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1. 发明申请

US20040175397A1 Citrullinylarginine dipeptide analogs and their dermatological uses as care and treatment agents 有权
标题翻译：柠檬酰精氨酸二肽类似物及其皮肤病学用途作为护理和治疗剂
公开(公告)号：US20040175397A1
公开(公告)日：2004-09-09
申请号：US10801592
申请日：2004-03-17
发明人： Marie-Christine Seguin
IPC分类号： A61K038/16 , A61K035/80
CPC分类号： A61Q19/08 , A61K8/44 , A61K8/64 , A61K8/9706 , A61K36/02 , A61K36/04 , A61K38/05 , A61Q19/00 , A61Q19/06
摘要： The present invention relates to an algal adduct of the citrullinylarginine natural dipeptide as well as to its dermatological use and the use of chemical analogs issued from the same dipeptide displaying no toxic potential, as skin and phanera care and treatment agents, the said analogs having the following general formula (I): 1 in which: R1 represents an acyl or acycloxy radical, R2 represents a hydroxyl, amine, alkylamine or alcoxy radical, R3 represents a hydrogen atom or a hydroxyl radical.
摘要翻译：本发明涉及瓜氨酸精氨酸天然二肽的藻类加合物以及其皮肤病学用途以及使用由不具有毒性潜力的相同二肽发出的化学类似物作为皮肤和香精护理和治疗剂，所述类似物具有通式（I）：其中：R1表示酰基或酰基，R2表示羟基，胺，烷基胺或烷氧基，R3表示氢原子或羟基。

2. 发明申请

US20040131636A1 Blood fluidity-improving health foods 审中-公开
标题翻译：血液流动性改善健康食品
公开(公告)号：US20040131636A1
公开(公告)日：2004-07-08
申请号：US10738998
申请日：2003-12-19
申请人： SHIRAKO CO., LTD.
发明人： Hiroshi Hagino , Masanobu Saito
IPC分类号： A61K035/80
CPC分类号： A61K36/04 , A23L17/60 , A23L33/105 , A23L33/12 , A23L33/16 , A61K36/03 , A61K2300/00
摘要： This invention provides a novel health food which is effective in prevention and treatment of life-style related diseases in organs in the circulatory system, such as hypertension, cerebral infarction, myocardial infarction etc. by improving blood fluidity. Phospholipid components or mineral components are collected from seaweeds of the genus Porphyra and/or seaweeds of the genus Undaria and then formed into a health food improving blood fluidity. This health food has an improving action on blood fluidity, and is thus effective in prevention and treatment of life-style related diseases in organs in the circulatory system, such as hypertension, cerebral infarction, myocardial infarction etc.
摘要翻译：本发明提供了一种新颖的保健食品，通过改善血液流动性，有效预防和治疗循环系统器官中的生命方式相关疾病，如高血压，脑梗死，心肌梗死等。磷脂成分或矿物成分从紫菜属紫菜和/或海草属的海草中收集，然后形成健康食品，改善血液流动性。这种保健食品对血液流动性有改善的作用，因此有效预防和治疗循环系统器官中的生活方式相关疾病，如高血压，脑梗死，心肌梗死等。

3. 发明申请

US20040096485A1 Products and methods for maintaining or increasing ceramide levels in skin 失效
标题翻译：用于维持或增加皮肤神经酰胺水平的产品和方法
公开(公告)号：US20040096485A1
公开(公告)日：2004-05-20
申请号：US10299161
申请日：2002-11-19
申请人： Kimberly-Clark Worldwide, Inc.
发明人： David W. Koenig , Jamie Joseph Van Gompel
IPC分类号： A61K035/72 , A61K035/80 , A61K009/70 , A61K035/78
CPC分类号： A61K8/0208 , A61K8/97 , A61K2800/70 , A61K2800/78 , A61Q19/00 , A61Q19/08
摘要： Disclosed are methods and products such as wet wipes and absorbents capable of providing a skin health benefit when utilized in the intended fashion. More specifically, the products described herein comprise an agent, such as a botanical extract, which is capable of increasing the activity of sphingomyelinase according to a Sphingomyelinase Activity Screening Test and/or decreasing the activity of ceramidase according to a Ceramidase Activity Screening Test. By increasing the activity of sphingomyelinase and/or decreasing the activity of ceramidase, the agents in combination with the products described herein are able to maintain or increase the level of ceramides in the skin leading to improved skin health.
摘要翻译：公开了当以预期的方式使用时能够提供皮肤健康益处的湿巾和吸收剂的方法和产品。更具体地，本文所述的产品包含根据鞘磷脂酶活性筛选试验能够增加鞘磷脂酶的活性和/或根据神经酰胺酶活性筛选试验降低神经酰胺酶的活性的试剂，例如植物提取物。通过增加鞘磷脂酶的活性和/或降低神经酰胺酶的活性，与本文所述产品组合的药剂能够维持或增加皮肤中神经酰胺的水平，从而改善皮肤健康。

4. 发明申请

US20040086546A1 Breath freshening and oral cleansing product with cinnamaldehyde 审中-公开
标题翻译：呼吸清新和口服清洁产品与肉桂醛
公开(公告)号：US20040086546A1
公开(公告)日：2004-05-06
申请号：US10607574
申请日：2003-06-25
发明人： James Roy Maxwell , Michael J. Greenberg
IPC分类号： A61K047/00 , A61K031/11 , A61K035/78 , A61K035/80
CPC分类号： A61K36/575 , A23G3/36 , A23L27/79 , A23L33/105 , A23V2002/00 , A61K8/02 , A61K8/0208 , A61K8/33 , A61K8/73 , A61K8/731 , A61K8/732 , A61K8/733 , A61K8/97 , A61K47/22 , A61Q11/00 , A61K2300/00 , A23V2250/5114 , A23V2250/5026 , A23V2250/5028 , A23V2250/6406 , A23V2250/1842 , A23V2250/24 , A23V2250/5036 , A23V2250/5108
摘要： A pullulan-free edible film composition for oral cleansing, breath freshening, and anti-microbial benefits includes a film forming agent and cinnamaldehyde. In a treatment process, effective amounts of cinnamaldehyde is delivered to the oral cavity by the edible film for convenient oral cleansing and breath freshening benefits. A method of making the pullulan-free edible film composition includes forming an aqueous solution of film forming agents and cinnamaldehyde and drying the aqueous solution to form a dry edible film.
摘要翻译：用于口腔清洁，呼吸清新和抗微生物益处的不结露链可食用膜组合物包括成膜剂和肉桂醛。在处理过程中，有效量的肉桂醛通过可食用膜递送到口腔，以方便口腔清洁和呼吸清新效果。制造无支链淀粉的可食用膜组合物的方法包括形成成膜剂和肉桂醛的水溶液，并干燥该水溶液以形成可干燥的可食用膜。

5. 发明申请

US20040081664A1 Oral delivery of a botanical 失效
标题翻译：口服交付植物药
公开(公告)号：US20040081664A1
公开(公告)日：2004-04-29
申请号：US10273981
申请日：2002-10-18
发明人： Robert Gow , John Pierce , Brian Pierce , William Birdsall
IPC分类号： A61K035/80 , A61K035/78
CPC分类号： A61K36/67 , A61K31/365 , A61K31/366 , A61K36/28 , A61K36/48 , A61K45/06 , C07D309/32 , C07D309/38 , C07D309/40 , C07D407/06 , A61K2300/00
摘要： A method of producing a processed kava product involves using an extraction solvent, such as liquid CO2, to preferentially extract different kavalactones from the source material at different rates. By controlling the extraction parameters and stopping the extraction before all of the kavalactones have been extracted or allowing the extracted kavalactones to be preferentially precipitated in one or more collection environments, a processed kava product can be produced that has a kavalactone distribution profile that can differ substantially from that of the source material. As a result, roots from a less desirable kava cultivar can be used to produce a processed kava product which has a kavalactone distribution profile that is similar to that of a highly desired cultivar. The kava paste can be further processed to produce a dry flowable powder suitable for use in, e.g., a tableting formula. A rapid dissolve tablet formulation for use in the delivery of kavalactones and other botanicals is also disclosed.
摘要翻译：生产加工的卡瓦产品的方法涉及使用诸如液体CO 2的提取溶剂以不同的速率从源材料中优先提取不同的卡维乳糖。通过控制提取参数并在所有的Kavalactone已被提取之前停止提取，或允许提取的kavalactones在一个或多个收集环境中优先沉淀，可以生产具有可以显着差异的Kavalactone分布分布的加工的卡瓦产品从源材料。结果，来自较不理想的卡拉品种的根可以用于生产加工的卡瓦产品，其具有与高度期望的品种相似的考卡内酯分布轮廓。可以进一步处理卡瓦酱以产生适用于例如压片配方的干燥可流动粉末。还公开了用于输送卡维内酯和其它植物药物的快速溶解片剂制剂。

6. 发明申请

US20020076431A1 Food or beverage additive containing fucoidan and food and beverage containing fucoidan 失效
标题翻译：含有岩藻依聚糖的食品或饮料添加剂和含有岩藻依聚糖的食品和饮料
公开(公告)号：US20020076431A1
公开(公告)日：2002-06-20
申请号：US09987715
申请日：2001-11-15
发明人： Yoshihisa Umeda , Hiroshi Kihara , Katsushige Ikai , Ikunoshin Kato
IPC分类号： A61K035/80 , A61K047/00 , A61K031/715
CPC分类号： A23G3/42 , A21D2/18 , A23C9/152 , A23F3/405 , A23L2/52 , A23L7/109 , A23L13/426 , A23L21/15 , A23L29/256 , A23L33/105 , C07H5/10
摘要： Food or beverage where fucoidan which is derived from a fucoidan-containing substance is contained therein, added thereto and/or diluted therein. Food or beverage where fucoidan which is derived from a fucoidan-containing substance and where algins are reduced or eliminated is contained therein. Apoptosis-inducing food or beverage where an effective amount of fucoidan having an apoptosis-inducing ability is contained therein.
摘要翻译：含有含岩藻依聚糖的物质的岩藻依聚糖含有，添加和/或稀释的食品或饮料。其中含有衍生自含岩藻依聚糖的物质和其中还原或除去藻酸盐的岩藻依聚糖的食品或饮料。其中含有有效量的具有凋亡诱导能力的岩藻依聚糖的诱导细胞凋亡的食物或饮料。

7. 发明申请

US20020009460A1 METHOD OF SEPARATING AND PRODUCING A LIPID RICH-LIPID/PROTEIN COMPLEX AND NATIVE PROTEINS FROM OIL SEEDS 失效
标题翻译：从油种分离和生产脂质丰富的脂质/蛋白复合物和原生质蛋白的方法
公开(公告)号：US20020009460A1
公开(公告)日：2002-01-24
申请号：US09093771
申请日：1998-06-09
发明人： MAKOTO WAKABAYASHI , SATOSHI SUZUKI , KENTARO KAWAMURA , HIROSHI OKADA , KOJI MITSUKI
IPC分类号： A61K039/385 , A61K035/80 , C09H001/04 , C07K017/00
CPC分类号： C11B1/04 , A23J1/14 , A23J3/14 , A23J3/16 , C11B1/10
摘要： A method of producing separated lipid-rich lipid/protein complex and native proteins from oil seeds, by adding a substance having the ability to aggregate lipids with proteins to a water extract of oil seeds, sedimenting or floating a lipid/protein complex having a lipid content of 45% or more as an aggregate, and recovering it for separation from native proteins.
摘要翻译：通过将具有将脂质与蛋白质聚合的能力的物质加入到油籽的水提取物中，从油种中产生分离的富含脂质的脂质/蛋白质复合物和天然蛋白质的方法，沉淀或漂浮具有脂质的脂质/蛋白质复合物作为骨料的含量为45％以上，并将其从天然蛋白质中回收分离。

8. 发明申请

US20040241185A1 Antiviral formulation from Indian seaweeds 审中-公开
标题翻译：来自印度海藻的抗病毒药物
公开(公告)号：US20040241185A1
公开(公告)日：2004-12-02
申请号：US10842968
申请日：2004-05-06
申请人： COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH
发明人： Anil Chatterji , V. K. Dhargalkar , P. K. Syeekumar , Savita Kotnala , Reena Rodrigues
IPC分类号： A61K035/80
CPC分类号： A61K36/03 , A61K2300/00
摘要： An extract with antiviral activity including a mixture of extracts from Spatoglossum asperum., Padina tetrastromatica, Sargassum tenerrimum, and Stoechospermum marginatum. Also, a process for preparation of the extracts, and a method of treatment using the extracts.
摘要翻译：具有抗病毒活性的提取物，包括来自from from属的提取物，Padina tetrastromatica，Sargassum tenerrimum和Stoechospermum margatum的混合物。此外，提取物的制备方法以及使用提取物的处理方法。

9. 发明申请

US20040208892A1 Methods of producing carbon-13 labeled biomass 有权
标题翻译：生产碳13标记生物质的方法
公开(公告)号：US20040208892A1
公开(公告)日：2004-10-21
申请号：US10417951
申请日：2003-04-16
发明人： Keith Darrel Evans , Stanley John Konopka , Eric Charles Henry , William Michael Houston
IPC分类号： A61K035/80 , C12N001/12
CPC分类号： A61K51/1296 , A61K35/748 , A61K49/0004
摘要： A method and apparatus for preparing uniform carbon-13 labeled biomass using a water soluble carbon-13 labeled carbon source, such as a null13Cnull-bicarbonate or null13Cnull-carbonate salt, is disclosed. The biomass is prepared in one or more sterile carboys filled with growth medium, in which acidity, oxygen, and biomass density are carefully monitored and maintained. By using a solid, water-soluble null13Cnull-bicarbonate or null13Cnull-carbonate salt as the sole carbon source, a biomass is provided which is uniformly and efficiently labeled with carbon-13. This method and apparatus is particularly useful for the growth of an edible carbon-13 labeled algal mass, with Spirulina platensis being a specific alga species. The biomass may be prepared in conformance with FDA current good manufacturing practice regulations, and may be harvested and formed into lyophilized bulk drug powder which may be further processed into various drug product forms which are useful for diagnostic tests or in pharmaceutical compositions.
摘要翻译：公开了一种使用水溶性碳-13标记的碳源（例如[13 C] - 碳酸氢盐或[13 C] - 碳酸盐）制备均匀的碳-13标记的生物质的方法和装置。在一个或多个填充有生长培养基的无菌碳水化合物中制备生物质，其中仔细监测和维持酸度，氧气和生物质密度。通过使用固体的水溶性[13 C] - 碳酸氢盐或[13 C] - 碳酸盐盐作为唯一的碳源，提供了用碳-13均匀有效地标记的生物质。该方法和装置对于可食用的碳-13标记藻类物质的生长特别有用，螺旋藻是特定的藻种。生物质可以根据目前良好的制造实践规定制备，并且可以收获并形成冻干的散装药物粉末，其可以进一步加工成用于诊断测试或药物组合物的各种药物产品形式。

10. 发明申请

US20040156818A1 Topical cosmetic composition with skin rejuvenation benefits 审中-公开
标题翻译：局部化妆品组合与皮肤复兴的好处
公开(公告)号：US20040156818A1
公开(公告)日：2004-08-12
申请号：US10773001
申请日：2004-02-05
申请人： Avon Products, Inc.
发明人： Michelle Lu , Michele Duggan , Gopinathan K. Menon , Eugenia H. Theophilus , Sujatha Dokka , Helen Wang
IPC分类号： A61K007/06 , A61K035/78 , A61K035/80
CPC分类号： A61K36/03 , A61K8/97 , A61K8/9706 , A61K36/185 , A61K36/23 , A61K36/42 , A61K36/53 , A61K36/537 , A61K36/58 , A61K36/76 , A61K36/87 , A61K36/88 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要： There are provided topical cosmetic compositions for improving the aesthetic appearance of skin and remediating the effects of aging, and methods of use thereof. One composition is a blend of neem seed cell broth and one or more additional botanical ingredients. Another composition has pomegranate fruit extract and, optionally, one or more additional botanical ingredients.
摘要翻译：提供了用于改善皮肤美学外观和修复老化效果的局部化妆品组合物及其使用方法。一种组合物是楝树种子细胞汤和一种或多种另外的植物成分的混合物。另一种组合物具有石榴果实提取物和任选的一种或多种另外的植物成分。

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