存在立即释放剂型以及两种或更多种延迟释放剂型，其中每种剂型具有不同的释放曲线，其中各个在不同时间达到C max。

49. 发明申请

US20020192298A1 Treatment of acne 失效
标题翻译：治疗痤疮
公开(公告)号：US20020192298A1
公开(公告)日：2002-12-19
申请号：US09840637
申请日：2001-04-23
发明人： Robert Edward Burrell , Hua Qing Yin
IPC分类号： A61K033/38
CPC分类号： A61K9/0014 , A61K9/14 , A61K9/70 , A61K33/24 , A61K33/38 , A61L15/46 , A61L17/145 , A61L27/30 , A61L29/10 , A61L31/082 , A61L2300/104 , A61L2300/404 , A61L2300/63 , Y10S514/859 , Y10S514/886 , Y10S514/887 , Y10S514/944 , Y10S514/951 , Y10S514/952 , Y10S514/953 , Y10S514/964 , Y10S514/965 , A61K2300/00
摘要： The invention relates to the use of one or more antimicrobial metals selected from silver, gold, platinum, and palladium but most preferably silver, preferably formed with atomic disorder, and preferably in a nanocrystalline form, for the treatment of a acne. The nanocrystalline antimicrobial metal of choice may be used in the form of a nanocrystalline coating of one or more antimicrobial metals, a nanocrystalline powder of one or more antimicrobial metals, or a solution containing dissolved species from a nanocrystalline powder or coating of one or more antimicrobial metals.
摘要翻译：本发明涉及一种或多种选自银，金，铂和钯但最优选银的抗微生物金属的使用，优选以原子紊乱形成，优选以纳米晶体形式用于治疗痤疮。所选择的纳米晶体抗微生物金属可以以一种或多种抗微生物金属的纳米晶体涂层的形式使用，一种或多种抗微生物金属的纳米晶体粉末，或含有来自纳米晶体粉末或一种或多种抗微生物剂金属。

50. 发明授权

US06479065B2 Process for the preparation of polymer-based sustained release compositions 失效
标题翻译：制备基于聚合物的持续释放组合物的方法
公开(公告)号：US06479065B2
公开(公告)日：2002-11-12
申请号：US09801272
申请日：2001-03-07
申请人： Warren E. Jaworowicz , James I. Wright
发明人： Warren E. Jaworowicz , James I. Wright
IPC分类号： C08J926
CPC分类号： A61K9/1647 , A61K9/1694 , Y10S514/964 , Y10S514/965
摘要： The invention relates to a sustained release composition and methods of forming and using said composition for the sustained release of biologically active agent. The sustained release compositions of the invention comprise a biocompatible polymer and a biologically active agent characterized by a porous center and a less porous outer layer wherein the center and outer layer consist of essentially the same materials. The sustained release compositions can be prepared by annealing at least a substantial portion of the exterior surface of a polymer/active agent matrix. The compositions which have been annealed exhibit a decrease in the release of agent over the first 24 hours following administration (i.e., reduced burst) and as a result can show an increase in the duration of sustained release thereby providing increased therapeutic benefits.
摘要翻译：本发明涉及缓释组合物和形成和使用所述组合物以持续释放生物活性剂的方法。本发明的持续释放组合物包含生物相容性聚合物和生物活性剂，其特征在于多孔中心和较少多孔外层，其中中心层和外层由基本上相同的材料组成。持续释放组合物可以通过使至少大部分的聚合物/活性剂基质的外表面退火来制备。已经退火的组合物在给药后的前24小时表现出试剂释放的降低（即，减少的爆发），结果可以显示持续释放的持续时间的增加，从而提供增加的治疗益处。

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